The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?
Open accessAbstract
Conventional radiotherapy, in addition to its well-established tumoricidal effects, can also activate the host immune system. Radiation therapy modulates tumour phenotypes, enhances antigen presentation and tumour immunogenicity, increases production of cytokines and alters the tumour microenvironment, enabling destruction of the tumour by the immune system. Investigating the combination of radiotherapy with immunotherapeutic agents, which also promote the host antitumour immune response is, therefore, a logical progression. As the spectrum of clinical use of stereotactic radiotherapy continues to broaden, the question arose as to whether the ablative radiation doses used can also stimulate immune responses and, if so, whether we can amplify these effects by combining immunotherapy and stereotactic ablative radiotherapy (SABR). In this Perspectives article, we explore the preclinical and clinical evidence supporting activation of the immune system following SABR. We then examine studies that provide data on the effectiveness of combining these two techniques — immunotherapy and SABR — in an approach that we have termed 'ISABR'. Lastly, we provide general guiding principles for the development of future clinical trials to investigate the efficacy of ISABR in the hope of generating further interest in these exciting developments.
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Cites
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Cited by
Using immunotherapy to boost the abscopal effect
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“[100] Additionally, DNA damage by radiotherapy is able to induce the expression of NKG2D ligands on tumour cells, [101,102] which may promote activation of NK cells and enhance their cytotoxicity against tumour cells.”
BackgroundMetformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1
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Improving immune–vascular crosstalk for cancer immunotherapy
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Time to abandon single-site irradiation for inducing abscopal effects
Brooks, E. D., & Chang, J. Y. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0119-7 · Cited by 313
Self-citation
Metadata
- Authors
- Bernstein, M. B., Krishnan, S., Hodge, J. W., & Chang, J. Y.
- Venue
- Nature Reviews Clinical Oncology
- Published
- 2016-03-08
- Volume
- 13
- Issue
- 8
- Pages
- 516-524
- ISSN
- 1759-4774 (ISSN-L)
- 1759-4782
- OpenAlex
- W2293494611
- Cited by
- 399
- References
- 12
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- green
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