The DOI matches its Crossref record; 268 of the 268 references it cites were found in a registry or an index.
Circadian rhythm as a therapeutic target
Open accessAbstract
The circadian clock evolved in diverse organisms to integrate external environmental changes and internal physiology. The clock endows the host with temporal precision and robust adaptation to the surrounding environment. When circadian rhythms are perturbed or misaligned, as a result of jet lag, shiftwork or other lifestyle factors, adverse health consequences arise, and the risks of diseases such as cancer, cardiovascular diseases or metabolic disorders increase. Although the negative impact of circadian rhythm disruption is now well established, it remains underappreciated how to take advantage of biological timing, or correct it, for health benefits. In this Review, we provide an updated account of the circadian system and highlight several key disease areas with altered circadian signalling. We discuss environmental and lifestyle modifications of circadian rhythm and clock-based therapeutic strategies, including chronotherapy, in which dosing time is deliberately optimized for maximum therapeutic index, and pharmacological agents that target core clock components and proximal regulators. Promising progress in research, disease models and clinical applications should encourage a concerted effort towards a new era of circadian medicine. Disregulation of circadian rhythms, as a result of jet lag or other lifestyle factors, can increase the risks of certain diseases. This Review analyses the different pathways involved in the regulation of the circadian clock and strategies that target the circadian systems.
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Cited by
Targeting hypoxia-inducible factors: therapeutic opportunities and challenges
Yuan, X., Ruan, W., Bobrow, B., Carmeliet, P., & