From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

Cited by (918)

Items 401–500 of 918

  1. p53 SUMOylation Mediates AOPP-Induced Endothelial Senescence and Apoptosis Evasion
    Yanjia Chen, Zhuanhua Liu, Hongyu Chen, Xingfu Huang, Xiaoxia Huang, Lei Yang, Qing Duo Liang, Jia‐Yi Wei, Qin Zhang, Xiaohua Guo et al. · 2022 · Frontiers in Cardiovascular Medicine
  2. Synergistic cytotoxicity of a prostate cancer-specific immunotoxin in combination with the BH3 mimetic ABT-737
    Theresa Noll, Susanne Schultze-Seemann, Irina Kuckuck, Marta Michalska, Philipp Wolf · 2017 · Cancer Immunology Immunotherapy
  3. Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis
    Enxiang Zhang, Shutao Yin, Xiaotong Lu, Linhu Ye, Lihong Fan, Hongbo Hu · 2018 · Nutrients
  4. Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide
    Abbas Hadji, Greta K. Schmitt, Mathew R. Schnorenberg, Lauren E. Roach, Connie M. Hickey, Logan B. Leak, Matthew Tirrell, James L. LaBelle · 2019 · Oncotarget
  5. C1QTNF6 regulates cell proliferation and apoptosis of NSCLC in vitro and in vivo
    Yaoguang Zhang, Ganzhu Feng · 2020 · Bioscience Reports
  6. Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting
    Erwin Pannecoucke, Maaike Van Trimpont, Johan Desmet, Tim Pieters, Lindy Reunes, Lisa Demoen, Marnik Vuylsteke, Stefan Loverix, Karen Vandenbroucke, Philippe Alard et al. · 2021 · Science Advances
  7. Knockdown of long non-coding RNA MIR155HG suppresses melanoma cell proliferation, and deregulated MIR155HG in melanoma is associated with M1/M2 balance and macrophage infiltration
    Rui Liu, Xian Liang Sun, Zhen Jie Hu, Caizhi Peng, Ting Wu · 2022 · Cells and Development
  8. Genetic mutations affecting mitochondrial function in cancer drug resistance
    Chanhaeng Lee, Sanghee Park, Sungjoo Kim Yoon · 2023 · Genes & Genomics
  9. Mutual induced-fit mechanism drives binding between intrinsically disordered Bim and cryptic binding site of Bcl-xL
    Gert‐Jan Bekker, Mitsugu Araki, Kanji Oshima, Yasushi Okuno, Narutoshi Kamiya · 2023 · Communications Biology
  10. CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax
    Mathieu Neault, Charles‐Étienne Lebert‐Ghali, Marilaine Fournier, Caroline Capdevielle, Elizabeth A.R. Garfinkle, Alyssa Obermayer, Anitria Cotton, Karine Boulay, Christina Sawchyn, Sarah St-Amand et al. · 2023 · Cell Reports
  11. Topical application of a BCL-2 inhibitor ameliorates imiquimod-induced psoriasiform dermatitis by eliminating senescent cells
    Huan Zhu, Jiao Jiang, Ming Yang, Mingming Zhao, Zhenghao He, Congli Tang, Cailing Song, Ming Zhao, Arne N. Akbar, Venkat R Reddy et al. · 2024 · Journal of Dermatological Science
  12. New insights into constitutive neutrophil death
    Tong Chen, Qian Ren, Fengxia Ma · 2025 · Cell Death Discovery
  13. Fatty acid synthase (FASN) inhibition cooperates with BH3 mimetic drugs to overcome resistance to mitochondrial apoptosis in pancreatic cancer
    Travis Vander Steen, Ingrid C. Espinoza, Cristina Duran, Guillem Casadevall, Eila Serrano‐Hervás, Elisabet Cuyàs, Sara Verdura, George W. Kemble, Scott H. Kaufmann, Robert R. McWilliams et al. · 2025 · Neoplasia
  14. Mycobacterium tuberculosis with different virulence reside within intact phagosomes and inhibit phagolysosomal biogenesis in alveolar macrophages of patients with pulmonary tuberculosis
