Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Galluzzi, Lorenzo, Bravo-San Pedro, José Manuel, Levine, Beth, Green, Douglas R., Kroemer, Guido·2017·Nature Reviews Drug Discovery

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Items 501–600 of 850

  1. Antioxidative Sirt1 and the Keap1-Nrf2 Signaling Pathway Impair Inflammation and Positively Regulate Autophagy in Murine Mammary Epithelial Cells or Mammary Glands Infected with Streptococcus uberis
    Sohrab Khan, Tian Wang, Eduardo Ruben Cobo, Bingchun Liang, Muhammad Asfandyar Khan, Maolin Xu, Weijie Qu, Jian Gao, Herman Wildrik Barkema, John Patrick Kastelic et al. · 2024 · Antioxidants
  2. A proton-catalyzing prodrug for PDT and glycolysis inhibition-synergistic therapy of tumor in spatiotemporal dimensions
    Miao Li, Xueying Sun, Xiuqin Ma, Tan Yang, Xiaoyi Jin, Yi Wang, Fan Yang, Qian Li, Honglei Zhan, Xiaojun Peng · 2024 · Science China Chemistry
  3. Regulation of PKCβ levels and autophagy by PML is essential for high-glucose-dependent mesenchymal stem cell adipogenesis
    Claudia Morganti, Sonia Missiroli, Magdalena Lebiedzińska, Letizia Ferroni, Lucia Morganti, Mariasole Perrone, Daniela Ramaccini, Savino Occhionorelli, Barbara Zavan, Mariusz Roman Wieckowski et al. · 2018 · International Journal of Obesity
  4. Inhibition of JNJ-26481585-mediated autophagy induces apoptosis via ROS activation and mitochondrial membrane potential disruption in neuroblastoma cells
    Vamsi Krishna Kommalapati, Dinesh Kumar, Anjana Devi Tangutur · 2020 · Molecular and Cellular Biochemistry
  5. Do You Remember Mitochondria?
    Flavia Messina, Francesco Cecconi, Carlo Rodolfo · 2020 · Frontiers in Physiology
  6. NQO1 Deficiency Aggravates Renal Injury by Dysregulating Vps34/ATG14L Complex during Autophagy Initiation in Diabetic Nephropathy
    Geum-Lan Hong, Kyung‐Hyun Kim, Chul‐Ho Lee, Tae‐Won Kim, Ju‐Young Jung · 2021 · Antioxidants
  7. The parkinsonian LRRK2 R1441G mutation shows macroautophagy-mitophagy dysregulation concomitant with endoplasmic reticulum stress
    Sokhna M. S. Yakhine-Diop, Mario Rodríguez‐Arribas, Saray Canales-Cortés, Guadalupe Martínez-Chacón, Elisabet Uribe-Carretero, Mercedes Blanco-Benítez, Gema Duque-González, Marta Paredes-Barquero, Eva Alegre-Cortés, Vicente E Climent et al. · 2021 · Cell Biology and Toxicology
  8. Downregulation of PTEN Promotes Autophagy via Concurrent Reduction in Apoptosis in Cardiac Hypertrophy in PPAR α−/− Mice
    Ritu Kumari, Aleepta Guha Ray, Dibyanti Mukherjee, V. Chander, D. Kar, Uppulapu Shravan Kumar, Deepak Bharadwaj P.V.P., S. Banerjee, Aditya Konar, A. Bandyopadhyay · 2022 · Frontiers in Cardiovascular Medicine
  9. Calorie restriction and breast cancer treatment: a mini-review
    Meden F. Isaac-Lam, Kelly DeMichael · 2022 · Journal of Molecular Medicine
  10. Promising horizon to alleviate Alzeheimer’s disease pathological hallmarks via inhibiting mTOR signaling pathway: A new application for a commonplace analgesic
    Leila Pourtalebi Jahromi, Zahra Sasanipour, Amir Azadi · 2017 · Medical Hypotheses
  11. Autophagy in periodontal disease: Evidence from a literature review
    Alejandro I. Lorenzo‐Pouso, Pablo Castelo‐Baz, Mário Pérez‐Sayáns, Jason Chu-Shern Lim, Yago Leira · 2019 · Archives of Oral Biology
