From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

Cited by (918)

Items 201–300 of 918

1. Integrated analysis of transcriptomic and metabolomic data to evaluate responses to hypersalinity stress in the gill of the razor clam (Sinonovacula constricta)
   Li Yan, Donghong Niu, Yinghan Wu, Zhiguo Dong, Jiale Li · 2021 · Comparative Biochemistry and Physiology Part D Genomics and Proteomics
2. Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice
   Xintong Wu, Abdur Rahman Ansari, Xin-Xin Pang, Huizhen Li, Zhe-Wei Zhang, You Luo, Muhammad Imran Arshad, Hui Song · 2019 · Archivum Immunologiae et Therapiae Experimentalis
3. Characteristics and prognostic value of potential dependency genes in clear cell renal cell carcinoma based on a large-scale CRISPR-Cas9 and RNAi screening database DepMap
   Bowen Shi, Jie Ding, Jun Qi, Zhengqin Gu · 2021 · International Journal of Medical Sciences
4. Novel synthetic drugs currently in clinical development for chronic lymphocytic leukemia
   Pawel J. Robak, Tadeusz Robak · 2017 · Expert Opinion on Investigational Drugs
5. Mineral trioxide aggregate affects cell viability and induces apoptosis of stem cells from human exfoliated deciduous teeth
   Chia‐Ling Tsai, Mu-Chan Ke, Yi‐Hao Chen, Hsi‐Kung Kuo, Hun-Ju Yu, Chueh-Tan Chen, Ya-Chi Tseng, Pei-Chin Chuang, Pei‐Chang Wu · 2018 · BMC Pharmacology and Toxicology
6. The Incomplete Puzzle of the BCL2 Proteins
   Flores-Romero, Hector, García-Sáez, Ana J. · 2019 · Cells
7. Molecular Approaches to Treating Pediatric Leukemias
   Michaela Kuhlen, Jan‐Henning Klusmann, Jessica I. Hoell · 2019 · Frontiers in Pediatrics
8. Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes via Mitochondrial Pathway
   Yu Wang, Yinghua Lan, Hongguang Lü · 2019 · Photochemistry and Photobiology
9. Myeloid cell leukemia 1 (MCL-1): Structural characteristics and application in cancer therapy
   Pooja Mittal, Sujata Singh, Rajesh Sinha, Anju Shrivastava, Archana Kumari Singh, Indrakant Kumar Singh · 2021 · International Journal of Biological Macromolecules
10. Dual-target Inhibitors Based on BRD4: Novel Therapeutic Approaches for Cancer
    Sitao Zhang, Yanzhao Chen, Chengsen Tian, Yujing He, Zeru Tian, Yichao Wan, Tingting Liu · 2020 · Current Medicinal Chemistry
11. HOXA9 Transcriptionally Promotes Apoptosis and Represses Autophagy by Targeting NF-κB in Cutaneous Squamous Cell Carcinoma
    Shuo Han, Xue Li, Xiaoting Liang, Liang Zhou · 2019 · Cells
12. Circular RNA has_circ_0000527 participates in proliferation, invasion and migration of retinoblastoma cells via miR ‐646/ BCL ‐2 axis
    Nan‐nan Chen, Dai‐ling Chao, Xiu‐gui Li · 2020 · Cell Biochemistry and Function
13. Targeting Bim via a lncRNA Morrbid Regulates the Survival of Preleukemic and Leukemic Cells
    Zhigang Cai, Fabiola Aguilera, Baskar Ramdas, Swapna Vidhur Daulatabad, Rajneesh Srivastava, Jonathan J. Kotzin, Martin P Carroll, Gerald B. W. Wertheim, Adam Williams, Sarath Chandra Janga et al. · 2020 · Cell Reports
14. Genetic or pharmacological reduction of cholangiocyte senescence improves inflammation and fibrosis in the Mdr2 mouse
    Mohammed Alsuraih, Steven P. O’Hara, Julie E. Woodrum, Nicholas Pirius, Nicholas F. LaRusso · 2021 · JHEP Reports
15. miR-663 sustains NSCLC by inhibiting mitochondrial outer membrane permeabilization (MOMP) through PUMA/BBC3 and BTG2
    Micol Eleonora Fiori, Lidia Villanova, Chiara Barbini, Maria Laura De Angelis, Ruggero D. Maria · 2018 · Cell Death and Disease
16. Novel Design Strategies to Enhance the Efficiency of Proteolysis Targeting Chimeras
    Chunlong Zhao, Frank J. Dekker · 2022 · ACS Pharmacology & Translational Science
17. Cross Talk Between Cellular Redox State and the Antiapoptotic Protein Bcl-2
    Sebastian Pohl, Mark Agostino, Arun Dharmarajan, Shazib Pervaiz · 2018 · Antioxidants and Redox Signaling
