The DOI matches its Crossref record; 190 of the 191 references it cites were found in a registry or an index.
Advances in islet encapsulation technologies
Open accessAbstract
Type 1 diabetes is an autoimmune disorder in which the immune system attacks and destroys insulin-producing islet cells of the pancreas. Although islet transplantation has proved to be successful for some patients with type 1 diabetes, its widespread use is limited by islet donor shortage and the requirement for lifelong immunosuppression. An encapsulation strategy that can prevent the rejection of xenogeneic islets or of stem cell-derived allogeneic islets can potentially eliminate both of these barriers. Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing us to get closer to the goal of encapsulated islet cell therapy for humans.
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“Three general strategies are being investigated: 1) use of immunosuppressive or immunomodulatory drugs; 2) use of a physical barrier (e.g., encapsulation) (288); and 3) gene editing for immune evasion and/or immune protection (289).”
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“One attractive method is to encapsulate the cells in a device with finely controlled pore size that facilitates the diffusion of small molecules like glucose and insulin but blocks immune cells from infiltrating the device.52”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [52]
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1 retracted
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Metadata
- Authors
- Desai, T., & Shea, L. D.
- Affiliations
- University of California, San Francisco (US)
- University of Michigan (US)
- Corresponding author
- Desai, Tejal
- Venue
- Nature Reviews Drug Discovery
- Published
- 2016-12-23
- Volume
- 16
- Issue
- 5
- Pages
- 338-350
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- PMC
- PMC11286215
- OpenAlex
- W2562591732
- Cited by
- 427
- References
- 191
- Citations by year
- 2026: 23 · 2025: 32 · 2024: 34 · 2023: 45 · 2022: 47 · 2021: 67 · 2020: 42 · 2019: 60 · 2018: 52 · 2017: 25
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Update notices
- correction (2017-05-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R01EB009910, R21EB000570)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- islet encapsulation, islet transplantation, type 1 diabetes, xenotransplantation, allogeneic islets, stem cell-derived islets, immunosuppression, biomaterials, nanotechnology
- MeSH terms
- Animals, Diabetes Mellitus, Type 1, Humans, Islets of Langerhans, Stem Cells, Tissue Donors, Islets of Langerhans Transplantation, Nanotechnology
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