  12. BCL2A1 and CCL18 Are Predictive Biomarkers of Cisplatin Chemotherapy and Immunotherapy in Colon Cancer Patients
    Taohua Yue, Xiangzheng Liu, Shuai Zuo, Jing Zhu, Jichang Li, Yucun Liu, Shanwen Chen, Pengyuan Wang · 2022 · Frontiers in Cell and Developmental Biology
  13. Pancreas Β-Cells in Type 1 and Type 2 Diabetes: Cell Death, Oxidative Stress and Immune Regulation. Recently Appearing Changes in Diabetes Consequences
    Elena G. Novoselova · 2024 · Cellular Physiology and Biochemistry
  14. TFEB signaling promotes autophagic degradation of NLRP3 to attenuate neuroinflammation in diabetic encephalopathy
    Yijia Lin, Lizhen Cheng, Yixin Chen, Wei Li, Qihao Guo, Ya Miao · 2024 · American Journal of Physiology-Cell Physiology
  15. LC3‐Associated Phagocytosis and Antigen Presentation
    Laure‐Anne Ligeon, Monica Loi, Christian Münz · 2018 · Current Protocols in Immunology
  16. Effects of Trichinella spiralis and its excretory/secretory products on autophagy of host muscle cells in vivo and in vitro
    Xiaoxiang Hu, Xiaolei Liu, Xue Bai, Yang Li, Jing Ding, Xuemin Jin, Chen Li, Yulu Zhang, Yanfeng Li, Yong Yang et al. · 2021 · PLoS neglected tropical diseases
  17. The LC3B FRET biosensor monitors the modes of action of ATG4B during autophagy in living cells
    Elif Begüm Gökerküçük, Angélique Cheron, Marc Tramier, Giulia Bertolin · 2023 · Autophagy
  18. Autosis as a selective type of cell death
    Lingge Bai, Qiong Wu, Xinyue Zhang, Yuting Zhao · 2023 · Frontiers in Cell and Developmental Biology
  19. Targeting autophagy drug discovery: Targets, indications and development trends
    Mengjia Jiang, Wayne Wu, Zijie Xiong, Zihong Ye, Zihong Ye, Zhiping Wu · 2024 · European Journal of Medicinal Chemistry
  20. To be or not to be cell autonomous? Autophagy says both
    Nina Fenouille, Anna Chiara Nascimbeni, Joëlle Botti, Nicolas Dupont, Étienne Morel, Patrice Codogno · 2017 · Essays in Biochemistry
  21. Updated Understanding of Cancer as a Metabolic and Telomere-Driven Disease, and Proposal for Complex Personalized Treatment, a Hypothesis
    Cristian Muresanu, Siva G. Somasundaram, Sergei Valentinovich Vissarionov, Luis Fernando Torres Solis, Arturo Solís Herrera, Cecil E. Kirkland, Gjumrakch Aliev · 2020 · International Journal of Molecular Sciences
  22. Identification of potential autophagy-associated lncRNA in prostate cancer
    Jun Li, Hong Du, Wenqiang Chen, Mingxing Qiu, Peng He, Zhiwei Ma · 2021 · Aging
  23. Non-enzymatic heparanase enhances gastric tumor proliferation via TFEB-dependent autophagy
    Min Yang, Bo Tang, Sumin Wang, Tang Li, Dalin Wen, Israël Vlodavsky, Shiming Yang · 2022 · Oncogenesis
  24. Genistein antagonizes gliadin-induced CFTR malfunction in models of celiac disease
    Speranza Esposito, Valeria Rachela Villella, Eleonora Ferrari, Romina Monzani, Antonella Tosco, Federica Rossin, Manuela D’Eletto, Alice Castaldo, Alessandro Luciani, Marco Silano et al. · 2019 · Aging
  25. Autophagy: Shedding Light on the Mechanisms and Multifaceted Roles in Cancers
    Hongmei You, Ling Wang, Hongwu Meng, Jun Li, Guo-ying Fang · 2025 · Biomolecules
  26. Tight association of autophagy and cell cycle in leukemia cells
    Alena Gschwind, Christian Marx, Marie D. Just, Paula Severin, Hannah Behring, Lisa Marx-Blümel, Sabine Becker, Linda Rothenburger, Martin Förster, James F. Beck et al. · 2022 · Cellular & Molecular Biology Letters