18. Hematologic Tumor Cell Resistance to the BCL-2 Inhibitor Venetoclax: A Product of Its Microenvironment?
    Joel D. Leverson, Dan Cojocari · 2018 · Frontiers in Oncology
19. Circular RNA 100146 Promotes Colorectal Cancer Progression by the MicroRNA 149/HMGA2 Axis
    Kunpeng Liu, Yuhua Mou, Xiufang Shi, Tingkun Liu, Zhanfeng Chen, Xingmei Zuo · 2020 · Molecular and Cellular Biology
20. Structural basis of BAK activation in mitochondrial apoptosis initiation
    Geetika Singh, Cristina D. Guibao, J. Seetharaman, Anup Aggarwal, Christy R. Grace, Dan E. McNamara, Sivaraja Vaithiyalingam, Michael Brett Waddell, Tudor Moldoveanu · 2022 · Nature Communications
21. Bcl-2 family inhibitors sensitize human cancer models to therapy
    Elisabetta Valentini, Marta Di Martile, Matteo Brignone, Marica Di Caprio, Isabella Manni, Michela Chiappa, Ilaria Sergio, Martina Chiacchiarini, Chiara Bazzichetto, Fabiana Conciatori et al. · 2023 · Cell Death and Disease
22. Emerging therapies for acute myeloid leukemia: translating biology into the clinic
    Simon Kavanagh, Tracy Murphy, Arjun Law, Dana Yehudai, Jenny Ho, Steve Chan, Aaron David Schimmer · 2017 · JCI Insight
23. Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development
    Sonia León‐Cabrera, Armando Vázquez-Sandoval, Emmanuel Molina-Guzman, Yael G. Delgado-Ramirez, Norma L. Delgado‐Buenrostro, Blanca E. Callejas, Yolanda I. Chirino, Carlos Pérez‐Plasencia, Miriam Rodríguez‐Sosa, Jonadab E. Olguín et al. · 2018 · Cancers
24. BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway
    Xiaohui Chen, Xihua Cao, Xuhuang Tu, Gulimiran Alitongbieke, Zebin Xia, Xiaotong Li, Ziwen Chen, Meimei Yin, Dan Xu, Shangjie Guo et al. · 2019 · Molecular Cancer Therapeutics
25. LCL161, a SMAC-mimetic, Preferentially Radiosensitizes Human Papillomavirus–negative Head and Neck Squamous Cell Carcinoma
    Linlin Yang, Bhavna Kumar, Changxian Shen, Songzhu Zhao, Dukagjin M. Blakaj, Tianyun Li, Mitchell Romito, Theodoros Nicholas Teknos, Terence Marques Williams · 2019 · Molecular Cancer Therapeutics
26. A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia
    Elena Arriazu, Carmen Vicente, Raffaella Pippa, Irene Peris, Elena Martínez‐Balsalobre, Patricia García Ramírez, Nerea Marcotegui, Ana Igea, Diego Alignani, J. Rifón et al. · 2020 · Blood Cancer Journal
27. Bioactive metal-containing nanomaterials for ferroptotic cancer therapy
    Weidong Fei, Yue Zhang, Yiqing Ye, Chaoqun Li, Yao Yao, Meng Zhang, Fanzhu Li, Caihong Zheng · 2020 · Journal of Materials Chemistry B
28. BI 2536 induces gasdermin E-dependent pyroptosis in ovarian cancer
    Jianting Huo, Yuhong Shen, Yuchen Zhang, Lifei Shen · 2022 · Frontiers in Oncology
29. Mitochondrial apoptosis is induced by Alkoxy phenyl-1-propanone derivatives through PP2A-mediated dephosphorylation of Bad and Foxo3A in CLL
    Mario Angelo Pagano, Elena V. Tibaldi, Pierfrancesco Molino, Federica Frezzato, Valentina Trimarco, Monica Facco, Giuseppe Zagotto, Giovanni Ribaudo, Luigi Leanza, Roberta Peruzzo et al. · 2018 · Leukemia
30. The chemical biology of apoptosis: Revisited after 17 years
    Shu Yang, Yujia Mao, Huijun Zhang, Yan Xu, Jing An, Ziwei Huang · 2019 · European Journal of Medicinal Chemistry
31. Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview
    Wuji Wang, Hong-Lan Wang, Yunluan Long, Zheng Li, Jingjie Li · 2023 · Biomolecules
32. Fatty acid synthase ( FASN ) signalome: A molecular guide for precision oncology
    Javier Abel Menéndez, Elisabet Cuyàs, José Antonio Encinar, Travis Vander Steen, Sara Verdura, Àngela Llop‐Hernández, Júlia López, Eila Serrano‐Hervás, Sílvia Osuna, Begoña Martı́n-Castillo et al. · 2023 · Molecular Oncology
33. Potential Analysis and Preparation of Chitosan Oligosaccharides as Oral Nutritional Supplements of Cancer Adjuvant Therapy
    Zhiwen Jiang, Hui Li, Jing Qiao, Yan Gong Yang, Yanting Wang, Wanshun Liu, Baoqin Han · 2019 · International Journal of Molecular Sciences
34. Dietary flavone from the Tetrastigma hemsleyanum vine triggers human lung adenocarcinoma apoptosis via autophagy
    Yonglu Li, Xinyu Feng, Yiru Zhang, Yaxuan Wang, Xin Yu, Ruoyi Jia, Ting Yu, Xiaodong Zheng, Qiang Chu · 2020 · Food & Function
35. Ethyl acetate extract of Tibetan medicine Rhamnella gilgitica ameliorated type II collagen-induced arthritis in rats via regulating JAK-STAT signaling pathway
    Jinsong Su, Qiuyue Li, Jia Liu, Hongling Wang, Xuanhao Li, Wüntrang Dhondrup, Chuan Liu, Qian Zhao, Ruyu Yao, Xianli Meng et al. · 2020 · Journal of Ethnopharmacology
36. pH-Responsive Pluronic F127–Lenvatinib-Encapsulated Halogenated Boron-Dipyrromethene Nanoparticles for Combined Photodynamic Therapy and Chemotherapy of Liver Cancer
    Jingjing Zong, Hao Peng, Xin Qing, Zhe Fan, Wenjing Xu, Xuanlong Du, Ruihua Shi, Yewei Zhang · 2021 · ACS Omega
37. Methylglyoxal-Derived Advanced Glycation End Product (AGE4)-Induced Apoptosis Leads to Mitochondrial Dysfunction and Endoplasmic Reticulum Stress through the RAGE/JNK Pathway in Kidney Cells
