Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214

Autophagy and Viruses: Adversaries or Allies?

Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,444

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Natural compounds modulate the autophagy with potential implication of stroke

Ahsan, A., Liu, M., Zheng, Y., Yan, W., Pan, L., Li, Y., Ma, S., Zhang, X., Cao, M., Wu, Z., et al. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.10.018 · Cited by 109

LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells

Wang, X., Lan, Z., He, J., Lai, Q., Yao, X., Li, Q., Liu, Y., Lai, H., Gu, C.-C., Yan, Q., et al. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0951-6 · Cited by 108

Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA

Wang, C., Qu, L., Li, S., Yin, F., Ji, L., Peng, W., Luo, H., Lu, D., Liu, X., Chen, X., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00567 · Cited by 109

Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan

Silvestrini, M. J., Johnson, J. R., Kumar, A. V., Thakurta, T. G., Blais, K., Neill, Z. A., Marion, S. W., St. Amand, V., Reenan, R. A., & Lapierre, L. R. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.063 · Cited by 101

Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease

Khambu, B., Yan, S., Huda, N., Liu, G., & Yin, X. (2018) · Liver Research · doi:10.1016/j.livres.2018.09.004 · Cited by 107

Natural Compounds and Autophagy: Allies Against Neurodegeneration

Stacchiotti, A., & Corsetti, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.555409 · Cited by 106

Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein

Fan, S., Yue, L., Wan, W., Zhang, Y., Zhang, B., Otomo, C., Li, Q., Lin, T., Hu, J., Xu, P., et al. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202109464 · Cited by 101

Molecular modulators of celastrol as the keystones for its diverse pharmacological activities

Ng, S. W., Chan, Y., Chellappan, D. K., Madheswaran, T., Zeeshan, F., Chan, Y. L., Collet, T., Gupta, G., Oliver, B. G. G., Wark, P. A. B., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.051 · Cited by 101

Till Death Do Us Part: The Marriage of Autophagy and Apoptosis

Cooper, K. F. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4701275 · Cited by 104

Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 infections to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease patients

Mahmud, S., Al-Mustanjid, M., Akter, F., Rahman, M. S., Ahmed, K., Rahman, M. H., Chen, W., & Moni, M. A. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab115 · Cited by 99

Radiation‐Induced Immunogenic Cell Death for Cancer Radioimmunotherapy

Liu, T., Pei, P., Shen, W., Hu, L. T., & Yang, K. (2023) · Small Methods · doi:10.1002/smtd.202201401 · Cited by 104

Carrier-Free Trehalose-Based Nanomotors Targeting Macrophages in Inflammatory Plaque for Treatment of Atherosclerosis

Wu, Z., Zhou, M., Tang, X., Zeng, J., Li, Y., Sun, Y., Huang, J., Chen, L., Wan, M., & Mao, C. (2022) · ACS Nano · doi:10.1021/acsnano.1c08391 · Cited by 97

Targeting autophagy in osteoporosis: From pathophysiology to potential therapy

Li, X., Xu, J., Dai, B., Wang, X., Guo, Q., & Qin, L. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101098 · Cited by 97

Emerging role of immunogenic cell death in cancer immunotherapy

Arimoto, K., Miyauchi, S., Liu, M., & Zhang, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1390263 · Cited by 103

Inside the β Cell: Molecular Stress Response Pathways in Diabetes Pathogenesis

Kulkarni, A., Muralidharan, C., May, S. C., Tersey, S. A., & Mirmira, R. G. (2022) · Endocrinology · doi:10.1210/endocr/bqac184 · Cited by 95

Macroautophagy and aging: The impact of cellular recycling on health and longevity

Nieto-Torres, J. L., & Hansen, M. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101020 · Cited by 93

Autophagy inhibitors for cancer therapy: Small molecules and nanomedicines

Chen, J., Wu, X., Yin, D., Jia, X.-H., Chen, X., Gu, Z., & Zhu, X. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108485 · Cited by 94

4-PBA ameliorates cellular homeostasis in fibroblasts from osteogenesis imperfecta patients by enhancing autophagy and stimulating protein secretion

Besio, R., Iula, G., Garibaldi, N., Cipolla, L., Sabbioneda, S., Biggiogera, M., Marini, J. C., Rossi, A., & Forlino, A. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.02.002 · Cited by 89

p53 at the Crossroads between Different Types of HDAC Inhibitor-Mediated Cancer Cell Death

Mrakovcic, M., Kleinheinz, J., & Fröhlich, L. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102415 · Cited by 90

Immune recognition of irradiated cancer cells

Wennerberg, E., Vanpouille‐Box, C., Bornstein, S., Yamazaki, T., Demaria, S., & Galluzzi, L. (2017) · Immunological Reviews · doi:10.1111/imr.12568 · Cited by 88

Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems

Tavakol, S., Ashrafizadeh, M., Deng, S., Azarian, M., Abdoli, A., Motavaf, M., Poormoghadam, D., Khanbabaei, H., Afshar, E. G., Mandegary, A., et al. (2019) · Biomolecules · doi:10.3390/biom9100530 · Cited by 92

Regulated Necrosis in Pulmonary Disease. A Focus on Necroptosis and Ferroptosis

Minagawa, S., Yoshida, M., Araya, J., Hara, H., Imai, H., & Kuwano, K. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0337tr · Cited by 89

Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity

Janji, B., Berchem, G., & Chouaı̈b, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00887 · Cited by 86

Disaccharide trehalose in experimental therapies for neurodegenerative disorders: Molecular targets and translational potential

Pupyshev, A. B., Klyushnik, T. P., Akopyan, A. A., Singh, S. K., & Tikhonova, M. A. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106373 · Cited by 83

HAMdb: a database of human autophagy modulators with specific pathway and disease information

Wang, N.-N., Dong, J., Zhang, L., Ouyang, D., Cheng, Y., Chen, A. F., Lu, A.-P., & Cao, D.-S. (2018) · Journal of Cheminformatics · doi:10.1186/s13321-018-0289-4 · Cited by 83

Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins

Li, J., Zhu, R., Chen, K., Zheng, H., Zhao, H., Yuan, C., Zhang, H., Wang, C., & Zhang, M. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0082-8 · Cited by 81

Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics

Chang, C., Young, L. N., Morris, K. L., von Bülow, S., Schöneberg, J., Yamamoto‐Imoto, H., Oe, Y., Yamamoto, K., Nakamura, S., Stjepanović, G., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.10.035 · Cited by 83

ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4 + T cell pathogenicity during CNS inflammation

Keller, C. W., Sina, C., Kotur, M. B., Ramelli, G., Mundt, S., Quast, I., Ligeon, L.-A., Weber, P., Becher, B., Münz, C., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713664114 · Cited by 81

Adiponectin receptor PAQR-2 signaling senses low temperature to promote C. elegans longevity by regulating autophagy

Chen, Y., Tao, J., Zhao, P., Tang, W., Xu, J., Zhang, K., & Zou, C. (2019) · Nature Communications · doi:10.1038/s41467-019-10475-8 · Cited by 80

Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics

Denzel, M. S., Lapierre, L. R., & Mack, H. I. D. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.08.001 · Cited by 82

Programmed Cell Death in Asthma: Apoptosis, Autophagy, Pyroptosis, Ferroptosis, and Necroptosis

Liu, L., Zhou, L., Wang, L., Zheng, P., Zhang, F., Mao, Z., Zhang, H., & Liu, H. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s417801 · Cited by 82

Autophagy Paradox of Cancer: Role, Regulation, and Duality

Verma, A. K., Bharti, P. S., Rafat, S., Bhatt, D., Goyal, Y., Pandey, K. K., Ranjan, S. K., Almatroodi, S. A., Alsahli, M. A., Rahmani, A. H., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8832541 · Cited by 78

Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models

Kerr, F., Bjedov, I., & Sofola-Adesakin, O. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00297 · Cited by 80

Autophagy in the cancer-immunity dialogue

Yamazaki, T., Pedro, J. M. B., Galluzzi, L., Kroemer, G., & Pietrocola, F. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.12.003 · Cited by 80

Advances in small-molecule fluorescent probes for the study of apoptosis

Ye, Y., Pan, J.-C., Wang, H., Zhang, X., Zhu, H., & Liu, X. (2024) · Chemical Society Reviews · doi:10.1039/d4cs00502c · Cited by 78

Drug discovery targeting the mTOR pathway

Martelli, A. M., Buontempo, F., & McCubrey, J. A. (2018) · Clinical Science · doi:10.1042/cs20171158 · Cited by 77

Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis

Zhang, N., Peng, F., Wang, Y., Li, Y., Wu, F., Wang, X., Cui, Y., Han, B., & He, G. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.36955 · Cited by 77

Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy

Ye, J., Lu, S., Wang, M., Ge, W., Liu, H., Qi, Y., Fu, J.-H., Zhang, Q., Zhang, B., Sun, G., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01170 · Cited by 76

Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo

Christ, M., Huesmann, H., Nagel, H., Kern, A., & Behl, C. (2019) · Cells · doi:10.3390/cells8030211 · Cited by 78

Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer

Ren, H., Bakas, N. A., Vamos, M., Chaikuad, A., Limpert, A. S., Wimer, C. D., Brun, S. N., Lambert, L. J., Tautz, L., Celeridad, M., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00873 · Cited by 77

High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding

Chiang, W., Wei, Y., Kuo, Y.-C., Wei, S., Zhou, A., Zou, Z., Yehl, J., Ranaghan, M. J., Skepner, A. P., Bittker, J. A., et al. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00421 · Cited by 75

LINC00470 Coordinates the Epigenetic Regulation of ELFN2 to Distract GBM Cell Autophagy

Liu, C., Fu, H., Liu, X., Lei, Q., Zhang, Y., She, X., Liu, Q., Liu, Q., Sun, Y., Li, G., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.06.019 · Cited by 75

Vascular autophagy in health and disease

Hughes, W. E., Beyer, A., & Gutterman, D. D. (2020) · Basic Research in Cardiology · doi:10.1007/s00395-020-0802-6 · Cited by 74

Targeting Autophagy to Counteract Obesity-Associated Oxidative Stress

Pietrocola, F., & Pedro, J. M. B. (2021) · Antioxidants · doi:10.3390/antiox10010102 · Cited by 77

The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases

Possemato, E., Barbera, L. L., Nobili, A., Krashia, P., & D’Amelio, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101907 · Cited by 76

Autophagy mediates glucose starvation-induced glioblastoma cell quiescence and chemoresistance through coordinating cell metabolism, cell cycle, and survival

Wang, L. Y., Shang, Z., Zhou, Y., Hu, X., Chen, Y., Fan, Y., Wei, X., Wu, L. L., Liang, Q., Zhang, J., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0242-x · Cited by 75

The application of nanoparticles-based ferroptosis, pyroptosis and autophagy in cancer immunotherapy

Deng, W., Shang, H., Tong, Y., Liu, X., Huang, Q., He, Y. T., Wu, J., Ba, X., Chen, Z., Chen, Y., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02297-8 · Cited by 80

The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions

Ke, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123940 · Cited by 78

KLF5 downregulation desensitizes castration-resistant prostate cancer cells to docetaxel by increasing BECN1 expression and inducing cell autophagy

Jia, J., Zhang, H., Shi, Q., Yang, C., Ma, J., Jin, B., Wang, X., He, D., & Guo, P. (2019) · Theranostics · doi:10.7150/thno.33282 · Cited by 71

Spermidine as a target for cancer therapy

Fan, J., Feng, Z., & Chen, N. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104943 · Cited by 70

Nanotechnology Reprogramming Metabolism for Enhanced Tumor Immunotherapy

Zhou, Y., Yuan, J. T., Xu, K., Li, S., & Liu, Y. (2024) · ACS Nano · doi:10.1021/acsnano.3c11260 · Cited by 73

Autophagy and Its Implications Against Early Full Nutrition Support in Critical Illness

Van Dyck, L., Casaer, M. P., & Gunst, J. (2018) · Nutrition in Clinical Practice · doi:10.1002/ncp.10084 · Cited by 70