  27. Research Progress on Autophagy Regulation by Active Ingredients of Traditional Chinese Medicine in the Treatment of Acute Lung Injury
    Jin-yan Dong, Honglin Yin, Hao Hao, Yang Liu · 2023 · Journal of Inflammation Research
  28. ROS-mediated NRF2/p-ERK1/2 signaling-involved mitophagy contributes to macrophages activation induced by CdTe quantum dots
    Na Liu, Ying Liang, Tingting Wei, Xiaoquan Huang, Ting Zhang, Meng Xiong Tang · 2024 · Toxicology
  29. Up-regulating autophagy by targeting the mTOR-4EBP1 pathway: a possible mechanism for improving cardiac function in mice with experimental dilated cardiomyopathy
    Bo Jin, Haiming Shi, Jun Zhu, Bangwei Wu, Quzhen Geshang · 2020 · BMC Cardiovascular Disorders
  30. Saikosaponin D Inhibits the Proliferation and Promotes the Apoptosis of Rat Hepatic Stellate Cells by Inducing Autophagosome Formation
    Hong Jiang, Jia Liu, Kun Zhang, Qingxin Zeng · 2021 · Evidence-based Complementary and Alternative Medicine
  31. Identification and Validation of Autophagy-Related Genes as Potential Biomarkers and Therapeutic Targets in Atrial Fibrillation
    Jiao Zhou, Yunlong Dong, Xiang Cai, Hongbo Yang, Tao Guo · 2021 · International Journal of General Medicine
  32. Therapeutic Aspects and Molecular Targets of Autophagy to Control Pancreatic Cancer Management
    Md. Ataur Rahman, Kazi Rejvee Ahmed, MD. Hasanur Rahman, Md. Anowar Khasru Parvez, In‐Seon Lee, Bonglee Kim · 2022 · Biomedicines
  33. The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush
    Mingxing Teng, Damian W. Young, Zhi Tan · 2022 · Journal of Medicinal Chemistry
  34. Expression of LC3B and FIP200/Atg17 in brain metastases of breast cancer
    Nooshin Hashemi Sadraei, Gaelle M. Muller-Greven, Fadi W. Abdul‐Karim, Ilya V. Ulasov, Erinn P. Downs-Kelly, Monica E. Burgett, Adam J. Lauko, Maha A. Qadan, Robert John Weil, Manmeet Singh Ahluwalia et al. · 2018 · Journal of Neuro-Oncology
  35. Lysosomotropic Features and Autophagy Modulators among Medical Drugs: Evaluation of Their Role in Pathologies
    Т. А. Короленко, Thomas Patrick Johnston, Václav Větvička · 2020 · Molecules
  36. Role of autophagy machinery dysregulation in bacterial chondronecrosis with osteomyelitis
    Alison Ramser, Elizabeth Greene, Adnan Ali Khalaf Alrubaye, Robert F. Wideman Jr., Sami Dridi · 2022 · Poultry Science
  37. Autophagy and Bacterial infections
    Ken Cadwell, Clara Abraham, Shai Bel, Santosh Chauhan, Jörn Coers, María Isabel Colombo, Jacob R Davis, Daniel Hofius, Hang Thi Thu Nguyen, Michinaga Ogawa et al. · 2025 · Autophagy Reports
  38. Inspiring Tactics with the Improvement of Mitophagy and Redox Balance for the Development of Innovative Treatment against Polycystic Kidney Disease
    Moeka Nakashima, Naoko Suga, Yuka Ikeda, Sayuri Yoshikawa, Satoru Matsuda · 2024 · Biomolecules
  39. Role of canonical and noncanonical autophagy pathways in shaping the life journey of B cells
    Yiwen Wang, Lan Wu, Luc Van Kaer · 2024 · Frontiers in Immunology
  40. Integrating Vascular Phenotypic and Proteomic Analysis in an Open Microfluidic Platform
    Sangmin Jung, Sunghun Cheong, Yoon-Ho Lee, Jungseub Lee, Jihye Lee, Min‐Seok Kwon, Young Sun Oh, Tae‐Wan Kim, Sungjae Ha, Sung Jae Kim et al. · 2024 · ACS Nano
