The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Transient receptor potential channels: targeting pain at the source
Open accessAbstract
Pain results from the complex processing of neural signals at different levels of the central nervous system, with each signal potentially offering multiple opportunities for pharmacological intervention. A logical strategy for developing novel analgesics is to target the beginning of the pain pathway, and aim potential treatments directly at the nociceptors — the high-threshold primary sensory neurons that detect noxious stimuli. The largest group of receptors that function as noxious stimuli detectors in nociceptors is the transient receptor potential (TRP) channel family. This Review highlights evidence supporting particular TRP channels as targets for analgesics, indicates the likely efficacy profiles of TRP-channel-acting drugs, and discusses the development pathways needed to test candidates as analgesics in humans.
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Citations
Cites
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
Molecular mechanisms of nociception
Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685 · cited 1×
“The specificity of putative TRPV1 actions beyond primary sensory neurons, where its expression levels are by far the highes”
BackgroundTRPV1 Channels Mediate Long-Term Depression at Synapses on Hippocampal Interneurons
Gibson, H. E., Edwards, J. G., Page, R. S., Van Hook, M. J., & Kauer, J. A. (2008) · Neuron · doi:10.1016/j.neuron.2007.12.027 · Cited by 388
Deletion of vanilloid receptor 1_expressing primary afferent neurons for pain control
Karai, L., Brown, D. C., Mannes, A. J., Connelly, S. T., Brown, J., Gandal, M., Wellisch, O. M., Neubert, J. K., Olah, Z., & Iadarola, M. J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20449 · Cited by 340
Cited by
Advances in TRP channel drug discovery: from target validation to clinical studies
Koivisto, A.-P., Belvisi, M. G., Gaudet, R., & Szallasi, A. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00268-4 · Cited by 537
How neuroimaging studies have challenged us to rethink: Is chronic pain a disease?
Tracey, I., & Bushnell, M. C. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.09.001 · Cited by 455
Transient receptor potential (TRP) channels: a clinical perspective
Kaneko, Y., & Szallasi, A. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12414 · Cited by 370
Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1
Park, C.-K., Xu, Z.-Z., Berta, T., Han, Q., Chen, G., Liu, X.-J., & Ji, R.-R. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.011 · Cited by 289
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain
Berta, T., Qadri, Y., Tan, P.-H., & Ji, R.-R. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1328057 · Cited by 257
Metadata
- Authors
- Patapoutian, A., Tate, S., & Woolf, C. J.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2009-01
- Volume
- 8
- Issue
- 1
- Pages
- 55-68
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W1996634599
- Cited by
- 646
- References
- 4
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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