The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Recent advances in the discovery and delivery of vaccine adjuvants
Open accessAbstract
Adjuvant design has historically had a touch of alchemy at its heart due to its reliance on the complex biology of innate immune activation. However, a new mechanistic understanding of innate immunity, combined with new adjuvant and delivery platforms for exploiting this knowledge, has led to significant advances recently. Although many challenges remain, the field is moving rapidly and the proper tools and methodologies are in place for the use of traditional drug discovery engines in guiding the development of vaccine adjuvants. In this review, we outline the current trends in immune potentiator, delivery system and adjuvant design that will shape the vaccines of the future.
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Cites
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells
Bernasconi, N. L., Traggiai, E., & Lanzavecchia, A. (2002) · Science · doi:10.1126/science.1076071 · Cited by 1,304
An ancient system of host defense
Medzhitov, R., & Janeway, C. A. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80024-1 · Cited by 327
Microparticles as vaccine adjuvants and delivery systems
O’Hagan, D. T., & Singh, M. (2003) · Expert Review of Vaccines · doi:10.1586/14760584.2.2.269 · Cited by 214
Self-citation
Cited by
The challenge of emerging and re-emerging infectious diseases
Morens, D. M., Folkers, G. K., & Fauci, A. S. (2004) · Nature · doi:10.1038/nature02759 · Cited by 2,103
Vaccine adjuvants: mechanisms and platforms
Zhao, T., Cai, Y., Jiang, Y., He, X., Wei, Y., Yu, Y., & Tian, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01557-7 · Cited by 1,020
Targeting the innate immune response with improved vaccine adjuvants
Pashine, A., Valiante, N. M., & Ulmer, J. B. (2005) · Nature Medicine · doi:10.1038/nm1210 · Cited by 555
Self-citationTargeting dendritic cells with biomaterials: developing the next generation of vaccines
Reddy, S. T., Swartz, M. A., & Hubbell, J. A. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.10.005 · Cited by 406
Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy
Demento, S. L., Eisenbarth, S. C., Foellmer, H. G., Platt, C., Caplan, M. J., Mark Saltzman, W., Mellman, I., Ledizet, M., Fikrig, E., Flavell, R. A., et al. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.03.034 · Cited by 290
Metadata
- Authors
- O'Hagan, D. T., & Valiante, N. M.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2003-09-01
- Volume
- 2
- Issue
- 9
- Pages
- 727-735
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W1968114019
- Cited by
- 434
- References
- 4
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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