  41. Autophagy in reproduction and pregnancy-associated diseases
    Asmita Singh, Maira L Perez, Oleksandr Kirsanov, Elizabeth Padilla‐Banks, Carlos M. A. Guardia · 2024 · iScience
  42. Pseudomonas plecoglossicida infection induces neutrophil autophagy-driven NETosis in large yellow croaker Larimichthys crocea
    Jia-Feng Cao, Jiong Chen · 2024 · Frontiers in Immunology
  43. Integrating bulk and single-cell RNA sequencing data: unveiling RNA methylation and autophagy-related signatures in chronic obstructive pulmonary disease patients
    Shi‐Xia Liao, Lanying Zhang, Ling-Mei Shi, Huaiyu Hu, Yanhui Gu, Ting-Hua Wang, Yao Ouyang, Peng-Peng Sun · 2025 · Scientific Reports
  44. Targeting autophagy in astrocytes: a potential for neurodegenerative disease intervention
    Maja Potokar, Jernej Jorgačevski · 2025 · Frontiers in Cellular Neuroscience
  45. Cucurbitacin E Exerts Anti-Proliferative Activity via Promoting p62-Dependent Apoptosis in Human Non-Small-Cell Lung Cancer A549 Cells
    Han‐Lin Hsu, Bo-Jyun Lin, Yu‐Chen Lin, Chih-Chieh Tu, Nham-Linh Nguyen, Ching‐Chiung Wang, Mei-Chuan Chen, Chun‐Han Chen · 2023 · Current Issues in Molecular Biology
  46. LncRNAs as Therapeutic Targets for Autophagy-involved Cardiovascular Diseases: A Review of Molecular Mechanism and T herapy Strategy
    Lihui Jin, Nanchao Hong, Xuefeng Ai, Jing Wang, Zhuoyan Li, Zhenyuan Han, Qi Zhang, Yu Yu, Kun Sun · 2020 · Current Medicinal Chemistry
  47. Nature Inspired Small Molecules for Chemical Biology
    Kamal Kumar, Herbert Waldmann · 2018 · Israel Journal of Chemistry
  48. Synthesis and biological characterization of clicked chloroquine copolymers as macromolecular inhibitors of cancer cell migration
    Fei Yu, Yazhe Wang, Hang Yu, Weimin Tang, Zhifeng Zhao, David Oupický · 2019 · Journal of Polymer Science Part A Polymer Chemistry
  49. Effects of different autophagy inhibitors on sensitizing KG ‐1 and HL ‐60 leukemia cells to chemotherapy
    Atousa Haghi, Mahdieh Salemi, Aila Fakhimahmadi, Mahnaz Mohammadi Kian, Hassan Yousefi, Marveh Rahmati, Saeed Mohammadi, Ardeshir Ghavamzadeh, Mohammad Amin Moosavi, Mohsen Nikbakht · 2020 · IUBMB Life
  50. Autophagy modulation changes mechano-chemical sensitivity of T24 bladder cancer cells
    Maximilian Jobst, Maliha Hossain, Endre Kiss, Janice Bergen, Doris Marko, Giorgia Del Favero · 2023 · Biomedicine & Pharmacotherapy
  51. Autophagy and mitophagy as potential therapeutic targets in diabetic heart condition: Harnessing the power of nanotheranostics
    Sagnik Nag, Oishi Mitra, Bhanu Maturi, Simran Preet Kaur, Ankita Saini, Muskan Nama, Soumik Roy, Souvik Samanta, Leena Chacko, Rohan Dutta et al. · 2024 · Asian Journal of Pharmaceutical Sciences
  52. The Mechanism of Acupuncture Regulating Autophagy: Progress and Prospect
    Jing He, Min He, Mengmeng Sun, Hongxiu Chen, Zhiqiang Dou, Ru Nie, Jun Zhou, Qingqing Tang, Cong Che, Jie Liu et al. · 2025 · Biomolecules
  53. Mild hyperthermia induced by gold nanorods acts as a dual-edge blade in the fate of SH-SY5Y cells via autophagy
    Maryam Ghafarkhani, Çığır Biray Avcı, Reza Rahbarghazi‬, Abbas Karimi, Majid Sadeghizadeh, Amir Zarebkohan, Farhad Bani · 2021 · Scientific Reports
  54. The dynamic changes in autophagy activity and its role in lung injury after deep hypothermic circulatory arrest
    Minjian Kong, Dongdong Wei, Xuebiao Li, Xian Zhu, Ze Hong, Ming Ni, Yifan Wang, Aiqiang Dong · 2022 · Journal of Cellular and Molecular Medicine
  55. Pharmacological modulation of autophagy for epilepsy therapy: Opportunities and obstacles
    Wenqing Chen, Jifa Zhang, Yiwen Zhang, Yiwen Zhang, Wanling Li, Leihao Sha, Yilin Xia, Lei Chen · 2023 · Drug Discovery Today
  56. Regulation and Functions of Autophagy During Animal Development
    Lucas J. Restrepo, Eric H. Baehrecke · 2024 · Journal of Molecular Biology
  57. Autophagy inhibition improves the targeted radionuclide therapy efficacy of 131I-FAP-2286 in pancreatic cancer xenografts
    Xingyu Liu, Danni Li, Tianbao Ma, Xiu Luo, Peng Ye, Tao Wang, Changjing Zuo, Jianming Cai · 2024 · Journal of Translational Medicine
  58. Facts and Myths: Efficacies of Repurposing Chloroquine and Hydroxychloroquine for the Treatment of COVID-19
    Md. Abdul Alim Al‐Bari · 2020 · Current Drug Targets
  59. In desmoid-type fibromatosis cells sorafenib induces ferroptosis and apoptosis, which are enhanced by autophagy inhibition
    Anne‐Rose W. Schut, Anne L. M. Vriends, Andrea Sacchetti, Milea J. M. Timbergen, Benjamin Aaron Alman, Mushriq Al‐Jazrawe, Dirk Jan Grünhagen, Cornelis Kees Verhoef, Stefan Sleijfer, Erik A.C. Wiemer · 2022 · European Journal of Surgical Oncology
  60. Associating Immunotherapy and Targeted Therapies: Facts and Hopes
    Sylvain Ladoire, Cédric Rébé, François Ghiringhelli · 2022 · Clinical Cancer Research
  61. Modulation of autophagy in human diseases strategies to foster strengths and circumvent weaknesses
    Shouping Xu, Shiyao Sui, Xianyu Zhang, Boran Pang, Lin Wan, Da Pang · 2019 · Medicinal Research Reviews
  62. Autophagy of naïve CD4+T cells in aging – the role of body adiposity and physical fitness
    Camila S. Padilha, Mehdi Kushkestani, Liliana Carina Pereira Baptista, Karsten Krüger, Fábio Santos Lira · 2023 · Expert Reviews in Molecular Medicine
  63. CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells
    Maria Alejandra Gonzalez Porras, Heather M. Gransee, Travis T. Denton, Dunxin Shen, Kevin L. Webb, C. Jeffrey Brinker, Achraf Noureddine, Gary Charles Sieck, Carlos Bernardo Mantilla · 2023 · Scientific Reports
  64. Atg5 knockout induces alternative autophagy via the downregulation of Akt expression
    Hye‐Gyo Kim, Myeong‐Han Ro, Michael Lee · 2023 · Toxicological Research
  65. Nanomedicine for cancer targeted therapy with autophagy regulation
    Ketai He, Mingkun Chen, Jiao Liu, Shufang Du, Changyu Ren, Jifa Zhang · 2024 · Frontiers in Immunology
  66. Harnessing endocytic pH gradients for cascaded formation of intracellular condensates to inhibit autophagy: A pathway to cancer therapy
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  67. Epimedium polysaccharides ameliorate ulcerative colitis by inhibiting oxidative stress and regulating autophagy
    Linxian Zhao, Tao Jiang, Yuxin Zhang, Zhen Shen · 2024 · Journal of the Science of Food and Agriculture
  68. Phase-separated Condensates in Autophagosome Formation and Autophagy Regulation
    Zheng Wang, Hong Zhang · 2025 · Journal of Molecular Biology
  69. The administration of exogenous HSP47 as a collagen-specific therapeutic approach
    Roberta Besio, Nadia Garibaldi, Alessandra Sala, Francesca Tonelli, Carla Aresi, Elisa Maffioli, Claudio Casali, Camilla Torriani, Marco Biggiogera, Simona Villani et al. · 2025 · JCI Insight
