The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Coronaviruses — drug discovery and therapeutic options
Open accessAbstract
In humans, infections with the human coronavirus (HCoV) strains HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 usually result in mild, self-limiting upper respiratory tract infections, such as the common cold. By contrast, the CoVs responsible for severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), which were discovered in Hong Kong, China, in 2003, and in Saudi Arabia in 2012, respectively, have received global attention over the past 12 years owing to their ability to cause community and health-care-associated outbreaks of severe infections in human populations. These two viruses pose major challenges to clinical management because there are no specific antiviral drugs available. In this Review, we summarize the epidemiology, virology, clinical features and current treatment strategies of SARS and MERS, and discuss the discovery and development of new virus-based and host-based therapeutic options for CoV infections.
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Cites
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
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Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
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Cited by
Guo (2020) · doi:10.1186/s40779-020-00240-0 · Cited by 4,735
The pathogenesis and treatment of the `Cytokine Storm' in COVID-19
Ye, Q., Wang, B., & Mao, J. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.03.037 · Cited by 2,761
Channappanavar, R., & Perlman, S. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0629-x · Cited by 2,524
The cytokine storm and COVID-19
Hu, B., Huang, S., & Yin, L. (2021) · Journal of Medical Virology · doi:10.1002/jmv.26232 · Cited by 1,655
Brann, D. H., Tsukahara, T., Weinreb, C., Lipovsek, M., Van den Berge, K., Gong, B., Chance, R., Macaulay, I. C., Chou, H.-J., Fletcher, R. B., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc5801 · Cited by 1,198
Metadata
- Authors
- Zumla, A., Chan, J. F. W., Azhar, E. I., Hui, D. S. C., & Yuen, K.-Y.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2016-02-12
- Volume
- 15
- Issue
- 5
- Pages
- 327-347
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2255243349
- Cited by
- 1,707
- References
- 8
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zumla, A., Chan, J. F. W., Azhar, E. I., Hui, D. S. C., & Yuen, K.-Y. (2016). Coronaviruses — drug discovery and therapeutic options. Nature Reviews Drug Discovery. https://doi.org/10.1038/nrd.2015.37
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
