Identification and validation of biomarkers for autism spectrum disorders
Open accessThe claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is a complete lack of pharmacological therapies motivated by concrete pathophysiological theories that influence either neurodevelopment in children or tackle the mechanisms behind autistic symptoms in adolescents and adults.
“(viii) There is a complete lack of pharmacological therapies that are motivated by concrete pathophysiological theories and influence either the neurodevelopment in children or tackle the mechanisms behind autistic symptoms in adolescents and adults (53, 54).”
From Can Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice? (2016) · cites this paper as [53]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318179964f · Cited by 3,399 · see citing works
Self-citationToward the future of psychiatric diagnosis: the seven pillars of RDoC
Cuthbert, B. N., & Insel, T. R. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-126 · Cited by 3,053 · see citing works
Sex/Gender Differences and Autism: Setting the Scene for Future Research
Lai, M.-C., Lombardo, M. V., Auyeung, B., Chakrabarti, B., & Baron-Cohen, S. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.10.003 · Cited by 1,120 · see citing works
Self-citation(2013) · Routledge eBooks · doi:10.4324/9780203494035-16 · Cited by 663 · see citing works
IQ in children with autism spectrum disorders: Data from the special needs and autism project (SNAP)
Charman, T., Pickles, A., Simonoff, E., Chandler, S., Loucas, T., & Baird, G. (2011) · Psychological Medicine · doi:10.1017/s0033291710000991 · Cited by 599 · see citing works
Self-citationEcker, C., Rocha-Rego, V., Johnston, P., Mourão-Miranda, J., Marquand, A. F., Daly, E., Brammer, M. J., Murphy, C. M., & Murphy, D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.08.024 · Cited by 387 · see citing works
Self-citationDifferent Functional Neural Substrates for Good and Poor Language Outcome in Autism
Lombardo, M. V., Pierce, K., Eyler, L. T., Barnes, C. C., Ahrens‐Barbeau, C., Solso, S., Campbell, K. M., & Courchesne, E. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.023 · Cited by 209 · see citing works
Self-citationDrug discovery for autism spectrum disorder: challenges and opportunities
Ghosh, A., Michalon, A., Lindemann, L., Fontoura, P., & Santarelli, L. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4102 · Cited by 108 · see citing works
EU-AIMS: a boost to autism research
Murphy, D., & Spooren, W. P. J. M. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3881 · Cited by 66 · see citing works
Self-citationSerotonin and the Neural Processing of Facial Emotions in Adults With Autism
Daly, E., Deeley, Q., Ecker, C., Craig, M., Hallahan, B. P., Murphy, C. M., Johnston, P., Spain, D., Gillan, N., Brammer, M. J., et al. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2012.513 · Cited by 56 · see citing works
Self-citationBuitelaar, J. K., Wilens, T. E., Zhang, S., Ning, Y., & Feldman, P. D. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01960.x · Cited by 41 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Eva Loth is at the Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK. eva.loth@kcl.ac.uk doi:10.1093/nrd.2015.7 Published online 31 Dec 2015 · DOI
Cited by
Sorted by citations
The Lancet Commission on the future of care and clinical research in autism
Lord, C., Charman, T., Havdahl, A., Carbone, P., Anagnostou, E., Boyd, B., Carr, T., de Vries, P. J., Dissanayake, C., Divan, G., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)01541-5 · Cited by 924 · see citing works
Self-citationDeriving reproducible biomarkers from multi-site resting-state data: An Autism-based example
Abraham, A., Milham, M. P., Di Martino, A., Craddock, R. C., Samaras, D., Thirion, B., & Varoquaux, G. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.10.045 · Cited by 701 · see citing works
The Female Autism Phenotype and Camouflaging: a Narrative Review
Hull, L., Petrides, K. V., & Mandy, W. (2020) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-020-00197-9 · Cited by 614 · see citing works
Big data approaches to decomposing heterogeneity across the autism spectrum
Lombardo, M. V., Lai, M.-C., & Baron-Cohen, S. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0321-0 · Cited by 537 · see citing works
Self-citationDevelopment and validation of the camouflaging autistic traits questionnaire (CAT-Q)
Hull, L., Mandy, W., Lai, M.-C., Baron-Cohen, S., Allison, C., Smith, P., & Petrides, K. V. (2019) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-018-3792-6 · Cited by 496 · see citing works
Self-citationLoth, E., Charman, T., Mason, L., Tillmann, J., Jones, E. J. H., Wooldridge, C., Ahmad, J., Auyeung, B., Brogna, C., Ambrosino, S., et al. (2017) · Molecular Autism · doi:10.1186/s13229-017-0146-8 · Cited by 299 · see citing works
Self-citationThe EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation
Charman, T., Loth, E., Tillmann, J., Crawley, D., Wooldridge, C., Goyard, D., Ahmad, J., Auyeung, B., Ambrosino, S., Banaschewski, T., et al. (2017) · Molecular Autism · doi:10.1186/s13229-017-0145-9 · Cited by 183 · see citing works
Self-citationAutism spectrum disorder in sub‐saharan africa: A comprehensive scoping review
Franz, L., Chambers, N., von Isenburg, M., & de Vries, P. J. (2017) · Autism Research · doi:10.1002/aur.1766 · Cited by 189 · see citing works
“Social-Cognitive and Developmental Neuroscience – Knowledge Gaps in SSA A very significant body of research has emerged from high-income countries on the social-cognitive and developmental neuroscience of ASD [Loth et al., 2016; Milosavljevic et al., 2016; Thomas, Davis, KarmiloffSmith, Knowland, & Charman, 2016].”
