The DOI matches its Crossref record; 125 of the 126 references it cites were found in a registry or an index.
Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy
Abstract
Autophagy is fundamental to the maintenance of intracellular homeostasis in virtually all human cells. Accordingly, defective autophagy predisposes healthy cells to undergoing malignant transformation. By contrast, malignant cells are able to harness autophagy to thrive, despite adverse microenvironmental conditions, and to resist therapeutic challenges. Thus, inhibition of autophagy has been proposed as a strategy to kill cancer cells or sensitize them to therapy; however, autophagy is also critical for optimal immune function, and mediates cell-extrinsic homeostatic effects owing to its central role in danger signalling by neoplastic cells responding to immunogenic chemotherapy and/or radiation therapy. In this Perspective, we discuss accumulating preclinical and clinical evidence in support of the all-too-often dismissed possibility that activating autophagy might be a relevant clinical objective that enables an increase in the effectiveness of immunogenic chemotherapy and/or radiation therapy.
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“ICD can be initiated by a relatively restricted set of stimuli, including viral infection, some FDA-approved chemotherapeutics (e.g., anthracyclines, bortezomib), specific forms of radiation therapy, and hypericin-based photodynamic therapy [854–861].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [856]
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Metadata
- Authors
- Galluzzi, L., Bravo-San Pedro, J. M., Demaria, S., Formenti, S. C., & Kroemer, G.
- Affiliations
- Inserm (FR)
- Weill Cornell Medicine (US)
- Karolinska University Hospital (SE)
- Corresponding author
- Galluzzi, Lorenzo
- Venue
- Nature Reviews Clinical Oncology
- Published
- 2016-11-15
- Volume
- 14
- Issue
- 4
- Pages
- 247-258
- ISSN
- 1759-4774 (ISSN-L)
- 1759-4782
- OpenAlex
- W2549172728
- Cited by
- 314
- References
- 126
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 22 · 2023: 36 · 2022: 36 · 2021: 30 · 2020: 43 · 2019: 45 · 2018: 43 · 2017: 30 · 2016: 1
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA198533, R01CA161891, R01CA201246)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- autophagy, autophagy activation, immunogenic chemotherapy, radiotherapy, cancer immunotherapy, antitumor immunity, autophagy inhibition, tumor microenvironment, tumor immunosuppression
- MeSH terms
- Autophagy, Clinical Trials as Topic, Forecasting, Humans, Immunotherapy, Neoplasms, Tumor Microenvironment
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