Cited by 2,568RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

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Design and development of polymers for gene delivery

Pack, Daniel W., Hoffman, Allan S., Pun, Suzie, Stayton, Patrick S.·2005·Nature Reviews Drug Discovery

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Abstract

The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally do not possess the required efficacy. In recent years, a variety of effective polymers have been designed specifically for gene delivery, and much has been learned about their structure-function relationships. With the growing understanding of polymer gene-delivery mechanisms and continued efforts of creative polymer chemists, it is likely that polymer-based gene-delivery systems will become an important tool for human gene therapy.

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Authors: Pack, D. W., Hoffman, A. S., Pun, S., & Stayton, P. S.
Affiliations: University of Illinois Urbana-Champaign (US)
University of Washington (US)
Corresponding author: Pack, Daniel W.
ORCID: Pack, Daniel W.
Pun, Suzie
Stayton, Patrick S.
Venue: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Published: 2005-07-01
Volume: 4
Issue: 7
Pages: 581-593
ISSN: 1474-1776 (ISSN-L)
1474-1784
DOI: 10.1038/nrd1775
OpenAlex: W2003414091
Cited by: 2,568
References: 181
Citations by year: 2026: 55 · 2025: 67 · 2024: 94 · 2023: 76 · 2022: 109 · 2021: 122 · 2020: 125 · 2019: 144 · 2018: 159 · 2017: 157 · 2016: 173 · 2015: 205 · 2014: 180 · 2013: 180 · 2012: 188
FWCI: 4.89
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Drug Discovery (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: gene therapy, structure-function relationship, polymer chemistry, non-viral vectors
MeSH terms: Animals, Cyclodextrins, Genetic Vectors, Humans, Imidazoles, Polymers, Drug Design, Genetic Therapy, Gene Transfer Techniques

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