Tisagenlecleucel — the first approved CAR-T-cell therapy: implications for payers and policy makers
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CAR T-cells are genetically modified cytotoxic T cells that target particular cancer-related antigens and were given clinical approval in 2017.
“They are genetically modified cytotoxic T cells that target particular cancer-related antigens and were given clinical approval in 2017.323”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [323]
Several viral vector mediated cellular and gene-therapy products, such as Kymriah for CAR-T immunotherapy on lymphoblastic leukemia, have gained FDA approval.
“Several viral vector mediated cellular and gene-therapy products, such as Kymriah for CAR-T immunotherapy on lymphoblastic leukemia, have already gained FDA approval.[27]”
From RNA delivery biomaterials for the treatment of genetic and rare diseases (2019) · cites this paper as [27]
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FDA approves tisagenlecleucel for B-cell ALL and tocilizumab for cytokine release syndrome
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- Authors
- Prasad, V.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Prasad, Vinay
- ORCID
- Prasad, Vinay
- Venue
- Nature Reviews Clinical Oncology
- Published
- 2017-10-04
- Volume
- 15
- Issue
- 1
- Pages
- 11-12
- ISSN
- 1759-4774 (ISSN-L)
- 1759-4782
- OpenAlex
- W2761202053
- Cited by
- 229
- References
- 5
- Citations by year
- 2026: 17 · 2025: 12 · 2024: 27 · 2023: 28 · 2022: 36 · 2021: 31 · 2020: 28 · 2019: 25 · 2018: 24 · 2017: 1
- FWCI
- 9.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Clinical Oncology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Economic and Financial Impacts of Cancer
- Keywords
- tisagenlecleucel, CAR T-cell therapy, FDA approval, health care costs, drug pricing, health policy, health insurance coverage, treatment toxicity, healthcare logistics
- MeSH terms
- Receptors, Chimeric Antigen, Humans, Immunotherapy, Neoplasms, Receptors, Antigen, T-Cell, Immunotherapy, Adoptive
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