Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Galluzzi, Lorenzo, Bravo-San Pedro, José Manuel, Levine, Beth, Green, Douglas R., Kroemer, Guido·2017·Nature Reviews Drug Discovery

Cited by (850)

Items 301–400 of 850

  1. Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I
    Lucas Robke, Yushi Futamura, Georgios Konstantinidis, Julian Wilke, Harumi Aono, Zhwan Mahmoud, Nobumoto Watanabe, Yao‐Wen Wu, Hiroyuki Osada, Luca Laraia et al. · 2018 · Chemical Science
  2. The Complex Role of Autophagy in Melanoma Evolution: New Perspectives From Mouse Models
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  3. The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity
    Rui Jia, Juan S. Bonifacino · 2021 · Journal of Biological Chemistry
  4. TFEB regulates pluripotency transcriptional network in mouse embryonic stem cells independent of autophagy–lysosomal biogenesis
    Anderson Tan, Renuka Prasad, Eek‐hoon Jho · 2021 · Cell Death and Disease
  5. Therapeutic Potential of Exploiting Autophagy Cascade Against Coronavirus Infection
    Subhajit Maity, Abhik Saha · 2021 · Frontiers in Microbiology
  6. Molecular mechanisms of mammalian autophagy
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  7. The role of autophagy in colorectal cancer: Impact on pathogenesis and implications in therapy
    Eglal Mahgoub, Jalal Taneera, Nabil D. Sulaiman, Maha Mohamed Saber-Ayad · 2022 · Frontiers in Medicine
  8. Systemic autophagy in the therapeutic response to anthracycline-based chemotherapy
    Castoldi, Francesca, Vacchelli, Erika, Zitvogel, Laurence, Maiuri, Maria Chiara, Pietrocola, Federico, Kroemer, Guido · 2019 · OncoImmunology
  9. Intermittent or continuous feeding: any difference during the first week?
    Lisa Van Dyck, Michael Paul Casaer · 2019 · Current Opinion in Critical Care
  10. Regulation of signaling pathways by β‐elemene in cancer progression and metastasis
    Muhammad Zahid Qureshi, Rükset Attar, Mirna Azalea Romero, Uteuliyev Yerzhan Sabitaliyevich, Sadykov Bolat Nurmurzayevich, Özlem Akilli Öztürk, Lara Hanna‐Wakim, Xiukun Lin, Ülkü Özbey, Armida Bakhytbekovna Yelekenova et al. · 2019 · Journal of Cellular Biochemistry
  11. Rejuvenation of Mesenchymal Stem Cells to Ameliorate Skeletal Aging
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  12. Challenges of Regulated Cell Death: Implications for Therapy Resistance in Cancer
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  13. Degradation of altered mitochondria by autophagy is impaired in Lafora disease
    Marcos Lahuerta, Carmen Aguado, Pablo Sánchez‐Martín, Pascual Sanz, Erwin Knecht · 2018 · FEBS Journal
  14. The role of host autophagy machinery in controllingToxoplasmainfection
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  15. Stress responses in stromal cells and tumor homeostasis
    Ilio Vitale, Gwenola Manic, Claudia Galassi, Lorenzo Galluzzi · 2019 · Pharmacology & Therapeutics
  16. Therapeutic Potential of Autophagy Modulation in Cholangiocarcinoma
    Héctor Perez‐Montoyo · 2020 · Cells
  17. Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis
    Qingya Shi, Fen Pei, Gary A. Silverman, Stephen C. Pak, David H. Perlmutter, Bing Liu, İvet Bahar · 2020 · International Journal of Molecular Sciences
  18. Inducing endoplasmic reticulum stress in cancer cells using graphene oxide-based nanoparticles
    Shalini Pandey, Aditi Nandi, Sudipta Basu, Nirmalya Ballav · 2020 · Nanoscale Advances
  19. Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes‐induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis
    Yuan Tian, Yue‐Hai Xiao, Tian Geng, Chao Sun, Jiang Gu, Kaifa Tang, Bei Liu, Yi‐Meng Liu, Sun Fa · 2020 · Biology of the Cell
  20. Impaired autophagy promotes hair loss in the C3H/HeJ mouse model of alopecia areata
    Rupali Gund, Angela M. Christiano · 2022 · Autophagy
  21. Amlexanox-Modified Platinum(IV) Complex Triggers Apoptotic and Autophagic Bimodal Death of Cancer Cells
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  22. Therapeutic implications of targeting autophagy and TGF-β crosstalk for the treatment of liver fibrosis
    Samaneh Siapoush, Ramazan Rezaei, Helia Alavifard, Behzad Hatami, Mohammad Reza Zali, Massoud Vosough, Shahrokh Lorzadeh, Marek Łoś, Kaveh Baghaei, Saeid Ghavami · 2023 · Life Sciences
  23. Comprehensive monitoring of mitochondrial viscosity variation during different cell death processes by a NIR mitochondria-targeting fluorescence probe
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  24. Feedback regulation of ubiquitination and phase separation of HECT E3 ligases
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  25. Her2-Targeted Therapy Induces Autophagy in Esophageal Adenocarcinoma Cells
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  26. Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis
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  27. Autophagy inhibition enhances the inhibitory�effects of ursolic acid on lung cancer cells
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  28. Drug discovery by targeting the protein–protein interactions involved in autophagy
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  29. Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma
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  30. On the relevance of precision autophagy flux control in vivo – Points of departure for clinical translation
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  31. Naringin Protects against Non‐Alcoholic Fatty Liver Disease by Promoting Autophagic Flux and Lipophagy
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  32. Inhibition of autophagy-related protein 7 enhances anti-tumor immune response and improves efficacy of immune checkpoint blockade in microsatellite instability colorectal cancer
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  33. Hypoxic tumor microenvironment: Destroyer of natural killer cell function
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  34. Autophagy in Rare (NonLysosomal) Neurodegenerative Diseases
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  35. Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γ/TGF-β Pathway
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  36. Flavonoids from Scutellaria barbata D. Don exert antitumor activity in colorectal cancer through inhibited autophagy and promoted apoptosis via ATF4/sestrin2 pathway
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  37. Correction of autophagy impairment inhibits pathology in the NOD.H-2h4 mouse model of primary Sjögren's syndrome
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  38. Norcantharidin alone or in combination with crizotinib induces autophagic cell death in hepatocellular carcinoma by repressing c-Met-mTOR signaling
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  39. Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8
    Zsófia Agod, Kitti Pázmándi, Dóra Bencze, György Vereb, Tamás Bı́ró, Attila Szabó, Éva Rajnavölgyi, Attila Bácsi, Pablo Engel, Árpád Lányi · 2018 · Frontiers in Immunology
  40. Dimethylaminomicheliolide ameliorates peritoneal fibrosis through the activation of autophagy
    Shuting Li, Fenfen Peng, Wangqiu Gong, Jiayu Wu, Yuxian Wang, Zhaozhong Xu, Wenting Liu, Hongyu Li, Bohui Yin, Ying Zhang et al. · 2019 · Journal of Molecular Medicine
  41. Substance P enhances BMSC osteogenic differentiation via autophagic activation
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  42. A functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy
    Thomas Neill, Aastha Kapoor, Christopher Xie, Simone Buraschi, Renato V. Iozzo · 2021 · Matrix Biology
  43. Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo
    Federica Albanese, Daniela Mercatelli, Luca Finetti, Giulia Lamonaca, Sara Pizzi, Derya R. Shimshek, Giovanni Bernacchia, Michele Morari · 2021 · Neurobiology of Disease
  44. Autophagy Modulation in Aggresome Formation: Emerging Implications and Treatments of Alzheimer’s Disease
    Md. Ataur Rahman, MD. Hasanur Rahman, A. N. M. Mamun-Or-Rashid, Hongik Hwang, Sooyoung Chung, Bonglee Kim, Hyewhon Rhim · 2022 · Biomedicines
  45. BL-918, a small-molecule activator of ULK1, induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy
    Wei Chiang Liu, Shiou Zhu, Yulin Guo, Long‐Fang Tu, Yongqi Zhen, Rongyan Zhao, Liang Ouyang, Hiroshi Kurihara, Rong‐Rong He, Bo Liu · 2022 · Acta Pharmacologica Sinica
  46. Mechanistical retinal drug targets and challenges
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  47. Tomatidine protects against ischemic neuronal injury by improving lysosomal function
    Anil Ahsan, Yanrong Zheng, Shijia Ma, Mengru Liu, Ming Cao, Yue Li, Wanqing Zheng, Xinyu Zhou, Minhang Xin, Weiwei Hu et al. · 2020 · European Journal of Pharmacology
  48. Inhibition of autophagy with chloroquine dysregulates mitochondrial quality control and energetics in adipocytes
