From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

Ashkenazi, Avi, Fairbrother, Wayne J., Leverson, Joel D., Souers, Andrew J.·2017·Nature Reviews Drug Discovery

Cited by (918)

Items 101–200 of 918

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    Ahmad J. Almalki, Tarek Salah Ibrahim, Ehab S. Taher, Mamdouh F. A. Mohamed, Mаhmoud Youns, Wael A. H. Hegazy, Amany M. M. Al‐Mahmoudy · 2022 · Molecules
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  4. Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis
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    Seiji Arai, Andreas S. Varkaris, Mannan Nouri, Sen Chen, Lisha Xie, Steven P. Balk · 2020 · eLife
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    Yifei Duan, Jingjing Li, Xue Jing, Xueli Ding, Yanan Yu, Qingxi Zhao · 2020 · Cancer Management and Research
  9. Effects of Physical Exercise on Autophagy and Apoptosis in Aged Brain: Human and Animal Studies
    D. Andreotti, J. N. Silva, Amanda Midori Matumoto, A. Orellana, Paloma Segura De Mello, E. Kawamoto · 2020 · Frontiers in Nutrition
  10. Local delivery of a senolytic drug in ischemia and reperfusion-injured heart attenuates cardiac remodeling and restores impaired cardiac function
    Ju‐Ro Lee, Bong‐Woo Park, Jae-Hyun Park, Songhyun Lim, Sung Pil Kwon, Ji‐Won Hwang, Hyeok Kim, Hun‐Jun Park, Byung‐Soo Kim · 2021 · Acta Biomaterialia
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    Zhi-Zheng Wang, Xing-Xing Shi, Guang-Yi Huang, Ge‐Fei Hao, Guang‐Fu Yang · 2023 · Trends in Biochemical Sciences
  12. A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice
    Yang Yang, Natacha Jn‐Simon, Yonghan He, Chunbao Sun, Peiyi Zhang, Wanyi Hu, Tian Tian, Huadong Zeng, Sreenivasulu Basha, Araceli S. Huerta et al. · 2025 · Nature Aging
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    Jason M. Brouwer, Ping Lan, Angus D. Cowan, Jonathan P. Bernardini, Richard W. Birkinshaw, Mark F. van Delft, Brad E. Sleebs, Adeline Y. Robin, Ahmad Z. Wardak, Iris K. L. Tan et al. · 2017 · Molecular Cell
  14. Cell death-based treatment of glioblastoma
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  15. A mini-review and perspective on ferroptosis-inducing strategies in cancer therapy
    Shuaifei Wang, Hongwei Liao, Fangyuan Li, Daishun Ling · 2019 · Chinese Chemical Letters
  16. MicroRNAs: Emerging oncogenic and tumor-suppressive regulators, biomarkers and therapeutic targets in lung cancer
    Shengjie Tang, Shuangjiang Li, Tao Liu, Yiwei He, Haiyang Hu, Yunhe Zhu, Shoujun Tang, Haining Zhou · 2021 · Cancer Letters
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  18. The dietary compound luteolin inhibits pancreatic cancer growth by targeting BCL-2
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  19. IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia
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  20. Discovery of a Novel BCL-X<sub>L</sub> PROTAC Degrader with Enhanced BCL-2 Inhibition
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  21. Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl-1 Proteins
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  22. Screening Strategies and Methods for Better Off-Target Liability Prediction and Identification of Small-Molecule Pharmaceuticals
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    Xinyu Chen, Yinghong Dai, Xin-xing Wan, Ximin Hu, Wenjuan Zhao, Xiao-xia Ban, Hao Wan, Kun Huang, Qí Zhāng, Kun Xiong · 2022 · Molecules
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  35. Programmed Cell Death: Central Player in Fungal Infections
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  40. Senolytic Targeting of Bcl-2 Anti-Apoptotic Family Increases Cell Death in Irradiated Sarcoma Cells
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  41. PROTACs: Novel tools for improving immunotherapy in cancer
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  44. New Quinoline-Based Heterocycles as Anticancer Agents Targeting Bcl-2
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  46. Hydrogen Sulfide Attenuates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin Signaling Pathway
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  47. NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death
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  48. Polymethoxyflavones from citrus inhibited gastric cancer cell proliferation through inducing apoptosis by upregulating RARβ, both in vitro and in vivo
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  51. Aging and Mesenchymal Stem Cells: Therapeutic Opportunities and Challenges in the Older Group
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  54. De novo coiled-coil peptides as scaffolds for disrupting protein–protein interactions
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  55. FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM
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  58. Bcl-2 on the brink of breakthroughs in cancer treatment
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  59. Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer
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  64. Unlocking the potential of PROTACs: A comprehensive review of protein degradation strategies in disease therapy
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  65. BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose
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  68. Design, synthesis and biological evaluation of novel HDAC inhibitors with improved pharmacokinetic profile in breast cancer
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  69. Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells
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  85. Over high or low dietary protein levels depressed the growth, TOR signaling, apoptosis, immune and anti-stress of abalone Haliotis discus hannai
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