    So-Ra Jeong, Kwang‐Won Lee · 2021 · International Journal of Molecular Sciences
38. Can preclinical drug development help to predict adverse events in clinical trials?
    Lap Hing Chi, Allan D. Burrows, Robin L. Anderson · 2021 · Drug Discovery Today
39. Probing Gallate-Mediated Selectivity and High-Affinity Binding of Epigallocatechin Gallate: a Way-Forward in the Design of Selective Inhibitors for Anti-apoptotic Bcl-2 Proteins
    Fisayo Andrew Olotu, Clement Agoni, Emmanuel A. Adeniji, Maryam Abdullahi, Mahmoud E. S. Soliman · 2018 · Applied Biochemistry and Biotechnology
40. A novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX
    Mengxia Shen, Jiafeng Fu, Yunna Zhang, Yanfen Chang, Xiaohong Li, Haipeng Cheng, Yujia Qiu, Min Shao, Yang Han, Yan Zhou et al. · 2024 · Aging Cell
41. BFL1 modulates apoptosis at the membrane level through a bifunctional and multimodal mechanism showing key differences with BCLXL
    Hector Flores‐Romero, Olatz Landeta, Begoña Ugarte‐Uribe, Katia Cosentino, Miguel García‐Porras, Ana J. García‐Sáez, Gorka Basáñez · 2018 · Cell Death and Differentiation
42. Synthesis and in vitro anti-bladder cancer activity evaluation of quinazolinyl-arylurea derivatives
    Jia-Nian Chen, Ting Li, Li Cheng, Tai-Sheng Qin, Yexiang Sun, Chu-Ting Chen, Yuezhen He, Guang Liu, Di Yao, Ying Wei et al. · 2020 · European Journal of Medicinal Chemistry
43. Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells
    Xuejian Zhou, Feifan Wang, Hongshen Wu, Xianwu Chen, Yan Zhang, Jun‐Tao Lin, Yueshu Cai, Jiayong Xiang, Ning He, Zhenghui Hu et al. · 2021 · International Journal of Biological Sciences
44. Macrovipecetin, a C-type lectin from Macrovipera lebetina venom, inhibits proliferation migration and invasion of SK-MEL-28 human melanoma cells and enhances their sensitivity to cisplatin
    Manel Ben Hammouda, Ichrak Riahi-Chebbi, Soumaya Souid, Houcemeddine Othman, Zohra Aloui, Najet Srairi‐Abid, Habib Karoui, Ammar Gasmi, Edith M. Magnenat, Timothy N. C. Wells et al. · 2017 · Biochimica et Biophysica Acta (BBA) - General Subjects
45. Phosphorylation alters Bim‐mediated Mcl‐1 stabilization and priming
    Conage‐Pough, Jason E., Boise, Lawrence H. · 2018 · The FEBS Journal
46. Targeting epidermal growth factor receptor and its downstream signaling pathways by natural products: A mechanistic insight
    Rutuja Damare, Kritika Engle, Gautam Kumar · 2024 · Phytotherapy Research
47. E-Jet 3D-Printed Scaffolds as Sustained Multi-Drug Delivery Vehicles in Breast Cancer Therapy
    Xiaoyin Qiao, Yikun Yang, Ruiying Huang, Xuelei Shi, Haoxiang Chen, Jian Wang, Yanxiang Chen, Yongjun Tan, Zhikai Tan · 2019 · Pharmaceutical Research
48. Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer’s Disease Mice
    yan peng, Rui Chi, Gang Liu, Weijie Tian, Jun Zhang, Rihui Zhang · 2022 · Neural Plasticity
49. Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice
    Peng Liu, Ruizhi Yao, Hongzhao Shi, Yang Liu, Shuai Lian, Yuying Yang, Huanmin Yang, Shize Li · 2019 · International Journal of Molecular Sciences
