The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
MicroRNAs and other non-coding RNAs as targets for anticancer drug development
Open accessAbstract
The first cancer-targeted microRNA (miRNA) drug — MRX34, a liposome-based miR-34 mimic — entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in April 2013, and miRNA therapeutics are attracting special attention from both academia and biotechnology companies. Although miRNAs are the most studied non-coding RNAs (ncRNAs) to date, the importance of long non-coding RNAs (lncRNAs) is increasingly being recognized. Here, we summarize the roles of miRNAs and lncRNAs in cancer, with a focus on the recently identified novel mechanisms of action, and discuss the current strategies in designing ncRNA-targeting therapeutics, as well as the associated challenges.
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Cites
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Cited by
Noncoding RNA therapeutics—Challenges and potential solutions
Winkle, M., El-Daly, S. M., Fabbri, M., & Calin, G. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00219-z · Cited by 1,551
Self-citationThe delivery of therapeutic oligonucleotides
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MicroRNAs as regulatory elements in immune system logic
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Self-citationCell-to-cell communication: microRNAs as hormones.
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Metadata
- Authors
- Ling, H., Fabbri, M., & Calin, G. A.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2013-10-31
- Volume
- 12
- Issue
- 11
- Pages
- 847-865
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2163169932
- Cited by
- 1,465
- References
- 24
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- green
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