    Elena Ufimtseva, Natalya Eremeeva, Sergey I. Bayborodin, Tatiana V. Umpeleva, Diana V. Vakhrusheva, Sergey Skornyakov · 2018 · Tuberculosis
  15. circEPSTI1 Acts as a ceRNA to Regulate the Progression of Osteosarcoma
    Xinyu Tan, Duxun Tan, Haomiao Li, Ye Lin, Zhishen Wen, Canjun Zeng · 2019 · Current Cancer Drug Targets
  16. HT-SuMD: making molecular dynamics simulations suitable for fragment-based screening. A comparative study with NMR
    Francesca Ferrari, Maicol Bissaro, Simone Fabbian, Jessica de Almeida Roger, Stefano Mammi, Stefano Moro, Massimo Bellanda, Mattia Sturlese · 2020 · Journal of Enzyme Inhibition and Medicinal Chemistry
  17. Physalis alkekengi var. franchetii Extracts Exert Antitumor Effects on Non-Small Cell Lung Cancer and Multiple Myeloma by Inhibiting STAT3 Signaling
    Yu‐Fei Fu, Fanfan Zhu, Zhongjun Ma, Bin Lü, Xi Wang, Chunyan Dai, Xiaoqiong Ma, Pei Liu, Hang Lv, Xin Chen et al. · 2021 · OncoTargets and Therapy
  18. Small molecule SJ572946 activates BAK to initiate apoptosis
    G. Sekar, Geetika Singh, Xingping Qin, Cristina D. Guibao, Brittany Schwam, Zintis Inde, Christy R. Grace, Weixing Zhang, Peter J. Slavish, Wenwei Lin et al. · 2022 · iScience
  19. Hypoxia Induces Apoptosis through HIF-1α Signaling Pathway in Human Uterosacral Ligaments of Pelvic Organ Prolapse
    Xinrui Zhao, Congcong Ma, Rui Li, Jing Xue, Lidong Liu, Peishu Liu · 2017 · BioMed Research International
  20. Enantiomeric trans β-aryl-δ-iodo-γ-lactones derived from 2,5-dimethylbenzaldehyde induce apoptosis in canine lymphoma cell lines by downregulation of anti-apoptotic Bcl-2 family members Bcl-xL and Bcl-2
    Aleksandra Pawlak, Witold Gładkowski, Justyna Kutkowska, Marcelina Mazur, Bożena Obmińska‐Mrukowicz, Andrzej Rapak · 2018 · Bioorganic & Medicinal Chemistry Letters
  21. Targeting the Nrf2/HO-1 aixs: A therapeutic strategy against regulated cell death in Alzheimer’s disease
    Zhiji Wang, Wenxin Feng, Xiaohua Li, Xia Yun, Shuang Wu, Lida Du, Hongquan Wang · 2026 · Ageing Research Reviews
  22. Artificial Infestation of Sarcoptes scabiei (Acari: Sarcoptidae) in Rabbits Exhibits Progressive Pathological Changes, Apoptosis, and Keratinization in the Skin
    Ke Guan, Jing Xu, Xiaobin Gu, Ran He, Yue Xie, Bo Jing, Xuerong Peng, Guangyou Yang · 2023 · International Journal of Molecular Sciences
  23. Platycodin D relieves rheumatoid arthritis by promoting apoptosis of mitochondria to inhibit activation of hedgehog pathway
    Peiting Li, Ying Huang, Ju Wang, Jiashun Zeng, Long Li · 2023 · Autoimmunity
  24. PROteolysis‐Targeting Chimeras (PROTACs) in leukemia: overview and future perspectives
    André T. S. Vicente, Jorge A. R. Salvador · 2024 · MedComm
  25. Exploring the Effects and Potential Mechanisms of Hesperidin for the Treatment of CPT-11-Induced Diarrhea: Network Pharmacology, Molecular Docking, and Experimental Validation
    Xinyao Shu, Ruitong Xu, Peiyu Xiong, Junyu Liu, Zubing Zhou, Tao Shen, Xiaobo Zhang · 2024 · International Journal of Molecular Sciences
  26. Knockdown of RNF2 enhances the radiosensitivity of squamous cell carcinoma in lung
    Jie Yang, Yu Fan, Jinlei Guan, Tao Wang, Changjiang Liu, Yuxiang Wang, Guangjie Liu, Shuchai Zhu · 2019 · Biochemistry and Cell Biology
  27. Stapled Peptides as HIF‐1α/p300 Inhibitors: Helicity Enhancement in the Bound State Increases Inhibitory Potency
    Kristina Hetherington, Zsófia Hegedüs, Thomas A. Edwards, Richard Barry Sessions, Adam S. Nelson, Andrew John Wilson · 2020 · Chemistry - A European Journal
  28. SPRY4 suppresses proliferation and induces apoptosis of colorectal cancer cells by repressing oncogene EZH2
    Jia Guo, Huadong Zhu, Qiang Li, Jianhua Dong, Wei Xiong, Kun Yu · 2021 · Aging
  29. Metformin Triggers Apoptosis and Induction of the G0/G1 Switch 2 Gene in Macrophages
    Xuming Hu, Huan Luo, Chunfeng Dou, Xujing Chen, Yi Huang, Liping Wang, Songlei Xue, Zhen Sun, Shihao Chen, Qi Xu et al. · 2021 · Genes
  30. L-Carnitine Alleviates the Myocardial Infarction and Left Ventricular Remodeling through Bax/Bcl-2 Signal Pathway
    Hao-Ran Li, Xiao-Ming Zheng, Yan Liu, Jing-Hui Tian, Jie‐Jian Kou, Jun-Zhuo Shi, Xiaobin Pang, Xinmei Xie, Yan Yu · 2022 · Cardiovascular Therapeutics
  31. Proteolysis Targeting Chimeric Molecules: Tuning Molecular Strategies for a Clinically Sound Listening
    Federica Pedrucci, Claudia Pappalardo, Giovanni Marzaro, Nicola Ferri, Alberto Ferlin, Luca De Toni · 2022 · International Journal of Molecular Sciences
  32. Understanding the Species Selectivity of Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors
    Bin Zhao, Allison L. Arnold, Marcelle A. Coronel, Joyce H. Lee, Taekyu Lee, Edward T. Olejniczak, Stephen W. Fesik · 2018 · Biochemistry
  33. Manganese‐CpG Nanocomposite Integrates ROS‐Induced Cell Apoptosis and STING‐Activated and Adjuvant‐Augmented Immune Responses for Tumor Elimination and Prevention
    Jie Chen, Jianxiu Lu, Yunyi Shan, Yanqiu Wang, Zhilong Xu, Juqun Xi, Lei Fan, Lizeng Gao · 2022 · Advanced Therapeutics
  34. Combined BCL-2 and PI3K/AKT Pathway Inhibition in KMT2A-Rearranged Acute B-Lymphoblastic Leukemia Cells
    Clemens Holz, Sandra Lange, Anett Sekora, Gudrun Knuebel, Saskia Krohn, Hugo Murua Escobar, Christian Junghanß, Anna Richter · 2023 · International Journal of Molecular Sciences
  35. Neuroinvasive virus utilizes a lipid droplet surface protein, perilipin2, to restrict apoptosis by decreasing Bcl-2 ubiquitination
    Qianruo Wang, Jianqing Zhao, Mai Zhang, Meixin Sun, Zhen Fang Fu, Ling Zhao, Ming Zhou · 2024 · Journal of Virology
  36. BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress
    Andreas S. Varkaris, Keshan Wang, Mannan Nouri, Nina V. Kozlova, Daniel R. Schmidt, Anastasia-Maria Stavridi, Seiji Arai, Nicholas Ambrosio, Larysa Poluben, Juan M. Jiménez‐Vacas et al. · 2025 · Nature Communications
  37. Flow Cytometry-Based Detection and Analysis of BCL-2 Family Proteins and Mitochondrial Outer Membrane Permeabilization (MOMP)
    Lindsey M. Ludwig, Katrina L. Maxcy, James L. LaBelle · 2018 · Methods in molecular biology
  38. Structure‐based design, synthesis, and evaluation of Bcl‐2/Mcl‐1 dual inhibitors
    Junjie Zhu, Ziqian Wang, Zongwei Guo, Xiaodong Zhang, Ting Song, Yafei Guo, Tong Ji, Zhichao Zhang · 2020 · Archiv der Pharmazie
  39. Wogonin reduces cardiomyocyte apoptosis from mitochondrial release of cytochrome c to improve doxorubicin‑induced cardiotoxicity
    Yun‐Jie Wei, Junhao Zhao, Jian Xiong, Jingjing Chai, Xi Yang, Junfeng Wang, Jiajuan Chen, Jing Wang · 2022 · Experimental and Therapeutic Medicine
  40. BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma
    Xiaohang Hang, Lei Zhao, Baohong Wu, Shujun Li, Pengpeng Liu, Jing Xu, Xinyuan Wang, Pengliang Chi, Chong Chen, Ting Niu et al. · 2022 · Oncogene
