Leptin signaling

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053 · see citing works

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637 · see citing works

Hypothalamic mTOR Signaling Regulates Food Intake

Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278 · see citing works

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

Bates, S. H., Stearns, W. H., Dundon, T. A., Schubert, M., Tso, A. W. K., Wang, Y., Banks, A. S., Lavery, H. J., Haq, A. K., Maratos-Flier, E., et al. (2003) · Nature · doi:10.1038/nature01388 · Cited by 1,010 · cited 2× · see citing works

Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications

Kelesidis, T., Kelesidis, I., Chou, S. H.-H., & Mantzoros, C. S. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-2-201001190-00008 · Cited by 667 · see citing works

A Key Role of Leptin in the Control of Regulatory T Cell Proliferation

Rosa, V. D., Procaccini, C., Calı̀, G., Pirozzi, G., Fontana, S., Zappacosta, S., Cava, A. L., & Matarese, G. (2007) · Immunity · doi:10.1016/j.immuni.2007.01.011 · Cited by 638 · see citing works

Key enzyme in leptin-induced anorexia

Niswender, K. D., Morton, G. J., Stearns, W. H., Rhodes, C. J., Myers, M. G., & Schwartz, M. W. (2001) · Nature · doi:10.1038/35101657 · Cited by 585 · see citing works

Recent advances in understanding leptin signaling and leptin resistance

Morris, D. L., & Rui, L. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00274.2009 · Cited by 467 · see citing works

The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity

Coppari, R., Ichinose, M., Lee, C. E., Pullen, A. E., Kenny, C. D., McGovern, R. A., Tang, V., Liu, S. M., Ludwig, T., Chua, S. C., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.004 · Cited by 457 · see citing works

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

Kitamura, T., Feng, Y., Kitamura, Y., Chua, S. C., Xu, A. W., Barsh, G. S., Rossetti, L., & Accili, D. (2006) · Nature Medicine · doi:10.1038/nm1392 · Cited by 449 · see citing works

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis.

Varela, L., & Horvath, T. L. (2012) · The EMBO Reports · doi:10.1038/embor.2012.174 · Cited by 426 · see citing works

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

Gao, Q., Wolfgang, M. J., Neschen, S., Morino, K., Horvath, T. L., Shulman, G. I., & Fu, X.-Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0303992101 · Cited by 385 · see citing works

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

Procaccini, C., Rosa, V. D., Galgani, M., Abanni, L., Calı̀, G., Porcellini, A., Carbone, F., Fontana, S., Horváth, T. L., Cava, A. L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.024 · Cited by 369 · see citing works

Leptin and Inflammation

Iikuni, N., Lam, Q. K., Lu, L., Matarese, G., & Cava, A. L. (2008) · Current Immunology Reviews · doi:10.2174/157339508784325046 · Cited by 366 · see citing works

Hypothalamic Proopiomelanocortin Neurons Are Glucose Responsive and Express KATPChannels

Ibrahim, N., Bosch, M. A., Smart, J. L., Qiu, J., Rubinstein, M., Rønnekleiv, O. K., Low, M. J., & Kelly, M. J. (2003) · Endocrinology · doi:10.1210/en.2002-221033 · Cited by 355 · see citing works

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice

Berglund, E. D., Vianna, C. R., Donato, J., Kim, M. H., Chuang, J.-C., Lee, C. E., Lauzon, D. A., Lin, P., Brule, L. J., Scott, M. M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59816 · Cited by 352 · see citing works

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

Hill, J. W., Williams, K. W., Ye, C., Luo, J., Balthasar, N., Coppari, R., Cowley, M. A., Cantley, L. C., Lowell, B. B., & Elmquist, J. K. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32964 · Cited by 348 · see citing works

Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms

Buettner, C., Muse, E. D., Cheng, A. M., Chen, L., Scherer, T., Pocai, A., Su, K., Cheng, B., Li, X., Harvey-White, J. D., et al. (2008) · Nature Medicine · doi:10.1038/nm1775 · Cited by 342 · see citing works

Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis

Kim, M.-S., Pak, Y. K., Jang, P., NamKoong, C., Choi, Y.-S., Won, J. C., Kim, K., Kim, S., Kim, H.-S., Park, J., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1731 · Cited by 333 · see citing works

Leptin signaling

Ahima, R. S., & Osei, S. Y. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.014 · Cited by 315 · see citing works

Selective Insulin and Leptin Resistance in Metabolic Disorders

Könner, A. C., & Brüning, J. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.004 · Cited by 304 · see citing works

Leptin as an immunomodulator

Procaccini, C., Jirillo, E., & Matarese, G. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.012 · Cited by 299 · see citing works

Leptin revisited: its mechanism of action and potential for treating diabetes

Coppari, R., & Bjørbæk, C. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3757 · Cited by 295 · see citing works

Leptin in human physiology and therapeutics

Dardeno, T. A., Chou, S. H.-H., Moon, H., Chamberland, J. P., Fiorenza, C. G., & Mantzoros, C. S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.06.002 · Cited by 288 · see citing works

p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake

Dagon, Y., Hur, E. E., Zheng, B., Wellenstein, K., Cantley, L. C., & Kahn, B. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.05.010 · Cited by 283 · see citing works

CNS leptin and insulin action in the control of energy homeostasis

Belgardt, B., & Brüning, J. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05799.x · Cited by 275 · see citing works

Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

Zhang, E. E., Chapeau, E. A., Hagihara, K., & Feng, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405041101 · Cited by 263 · see citing works

Leptin's Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals

Moon, H., Dalamaga, Μ., Kim, S. Y., Pοlyzos, S. A., Hamnvik, O. R., Magkos, F., Paruthi, J., & Mantzoros, C. S. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1053 · Cited by 257 · see citing works