    Hafiz Muhammad Ahmad Javaid, Hwayeon Lim, Sooim Shin, Joo Young Huh · 2022 · Archives of Pharmacal Research
  49. Oxidized Phospholipids in Tumor Microenvironment Stimulate Tumor Metastasis via Regulation of Autophagy
    Jin Kyung Seok, Eun‐Hee Hong, Gabsik Yang, Hye‐Eun Lee, Sin-Eun Kim, Kwang‐Hyeon Liu, Han Chang Kang, Yong‐Yeon Cho, Hye Suk Lee, Joo Young Lee · 2021 · Cells
  50. Interplay of autophagy and cancer stem cells in hepatocellular carcinoma
    Magdelyn Mei-Theng Wong, Hui-Yin Chan, Norazlin Abdul Aziz, Thamil Selvee Ramasamy, Jan Jin Bong, Ewe Seng Ch’ng, Subasri Armon, Suat‐Cheng Peh, Sin‐Yeang Teow · 2021 · Molecular Biology Reports
  51. Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors
    Dennis X. Hu, Snahel D. Patel, Huifen Chen, Shu‐Mei Wang, Steven T. Staben, Yoana N. Dimitrova, Heidi Ackerly Wallweber, Joanna Y. Lee, Grace Ka Yan Chan, Christopher J. Sneeringer et al. · 2021 · Journal of Medicinal Chemistry
  52. New drugs in preclinical and early stage clinical development in the treatment of heart failure
    Juan Luis Tamargo, Ricardo Caballero, Eva Delpón · 2018 · Expert Opinion on Investigational Drugs
  53. Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy
    Andrea Martello, Angela Lauriola, David J. Mellis, Elisa Parish, John C. Dawson, Lisa H.J. Imrie, Martina Vidmar, Noor Gammoh, Tijana Mitić, Mairi Brittan et al. · 2020 · EMBO Reports
  54. Emerging dimensions of autophagy in melanoma
    Christian Ronquillo Pangilinan, Daniel J. Klionsky, Chengyu Liang · 2024 · Autophagy
  55. Ubiquitination regulates autophagy in cancer: simple modifications, promising targets
    Yihui Wu, Yifei Chen, Xianyan Tian, Genbao Shao, Qiong Lin, Aiqin Sun · 2024 · Journal of Translational Medicine
  56. Drug Nanorod-Mediated Intracellular Delivery of microRNA-101 for Self-sensitization via Autophagy Inhibition
    Xiaofei Xin, Xiaoqing Du, Qingqing Xiao, Helena S. Azevedo, Wei He, Lifang Yin · 2019 · Nano-Micro Letters
  57. An Updated Review on Implications of Autophagy and Apoptosis in Tumorigenesis: Possible Alterations in Autophagy through Engineered Nanomaterials and Their Importance in Cancer Therapy
    Habib Ghaznavi, Milad Shirvaliloo, Amir Zarebkohan, Zinat Shams, Fatemeh Radnia, Zahra Bahmanpour, Saman Sargazi, Ramin Saravani, Sakine Shirvalilou, Omolbanin Shahraki et al. · 2021 · Molecular Pharmacology
  58. Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism
    Alexander S. Häusl, Thomas Bajaj, Lea M. Brix, Max L. Pöhlmann, Kathrin Hafner, Meri De Angelis, Joachim Nagler, Frederik Dethloff, Georgia Balsevich, Karl‐Werner Schramm et al. · 2022 · Science Advances
  59. Blockade of CXCR4 promotes macrophage autophagy through the PI3K/AKT/mTOR pathway to alleviate coronary heart disease
    Fangqin Li, Jin Peng, Yanlin Lu, Ming Zhou, Jingwei Liang, Cuiyun Le, Jiuyang Ding, Jiawen Wang, Jialin Dai, Changwu Wan et al. · 2023 · International Journal of Cardiology
  60. Immunosuppressive Cell Death in Cancer
    Galluzzi, Lorenzo, Buqué, Aitziber, Kepp, Oliver, Zitvogel, Laurence, Kroemer, Guido · 2017 · Nature Reviews Immunology
  61. Two-Membrane Hybrid Nanobiomimetic Delivery System for Targeted Autophagy Inhibition of Activated Hepatic Stellate Cells To Synergistically Treat Liver Fibrosis
    Yaowen Zhang, Li‐Shuang Hou, Jie‐Hua Xing, Tang-Rui Zhang, Siyuan Zhou, Bang‐Le Zhang · 2023 · ACS Applied Materials & Interfaces
  62. New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis
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  63. CircSEC24B activates autophagy and induces chemoresistance of colorectal cancer via OTUB1-mediated deubiquitination of SRPX2
    Di Wang, Yongge Li, Weilong Chang, Meina Feng, Yiming Yang, Xiuxiang Zhu, Zhibo Liu, Yang Fu · 2024 · Cell Death and Disease
  64. Dendrogenin A Synergizes with Cytarabine to Kill Acute Myeloid Leukemia Cells In Vitro and In Vivo
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  65. Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions
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  66. An Overview of Autophagy in Helicobacter pylori Infection and Related Gastric Cancer
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  67. Shining Light on Autophagy in Skin Pigmentation and Pigmentary Disorders
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  73. PEST-containing nuclear protein regulates cell proliferation, migration, and invasion in lung adenocarcinoma
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