BackgroundCan Bayesian Theories of Autism Spectrum Disorder Help Improve Clinical Practice?
Haker, H., Schneebeli, M., & Stephan, K. E. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00107 · Cited by 130 · see citing works
Bast, N., Poustka, L., & Freitag, C. M. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13795 · Cited by 121 · see citing works
Lefebvre, A., Delorme, R., Delanoë, C., Amsellem, F., Beggiato, A., Germanaud, D., Bourgeron, T., Toro, R., & Dumas, G. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00662 · Cited by 58 · see citing works
Self-citationThe meaning of significant mean group differences for biomarker discovery
Loth, E., Ahmad, J., Chatham, C., López, B., Carter, B., Crawley, D., Oakley, B., Hayward, H., Cooke, J., San José Cáceres, A., et al. (2021) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1009477 · Cited by 52 · see citing works
Self-citationNeuromarkers for Mental Disorders: Harnessing Population Neuroscience
Jollans, L., & Whelan, R. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00242 · Cited by 56 · see citing works
Lesch, K. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12574 · Cited by 12 · see citing works
- Authors
- Loth, E., Spooren, W., Ham, L. M., Isaac, M. B., Auriche-Benichou, C., Banaschewski, T., Baron-Cohen, S., Broich, K., Bölte, S., Bourgeron, T., Charman, T., Collier, D., de Andres-Trelles, F., Durston, S., Ecker, C., Elferink, A., Haberkamp, M., Hemmings, R., Johnson, M. H., Jones, E. J. H., Khwaja, O. S., Lenton, S., Mason, L., Mantua, V., Meyer-Lindenberg, A., Lombardo, M. V., O'Dwyer, L., Okamoto, K., Pandina, G. J., Pani, L., Persico, A. M., Simonoff, E., Tauscher-Wisniewski, S., Llinares-Garcia, J., Vamvakas, S., Williams, S., Buitelaar, J. K., & Murphy, D. G. M.
- Affiliations
- King's College London (GB)
- F. Hoffmann-La Roche AG (CH)
- European Medicines Agency (NL)
- Agence Nationale de Sécurité du Médicament et des Produits de Santé (FR)
- Heidelberg University (DE)
- Federal Institute for Drugs and Medical Devices (DE)
- Karolinska Institutet (SE)
- Institut Pasteur (FR)
- Eli Lilly (United Kingdom) (GB)
- University Medical Center Utrecht (NL)
- Medicines and Healthcare products Regulatory Agency (GB)
- Birkbeck, University of London (GB)
- Medicines Evaluation Board (NL)
- Italian Medicines Agency (IT)
- University of Cambridge (GB)
- Janssen Research & Development (United States) (US)
- Università Campus Bio-Medico (IT)
- Radboud University Medical Center (NL)
- Corresponding author
- Loth, Eva
- ORCID
- Loth, Eva
- Ham, Lindsay M.
- Banaschewski, Tobias
- Broich, Karl
- Bölte, Sven
- Bourgeron, Thomas
- Charman, Tony
- Collier, David
- Ecker, Christine
- Haberkamp, Marion
- Johnson, Mark H.
- Jones, Emily J. H.
- Mason, Luke
- Lombardo, Michael V.
- Okamoto, Koichi
- Pandina, Gahan J.
- Pani, Luca
- Persico, Antonio M.
- Simonoff, Emily
- Buitelaar, Jan K.
- Murphy, Declan G. M.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2015-12-31
- Volume
- 15
- Issue
- 1
- Pages
- 70-70
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2232639819
- Cited by
- 140
- References
- 11
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 16 · 2020: 11 · 2019: 20 · 2018: 19 · 2017: 17 · 2016: 14 · 2015: 1
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Research Portal (King's College London) (submittedVersion)
- HAL (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- BIROn (Birkbeck, University of London) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institute for Health and Care Research (RP-PG-0606-1045, NF-SI-0514-10073)
- Medical Research Council (MR/N026063/1, MR/K021389/1)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- autism spectrum disorder, biomarkers, drug discovery, neurodevelopmental disorders, social communication deficits, sensory disturbances, preclinical drug development, Innovative Medicines Initiative
- MeSH terms
- Autism Spectrum Disorder, Adolescent, Adult, Child, Child, Preschool, Female, Humans, Male, Reproducibility of Results, Biomarkers, Young Adult, Endophenotypes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
