Cited by 2,568RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

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Design and development of polymers for gene delivery

Pack, Daniel W., Hoffman, Allan S., Pun, Suzie, Stayton, Patrick S.·2005·Nature Reviews Drug Discovery

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Abstract

The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally do not possess the required efficacy. In recent years, a variety of effective polymers have been designed specifically for gene delivery, and much has been learned about their structure-function relationships. With the growing understanding of polymer gene-delivery mechanisms and continued efforts of creative polymer chemists, it is likely that polymer-based gene-delivery systems will become an important tool for human gene therapy.

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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.
Felgner, P. L., Gadek, T. R., Holm, M., Roman, R., Chan, H. W., Wenz, M., Northrop, J. P., RINGOLD, G. M., & Danielsen, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7413 · Cited by 4,954
Starburst Dendrimers: Molecular‐Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter
Tomalia, D. A., Naylor, A. M., & Goddard, W. A. (1990) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199001381 · Cited by 3,222
Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin
Skehel, J. J., & Wiley, D. C. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.531 · Cited by 2,706
Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease
Cavazzana, M., Hacein‐Bey‐Abina, S., Basile, G. D. S., Gross, F., Yvon, E. S., Nusbaum, P., Selz, F., Hue, C., Dogniaux, S., Casanova, J., et al. (2000) · Science · doi:10.1126/science.288.5466.669 · Cited by 2,685
Cyclodextrin-based pharmaceutics: past, present and future
Davis, M. E., & Brewster, M. E. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1576 · Cited by 2,057
The Basic Science of Gene Therapy
Mulligan, R. C. (1993) · Science · doi:10.1126/science.8493530 · Cited by 1,741
Gene therapy - promises, problems and prospects
Verma, I. M., & Somia, N. (1997) · Nature · doi:10.1038/38410 · Cited by 1,681
T Lymphocyte-Directed Gene Therapy for ADA − SCID: Initial Trial Results After 4 Years
Blaese, R. M., Culver, K. W., Miller, A. D., Carter, C. S., Fleisher, T. A., Clerici, M., Shearer, G. M., Chang, L., Chiang, Y. L., Tolstoshev, P., et al. (1995) · Science · doi:10.1126/science.270.5235.475 · Cited by 1,546
Endocytosis
Mukherjee, S., Ghosh, R. K., & Maxfield, F. R. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.759 · Cited by 1,338

Show all 181 references

Research works printed but not linked: 4

Schaffer, D. V. in Chemical Engineering 125 (Massachusetts Institute of Technology, Cambridge, Massachusetts, 1998).
Wilson, G., Dean, B. S., Wang, G. & Dean, D. A. DNA vector chemistry: the covalent attachment of signal peptides to plasmid DNA. J. Biol. Chem. 16, 80–85 (1998).
Henry, S., Pirie, C., Stayton, P. S. & Hoffman, A. S. Membrane–disruption ability of maleic anhydride copolymers at endosomal pHs. Biomacromolecules (in the press).
El-Sayed, M., Hoffman, A. S. & Stayton, P. S. Influence of composition of novel pH-sensitive and glutathione-reactive polymeric carriers on their membrane-destabilizing activity. J. Control. Release (in the press).

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Authors: Pack, D. W., Hoffman, A. S., Pun, S., & Stayton, P. S.
Affiliations: University of Illinois Urbana-Champaign (US)
University of Washington (US)
Corresponding author: Pack, Daniel W.
ORCID: Pack, Daniel W.
Pun, Suzie
Stayton, Patrick S.
Venue: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Published: 2005-07-01
Volume: 4
Issue: 7
Pages: 581-593
ISSN: 1474-1776 (ISSN-L)
1474-1784
DOI: 10.1038/nrd1775
OpenAlex: W2003414091
Cited by: 2,568
References: 181
Citations by year: 2026: 55 · 2025: 67 · 2024: 94 · 2023: 76 · 2022: 109 · 2021: 122 · 2020: 125 · 2019: 144 · 2018: 159 · 2017: 157 · 2016: 173 · 2015: 205 · 2014: 180 · 2013: 180 · 2012: 188
FWCI: 4.89
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Drug Discovery (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: gene therapy, structure-function relationship, polymer chemistry, non-viral vectors
MeSH terms: Animals, Cyclodextrins, Genetic Vectors, Humans, Imidazoles, Polymers, Drug Design, Genetic Therapy, Gene Transfer Techniques

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