50. The underestimated role of mitochondria in vitiligo: From oxidative stress to inflammation and cell death
    Yi Lin, Yuecen Ding, Yue Wu, Yiwen Yang, Ziqi Liu, Leihong Flora Xiang, Chengfeng Zhang · 2023 · Experimental Dermatology
51. Significance of TRAIL/Apo-2 ligand and its death receptors in apoptosis and necroptosis signalling: Implications for cancer-targeted therapeutics
    Avik Maji, Abhik Paul, Arnab Sarkar, Sourin Nahar, Rudranil Bhowmik, Ajeya Samanta, Pankaj Nahata, Balaram Ghosh, Sanmoy Karmakar, Tapan Kumar Maity · 2024 · Biochemical Pharmacology
52. Nanoformulated ABT-199 to effectively target Bcl-2 at mitochondrial membrane alleviates airway inflammation by inducing apoptosis
    Baoping Tian, Fangyuan Li, Ruiqing Li, Xi Hu, Tianwen Lai, Jingxiong Lu, Yun Fu Zhao, Yang Du, Zeyu Liang, Chen Zhu et al. · 2018 · Biomaterials
53. Molecular dynamic simulations on an inhibitor of anti-apoptotic Bcl-2 proteins for insights into its interaction mechanism for anti-cancer activity
    Aarti Anantram, Harish Kundaikar, Mariam Sohel Degani, Arati Prabhu · 2018 · Journal of Biomolecular Structure and Dynamics
54. Progress of small molecules for targeted protein degradation: PROTACs and other technologies
    Hongyi Zhao, Minhang Xin, San‐Qi Zhang · 2023 · Drug Development Research
55. Assessing the anticancer effects associated with food products and/or nutraceuticals using in vitro and in vivo preclinical development-related pharmacological tests
    Florence Lefranc, Nurhayat Tabanca, Robert Kiss A · 2017 · Seminars in Cancer Biology
56. Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines
    Tiane Cristine Finimundy, Rui M.V. Abreu, Natalia Bonetto, Fernando Joel Scariot, Aldo José Pinheiro Dillon, Sérgio Echeverrigaray, Lillian Barros, Isabel C.F.R. Ferreira, João Antônio Pêgas Henriques, Mariana Roesch‐Ely · 2018 · Food and Chemical Toxicology
57. Micro-Economics of Apoptosis in Cancer: ncRNAs Modulation of BCL-2 Family Members
    Lidia Villanova, Silvia Careccia, Ruggero D. Maria, Micol Eleonora Fiori · 2018 · International Journal of Molecular Sciences
58. The role of programmed cell death in organ dysfunction induced by opportunistic pathogens
    Wang Yangyanqiu, Li Weng, Xunyao Wu, Bin Du · 2025 · Critical Care
59. A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy
    Kelly G. Bryant, Young Chan Chae, Rogelio L. Martinez, John C. Gordon, Khaled M. Elokely, Andrew V. Kossenkov, Steven Grant, Wayne E. Childers, Magid A. Abou-Gharbia, Dario C. Altieri · 2017 · Oncotarget
60. The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma
    Kyle L. Runckel, Matthew John Barth, Cory K. Mavis, Juan J. Gu, Francisco J. Hernandez‐Ilizaliturri · 2018 · Blood Advances
61. Aberrant mitochondrial function in ageing and cancer
    Julia C. Whitehall, Laura C. Greaves · 2019 · Biogerontology
62. Combining triptolide with ABT-199 is effective against acute myeloid leukemia through reciprocal regulation of Bcl-2 family proteins and activation of the intrinsic apoptotic pathway
    Yuanfei Shi, Long Liu, Lingli He, Jing Ye, Zhijuan Lin, Delin Yuan, Manman Deng, Zhihong Fang, Bing Z. Carter, Bing Xu · 2020 · Cell Death and Disease