  41. Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain
    Jingyi Zhou, Ruirui Yang, Jie Chang, Jia Song, Zisheng Fan, Yinghui Zhang, Cheng-hao Lu, Hualiang Jiang, Ming-yue Zheng, Sulin Zhang · 2022 · Acta Pharmacologica Sinica
  42. AML under the Scope: Current Strategies and Treatment Involving FLT3 Inhibitors and Venetoclax-Based Regimens
    Szymon Milnerowicz, Julia Milnerowicz, Paulina Skowera, Magdalena Stelmach, Monika Lejman · 2023 · International Journal of Molecular Sciences
  43. Deletion of ApoM gene induces apoptosis in mouse kidney via mitochondrial and endoplasmic reticulum stress pathways
    Wenjun Pei, Yali Wu, Xiao Zhang, Kangjia Lv, Yang Zhang, Zihui Li, Feiteng Liang, Chengye Dai, Lizhuo Wang, Jialin Gao et al. · 2018 · Biochemical and Biophysical Research Communications
  44. Reprogramming factors induce proliferation and inhibit apoptosis of melanoma cells by changing the expression of particular genes
    Yang Wang, Huajun Sun, Rong‐Gui Li, Xiaomei Wang, Zhiqiang Cheng, Nan Lou · 2018 · Molecular Medicine Reports
  45. Targeting the B-cell lymphoma 2 anti-apoptotic proteins for cervical cancer treatment
    Siti Fairus Abdul Rahman, Benedict Shi Xiang Lian, Nethia Mohana‐Kumaran · 2020 · Future Oncology
  46. Morin decreases acrolein-induced cell injury in normal human hepatocyte cell line LO2
    Zhao Yin, Hongyang Guo, Kaiyu Jiang, Juanying Ou, Mingfu Wang, Caihuan Huang, Fu Liu, Weibin Bai, Jie Zheng, Shiyi Ou · 2020 · Journal of Functional Foods
  47. Tiao Geng decoction inhibits tributyltin chloride-induced GT1-7 neuronal apoptosis through ASK1/MKK7/JNK signaling pathway
    Shengnan Li, Chao Cong, Yang Liu, Xiaofei Liu, Huicong Liu, Li Zhao, Xianwei Gao, Wenjia Gui, Lianwei Xu · 2020 · Journal of Ethnopharmacology
  48. ANO1 Expression Orchestrates p27Kip1/MCL1-Mediated Signaling in Head and Neck Squamous Cell Carcinoma
    Artemis Filippou, Henna Pehkonen, Piia‐Riitta Karhemo, Juho Väänänen, Anni I. Nieminen, Juha T. Klefström, Reidar A. Grenman, Antti A. Mäkitie, Heikki Joensuu, Outi M. Monni · 2021 · Cancers
  49. Crosstalk between miRNAs and signaling pathways involved in pancreatic cancer and pancreatic ductal adenocarcinoma
    Ziba Lotfi, Shiva Najjary, Fariba Lotfi, Mohammad Ali Amini, Amir Baghbanzadeh, Darya Javad Rashid, Elmira Roshani Asl, Behzad Baradaran, Ahad Mokhtarzadeh · 2021 · European Journal of Pharmacology
  50. Asiatic Acid Induces Endoplasmic Reticulum Stress and Activates the Grp78/IRE1α/JNK and Calpain Pathways to Inhibit Tongue Cancer Growth
    Jialin Li, Kan Chen, Jianhua Huang, Dongqing Chu, Miaomiao Tian, Keqiang Huang, Chunyu Ma · 2021 · Frontiers in Pharmacology
  51. Jinlong Capsule (JLC) inhibits proliferation and induces apoptosis in human gastric cancer cells in vivo and in vitro
    Dan Li, Tengyang Ni, Tao Li, Feng Jin, Haibo Wang, Jun Feng, Guang Zhu, Yayun Qian, Yanbing Ding, Masataka Sunagagwa et al. · 2018 · Biomedicine & Pharmacotherapy
  52. Multifaceted Roles of Bcl-2 Family Proteins: Regulatory Roles in Apoptosis, Physiological Functions, and Therapeutic Potential
    Nisreen Salah Majeed, Asmaa Alsalam, Shahd Rajab Farhan, Sumaya Ayad Abdulrazzaq, Soumya Vettiyatil Menon, Mandeep Kaur, Mandeep Singh, Beneen Husseen, Mohammed Abed Jawad, Razzagh Abedi‐Firouzjah · 2025 · Current Medical Science