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells

Kievit, P., Howard, J. K., Badman, M. K., Balthasar, N., Coppari, R., Mori, H., Lee, C. E., Elmquist, J. K., Yoshimura, A., & Flier, J. S. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.06.010 · Cited by 242 · see citing works

A phosphatidylinositol 3-kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding

Zhao, A. Z., Huan, J.-N., Gupta, S., Pal, R., & Sahu, A. (2002) · Nature Neuroscience · doi:10.1038/nn885 · Cited by 242 · see citing works

Challenges and Opportunities of Defining Clinical Leptin Resistance

Myers, M. G., Heymsfield, S. B., Haft, C. R., Kahn, B. B., Laughlin, M. R., Leibel, R. L., Tschöp, M. H., & Yanovski, J. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.002 · Cited by 241 · see citing works

Leptin Induces Insulin-like Signaling That Antagonizes cAMP Elevation by Glucagon in Hepatocytes

Zhao, A. Z., Shinohara, M. M., Huang, D., Shimizu, M., Eldar-Finkelman, H., Krebs, E. G., Beavo, J. A., & Bornfeldt, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11348 · Cited by 238 · see citing works

Leptin Activates Human B Cells to Secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 Signaling Pathway

Agrawal, S., Gollapudi, S. V. S., Su, H., & Gupta, S. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9507-1 · Cited by 232 · see citing works

Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines

Zhao, Y., Sun, R., You, L., Gao, C., & Tian, Z. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02838-3 · Cited by 229 · see citing works

Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons

Huo, L., Gamber, K., Greeley, S., Silva, J., Huntoon, N., Leng, X.-H., & Bjørbæk, C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.05.003 · Cited by 226 · cited 1× · see citing works

Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

Gao, S., Kinzig, K. P., Aja, S., Scott, K. A., Keung, W., Kelly, S., Strynadka, K., Chohnan, S., Smith, W. W., Tamashiro, K. L. K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708385104 · Cited by 215 · see citing works

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

Banno, R., Zimmer, D., De Jonghe, B. C., Atienza, M., Rak, K., Yang, W., & Bence, K. K. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39620 · Cited by 214 · see citing works

Apoptotic Pathways Are Inhibited by Leptin Receptor Activation in Neutrophils

Bruno, A., Conus, S., Schmid, I., & Simon, H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.8090 · Cited by 211 · see citing works

Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications

Paz-Filho, G., Mastronardi, C. A., Franco, C. B., Wang, K. B., Wong, M., & Licinio, J. (2012) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302012000900001 · Cited by 211 · see citing works

Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling

Morrison, C. D., Morton, G. J., Niswender, K. D., Gelling, R. W., & Schwartz, M. W. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00094.2005 · Cited by 210 · see citing works

Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin

Rahmouni, K., Sigmund, C. D., Haynes, W. G., & Mark, A. L. (2008) · Diabetes · doi:10.2337/db08-0822 · Cited by 207 · see citing works

Immunological functions of leptin and adiponectin

Carbone, F., Rocca, C. L., & Matarese, G. (2012) · Biochimie · doi:10.1016/j.biochi.2012.05.018 · Cited by 204 · see citing works

FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake

Ren, H., Orozco, I. J., Su, Y., Suyama, S., Juárez, R. G., Horváth, T. L., Wardlaw, S. L., Plum, L., Arancio, O., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.04.032 · Cited by 201 · see citing works

Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis

Blouet, C., Ono, H., & Schwartz, G. J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.004 · Cited by 197 · see citing works

The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity

Cota, D., Matter, E. K., Woods, S. C., & Seeley, R. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1389-08.2008 · Cited by 191 · see citing works

Leptin at the Intersection of Neuroendocrinology and Metabolism: Current Evidence and Therapeutic Perspectives

Dalamaga, Μ., Chou, S. H.-H., Shields, K. S., Papageorgiou, P., Pοlyzos, S. A., & Mantzoros, C. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.010 · Cited by 191 · see citing works

Leptin signaling and circuits in puberty and fertility

Elias, C. F., & Purohit, D. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1095-1 · Cited by 190 · see citing works

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

Plum, L., Lin, H. V., Dutia, R., Tanaka, J., Aizawa, K. S., Matsumoto, M., Kim, A. J., Cawley, N. X., Paik, J.-H., Loh, Y. P., et al. (2009) · Nature Medicine · doi:10.1038/nm.2026 · Cited by 176 · see citing works

Leptin Activates a Novel CNS Mechanism for Insulin-Independent Normalization of Severe Diabetic Hyperglycemia

German, J. P., Thaler, J. P., Wisse, B. E., Oh-I, S., Sarruf, D. A., Matsen, M. E., Fischer, J. D., Taborsky, G. J., Schwartz, M. W., & Morton, G. J. (2011) · Endocrinology · doi:10.1210/en.2010-0890 · Cited by 169 · cited 1× · see citing works

Role of leptin in the pancreatic β-cell: effects and signaling pathways

Marroquí, L., González, A., Ñeco, P., Caballero‐Garrido, E., Vieira, E. C., Ripoll, C., Nadal, Á., & Quesada, I. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0025 · Cited by 151 · see citing works

FOXO1 in the ventromedial hypothalamus regulates energy balance

Kim, K. W., Donato, J., Berglund, E. D., Choi, Y., Kohno, D., Elias, C. F., DePinho, R. A., & Elmquist, J. K. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62848 · Cited by 137 · see citing works

Molecular mechanisms of central leptin resistance in obesity

Jung, C. H., & Kim, M.-S. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0020-y · Cited by 134 · see citing works

Central nervous control of energy and glucose balance: focus on the central melanocortin system

