Advances in islet encapsulation technologies

Molecular Biology of the Cell

Alberts, B., Johnson, A., Lewis, J. H., Morgan, D. O., RAFF, M. C., Roberts, K. J., & Walter, P. (2017) · W.W. Norton eBooks · doi:10.1201/9781315735368 · Cited by 7,937

Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen

Shapiro, A. M. J., Lakey, J. R. T., Ryan, E. A., Korbutt, G. S., Toth, E., Warnock, G. L., Kneteman, N. M., & Rajotte, R. V. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430401 · Cited by 5,237

Mesenchymal stem cells in health and disease

Uccelli, A., Moretta, L., & Pistoia, V. (2008) · Nature reviews. Immunology · doi:10.1038/nri2395 · Cited by 3,838

Macrophage activation and polarization

Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160

Introduction to Protein Structure

Brändén, C.-I., & Tooze, J. (2012) · Garland Science eBooks · doi:10.1201/9781136969898 · Cited by 2,398

Microencapsulated Islets as Bioartificial Endocrine Pancreas

Lim, F., & Sun, A. M. (1980) · Science · doi:10.1126/science.6776628 · Cited by 2,377

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

Thomlinson, R. H., & Gray, L. H. (1955) · British Journal of Cancer · doi:10.1038/bjc.1955.55 · Cited by 2,228

Generation of Functional Human Pancreatic β Cells In Vitro

Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.040 · Cited by 2,025

International trial of the Edmonton protocol for islet transplantation

Shapiro, A. M. J., Ricordi, C., Hering, B. J., Auchincloss, H., Lindblad, R., Robertson, R. P., Secchi, A., Brendel, M. D., Berney, T., Brennan, D. C., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061267 · Cited by 1,942

Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells

D’Amour, K. A., Bang, A. G., Eliazer, S., Kelly, O., Agulnick, A. D., Smart, N. G., Moorman, M. A., KROON, E. J., Carpenter, M. K., & Baetge, E. E. (2006) · Nature Biotechnology · doi:10.1038/nbt1259 · Cited by 1,913

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

Kroon, E., Martinson, L. A., Kadoya, K., Bang, A. G., Kelly, O. G., Eliazer, S., Young, H., Richardson, M., Smart, N. G., Cunningham, J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1393 · Cited by 1,843

Efficient differentiation of human embryonic stem cells to definitive endoderm

D'Amour, K. A., Agulnick, A. D., Eliazer, S., Kelly, O. G., Kroon, E., & Baetge, E. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1163 · Cited by 1,730

Five-Year Follow-Up After Clinical Islet Transplantation

Ryan, E. A., Paty, B. W., Senior, P. A., Bigam, D., Alfadhli, E., Kneteman, N. M., Lakey, J. R. T., & Shapiro, A. M. J. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2060 · Cited by 1,641

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

Rezania, A., Bruin, J. E., Arora, P., Rubin, A., Batushansky, I., Asadi, A., O'Dwyer, S., Quiskamp, N., Mojibian, M., Albrecht, T., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3033 · Cited by 1,575

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

Bluestone, J. A., Buckner, J. H., Fitch, M., Gitelman, S. E., Gupta, S., Hellerstein, M. K., Herold, K. C., Lares, A., Lee, M. R., Li, K., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aad4134 · Cited by 1,033

Semipermeable Microcapsules

Chang, T. M. S. (1964) · Science · doi:10.1126/science.146.3643.524 · Cited by 1,016

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

Veiseh, O., Doloff, J. C., Ma, M., Vegas, A. J., Tam, H. H., Bader, A. R., Li, J., Langan, E., Wyckoff, J., Loo, W. S., et al. (2015) · Nature Materials · doi:10.1038/nmat4290 · Cited by 897

Improvement in outcomes of clinical islet transplantation: 1999–2010

Barton, F. B., Rickels, M. R., Alejandro, R., Hering, B. J., Wease, S., Naziruddin, B., Oberholzer, J., Odorico, J. S., Garfinkel, M. R., Levy, M., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0063 · Cited by 725

Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice

Vegas, A. J., Veiseh, O., Gürtler, M., Millman, J. R., Pagliuca, F. W., Bader, A. R., Doloff, J. C., Li, J., Chen, M., Olejnik, K., et al. (2016) · Nature Medicine · doi:10.1038/nm.4030 · Cited by 710

Proangiogenic scaffolds as functional templates for cardiac tissue engineering

Madden, L. R., Mortisen, D. J., Sussman, E. M., Dupras, S. K., Fugate, J. A., Cuy, J. L., Hauch, K. D., Laflamme, M. A., Murry, C. E., & Ratner, B. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006442107 · Cited by 662

Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation

Soon‐Shiong, P., Heintz, R. E., Merideth, N. R., Yao, Q. X., Yao, Z., Zheng, T., Murphy, M. B., Moloney, M., Schmehl, M., Harris, M., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90067-1 · Cited by 659

Phase 3 trial of transplantation of human islets in type 1 diabetes complicated by severe hypoglycemia

Hering, B. J., Clarke, W. R., Bridges, N. D., Eggerman, T. L., Alejandro, R., Bellin, M. D., Chaloner, K., Czarniecki, C. W., Goldstein, J. S., Hunsicker, L. G., et al. (2016) · Diabetes Care · doi:10.2337/dc15-1988 · Cited by 645

Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro

Russ, H. A., Parent, A. V., Ringler, J. J., Hennings, T. G., Nair, G. G., Shveygert, M., Guo, T., Puri, S., Haataja, L., Cirulli, V., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201591058 · Cited by 591

Maturation of Human Embryonic Stem Cell–Derived Pancreatic Progenitors Into Functional Islets Capable of Treating Pre-existing Diabetes in Mice

Rezania, A., Bruin, J. E., Riedel, M. J., Mojibian, M., Asadi, A., Xu, J., Gauvin, R., Narayan, K., Karanu, F., O’Neil, J. J., et al. (2012) · Diabetes · doi:10.2337/db11-1711 · Cited by 582

Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates

Vegas, A. J., Veiseh, O., Doloff, J. C., Ma, M., Tam, H. H., Bratlie, K., Li, J., Bader, A. R., Langan, E., Olejnik, K., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3462 · Cited by 551

Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates

Hering, B. J., Wijkstrom, M. N., Graham, M. L., Hårdstedt, M., Aasheim, T. C., Jie, T., Ansite, J. D., Nakano, M., Cheng, J. J., Li, W. S., et al. (2006) · Nature Medicine · doi:10.1038/nm1369 · Cited by 548

Cell‐demanded release of VEGF from synthetic, biointeractive cell‐ingrowth matrices for vascularized tissue growth

Zisch, A. H., Lütolf, M. P., Ehrbar, M., Raeber, G. P., Rizzi, S. C., Davies, N. H., Schmoekel, H. G., Bezuidenhout, D., Djonov, V., Zilla, P., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-1041fje · Cited by 545

Mechanisms of mesenchymal stromal cell immunomodulation

English, K. (2012) · Immunology and Cell Biology · doi:10.1038/icb.2012.56 · Cited by 533

Neovascularization of synthetic membranes directed by membrane microarchitecture

Brauker, J. H., Carr‐Brendel, V. E., Martinson, L. A., Crudele, J., Johnston, W. D., & Johnson, R. C. (1995) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820291208 · Cited by 517

Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies

Hentze, H., Soong, P. L., Wang, S. T., Phillips, B. W., Putti, T. C., & Dunn, N. R. (2009) · Stem Cell Research · doi:10.1016/j.scr.2009.02.002 · Cited by 514

Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells

Luz‐Crawford, P., Kurte, M., Bravo-Alegria, J. B., Contreras-López, R. A., Nova‐Lamperti, E., Téjédor, G., Noël, D., Jørgensen, C., Figueroa, F. E., Djouad, F., et al. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt216 · Cited by 489

Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways

Cardona, K., Korbutt, G. S., Milas, Z. L., Lyon, J. G., Cano, J., Jiang, W., Bello-Laborn, H., Hacquoil, B., Strobert, E. A., Gangappa, S., et al. (2006) · Nature Medicine · doi:10.1038/nm1375 · Cited by 478

Indexed Pain Journals

(U.S.), N. L. O. M. (2008) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.1080/15360280801989377 · Cited by 474

Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice

Lau, H. T., Yu, M., Fontana, A., & Stoeckert, C. J. (1996) · Science · doi:10.1126/science.273.5271.109 · Cited by 445

Effect of Hypoxia on Insulin Secretion by Isolated Rat and Canine Islets of Langerhans

Dionne, K., Colton, C., & Lyarmush, M. (1993) · Diabetes · doi:10.2337/diab.42.1.12 · Cited by 438

Islet Transplantation as a Treatment for Diabetes — A Work in Progress

Robertson, R. P. (2004) · New England Journal of Medicine · doi:10.1056/nejmra032425 · Cited by 434

Preventing hypoxia-induced cell death in beta cells and islets via hydrolytically activated, oxygen-generating biomaterials

Pedraza, E., Coronel, M. M., Fraker, C. A., Ricordi, C., & Stabler, C. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113560109 · Cited by 399

Induction of Cytokine Production from Human Monocytes Stimulated with Alginate

Otterlei, M., Østgaard, K., Skjåk‐Bræk, G., Smidsrød, O., Soon‐Shiong, P., & Espevik, T. (1991) · Journal of Immunotherapy · doi:10.1097/00002371-199108000-00007 · Cited by 398

A prevascularized subcutaneous device-less site for islet and cellular transplantation

Pepper, A. R., Gala-Lopez, B., Pawlick, R., Merani, S., Kin, T., & Shapiro, A. M. J. (2015) · Nature Biotechnology · doi:10.1038/nbt.3211 · Cited by 381

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

Elias, D., Reshef, T., Birk, O. S., van der Zee, R., WALKER, M. D., & Cohen, I. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3088 · Cited by 370

Cell-Demanded Liberation of VEGF 121 From Fibrin Implants Induces Local and Controlled Blood Vessel Growth

Ehrbar, M., Djonov, V., Schnell, C., Tschanz, S. A., Martiny‐Baron, G., Schenk, U., Wood, J. M., Burri, P. H., Hubbell, J. A., & Zisch, A. H. (2004) · Circulation Research · doi:10.1161/01.res.0000126411.29641.08 · Cited by 362

Microencapsulated Pancreatic Islet Allografts Into Nonimmunosuppressed Patients With Type 1 Diabetes

Calafiore, R., Basta, G., Luca, G., Lemmi, A., Montanucci, M. P., Calabrese, G., Racanicchi, L., Mancuso, F., & Brunetti, P. (2006) · Diabetes Care · doi:10.2337/diacare.29.01.06.dc05-1270 · Cited by 342

Introduction to protein structure

Perham, R. N. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90409-3 · Cited by 335

The chemokine CXCL12 regulates monocyte-macrophage differentiation and RUNX3 expression

Sánchez-Martín, L., Estecha, A., Samaniego, R., Sánchez‐Ramón, S., Vega, M. A., & Sánchez‐Mateos, P. (2010) · Blood · doi:10.1182/blood-2009-12-258186 · Cited by 334

Creating immune privilege: active local suppression that benefits friends, but protects foes

Mellor, A. L., & Munn, D. H. (2007) · Nature reviews. Immunology · doi:10.1038/nri2233 · Cited by 329

Safety and Viability of Microencapsulated Human Islets Transplanted Into Diabetic Humans

Tuch, B., Keogh, G., Williams, L., Wu, W., Foster, J., Vaithilingam, V., & Philips, R. (2009) · Diabetes Care · doi:10.2337/dc09-0744 · Cited by 329

Maintenance of beta-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship

Rn, W., & Rosenberg, L. A. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1630181 · Cited by 322

An encapsulation system for the immunoisolation of pancreatic islets

Wang, T. G., Lacı́k, I., Briššová, M., Anilkumar, A. V., Prokop, A., Hunkeler, D. J., Green, R., Shahrokhi, K. A., & Powers, A. C. (1997) · Nature Biotechnology · doi:10.1038/nbt0497-358 · Cited by 318

Encapsulated islets for diabetes therapy: History, current progress, and critical issues requiring solution

Scharp, D. W., & Marchetti, P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.018 · Cited by 314

Following TRAIL’s path in the immune system

Falschlehner, C., Schaefer, U., & Walczak, H. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03058.x · Cited by 312

Oxygen generating scaffolds for enhancing engineered tissue survival

Oh, S. H., Ward, C. L., Atala, A., Yoo, J. J., & Harrison, B. S. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.065 · Cited by 309

Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease

Miller, S. D., Turley, D. M., & Podojil, J. R. (2007) · Nature reviews. Immunology · doi:10.1038/nri2153 · Cited by 294

Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets

van der Windt, D. J., Bottino, R., Casu, A., Campanile, N., Smetanka, C., He, J., Murase, N., Hara, H., Ball, S. F., Loveland, B. E., et al. (2009) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02850.x · Cited by 294

Complete Protection of Islets Against Allorejection and Autoimmunity by a Simple Barium-Alginate Membrane

Duvivier-Kali, V. F., Omer, A., Parent, R. J., O’Neil, J. J., & Weir, G. C. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1698 · Cited by 292

Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and -9

Ding, Y., Xu, D., Feng, G. L., Bushell, A., Muschel, R. J., & Wood, K. J. (2009) · Diabetes · doi:10.2337/db09-0317 · Cited by 289

Transplantation of human islets without immunosuppression

Ludwig, B., Reichel, A., Steffen, A., Zimerman, B., Schally, A. V., Block, N. L., Colton, C. K., Ludwig, S., Kersting, S., Bonifacio, E. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317561110 · Cited by 286

Effect of Electrospun Fiber Diameter and Alignment on Macrophage Activation and Secretion of Proinflammatory Cytokines and Chemokines

Saino, E., Focarete, M. L., Gualandi, C., Emanuele, E., Cornaglia, A. I., Imbriani, M., & Visai, L. (2011) · Biomacromolecules · doi:10.1021/bm200248h · Cited by 285

The use of human mesenchymal stem cells encapsulated in RGD modified alginate microspheres in the repair of myocardial infarction in the rat

Yu, J., Du, K. T., Fang, Q., Gu, Y., Mihardja, S. S., Sievers, R. E., Wu, J. C., & Lee, R. J. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.078 · Cited by 280

Enrichment of human embryonic stem cell‐derived NKX6.1‐expressing pancreatic progenitor cells accelerates the maturation of insulin‐secreting cells in vivo

Rezania, A., Bruin, J. E., Xu, J., Narayan, K., Fox, J., O'Neil, J., & Kieffer, T. (2013) · Stem Cells · doi:10.1002/stem.1489 · Cited by 269

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

Putnam, A. L., Safinia, N., Medvec, A. R., Laszkowska, M., Wray, M., Mintz, M. A., Trotta, E., Szot, G. L., Liu, W., Lares, A., et al. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12433 · Cited by 268

Oxygen producing biomaterials for tissue regeneration

Harrison, B. S., Eberli, D., Lee, S. J., Atala, A., & Yoo, J. J. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.07.003 · Cited by 254

Prolonged survival of transplanted islets of Langerhans encapsulated in a biocompatible membrane

O’Shea, G. M., Goosen, M. F. A., & Sun, A. M. (1984) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(84)90107-1 · Cited by 253

Alginate Macroencapsulation of Pig Islets Allows Correction of Streptozotocin-Induced Diabetes in Primates up to 6 Months Without Immunosuppression

Dufrane, D., Goebbels, R., & Gianello, P. (2010) · Transplantation · doi:10.1097/tp.0b013e3181f6e267 · Cited by 248

Long-Term Metabolic and Immunological Follow-Up of Nonimmunosuppressed Patients With Type 1 Diabetes Treated With Microencapsulated Islet Allografts

Basta, G., Montanucci, P., Luca, G., Boselli, C., Noya, G., Barbaro, B., Qi, M., Kinzer, K. P., Oberholzer, J., & Calafiore, R. (2011) · Diabetes Care · doi:10.2337/dc11-0731 · Cited by 245

Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets.

Hauge-Evans, A. C., Squires, P. E., Persaud, S. J., & Jones, P. M. (1999) · Diabetes · doi:10.2337/diabetes.48.7.1402 · Cited by 244

The topographical effect of electrospun nanofibrous scaffolds on the in vivo and in vitro foreign body reaction

Cao, H., Mchugh, K., Chew, S. Y., & Anderson, J. M. (2010) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32609 · Cited by 243

Growth of Cells In Vivo in Diffusion Chambers. I. Survival of Homografts in Immunized Mice 2

Algire, G. H., Weaver, J. M., & Prehn, R. T. (1954) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/15.3.493 · Cited by 237

Long-term reversal of diabetes by the injection of immunoprotected islets.

Soon‐Shiong, P., Feldman, E. C., Nelson, R., Heintz, R., Yao, Q., Yao, Z., Zheng, T., Merideth, N. R., Skjåk‐Bræk, G., & Espevik, T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5843 · Cited by 237

Neuroprotective Gene Therapy for Huntington's Disease, Using Polymer-Encapsulated Cells Engineered to Secrete Human Ciliary Neurotrophic Factor: Results of a Phase I Study

Bloch, J., Bachoud‐Lévi, A., Déglon, N., Lefaucheur, J. P., Winkel, L., Palfi, S., Nguyen, J. P., Bourdet, C., Rémy, P., Brugières, P., et al. (2004) · Human Gene Therapy · doi:10.1089/hum.2004.15.968 · Cited by 231

The multiple faces of CXCL12 (SDF-1α) in the regulation of immunity during health and disease

Karin, N. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0909602 · Cited by 224

The role of genetically engineered pigs in xenotransplantation research

Cooper, D. K. C., Ekser, B., Ramsoondar, J., Phelps, C. J., & Ayares, D. (2015) · The Journal of Pathology · doi:10.1002/path.4635 · Cited by 222