  53. FOXM1 induces therapy resistance and inhibits apoptosis in a variety of human cancers
    Sanjeev Raghuwanshi, Andrei L. Gartel · 2026 · Cell Death and Disease
  54. 4,8-Dicarboxyl-8,9-iridoid-1-glycoside inhibits apoptosis in human osteoarthritis chondrocytes via enhanced c-MYC-mediated cholesterol metabolism in vitro
    WeiBing Wang, HaiMin Mai, Xu Huang, Baosheng Jing, Cuiyu Yu, XiaoTing Li, DanGui Chen, Yuan Huang, MeiMang Shao, Tao Pan · 2023 · Arthritis Research & Therapy
  55. Venetoclax-Related Neutropenia in Leukemic Patients: A Comprehensive Review of the Underlying Causes, Risk Factors, and Management
    Laura Giuseppina Di Pasqua, Murwan Mahmoud Abdallah, Fausto Feletti, Mariapia Vairetti, Andrea Ferrigno · 2024 · Pharmaceuticals
  56. Emerging anticancer potential and mechanisms of snake venom toxins: A review
    Xijun Guo, Yuanfeng Fu, Junbo Peng, Ying Fu, Shuai Dong, Ren‐Bo Ding, Xingzhu Qi, Jiaolin Bao · 2024 · International Journal of Biological Macromolecules
  57. Overview of BH3 mimetics in ovarian cancer
    Donatella Del Bufalo, Giovanna L.M. Damia · 2024 · Cancer Treatment Reviews
  58. Bcl-2 and Bcl-xL in Diabetes: Contributions to Endocrine Pancreas Viability and Function
    Atenea Alexandra Perez-Serna, Daniel Guzman-Llorens, Reinaldo Sousa dos Santos, Laura Marroquí · 2025 · Biomedicines
  59. Cyclin-dependent kinase 1 (CDK1) in cancers: from upstream regulation to downstream substrates and therapeutic inhibitors
    Xi Chen, Xiaobo Wang, Jia Wang, Xinwen Nie, Jinqi Ji, Xuesha Liu, Haoran Tian, Chenghua Li · 2025 · European Journal of Medicinal Chemistry
  60. The Key Target and Molecular Mechanism of the Volatile Component of Scutellaria baicalensis Georgi in Acute Lung Injury Based on Network Pharmacology
    Guosong Zhu, Jiaqiang Zhang, Yali Yang, Haoran Zhang, Wenwen Jin, Fangchu Su, Junting Liang, Kaiwei Wang, Jianhua Zhang, Chuanliang Chen · 2021 · Frontiers in Pharmacology
  61. Up-regulation of PUMA caused the activation of p53 phosphorylation and acetylation, enhancing the interaction between PUMA and Bcl-X and mediating arsenic-induced apoptosis
    Qian Zhou, Jinyao Yin, Jingwen Tan, Shuting Li, Chenglan Jiang, Yuefeng He · 2021 · Toxicology and Applied Pharmacology
  62. Schisandrin B Inhibits NLRP3 Inflammasome Pathway and Attenuates Early Brain Injury in Rats of Subarachnoid Hemorrhage
    Song Chen, Yi-hang Ding, Song‐sheng Shi, Xian-kun Tu · 2022 · Chinese Journal of Integrative Medicine
  63. Novel Compounds Synergize With Venetoclax to Target KMT2A-Rearranged Pediatric Acute Myeloid Leukemia
    Claudia Tregnago, Maddalena Benetton, Ambra Da Ros, Giulia Borella, Giorgia Longo, Katia Polato, Samuela Francescato, Alessandra Biffi, Martina Pigazzi · 2022 · Frontiers in Pharmacology
  64. Stayin’ alive: BCL-2 proteins in the hematopoietic system
    Patricia M. A. Zehnle, Ying Wu, Henrike Pommerening, Miriam Erlacher · 2022 · Experimental Hematology
  65. Bcl‐xL as prognostic marker and potential therapeutic target in cholangiocarcinoma
    Paula Hoffmeister‐Wittmann, Andreas Möck, Federico Nichetti, Felix Korell, Christoph E. Heilig, Anna‐Lena Scherr, Michael Günther, Thomas Albrecht, Eblina Kelmendi, Kaiyu Xu et al. · 2022 · Liver International
  66. Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes
    Samir H. Barghout, Mandeep Kaur Mann, Ahmed M. Aman, Yifan Yu, Matthew G. Alteen, Aaron David Schimmer, Matthieu Schapira, C.H. Arrowsmith, Dalia Baršytė-Lovejoy · 2022 · ACS Chemical Biology
  67. Strategic disruption of nuclear pores structure, integrity and barrier for nuclear apoptosis
    Victor Shahin · 2017 · Seminars in Cell and Developmental Biology
  68. Development of high potent and selective Bcl-2 inhibitors bearing the structural elements of natural product artemisinin
    Xiaohua Liu, Yu Zhang, Wenjing Huang, Jia Luo, Li Yang, Wenfu Tan, Ao Zhang · 2018 · European Journal of Medicinal Chemistry
  69. Antileukemic effect of caffeic acid 3,4-dihydroxyphenetyl ester. Evidences for its mechanisms of action
    Mingmin Tang, Xin Xie, Muran Shi, Wenxiu Xin, Guowan Zheng, Yanhua Zhang, Zhizhen Zhang, Xiao‐Yuan Lian · 2020 · Phytomedicine
  70. miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells
    Yuefan Li, Xiaofei Li, Ling Wang, Na Han, Gang Yin · 2020 · Biotechnology Letters
  71. Fork Head Box Class O1 (FOXO1) Activates Bim Expression to Mediate Cardiac Apoptosis in Chronic Intermittent Hypoxia-Induced Cardiac Hypertrophy
    Guangcai Li, Meng Jin, Yuan Zhang He, Jie Ren, Minghua Zhang, Yilin Chen, Xiong Lan, Jianhua Zhong, Huiguo Liu · 2017 · Medical Science Monitor
  72. Gene Mutations and Targeted Therapies of Myeloid Sarcoma
    Leihua Fu, Zhijian Zhang, Zhe Chen, Jiaping Fu, Pan Hong, Weiying Feng · 2023 · Current Treatment Options in Oncology
  73. Tetrahedral framework nucleic acids promote the proliferation and differentiation potential of diabetic bone marrow mesenchymal stem cell
    Yanjing Li, Jiayin Li, Yuqi Chang, Yunfeng Lin, Lei Sui · 2023 · Chinese Chemical Letters
  74. Immune checkpoint-regulatable hydrogel-immobilized nanotherapeutics for post-surgical treatment of osteosarcoma
    Da‐Wang Zhao, Zhiliang Gao, Meng Si, Rui Hu, Xue Ma, Kaiwen Liu, Yixiang Zhao, Qiting He, Xiangzhen Kong, Chunwang Jia et al. · 2024 · Chemical Engineering Journal
  75. 6-Gingerol activates the Nrf2 signaling pathway to alleviate hydrogen peroxide induced oxidative stress on primary chicken embryo hepatocytes
    Kaige Yang, Yunqi Lu, Zhiguang Yue, Sanjun Jin, Ping Wang, Chaoqi Liu, Lijun Wang, Qingqiang Yin, Xiaowei Dang, Hongwei Guo et al. · 2024 · Journal of Functional Foods
  76. Mulberry leaf benefits the intestinal epithelial barrier via direct anti-oxidation and indirect modulation of microbiota in pigs
    Hui Yan, Shurui Yan, Zaiyao Li, Tingting Zhang, Jun He, Bing Yu, Jie Yu, Junqiu Luo, Aimin Wu, Junning Pu et al. · 2024 · Phytomedicine
  77. Phytochemical innovations in oral cancer therapy: targeting oncogenic pathways with natural compounds
    Punniyakoti V. Thanikachalam, Mahalakshmi Devaraji, Nandhini Jayaprakash, Harshitha Sivakumar, D. Balamurugan D. Balamurugan, Harish Kanna Shanmugan · 2025 · Journal of Complementary and Integrative Medicine
  78. A literature review of the patent publications on venetoclax – a selective Bcl-2 inhibitor: discovering the therapeutic potential of a novel chemotherapeutic agent
    Nina Žigart, Zdenko Časar · 2019 · Expert Opinion on Therapeutic Patents
  79. Evaluation of the biological activities of olivetoric acid, a lichen-derived molecule, in human hepatocellular carcinoma cells
    Buğrahan Emsen, Gökhan Sadı, Aykut Bostancı, Nuray Gursoy, Ayça Emsen, Alı Aslan · 2021 · RENDICONTI LINCEI