Xu, Y., Elmquist, J. K., & Fukuda, M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06248.x · Cited by 133 · see citing works

Effects of leptin and adiponectin on pancreatic β-cell function

Lee, Y., Magkos, F., Mantzoros, C. S., & Kang, E. S. (2011) · Metabolism · doi:10.1016/j.metabol.2011.04.008 · Cited by 132 · see citing works

Intracellular Mechanisms Involved in Leptin Regulation of Sympathetic Outflow

Rahmouni, K., Haynes, W. G., Morgan, D. A., & Mark, A. L. (2003) · Hypertension · doi:10.1161/01.hyp.0000048342.54392.40 · Cited by 120 · see citing works

Specific Physiological Roles for Signal Transducer and Activator of Transcription 3 in Leptin Receptor-Expressing Neurons

Piper, M. L., Unger, E. K., Myers, M. G., & Xu, A. W. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0389 · Cited by 113 · see citing works

Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity

Lee, J.-Y., Muenzberg, H., Gavrilova, O., Reed, J. A., Berryman, D., Villanueva, E. C., Louis, G. W., Leinninger, G. M., Bertuzzi, S., Seeley, R. J., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001639 · Cited by 90 · see citing works

Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis

Hill, J. W., Xu, Y., Preitner, F., Fukuda, M., Cho, Y.-R., Luo, J., Balthasar, N., Coppari, R., Cantley, L. C., Kahn, B. B., et al. (2009) · Endocrinology · doi:10.1210/en.2009-0454 · Cited by 88 · see citing works

Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic β-cells

Laubner, K., Kieffer, T. J., Lam, N. T., Niu, X., Jakob, F., & Seufert, J. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3410 · Cited by 85 · see citing works

SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis

Kim, K. W., Sohn, J.-W., Kohno, D., Xu, Y., Williams, K., & Elmquist, J. K. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.019 · Cited by 76 · see citing works

Intracellular Leptin-Signaling Pathways in Hypothalamic Neurons: The Emerging Role of Phosphatidylinositol-3 Kinase-Phosphodiesterase-3B-cAMP Pathway

Sahu, A. (2011) · Neuroendocrinology · doi:10.1159/000326785 · Cited by 73 · see citing works

Central leptin action improves skeletal muscle AKT, AMPK, and PGC1α activation by hypothalamic PI3K-dependent mechanism

Roman, E. A. F. R., Reis, D., Romanatto, T., Maimoni, D., Ferreira, E. A., Santos, G. A., Torsoni, A. S., Velloso, L. A., & Torsoni, M. A. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.007 · Cited by 71 · see citing works

Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis

Jiang, L., You, J., Yu, X., Gonzalez, L., Yu, Y., Wang, Q. A., Yang, G., Li, W., Cai, L., & Liu, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804589105 · Cited by 62 · see citing works

Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism

Scherer, T., & Buettner, C. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9190-4 · Cited by 60 · see citing works

The PI3K signaling pathway mediates the biological effects of leptin

Donato, J., Frazão, R., & Elias, C. F. (2010) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302010000700002 · Cited by 60 · see citing works

Stimulation of cardiac fatty acid oxidation by leptin is mediated by a nitric oxide–p38 MAPK-dependent mechanism

Sharma, V. K., Mustafa, S., Patel, N., Wambolt, R. B., Allard, M. F., & McNeill, J. H. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.06.037 · Cited by 38 · see citing works

The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging

Kennedy, B. K., & Lamming, D. W. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.009 · Cited by 544 · see citing works

Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution

Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works

STAT3 in the systemic inflammation of cancer cachexia

Zimmers, T. A., Fishel, M. L., & Bonetto, A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.02.009 · Cited by 223 · see citing works

Leptin action in normal and pathological pregnancies

Pérez‐Pérez, A., Toro, A. R., Vilariño‐García, T., Maymó, J. L., Guadix, P., Dueñas, J. L., Sánchez, M. F., Varone, C. L., & Sánchez‐Margalet, V. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13369 · Cited by 209 · see citing works

Lysosome: The metabolic signaling hub

Lamming, D. W., & Bar‐Peled, L. (2018) · Traffic · doi:10.1111/tra.12617 · Cited by 183 · see citing works

The central moTOR of metabolism

Simcox, J., & Lamming, D. W. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.02.024 · Cited by 163 · see citing works

Molecular Mechanisms of Cancer-Induced Sleep Disruption

Walker, W. H., II, & Borniger, J. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112780 · Cited by 146 · see citing works

Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system

Barnes, M. A., Carson, M. J., & Nair, M. G. (2015) · Cytokine · doi:10.1016/j.cyto.2015.01.008 · Cited by 110 · see citing works

Cognitive and autonomic determinants of energy homeostasis in obesity

Richard, D. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.103 · Cited by 109 · see citing works

Pilot in vivo investigation of cerium oxide nanoparticles as a novel anti-obesity pharmaceutical formulation

Rocca, A., Moscato, S., Ronca, F., Nitti, S., Mattoli, V., Gıorgı, M., & Ciofani, G. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.05.001 · Cited by 102 · see citing works

Leptin in Atherosclerosis: Focus on Macrophages, Endothelial and Smooth Muscle Cells

Raman, P., & Khanal, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115446 · Cited by 96 · see citing works

Role of Leptin in Non-Alcoholic Fatty Liver Disease

Jiménez‐Cortegana, C., García-Galey, A., Tami, M., Bellido, P. D. P., Carmona, I., López, S., Álba, G., & Sánchez‐Margalet, V. (2021) · Biomedicines · doi:10.3390/biomedicines9070762 · Cited by 96 · see citing works

Exploring the emerging complexity in transcriptional regulation of energy homeostasis

Lempradl, A. M., Pospisilik, J. A., & Penninger, J. M. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3941 · Cited by 94 · see citing works

Adipocytes, aldosterone and obesity-related hypertension

Cat, A. N. D., Friederich‐Persson, M., White, A. D., & Touyz, R. M. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0025 · Cited by 93 · see citing works

Brain Signaling Systems in the Type 2 Diabetes and Metabolic Syndrome: Promising Target to Treat and Prevent These Diseases

Shpakov, A. O., Derkach, K. V., & Berstein, L. M. (2015) · Future Science OA · doi:10.4155/fso.15.23 · Cited by 92 · see citing works

PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation

Gao, Q., Jia, Y., Yang, G., Zhang, X., Boddu, P. C., Petersen, B. E., Narsingam, S., Zhu, Y.-J., Thimmapaya, B., Kanwar, Y. S., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.01.018 · Cited by 91 · see citing works

Leptin and Nutrition in Gestational Diabetes

Pérez‐Pérez, A., Vilariño‐García, T., Guadix, P., Dueñas, J. L., & Sánchez‐Margalet, V. (2020) · Nutrients · doi:10.3390/nu12071970 · Cited by 91 · see citing works

Beneficial Effects of Anti-Inflammatory Diet in Modulating Gut Microbiota and Controlling Obesity

Bagheri, S., Zolghadri, S., & Stanek, A. (2022) · Nutrients · doi:10.3390/nu14193985 · Cited by 85 · see citing works

Diminished mTOR signaling: a common mode of action for endocrine longevity factors

Lamming, D. W. (2014) · SpringerPlus · doi:10.1186/2193-1801-3-735 · Cited by 74 · see citing works

Leptin in osteoarthritis and rheumatoid arthritis: Player or bystander?

Ait Eldjoudi, D., Cordero Barreal, A., Gonzalez-Rodríguez, M., Ruiz-Fernández, C., Farrag, Y., Farrag, M., Lago, F., Capuozzo, M., Gonzalez-Gay, M. A., Mera Varela, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052859 · Cited by 72 · see citing works

Protein tyrosine phosphatase 1B ( PTP1B ) function, structure, and inhibition strategies to develop antidiabetic drugs

Coronell‐Tovar, A., Pardo, J. P., Rodríguez‐Romero, A., Sosa‐Peinado, A., Vásquez-Bochm, L. X., Cano‐Sánchez, P., Álvarez‐Añorve, L. I., & González‐Andrade, M. (2024) · FEBS Letters · doi:10.1002/1873-3468.14901 · Cited by 70 · see citing works

The role of leptin and obesity on male infertility

Khodamoradi, K., Parmar, M., Khosravizadeh, Z., Kuchakulla, M., Manoharan, M., & Arora, H. (2020) · Current Opinion in Urology · doi:10.1097/mou.0000000000000762 · Cited by 69 · see citing works

Leptin, Both Bad and Good Actor in Cancer

Jiménez‐Cortegana, C., López-Saavedra, A., Sánchez-Jiménez, F., Pérez‐Pérez, A., Castiñeiras, J., Virizuela-Echaburu, J. A., de la Cruz‐Merino, L., & Sánchez‐Margalet, V. (2021) · Biomolecules · doi:10.3390/biom11060913 · Cited by 67 · see citing works

Modulation of leptin resistance by food compounds

Aragonès, G., Ardid‐Ruiz, A., Ibars, M., Suárez, M., & Bladé, C. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500964 · Cited by 67 · see citing works

STAT3: The art of multi-tasking of metabolic and immune functions in obesity

Hu, W., Lv, J., Han, M., Yang, Z. P., Li, T. X., Jiang, S., & Yang, Y. (2018) · Progress in Lipid Research · doi:10.1016/j.plipres.2018.04.002 · Cited by 64 · see citing works

Leptin Potentiates BMP9-Induced Osteogenic Differentiation of Mesenchymal Stem Cells Through the Activation of JAK/STAT Signaling

Zhang, B., Yang, L., Zeng, Z., Feng, Y., Wang, X., Wu, X., Luo, H., Zhang, J., Zhang, M., Pakvasa, M., et al. (2020) · Stem Cells and Development · doi:10.1089/scd.2019.0292 · Cited by 63 · see citing works

Leptin regulates exon-specific transcription of the Bdnf gene via epigenetic modifications mediated by an AKT/p300 HAT cascade

Li, C., Meng, F., Lei, Y., Liu, J., Liu, J., Zhang, J., Liu, F., Liu, C., Guo, M., & Lu, X. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00922-0 · Cited by 62 · see citing works

The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect

Derkach, K. V., Zakharova, I. O., Zorina, I. I., Bakhtyukov, A. A., Romanova, I. V., Bayunova, L. V., & Shpakov, A. O. (2019) · PLoS ONE · doi:10.1371/journal.pone.0213779 · Cited by 60 · see citing works

Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2

Bhardwaj, P., Iyengar, N. M., Zahid, H., Carter, K. M., Byun, D. J., Choi, M. H., Sun, Q., Savenkov, O., Louka, C., Liu, C., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.ade1857 · Cited by 58 · see citing works

Leptin signaling and leptin resistance

Liu, J., Lai, F., Hou, Y., & Zheng, R. (2022) · Medical Review · doi:10.1515/mr-2022-0017 · Cited by 55 · see citing works

A Review of Recent Developments in the Molecular Mechanisms of Bone Healing

Rodriguez-Merchan, E. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020767 · Cited by 54 · see citing works

Leptin as a Key between Obesity and Cardiovascular Disease

Kang, K., Ok, M., & Lee, S. (2020) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes20120 · Cited by 53 · see citing works

Leptin in normal physiology and leptin resistance

Li, S., & Li, X. (2015) · 中国科学通报：英文版 · doi:10.1007/s11434-015-0951-4 · Cited by 51 · see citing works

