The DOI matches its Crossref record; 224 of the 224 references it cites were found in a registry or an index.
Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases
Open accessAbstract
Hypoxia-inducible factors (HIFs) are stabilized during adverse inflammatory processes associated with disorders such as inflammatory bowel disease, pathogen infection and acute lung injury, as well as during ischaemia–reperfusion injury. HIF stabilization and hypoxia-induced changes in gene expression have a profound impact on the inflamed tissue microenvironment and on disease outcomes. Although the mechanism that initiates HIF stabilization may vary, the final molecular steps that control HIF stabilization converge on a set of oxygen-sensing prolyl hydroxylases (PHDs) that mark HIFs for proteasomal degradation. PHDs are therefore promising therapeutic targets. In this Review, we discuss the emerging potential and associated challenges of targeting the PHD–HIF pathway for the treatment of inflammatory and ischaemic diseases.
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2 retracted
Hart, M. L., Grenz, A., Gorzolla, I. C., Schittenhelm, J., Dalton, J. H., & Eltzschig, H. K. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.0903617 · Cited by 121
Self-citationRetractedHart, M. L., Gorzolla, I. C., Schittenhelm, J., Dalton, J. H., & Eltzschig, H. K. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700997 · Cited by 116
Self-citationRetractedChen, Y., Wang, L., Kang, Q., Zhang, X., Yu, G., Wan, X., Wang, J., & Zhu, K. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477308 · Cited by 10,679
Acute Respiratory Distress Syndrome: The Berlin Definition
(2012) · JAMA · doi:10.1001/jama.2012.5669 · Cited by 8,731
Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.
Murry, C. E., Jennings, R. B., & Reimer, K. A. (1986) · Circulation · doi:10.1161/01.cir.74.5.1124 · Cited by 7,812
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212
Jaakkola, P., Mole, D. R., Tian, Y.-M., Wilson, M. I., Gielbert, J., Gaskell, S. J., Kriegsheim, A. V., Hebestreit, H. F., Mukherji, M., Schofield, C. J., et al. (2001) · Science · doi:10.1126/science.1059796 · Cited by 5,535
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
The Acute Respiratory Distress Syndrome
Matthay, M. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605303342209 · Cited by 4,923
Cited by
Zheng, L., Kelly, C. J., & Colgan, S. P. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00191.2015 · Cited by 499
Self-citationCircadian rhythm as a therapeutic target
Ruan, W., Yuan, X., & Eltzschig, H. K. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00109-w · Cited by 486
Self-citationGupta, N., & Wish, J. B. (2017) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2016.12.011 · Cited by 444
Hypoxia signaling in human diseases and therapeutic targets
Lee, J. W., Ko, J., Ju, C., & Eltzschig, H. K. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0235-1 · Cited by 384
Self-citationStructural integration in hypoxia-inducible factors
Wu, D., Potluri, N., Lu, J., Kim, Y., & Rastinejad, F. (2015) · Nature · doi:10.1038/nature14883 · Cited by 346
Metadata
- Authors
- Eltzschig, H. K., Bratton, D. L., & Colgan, S. P.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2014-10-31
- Volume
- 13
- Issue
- 11
- Pages
- 852-869
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2039765075
- Cited by
- 366
- References
- 224
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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