  80. ZNF217: the cerberus who fails to guard the gateway to lethal malignancy.
    Yingpu Li, Hao Wu, Qin Wang, Shouping Xu · 2021 · PubMed Central
  81. CD157 signaling promotes survival of acute myeloid leukemia cells and modulates sensitivity to cytarabine through regulation of anti-apoptotic Mcl-1
    Yuliya Yakymiv, Stefania Augeri, Cristiano Bracci, Sara Marchisio, Semra Aydin, Stefano D’Ardìa, Massimo Massaia, Enza Ferrero, Erika Ortolan, Ada Funaro · 2021 · Scientific Reports
  82. Diallyl trisulfide plays an antifibrotic role by inhibiting the expression of Bcl‐2 in hepatic stellate cells
    Huai Pang, Cuizhe Wang, Jing Ye, Lulu Wang, Xiaoming Zhou, Xiaomeng Ge, Jun Zhang, Qinghua Liu · 2022 · Journal of Biochemical and Molecular Toxicology
  83. Novel deoxyribonucleic acid methylation perturbations in workers exposed to vinyl chloride
    Xiaotian Zhao, Yan Hao, Qian Wang, Yongmei Shen, Ying Cheng, Ben Li, Yi Gao, Tong Wang, Yulan Qiu · 2022 · Toxicology and Industrial Health
  84. The EPRS-ATF4-COLI pathway axis is a potential target for anaplastic thyroid carcinoma therapy
    Li Mi, Jiaye Liu, Yujie Zhang, Anping Su, Minghai Tang, Zhichao Xing, Ting He, Tao Wei, Zhihui Li, Wenshuang Wu · 2024 · Phytomedicine
  85. Unveiling the unique role of TSPAN7 across tumors: a pan-cancer study incorporating retrospective clinical research and bioinformatic analysis
    Bingnan Lu, Yifan Liu, Yuntao Yao, Dawei Zhu, Xiangmin Zhang, Keqin Dong, Xiao Xu, Donghao Lv, Zihui Zhao, Haoyu Zhang et al. · 2024 · Biology Direct
  86. Cyclin-dependent kinase 2 inhibitor SU9516 increases sensitivity of colorectal carcinoma cells Caco-2 but not HT29 to BH3 mimetic ABT-737
    Andrea Štefaniková, Katarína Klačanová, Ivana Pilchová, Jozef Hatok, Peter Račay · 2017 · General Physiology and Biophysics
  87. Structure-Guided Development of Potent Benzoylurea Inhibitors of BCL-XL and BCL-2
    Michael J. Roy, Amelia Vom, Toru Okamoto, Brian James Smith, Richard W. Birkinshaw, Hong Jun Yang, Houda Abdo, Christine A White, David Segal, David C.S. Huang et al. · 2021 · Journal of Medicinal Chemistry
  88. Mitochondrially targeted tamoxifen as anticancer therapy: case series of patients with renal cell carcinoma treated in a phase I/Ib clinical trial
    Zuzana Bielčiková, Lukáš Werner, Jan Štursa, Vladimír Černý, Ľudmila Křížová, Jiří Špaček, Stanislav Hloušek, Michal Vočka, Olga Bartošová, Michal Pešta et al. · 2023 · Therapeutic Advances in Medical Oncology
  89. Design, Synthesis, and Evaluation of BCL‐2 Targeting PROTACs
    Aleša Bricelj, Yuen Lam Dora Ng, Martina Gobec, Robert D. Kuchta, Wanyi Hu, Špela Javornik, Miha Rožič, Michael Gütschow, Guangrong Zheng, Jan Krönke et al. · 2024 · Chemistry - A European Journal
  90. Evaluation of Cross-Talk and Alleviate Potential of Cytotoxic Factors Induced by Deoxynivalenol in IPEC-J2 Cells Interference with Curcumin
    Qiyuan Wang, Aike Li, Hao Yu, Chuanqi Wang, Ting Wang, Jing Zhang · 2024 · International Journal of Molecular Sciences