The Role of Adipokines in Intervertebral Disc Degeneration

Sharma, A. (2018) · Medical Sciences · doi:10.3390/medsci6020034 · Cited by 51 · see citing works

Hypothalamic REV-ERB nuclear receptors control diurnal food intake and leptin sensitivity in diet-induced obese mice

Adlanmérini, M., Nguyen, H. C. B., Krusen, B. M., Teng, C. W., Geisler, C. E., Peed, L. C., Carpenter, B. J., Hayes, M. R., & Lazar, M. A. (2020) · Journal of Clinical Investigation · doi:10.1172/jci140424 · Cited by 51 · see citing works

Exploring the Homeostatic and Sensory Roles of the Immune System

Marques, R. E., Marques, P. E., Guabiraba, R., & Teixeira, M. M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00125 · Cited by 50 · see citing works

Leptin-Activity Modulators and Their Potential Pharmaceutical Applications

Greco, M., Santo, M. D., Comandé, A., Belsito, E. L., Andò, S., Liguori, A., & Leggio, A. (2021) · Biomolecules · doi:10.3390/biom11071045 · Cited by 48 · see citing works

Metabolic Impact on the Hypothalamic Kisspeptin-Kiss1r Signaling Pathway

Wahab, F., Atika, B., Ullah, F., Shahab, M., & Behr, R. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00123 · Cited by 48 · see citing works

The effects of physical activity on adipokines in individuals with overweight/obesity across the lifespan: A narrative review

Saeidi, A., Haghighi, M. M., Kolahdouzi, S., Daraei, A., Abderrahman, A. B., Essop, M. F., Laher, I., Hackney, A. C., & Zouhal, H. (2020) · Obesity Reviews · doi:10.1111/obr.13090 · Cited by 48 · see citing works

Nutritional modulation of leptin expression and leptin action in obesity and obesity-associated complications

la Paz, S. M., Pérez‐Pérez, A., Vilariño‐García, T., Jiménez‐Cortegana, C., Muriana, F. J. G., Millán-Linares, M. C., & Sánchez‐Margalet, V. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108561 · Cited by 46 · see citing works

Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Ruszała, M., Niebrzydowska-Tatus, M., Pilszyk, A., Kimber-Trojnar, Ż., Trojnar, M. P., & Leszczyńska‐Gorzelak, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111578 · Cited by 46 · see citing works

Evaluation of the Effects and Mechanism of L-Citrulline on Anti-obesity by Appetite Suppression in Obese/Diabetic KK-Ay Mice and High-Fat Diet Fed SD Rats

Kudo, M., Yoshitomi, H., Momoo, M., Suguro, S., Yamagishi, Y., & Gao, M. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-01002 · Cited by 44 · see citing works

MicroRNA-21-Enriched Exosomes as Epigenetic Regulators in Melanomagenesis and Melanoma Progression: The Impact of Western Lifestyle Factors

Melnik, B. C., John, S. M., Carrera‐Bastos, P., & Schmitz, G. (2020) · Cancers · doi:10.3390/cancers12082111 · Cited by 43 · see citing works

Regulation of placental amino acid transport in health and disease

Shimada, H., Powell, T. L., & Jansson, T. (2024) · Acta Physiologica · doi:10.1111/apha.14157 · Cited by 42 · see citing works

Catabolic and proinflammatory effects of leptin in chondrocytes are regulated by suppressor of cytokine signaling-3

Koskinen-Kolasa, A., Vuolteenaho, K., Korhonen, R., Moilanen, T. P. S., & Moilanen, E. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1112-0 · Cited by 42 · see citing works

Effect of dietary macronutrients on the expression of cholecystokinin, leptin, ghrelin and neuropeptide Y in gilthead sea bream ( Sparus aurata )

Babaei, S., Sáez-Arteaga, A., Caballero‐Solares, A., Fernández, F., Baanante, I. V., & Metón, I. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.10.003 · Cited by 40 · see citing works

Peripheral action of kisspeptin at reproductive tissues—role in ovarian function and embryo implantation and relevance to assisted reproductive technology in livestock: a review

D’Occhio, M. J., Campanile, G., & Baruselli, P. S. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa135 · Cited by 40 · see citing works

New Actors Driving the Epithelial–Mesenchymal Transition in Cancer: The Role of Leptin

Olea‐Flores, M., Juárez-Cruz, J. C., Zuñiga‐Eulogio, M. D., Acosta, E., García-Rodríguez, E., Zacapala-Gómez, A. E., Catalán, M. A. M., Ortiz‐Ortiz, J., Ortuño‐Pineda, C., & Navarro‐Tito, N. (2020) · Biomolecules · doi:10.3390/biom10121676 · Cited by 39 · see citing works

20years of leptin: Role of leptin in cardiomyocyte physiology and physiopathology

Feijóo‐Bandín, S., Portolés, M., Roselló‐Lletí, E., Rivera, M., González‐Juanatey, J. R., & Lago, F. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.02.016 · Cited by 39 · see citing works

Bones and Hormones: Interaction between Hormones of the Hypothalamus, Pituitary, Adipose Tissue and Bone

Niwczyk, O., Grymowicz, M., Szczęsnowicz, A., Hajbos, M., Kostrzak, A., Budzik, M. P., Maciejewska-Jeske, M., Bala, G., Smolarczyk, R., & Męczekalski, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076840 · Cited by 38 · see citing works

Pregnancy-induced adaptation of central sensitivity to leptin and insulin

Aung, Z. K., Grattan, D. R., & Ladyman, S. R. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110933 · Cited by 37 · see citing works