Autophagy in asthma and chronic obstructive pulmonary disease

Barnes, P. J., Baker, J. R., & Donnelly, L. (2022) · Clinical Science · doi:10.1042/cs20210900 · Cited by 73

Programmed cell death: molecular mechanisms, biological functions, diseases, and therapeutic targets

Qian, S., Long, Y., Tan, G., Li, X., Xiang, B., Tao, Y., Xie, Z., & Zhang, X. (2024) · MedComm · doi:10.1002/mco2.70024 · Cited by 81

EGCG protects vascular endothelial cells from oxidative stress-induced damage by targeting the autophagy-dependent PI3K-AKT-mTOR pathway

Meng, J., Chen, Y., Wang, J., Qiu, J.-L., Chang, C., Bi, F., Wu, X., & Liu, W. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.01.92 · Cited by 69

Isoginkgetin, a potential CDK6 inhibitor, suppresses SLC2A1/GLUT1 enhancer activity to induce AMPK-ULK1-mediated cytotoxic autophagy in hepatocellular carcinoma

Yao, J., Tang, S., Shi, C., Lin, Y., Ge, L., Chen, Q., Ou, B., Liu, D., Miao, Y., Xie, Q., et al. (2022) · Autophagy · doi:10.1080/15548627.2022.2119353 · Cited by 69

Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells

Merkley, S. D., Chock, C. J., Yang, X. O., Harris, J., & Castillo, E. F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02914 · Cited by 68

Cardiac Autophagy in Sepsis

Sun, Y., Cai, Y., & Zang, Q. S. (2019) · Cells · doi:10.3390/cells8020141 · Cited by 69

The effect of miRNA and autophagy on colorectal cancer

Long, J., He, Q., Yin, Y., Lei, X., Li, Z., & Zhu, W. (2020) · Cell Proliferation · doi:10.1111/cpr.12900 · Cited by 69

Mitophagy, a Form of Selective Autophagy, Plays an Essential Role in Mitochondrial Dynamics of Parkinson’s Disease

Wang, X., Feng, S., Wang, Y., Yuan, Y., Li, Z., Chen, N., Wang, Z., & Zhang, Y. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01039-w · Cited by 66

A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB

Lin, Y., Shi, Q., Yang, G., Shi, F., Zhou, Y., Wang, T., Xu, P., Li, P., Liu, Z., Sun, H., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2213670120 · Cited by 66

Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle–Mediated Lysosome–Autophagy System

Liu, J., Kang, Y., Yin, S., Chen, A., Wu, J., Liang, H., & Shao, L. (2019) · Small · doi:10.1002/smll.201901073 · Cited by 65

Comprehensive autophagy evaluation in cardiac disease models

Kaludercic, N., Maiuri, M. C., Kaushik, S., Fernández, Á. F., de Bruijn, J., Castoldi, F., Chen, Y., Ito, J., Mukai, R., Murakawa, T., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvz233 · Cited by 64

Role of autophagy and regulatory mechanisms in alcoholic cardiomyopathy

Wang, S., & Ren, J. T. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.03.016 · Cited by 64

Therapeutic modulation of autophagy: which disease comes first?

Maiuri, M. C., & Kroemer, G. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0290-0 · Cited by 66

Cellular stress due to impairment of collagen prolyl hydroxylation complex is rescued by the chaperone 4-phenylbutyrate

Besio, R., Garibaldi, N., Leoni, L., Cipolla, L., Sabbioneda, S., Biggiogera, M., Mottes, M., Aglan, M., Otaify, G. A., Temtamy, S. A., et al. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.038521 · Cited by 63

Autophagy and cancer cell metabolism

Anderson, C. M., & Macleod, K. F. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.06.002 · Cited by 63

Autophagy promotes triple negative breast cancer metastasis via YAP nuclear localization

Chen, W., Bai, Y., Patel, C., & Geng, F. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.09.133 · Cited by 63

Naringenin Upregulates AMPK-Mediated Autophagy to Rescue Neuronal Cells From β-Amyloid (1–42) Evoked Neurotoxicity

Ahsan, A. U., Sharma, V. L., Wani, A., & Chopra, M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01969-4 · Cited by 65