63. Developments and challenges of FLT3 inhibitors in acute myeloid leukemia
    Shuai‐Shuai Ge, Songbai Liu, Shengli Xue · 2022 · Frontiers in Oncology
64. Discovery of the major 15–30 nt mammalian small RNAs, their biogenesis and function
    Hejin Lai, Ning Feng, Qiwei Zhai · 2023 · Nature Communications
65. First in human phase 1 study of DT2216, a selective BCL-xL degrader, in patients with relapsed/refractory solid malignancies
    Daruka Mahadevan, Minal A. Barve, Devalingam Mahalingam, Jay Parekh, Michael R. Kurman, James Fredric Strauss, Larry M. Tremaine, Robert Hromas, Joshua Sills, John McCulloch et al. · 2025 · Journal of Hematology & Oncology
66. BCL-2 selective inhibitor ABT-199 primes rhabdomyosarcoma cells to histone deacetylase inhibitor-induced apoptosis
    Ulrike Heinicke, Tinka Haydn, Sarah Kehr, Meike Vogler, Simone Fulda · 2018 · Oncogene
67. Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism
    Frank A. Lincoln, Dirke Imig, Chiara Boccellato, Viktorija Jurić, Janis Noonan, Roland E. Kontermann, Frank Allgöwer, Brona M. Murphy, Markus Rehm · 2018 · Cell Death and Disease
68. Recent Advances in the Anticancer Applications of Benzimidazole Derivatives
    Mohammad Mavvaji, Senem Akkoç · 2023 · ChemistrySelect
69. A new perspective on membrane-embedded Bax oligomers using DEER and bioresistant orthogonal spin labels
    Markus Teucher, Hui Zhang, Verian Bader, Konstanze F. Winklhofer, Ana J. García‐Sáez, Andrzej Rajca, Stephanie Bleicken, Enrica Bordignon · 2019 · Scientific Reports
70. Photocatalytic proximity labelling of MCL-1 by a BH3 ligand
    Hester A. Beard, Jacob R. Hauser, Martin Walko, Rachel M. George, Andrew John Wilson, Robin S. Bon · 2019 · Communications Chemistry
71. BH3 Mimetics in Hematologic Malignancies
    Pavel Klener, Dana Sovilj, Nicol Renešová, Ladislav Anděra · 2021 · International Journal of Molecular Sciences
72. Ionic liquid-mediated delivery of a BCL-2 inhibitor for topical treatment of skin melanoma
    Md Nurul Huda, Isaac G. Deaguero, Edgar A. Borrego, Raj Kumar, Tamanna Islam, Humayra Afrin, Armando Varela-Ramı́rez, Renato J. Aguilera, Eden E. L. Tanner, Md Nurunnabi · 2022 · Journal of Controlled Release
73. Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach
    Guiqin Zhang, Priyadarshani Nadeeshika Samarawickrama, Li Gui, Yuan Ma, Mei Cao, Hong Zhu, Wei Li, Honglin Yang, Kecheng Li, Yang Yang et al. · 2024 · Aging and Disease
74. Targeted protein degradation in hematologic malignancies: clinical progression towards novel therapeutics
    Yupiao Feng, Xinting Hu, Xin Wang · 2024 · Biomarker Research
75. PPI inhibitor and stabilizer development in human diseases
    Jürgen Bosch · 2017 · Drug Discovery Today Technologies
76. Functional BCL-2 rs2279115 Promoter Noncoding Variant Contributes to Glioma Predisposition, Especially in Males
    Xiaoguang Qiu, Yidong Chen, Jupeng Yuan, Nasha Zhang, Tianshui Lei, Jie Liu, Ming Yang · 2018 · DNA and Cell Biology