Novel Mechanisms of Compromised Lymphatic Endothelial Cell Homeostasis in Obesity: The Role of Leptin in Lymphatic Endothelial Cell Tube Formation and Proliferation

Sato, A., Kamekura, R., Kawata, K., Kawada, M., Jitsukawa, S., Yamashita, K., Sato, N., Himi, T., & Ichimiya, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158408 · Cited by 33 · see citing works

Inhibition of mTOR's Catalytic Site by PKI-587 Is a Promising Therapeutic Option for Gastroenteropancreatic Neuroendocrine Tumor Disease

Freitag, H., Christen, F., Lewens, F., Grass, I., Briest, F., Iwaszkiewicz, S., Siegmund, B., & Grabowski, P. (2016) · Neuroendocrinology · doi:10.1159/000448843 · Cited by 33 · see citing works

Translating Mechanism-Based Strategies to Break the Obesity−Cancer Link: A Narrative Review

Smith, L. A., O’Flanagan, C. H., Bowers, L. W., Allott, E. H., & Hursting, S. D. (2017) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2017.08.112 · Cited by 31 · see citing works

SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle

Koo, Y. D., Lee, J. S., Lee, S., Quaresma, P. G. F., Bhat, R. V., Haynes, W. G., Park, Y. J., Kim, Y., Chung, S. S., & Park, K. S. (2019) · Metabolism · doi:10.1016/j.metabol.2019.03.004 · Cited by 29 · see citing works

A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network

Ignatieva, E. V., Afonnikov, D. A., Saik, O., Rogaev, E. I., & Kolchanov, N. A. (2016) · BMC Genetics · doi:10.1186/s12863-016-0466-2 · Cited by 28 · see citing works

Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss

Guan, D., Men, Y., Bartlett, A., Hernández, M. A. S., Xu, J., Yi, X., Li, H.-S., Kong, D., Mazitschek, R., & Özcan, U. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.02.007 · Cited by 27 · see citing works

Low-Protein Diets Supplemented with Isoleucine Alleviate Lipid Deposition in Broilers Through Activating AMPK and JAK2/STAT3 Signaling Pathways

Ma, S., Zhang, K., Shi, S., Li, X., Che, C., Chen, P., & Liu, H. (2022) · Poultry Science · doi:10.1016/j.psj.2022.102441 · Cited by 27 · see citing works

Gastric ghrelin, GOAT , leptin, and leptinR expression as well as peripheral serotonin are dysregulated in humans with obesity

Ritze, Y., Schollenberger, A. E., Sinno, M. H., Bühler, N. E. M., Böhle, M., Bárdos, G., Sauer, H., Mack, I., Enck, P., Zipfel, S., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12773 · Cited by 25 · see citing works

Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children

de Lima, R. M. S., Barth, B., Arcego, D. M., Filho, E. J. D. M., Patel, S. H., Wang, Z., Pokhvisneva, I., Parent, C. I., Levitan, R. D., Kobor, M. S., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03992-8 · Cited by 23 · see citing works

High Intensity Interval Training can Ameliorate Hypothalamic Appetite Regulation in Male Rats with Type 2 Diabetes: The Role of Leptin

Khoramipour, K., Rezaei, M. H., Madadizadeh, E., Hosseini, M. S., Soltani, Z., Schierbauer, J., & Moser, O. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01421-w · Cited by 23 · see citing works

Electroacupuncture inhibits weight gain in diet-induced obese rats by activating hypothalamicLKB1-AMPK signaling

Xu, J., Chen, L., Tang, L., Chang, L., Liu, S., Tan, J., Chen, Y., Ren, Y., Liang, F., & Cui, J. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0667-7 · Cited by 22 · see citing works

Altered intestinal neuroendocrine gene expression in humans with obesity

Ritze, Y., Hengelhaupt, C., Bárdos, G., Ernst, B., Thurnheer, M., D’Haese, J. G., Bischoff, S. C., & Schultes, B. (2015) · Obesity · doi:10.1002/oby.21253 · Cited by 22 · see citing works

Molecular targeting of obesity pathways in cancer

Surmacz, E., & Otvos, L. J. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0007 · Cited by 22 · see citing works

Short-term Cudrania tricuspidata fruit vinegar administration attenuates obesity in high-fat diet-fed mice by improving fat accumulation and metabolic parameters

Choi, J., Kim, M.-K., Yeo, S., & Kim, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-78166-9 · Cited by 22 · see citing works

Function and Regulation of Bone Marrow Adipose Tissue in Health and Disease: State of the Field and Clinical Considerations

Zhang, X., Tian, L., Majumdar, A., & Scheller, E. L. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230016 · Cited by 22 · see citing works

Overexpression of Na+/Mg2+ exchanger SLC41A1 attenuates pro-survival signaling

Sponder, G., Abdulhanan, N., Fröhlich, N., Mastrototaro, L., Aschenbach, J. R., Röntgen, M., Pilchová, I., Cibulka, M., Račay, P., & Kolísek, M. (2017) · Oncotarget · doi:10.18632/oncotarget.23598 · Cited by 21 · see citing works

GPR10 gene deletion in mice increases basal neuronal activity, disturbs insulin sensitivity and alters lipid homeostasis

Pražienková, V., Funda, J., Pirník, Z., Karnošová, A., Hrubá, L., Kořínková, L., Neprašová, B., Janovská, P., Benzce, M., Kadlecová, M., et al. (2021) · Gene · doi:10.1016/j.gene.2021.145427 · Cited by 20 · see citing works

Leptin induces leiomyoma cell proliferation and extracellular matrix deposition via JAK2/STAT3 and MAPK/ERK pathways

Reschke, L. D., Afrin, S., Sabah, M. E., Charewycz, N., Miyashita‐Ishiwata, M., & Borahay, M. A. (2022) · F&S Science · doi:10.1016/j.xfss.2022.05.001 · Cited by 19 · see citing works