Autophagy in the Heart

Yamaguchi, O. (2019) · Circulation Journal · doi:10.1253/circj.cj-18-1065 · Cited by 62

Enhancement of hepatic autophagy increases ureagenesis and protects against hyperammonemia

Soria, L. R., Allegri, G., Melck, D., Pastore, N., Annunziata, P., Paris, D., Polishchuk, E., Nusco, E., Thöny, B., Motta, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714670115 · Cited by 61

Melatonin as an endogenous regulator of diseases: The role of autophagy

Roohbakhsh, A., Shamsizadeh, A., Hayes, A. W., Reiter, R. J., & Karimi, G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.022 · Cited by 59

Strategies for the etiological therapy of cystic fibrosis

Maiuri, L., Raia, V., & Kroemer, G. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.126 · Cited by 60

Autophagy-related long non-coding RNA signature for ovarian cancer

Meng, C., Zhou, J.-Q., & Liao, Y.-S. (2020) · Journal of International Medical Research · doi:10.1177/0300060520970761 · Cited by 59

Repurposing antifungal drugs for cancer therapy

Weng, N., Zhang, Z., Tan, Y., Zhang, X., Wei, X., & Zhu, Q. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2022.08.018 · Cited by 60

Autophagy and T cell metabolism

Dowling, S. D., & Macián, F. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.033 · Cited by 59

Bioactive Compound Collections: From Design to Target Identification

Laraia, L., Robke, L., & Waldmann, H. (2018) · Chem · doi:10.1016/j.chempr.2018.01.012 · Cited by 61

The role of radiation induced oxidative stress as a regulator of radio-adaptive responses

Sisakht, M., Darabian, M., Mahmoodzadeh, A., Bazı, A., Shafiee, S. M., Mokarram, P., & Khoshdel, Z. (2020) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1721597 · Cited by 60

Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles

Deng, Z., Dong, Y., Zhou, X., Lu, J.-H., & Yue, Z. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.12.009 · Cited by 58

Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender

Porcu, C., Sideri, S., Martini, M., Cocomazzi, A., Galli, A., Tarantino, G., & Balsano, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123948 · Cited by 58

The protease activity of human ATG4B is regulated by reversible oxidative modification

Zheng, X., Yang, Z., Gu, Q., Xia, F., Fu, Y., Liu, P., Yin, X., & Li, M. (2019) · Autophagy · doi:10.1080/15548627.2019.1709763 · Cited by 62

Minimized combinatorial CRISPR screens identify genetic interactions in autophagy

Diehl, V., Wegner, M., Grumati, P., Husnjak, K., Schaubeck, S., Gubaš, A., Shah, V. J., Polat, I. H., Langschied, F., Prieto‐Garcia, C., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab309 · Cited by 55

Dual pathway reduction of Mo4+ and photogenerated electrons restore catalytic sites to enhance heterogeneous peroxymonosulfate activation system

Li, J., Hu, C., Liu, B., & Liu, Z. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.139246 · Cited by 58

Mitochondrial dysfunction as a therapeutic strategy for neurodegenerative diseases: Current insights and future directions

Gu, Y., Zhao, X., Zhang, N., Yang, Y., Yi, Y., Shao, Q.-H., Liu, M.-X., & Zhang, X.-L. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102577 · Cited by 60

Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy

Zhang, J. C., Wang, G., Zhou, Y., Chen, Y., Ouyang, L., & Liu, B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2759-2 · Cited by 59

The effects of caloric restriction and its mimetics in Alzheimer's disease through autophagy pathways

Yang, Y., & Zhang, L. (2020) · Food & Function · doi:10.1039/c9fo02611h · Cited by 57

Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy

García-Martínez, E., Smith, M. M., Buqué, A., Aranda, F., de la Peña, F. A., Rubio, A. I., Cánovas, M. S., Conesa, M. A. V., Fucikova, J. P., Špíšek, R., et al. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1433982 · Cited by 56

Genetic aberrations in macroautophagy genes leading to diseases

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The role of epithelial-mesenchymal transition and autophagy in pancreatic ductal adenocarcinoma invasion

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