Six-Month Survival of Microencapsulated Pig Islets and Alginate Biocompatibility in Primates: Proof of Concept

Dufrane, D., Goebbels, R., Saliez, A., Guiot, Y., & Gianello, P. (2006) · Transplantation · doi:10.1097/01.tp.0000208610.75997.20 · Cited by 219

Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice

Bruin, J. E., Rezania, A., Xu, J., Narayan, K., Fox, J. K., O’Neil, J. J., & Kieffer, T. J. (2013) · Diabetologia · doi:10.1007/s00125-013-2955-4 · Cited by 216

Enhanced Oxygen Supply Improves Islet Viability in a New Bioartificial Pancreas

Barkai, U., Weir, G. C., Colton, C. K., Ludwig, B., Bornstein, S. R., Brendel, M. D., Neufeld, T., Bremer, C., Leon, A., Evron, Y., et al. (2013) · Cell Transplantation · doi:10.3727/096368912x657341 · Cited by 202

Device design and materials optimization of conformal coating for islets of Langerhans

Tomei, A. A., Manzoli, V., Fraker, C. A., Giraldo, J. A., Velluto, D., Najjar, M., Pileggi, A., Molano, R. D., Ricordi, C., Stabler, C. L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402216111 · Cited by 198

Anti-inflammatory peptide-functionalized hydrogels for insulin-secreting cell encapsulation

Su, J., Hu, B.-H., Lowe, W. L., Kaufman, D. B., & Messersmith, P. B. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.045 · Cited by 197

Bioengineering the Ovarian Follicle Microenvironment

Shea, L. D., Woodruff, T. K., & Shikanov, A. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-105131 · Cited by 186

Long-Term Control of Diabetes in Immunosuppressed Nonhuman Primates (NHP) by the Transplantation of Adult Porcine Islets

Shin, J., Kim, J. M., Kim, J. S., Min, B. H., Kim, Y. H., Kim, H. J., Jang, J. Y., Yoon, I. H., Kang, H., Kim, J. I., et al. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13345 · Cited by 185

Reversal of Diabetes by Pancreatic Islet Transplantation into a Subcutaneous, Neovascularized Device

Pileggi, A., Molano, R. D., Ricordi, C., Zahr, E., Collins, J., Valdes, R., & Inverardi, L. (2006) · Transplantation · doi:10.1097/01.tp.0000203858.41105.88 · Cited by 184

Production of purified alginates suitable for use in immunoisolated transplantation

Klöck, G., Frank, H., Houben, R., Zekorn, T., Horcher, A., Siebers, U., WOEHRLE, M., Federlin, K., & Zimmermann, U. (1994) · Applied Microbiology and Biotechnology · doi:10.1007/bf00173321 · Cited by 182

AN ATTACK OF TETANUS

Cole, L. B., Youngman, H. R., & Gandy, A. P. (1968) · The Lancet · doi:10.1016/s0140-6736(68)92425-2 · Cited by 172

Evaluation of alginate purification methods: Effect on polyphenol, endotoxin, and protein contamination

Dusseault, J., Tam, S. K., Ménard, M., Polizu, S., Jourdan, G., Yahia, L., & Hallé, J. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30541 · Cited by 169

Islet Transplantation and Encapsulation: An Update on Recent Developments

Vaithilingam, V., & Tuch, B. E. (2011) · The Review of Diabetic Studies · doi:10.1900/rds.2011.8.51 · Cited by 167

The Antidiabetic Effect of Mesenchymal Stem Cells Is Unrelated to Their Transdifferentiation Potential But to Their Capability to Restore Th1/Th2 Balance and to Modify the Pancreatic Microenvironment

Ezquer, F. E., Ezquer, M., Contador, D., Ricca, M., Simon, V., & Conget, P. A. (2012) · Stem Cells · doi:10.1002/stem.1132 · Cited by 165

Cellular Hypoxia of Pancreatic β-Cells Due to High Levels of Oxygen Consumption for Insulin Secretion in Vitro

Sato, Y., Endo, H., Okuyama, H., Takeda, T., Iwahashi, H., Imagawa, A., Yamagata, K., Shimomura, I., & Inoue, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.194738 · Cited by 164

PIG-TO-MONKEY ISLET XENOTRANSPLANTATION USING MULTI-TRANSGENIC PIGS

Bottino, R., Wijkstrom, M., van der Windt, D. J., Hara, H., Ezzelarab, M., Murase, N., Bertera, S., He, J., Phelps, C., Ayares, D., et al. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12868 · Cited by 163

Islet Vasculature as a Regulator of Endocrine Pancreas Function

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Oxygen supply to encapsulated therapeutic cells.

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