  70. Distinct Types of Regulated Cell Death in Melanoma
    Qi Wu, Shuang A. Liang, Guo-Jun Shi, Guoliang Meng, Shengju Yang · 2025 · Cells
  71. Development of a p62 biodegrader for autophagy targeted degradation
    Zacharias Thiel, David Marcellin, Carole Manneville, Benedikt Goretzki, Luca Egger, Rob Maher, Noémie Siccardi, Laura Torres, Alexandra Probst, Catrin Swantje Müller et al. · 2025 · Nature Communications
  72. Autophagy modulation in cancer
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  73. Improvement of ACK1-targeted therapy efficacy in lung adenocarcinoma using chloroquine or bafilomycin A1
    Jinhong Zhu, Kui Cao, Meng Zhao, Keru Ma, Xiangyu Jiang, Yuwen Bai, Xiaodong Ling, Jianqun Ma · 2023 · Molecular Medicine
  74. Cancer Cell-Specific Autophagy Activation Using Phosphorus-Based Nanoplatform as Anabolism Activator
    Yiqi Li, Qilong Fang, Jiang-Yi-Hui Sheng, Xiaodong Hu, Yanbing Yang, Yun Zhang, Long Chen, Jie Tan, Quan Yuan, Weihong Tan · 2023 · ACS Materials Letters
  75. Transcription Factor EB: A Promising Therapeutic Target for Ischemic Stroke
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  76. Scoparone induces autophagic cell death via the PAK1/AKT axis in colorectal cancer
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  77. Review on the role of autophagy in the toxicity of nanoparticles and the signaling pathways involved
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  78. Autophagy inducing cyclic peptides constructed by methionine alkylation
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  79. Hepatic Tumor Cell Morphology Plasticity under Physical Constraints in 3D Cultures Driven by YAP–mTOR Axis
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  89. Development of a High-Throughput, Compound-Multiplexed Fluorescence Polarization Assay to Identify ATG5–ATG16L1 Protein–Protein Interaction Inhibitors
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  90. Photothermal Killing of A549 Cells and Autophagy Induction by Bismuth Selenide Particles
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  91. Mechanisms of Survival of Cytomegalovirus-Infected Tumor Cells
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  92. Study on the multitarget mechanism of alliin activating autophagy based on network pharmacology and molecular docking
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  93. Autophagy Dysfunction: The Kernel of Hair Loss?
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  96. Maternal Overnutrition During Gestation in Sheep Alters Autophagy Associated Pathways in Offspring Heart
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  97. RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and potential biomarkers
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  98. Autophagy Induced by BCL2-Related ceRNA Network Participates in the Occurrence of COPD
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  99. Interaction between Autophagy and Senescence in Pancreatic Beta Cells
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  100. Discordant placental oxygenation and autophagy in twin anemia-polycythemia sequence (TAPS)
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