Function and Regulation of Bone Marrow Adipose Tissue in Health and Disease: State of the Field and Clinical Considerations

Zhang, X., Tian, L., Majumdar, A., & Scheller, E. L. (2024) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2024.tb00300.x · Cited by 18 · see citing works

JAK inhibitors: an evidence-based choice of the most appropriate molecule

Antonioli, L., Armuzzi, A., Fantini, M. C., & Fornai, M. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1494901 · Cited by 18 · see citing works

Anti-obesity effects of Ishophloroglucin A from the brown seaweed Ishige okamurae (Yendo) via regulation of leptin signal in ob/ob mice

Kang, N., Oh, S., Kim, S.-Y., Ahn, H., Son, M., Heo, S., Byun, K., & Jeon, Y. (2021) · Algal Research · doi:10.1016/j.algal.2021.102533 · Cited by 18 · see citing works

miRNA and leptin signaling in metabolic diseases and at extreme environments

Mondal, S., Rathor, R., Singh, S. N., & Suryakumar, G. (2024) · Pharmacology Research & Perspectives · doi:10.1002/prp2.1248 · Cited by 18 · see citing works

Impact of obesity‑associated myeloid‑derived suppressor cells on cancer risk and progression (Review)

Jiménez‐Cortegana, C., Gutiérrez‐García, C., Sánchez-Jiménez, F., Vilariño‐García, T., Flores-Campos, R., Pérez‐Pérez, A., Garnacho, C., Sánchez‐León, M., García-Domínguez, D. J., Hontecillas‐Prieto, L., et al. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5667 · Cited by 17 · see citing works

Adiponectin, in contrast to leptin, is not associated with body mass index, waist circumference and HOMA-IR in subjects of a west-African population

Awèdé, B., Adovoekpe, D., Adehan, G., MacFarlane, N. G., Azonbakin, S. A., Dossou, E., Amoussou-Guenou, M., & Djrolo, F. (2018) · Physiological Reports · doi:10.14814/phy2.13718 · Cited by 17 · see citing works

A Fragrant Environment Containing α-Pinene Suppresses Tumor Growth in Mice by Modulating the Hypothalamus/Sympathetic Nerve/Leptin Axis and Immune System

Kusuhara, M., Maruyama, K., Ishii, H., Masuda, Y., Sakurai, K., Tamai, E., & Urakami, K. (2019) · Integrative Cancer Therapies · doi:10.1177/1534735419845139 · Cited by 17 · see citing works

Leptin: an unappreciated key player in SLE

Yuan, Q., Chen, H., Li, X., & Wei, J. (2019) · Clinical Rheumatology · doi:10.1007/s10067-019-04831-8 · Cited by 17 · see citing works

Leptin and Its Role in Oxidative Stress and Apoptosis: An Overview

Gelen, V., Kükürt, A., Şengül, E., & Deveci, H. A. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.101237 · Cited by 16 · see citing works

Adipocyte and Adipokines Promote a Uterine Leiomyoma Friendly Microenvironment

Afrin, S., Ramaiyer, M. S., Begum, U. A. M., & Borahay, M. A. (2023) · Nutrients · doi:10.3390/nu15030715 · Cited by 16 · see citing works

Extracellular glucose-dependent IPSC enhancement by leptin in fast-spiking to pyramidal neuron connections via JAK2-PI3K pathway in the rat insular cortex

Murayama, S., Yamamoto, K., Fujita, S., Takei, H., Inui, T., Ogiso, B., & Kobayashi, M. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.021 · Cited by 15 · see citing works

Leptin modulates gene expression in the heart and cardiomyocytes towards mitigating ischemia-induced damage

Alkhaleq, H. A., Kornowski, R., Waldman, M., Levy, E., Zemel, R. R., Nudelman, V., Shainberg, A., Miskin, R., & Hochhauser, E. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112373 · Cited by 15 · see citing works

Adipokines regulate mesenchymal stem cell osteogenic differentiation

Xu, Z., Xiong, C.-W., Miao, K., Yu, Z.-T., Zhang, J., Yu, C., Huang, Y., & Zhou, X. (2023) · World Journal of Stem Cells · doi:10.4252/wjsc.v15.i6.502 · Cited by 15 · see citing works

Red raspberry (Rubus ideaus) supplementation mitigates the effects of a high-fat diet on brain and behavior in mice

Carey, A. N., Pintea, G. I., Leuven, S. V., Gildawie, K. R., Squiccimara, L., Fine, E., Rovnak, A., & Harrington, M. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1641284 · Cited by 14 · see citing works

Leptin modulates gene expression in the heart, cardiomyocytes and the adipose tissue thus mitigating LPS-induced damage

Alkhaleq, H. A., Kornowski, R., Waldman, M., Zemel, R. R., Lev, D., Shainberg, A., Miskin, R., & Hochhauser, E. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112647 · Cited by 14 · see citing works

Alternate-day fat diet and exenatide modulate the brain leptin JAK2/STAT3/SOCS3 pathway in a fat diet-induced obesity and insulin resistance mouse model

Tawfik, M. K., Badran, D. I., Keshawy, M. M., Makary, S., & Abdo, M. (2022) · Archives of Medical Science · doi:10.5114/aoms/158534 · Cited by 14 · see citing works

Chronic exposure to methylmercury enhances the anorexigenic effects of leptin in C57BL/6J male mice

Ferrer, B., Prince, L. M., Tinkov, A. A., Santamarı́a, A., Farina, M., da Rocha, J. B. T., Bowman, A. B., & Aschner, M. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111924 · Cited by 14 · see citing works

Weight Regain after Metabolic Surgery: Beyond the Surgical Failure

Salazar, J. J., Durán, P., Garrido, B., Parra, H., Hernández, M., Cano, C., Áñez, R., García-Pacheco, H., Cubillos-Valencia, G., Vasquez, N., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13041143 · Cited by 13 · see citing works

Esophageal and Gastric Dysmotilities are Associated with Altered Glucose Homeostasis and Plasma Levels of Incretins and Leptin

Hammersjö, R., Roth, B., Höglund, P., & Ohlsson, B. (2016) · The Review of Diabetic Studies · doi:10.1900/rds.2016.13.79 · Cited by 13 · see citing works

Cellular and molecular overview of gestational diabetes mellitus: Is it predictable and preventable?

