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Cited by 293

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

Leptin revisited: its mechanism of action and potential for treating diabetes

Open access
Coppari, Roberto, Bjørbæk, Christian·2012·Nature Reviews Drug Discovery
DOI 10.1038/nrd3757
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Abstract

Since the discovery of leptin in 1994, we now have a better understanding of the cellular and molecular mechanisms underlying its biological effects. In addition to its established anti-obesity effects, leptin exerts antidiabetic actions that are independent of its regulation of body weight and food intake. In particular, leptin can correct diabetes in animal models of type 1 and type 2 diabetes. In addition, long-term leptin replacement therapy improves glycaemic control, insulin sensitivity and plasma triglycerides in patients with severe insulin resistance due to lipodystrophy. These results have spurred enthusiasm for the use of leptin therapy to treat diabetes. Here, we review the current understanding of the glucoregulatory functions of leptin, emphasizing its central mechanisms of action and lessons learned from clinical studies, and discuss possible therapeutic applications of leptin in the treatment of type 1 and type 2 diabetes.

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Metadata

Authors
Coppari, R., & Bjørbæk, C.
Venue
Nature Reviews Drug Discovery
Publisher
Springer Science and Business Media LLC
Published
2012-08-31
Volume
11
Issue
9
Pages
692-708
ISSN
  • 1474-1776 (ISSN-L)
  • 1474-1784
DOI
10.1038/nrd3757
OpenAlex
W2008768221
Cited by
293
References
74
FWCI
3.22
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Leptin revisited: its mechanism of action and potential for treating diabetes. https://app.cochat.ai/papers/10.1038/nrd3757
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Coppari, R., & Bjørbæk, C. (2012). Leptin revisited: its mechanism of action and potential for treating diabetes. Nature Reviews Drug Discovery. https://doi.org/10.1038/nrd3757

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.