77. Synthesis, Anticancer Activities and Molecular Docking Studies of a Novel Class of 2-Phenyl-5,6,7,8-tetrahydroimidazo [1,2-b]pyridazine Derivatives Bearing Sulfonamides
    Otmane Bourzikat, Abdelmoula El Abbouchi, Hamza Ghammaz, Nabil El Brahmi, Elmostfa El Fahime, Arnaud Pâris, Richard Daniellou, Franck Suzenet, Gérald Guillaumet, Saı̈d El Kazzouli · 2022 · Molecules
78. The therapeutic effect of wasp venom (Vespa magnifica, Smith) and its effective part on rheumatoid arthritis fibroblast-like synoviocytes through modulating inflammation, redox homeostasis and ferroptosis
    Lianli Ni, Yi-Hao Che, Hong-Mei Sun, Bo Wang, Meiyu Wang, Zizhong Yang, Heng Liu, Huai Xiao, Da‐Song Yang, Huilin Zhu et al. · 2023 · Journal of Ethnopharmacology
79. Inhibitory Effect of Arachis hypogaea (Peanut) and Its Phenolics against Methylglyoxal-Derived Advanced Glycation End Product Toxicity
    S. R. Park, Moon Ho Do, Jae Hyuk Lee, Minsun Jeong, Oh Lim, Sun Yeou Kim · 2017 · Nutrients
80. Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2
    Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, Keigo Okada, Ayako Nogami, Gaku Oshikawa, Toshikage Nagao, Osamu Miura · 2018 · Oncotarget
81. Proanthocyanidin Polymer-Rich Fraction of Stryphnodendron adstringens Promotes in Vitro and in Vivo Cancer Cell Death via Oxidative Stress
    Vanessa Kaplum, Anelise Cardoso Ramos, Márcia Edilaine Lopes Consolaro, Maria Aparecida Fernandez, Tânia Ueda‐Nakamura, Benedito Prado Dias Filho, Sueli de Oliveira Silva, João Carlos Palazzo de Mello, Celso Vataru Nakamura · 2018 · Frontiers in Pharmacology
82. Therapeutics Targeting the Core Apoptotic Machinery
    Hamilton, Claudia, Fox, Jennifer P., Longley, Daniel B., Higgins, Catherine A. · 2021 · Cancers
83. Overexpressed DEPDC1B contributes to the progression of hepatocellular carcinoma by CDK1
    Xiaowei Dang, Qi Pan, Zhen-Hai Lin, Hao‐Hao Wang, Lu-Hao Li, Lin Li, Dongqi Shen, Pei-Ju Wang · 2021 · Aging
84. Cellular senescence imaging and senolysis monitoring in cancer therapy based on a β-galactosidase-activated aggregation-induced emission luminogen
    Peili Cen, Chunyi Cui, Jiani Huang, Hetian Chen, Fei Hua Wu, Jiaqi Niu, Yan Zhong, Chentao Jin, Weihong Zhu, Hong Zhang et al. · 2024 · Acta Biomaterialia
85. A Hierarchical Graph Neural Network Framework for Predicting Protein-Protein Interaction Modulators With Functional Group Information and Hypergraph Structure
    Zitong Zhang, Lingling Zhao, Junjie Wang, Chunyu Wang · 2024 · IEEE Journal of Biomedical and Health Informatics
86. Macrocyclic peptides as regulators of protein-protein interactions
    Yang Zi Jiang, Hongyi Long, Yu‐Jie Zhu, Yi Zeng · 2018 · Chinese Chemical Letters
87. Phytosterols and triterpenes fromMorinda lucidaBenth (Rubiaceae) as potential inhibitors of anti-apoptotic BCL-XL, BCL-2, and MCL-1: an in-silico study
    Kayode Ezekiel Adewole, Ahmed Adebayo Ishola · 2019 · Journal of Receptors and Signal Transduction
88. Tomentosin induces apoptotic pathway by blocking inflammatory mediators via modulation of cell proteins in AGS gastric cancer cell line
    Hongwei Yang, Hongchao Zhao, Xinhua Dong, Zhen Yang, Weilong Chang · 2020 · Journal of Biochemical and Molecular Toxicology
89. PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors
    Peiyi Zhang, Xuan Zhang, Xingui Liu, Sajid Ullah Khan, Daohong Zhou, Guangrong Zheng · 2020 · Exploration of Targeted Anti-tumor Therapy
90. Downregulation of CDC20 suppressed cell proliferation, induced apoptosis, triggered cell cycle arrest in osteosarcoma cells, and enhanced chemosensitivity to cisplatin
    Yi Gao, Caili Guo, Shuqin Fu, Yibing Cheng, Chunlan Song · 2020 · Neoplasma
91. Marizomib sensitizes primary glioma cells to apoptosis induced by a latest-generation TRAIL receptor agonist
    Chiara Boccellato, Emily Kolbe, Nathalie Peters, Viktorija Jurić, Gavin Fullstone, Maïté Verreault, Ahmed Idbaïh, Martine L.M. Lamfers, Brona M. Murphy, Markus Rehm · 2021 · Cell Death and Disease
92. Artesunate, a new antimalarial clinical drug, exhibits potent anti‐AML activity by targeting the ROS/Bim and TFRC/Fe2+ pathways
    Yi Liu, Han Li, Zhihong Luo, Yu You, Jingzhao Yang, Min Zhang, Betty Yuen Kwan Law, Zan Huang, Wenhua Li · 2022 · British Journal of Pharmacology
93. Schiff bases as linker in the development of quinoline-sulfonamide hybrids as selective cancer-associated carbonic anhydrase isoforms IX/XII inhibitors: A new regioisomerism tactic
    Afaf El‐Malah, Ehab S. Taher, Andrea Angeli, Samar S. Elbaramawi, Zeinab Mahmoud, Nour Moustafa, Claudiu Trandafir Supuran, Tarek Salah Ibrahim · 2022 · Bioorganic Chemistry
94. STAT3 inhibition enhances gemcitabine sensitivity in pancreatic cancer by suppressing EMT, immune escape and inducing oxidative stress damage
    Hangcheng Guo, Zujian Hu, Xuejia Yang, Ziwei Yuan, Yuanyuan Gao, Jiawei Chen, Lili Xie, Chaoyue Chen, Yangyang Guo, Yongheng Bai · 2023 · International Immunopharmacology
95. Evaluating venetoclax and its potential in treatment-naïve acute myeloid leukemia
    Tristan E. Knight, Holly J. Edwards, Jeffrey Warren Taub, Yubin Ge · 2019 · Cancer Management and Research
96. Role and regulation of FOXO3a: new insights into breast cancer therapy
    Wenqiu Mei, Bingyin Mei, Jing Chang, Yifei Liu, Yanhong Zhou, Ni Zhu, Meichun Hu · 2024 · Frontiers in Pharmacology
97. Recent advances in dual PROTACs degrader strategies for disease treatment
    Jianyu Liu, Yanzhuo Liu, Jiao Tang, Qianyuan Gong, Guoyi Yan, Hengrui Fan, Xueping Zhang, Chunlan Pu · 2024 · European Journal of Medicinal Chemistry
98. Synthesis and in vitro antiproliferative evaluation of PEGylated triterpene acids
    Marta Medina‐O’Donnell, Francisco Rivas, Fernando J. Reyes‐Zurita, Antonio Martı́nez, Francisco Galisteo-González, José Antonio Lupiáñez, Andrés Parra · 2017 · Fitoterapia
99. Retracted: MicroRNA‐132 attenuates LPS‐induced inflammatory injury by targeting TRAF6 in neuronal cell line HT‐22
    Yangfei Ji, Dan Wang, Yan‐Ru Liu, Xingrong Ma, Hong Lu, Boai Zhang · 2018 · Journal of Cellular Biochemistry · Retracted
100. A Hopeful Natural Product, Pristimerin, Induces Apoptosis, Cell Cycle Arrest, and Autophagy in Esophageal Cancer Cells
     Peng Huang, Li‐Ying Sun, Yanqiao Zhang · 2019 · Analytical Cellular Pathology