Cited by 427Pancreatic function and diabetesTissue Engineering and Regenerative MedicineDiabetes and associated disorders

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Advances in islet encapsulation technologies

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Desai, Tejal, Shea, Lonnie D.·2017·Nature Reviews Drug Discovery

DOI 10.1038/nrd.2016.232PMC PMC11286215

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Abstract

Type 1 diabetes is an autoimmune disorder in which the immune system attacks and destroys insulin-producing islet cells of the pancreas. Although islet transplantation has proved to be successful for some patients with type 1 diabetes, its widespread use is limited by islet donor shortage and the requirement for lifelong immunosuppression. An encapsulation strategy that can prevent the rejection of xenogeneic islets or of stem cell-derived allogeneic islets can potentially eliminate both of these barriers. Although encapsulation technology has met several challenges, the convergence of expertise in materials, nanotechnology, stem cell biology and immunology is allowing us to get closer to the goal of encapsulated islet cell therapy for humans.

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Authors: Desai, T., & Shea, L. D.
Affiliations: University of California, San Francisco (US)
University of Michigan (US)
Corresponding author: Desai, Tejal
ORCID: Desai, Tejal
Shea, Lonnie D.
Venue: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Published: 2016-12-23
Volume: 16
Issue: 5
Pages: 338-350
ISSN: 1474-1776 (ISSN-L)
1474-1784
DOI: 10.1038/nrd.2016.232
PMC: PMC11286215
OpenAlex: W2562591732
Cited by: 427
References: 191
Citations by year: 2026: 23 · 2025: 32 · 2024: 34 · 2023: 45 · 2022: 47 · 2021: 67 · 2020: 42 · 2019: 60 · 2018: 52 · 2017: 25
FWCI: 8.73
Type: journal article
Language: en
Update notices: correction (2017-05-01)
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Drug Discovery (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Biomedical Imaging and Bioengineering (R01EB009910, R21EB000570)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords: islet encapsulation, islet transplantation, type 1 diabetes, xenotransplantation, allogeneic islets, stem cell-derived islets, immunosuppression, biomaterials, nanotechnology
MeSH terms: Animals, Diabetes Mellitus, Type 1, Humans, Islets of Langerhans, Stem Cells, Tissue Donors, Islets of Langerhans Transplantation, Nanotechnology

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