  91. Molecular Hybrids of Quinoline and Sulfonamide: Design, Synthesis and in Vitro Anticancer Studies
    Padyala Panduranga, Parameshwar Makam, Naresh Kumar Katari, Rambabu Gundla, Sreekantha Babu Jonnalagadda, Bharat Kumar Tripuramallu · 2024 · ChemistryOpen
  92. Antimicrobial dual-crosslinked hydrogel synergizes bioengineered extracellular vesicles for enhanced diabetic wound healing
    Yikun Ju, Yang Pu, Xiangjun Liu, Rui Wu, Naisi Shen, Nancy Hsiung, Anqi Yang, Chi Zhang, Bairong Fang, Liangle Liu · 2025 · Materials Today Bio
  93. Dual Bcl-XL /Bcl-2 inhibitors discovered from DNA-encoded libraries using a fragment pairing strategy
    Jean‐Pierre Daguer, Arthur Gonse, Yevhenii Shchukin, Lluc Farrera Soler, Sofía Barluenga, Nicolas Winssinger · 2021 · Bioorganic & Medicinal Chemistry
  94. Expression Differences in BCL2 Family Members between Uveal and Cutaneous Melanomas Account for Varying Sensitivity to BH3 Mimetics
    Nabanita Mukherjee, Chiara R. Dart, Carol M. Amato, Adam Honig-Frand, James R. Lambert, Karoline A. Lambert, William Allen Robinson, Richard P. Tobin, Martin D. McCarter, Kasey L. Couts et al. · 2021 · Journal of Investigative Dermatology
  95. Design, synthesis and biological evaluation of novel diosgenin–benzoic acid mustard hybrids with potential anti-proliferative activities in human hepatoma HepG2 cells
    Jinling Zhang, Wenbao Wang, Yanzhao Tian, Liwei Ma, Lin Zhou, Hao Xuan Sun, Yukun Ma, Huiling Hou, Xiaoli Wang, Jin Ye et al. · 2022 · Journal of Enzyme Inhibition and Medicinal Chemistry
  96. Profiling protein–protein interactions to predict the efficacy of B-cell-lymphoma-2-homology-3 mimetics for acute myeloid leukaemia
    Changju Chun, Ja Min Byun, Minkwon Cha, Hong-Won Lee, Byungsan Choi, Hyunwoo Kim, Saem Hong, Yunseo Lee, Ha Young Park, Youngil Koh et al. · 2024 · Nature Biomedical Engineering
  97. In vitro and computational studies showed that perezone inhibits PARP-1 and induces changes in the redox state of K562 cells
    Maricarmen Hernández Rodríguez, Pablo I. Mendoza Sánchez, Martha Edith Macías Pérez, Erika Rosales Cruz, Elvia Mera Jiménez, María Inés Nicolás‐Vázquez, René Miranda Ruvalcaba · 2019 · Archives of Biochemistry and Biophysics
  98. Substituted Piperazines as Novel Potential Radioprotective Agents
    Alžběta Filipová, Jan Marek, Radim Havelek, Jaroslav Pejchal, Marcela Jeličová, Jana Čížková, Martina Majorošová, Ľubica Múčková, Tomas Kucera, Lukáš Prchal et al. · 2020 · Molecules
  99. Demethoxycurcumin increases the sensitivity of cisplatin‑resistant non‑small lung cancer cells to cisplatin and induces apoptosis by activating the caspase signaling pathway
    Yun Chen, Chaojin Hong, Xiaochen Chen, Zhiquan Qin · 2020 · Oncology Letters
  100. BH3 Mimetic Sensitivity of Colorectal Cancer Cell Lines in Correlation with Molecular Features Identifies Predictors of Response
    Le Zhang, Prashanthi Ramesh, Maxime Steinmetz, Jan Paul Medema · 2021 · International Journal of Molecular Sciences