Lim, P.-Q., Lai, Y.-J., Ling, P., & Chen, K.-H. (2023) · World Journal of Diabetes · doi:10.4239/wjd.v14.i11.1693 · Cited by 12 · see citing works

Tetra-Primer Amplification-Refractory Mutation System (ARMS)—PCR for Genotyping Mouse Leptin Gene Mutation

Chen, J., Xu, X., Dalhaimer, P., & Zhao, L. (2022) · Animals · doi:10.3390/ani12192680 · Cited by 12 · see citing works

Obesity and Risk for Lymphoma: Possible Role of Leptin

Jiménez‐Cortegana, C., Hontecillas‐Prieto, L., García-Domínguez, D. J., Zapata, F., Carrión, N. P., Sánchez-León, M. L., Tami, M., Pérez‐Pérez, A., Sánchez-Jiménez, F., Vilariño‐García, T., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415530 · Cited by 12 · see citing works

The influence of chronic and subacute exposure to lead on the levels of prolactin, leptin, osteopontin, and follistatin in humans

Dobrakowski, M., Kasperczyk, A., Czuba, Z. P., Machoń‐Grecka, A., Szlacheta, Z., & Kasperczyk, S. (2016) · Human & Experimental Toxicology · doi:10.1177/0960327116658106 · Cited by 12 · see citing works

Leptin treatment of in vitro cultured embryos increases outgrowth rate of inner cell mass during embryonic stem cell derivation

Taşkın, A. C., Kocabay, A., Ebrahımı, A., Karahüseyinoğlu, S., Şahin, G. N., Özçimen, B., Ruacan, A., & Önder, T. T. (2019) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-019-00367-y · Cited by 11 · see citing works

Leptin Induces MMP-1 Expression Through the RhoA/ERK1/2/NF-κB Axis in Human Intervertebral Disc Cartilage Endplate-Derived Stem Cells

Hua, K., Li, L.-H., Yu, H.-C., Wong, W.-T., & Hsu, H.-T. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s431026 · Cited by 11 · see citing works

Increased Permeability of the Blood–Brain Barrier in a Diabetic Mouse Model (Leprdb/db Mice)

Alshammari, M. A., Alshehri, A. O., Alqahtani, F., Khan, M. R., Bakhrebah, M. A., Alasmari, F. F., Alshammari, T. K., & AlSharari, S. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147768 · Cited by 10 · see citing works

Leptin-dependent neurotoxicity via induction of apoptosis in adult rat neurogenic cells

Segura, S., Efthimiadi, L., Porcher, C., Courtes, S., Coronas, V., Krantic, S. M., & Moyse, E. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00350 · Cited by 10 · see citing works

Directional Immobilization of Proteins on Gold Nanoparticles Is Essential for Their Biological Activity: Leptin as a Case Study

Mangini, V., Maggi, V., Trianni, A., Melle, F., Luca, E. D., Pennetta, A., Sole, R. D., Ventura, G., Cataldi, T. R. I., & Fiammengo, R. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00748 · Cited by 10 · see citing works

Prenatal programming of the small intestine in piglets: the effect of supplementation with 3-hydroxy-3-methylbutyric acid (HMB) in pregnant sows on the structure of jejunum of their offspring

Tomaszewska, E., Prost, Ł., Dobrowolski, P., Chand, D. K. P., Donaldson, J., Czech, A., Klebaniuk, R., Fabjanowska, J., & Muszyński, S. (2021) · Annals of Animal Science · doi:10.2478/aoas-2021-0075 · Cited by 10 · see citing works

Lack of association between leptin G-2548A polymorphisms and obesity risk: Evidence based on a meta-analysis

Yan, J. Y., Wang, X., Tao, H., Wang, Y., Luo, M., & Lin, F. (2015) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2015.01.002 · Cited by 10 · see citing works

A cross-talk between leptin and 17β-estradiol in vitellogenin synthesis in rainbow trout Oncorhynchus mykiss liver

Paolucci, M., Coccia, E., Imperatore, R., & Varricchio, E. (2019) · Fish Physiology and Biochemistry · doi:10.1007/s10695-019-00720-8 · Cited by 10 · see citing works

Leptin Sign al Transduction—A 2009 Update

Gertler, P. A. (2009) · CRC Press eBooks · doi:10.1201/9781498713146-6

Leptin‐induced signal transduction pathways

Hegyi, K., Fülöp, K., Kovács, K., Tóth, S., & Falus, A. (2004) · Cell Biology International · doi:10.1016/j.cellbi.2003.12.003 · Cited by 246 · see citing works

Leptin receptor signaling and the regulation of mammalian physiology

Villanueva, E. C., & Myers, M. G. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.232 · Cited by 231 · see citing works

Intracellular signalling pathways activated by leptin

õnica, C. ́. (2006)

Leptin Signaling in the Central Nervous System

Rahmouni, K., Haynes, W. G., & Mark, A. L. (2004) · Elsevier eBooks · doi:10.1016/b978-012589762-4/50022-0 · Cited by 3 · see citing works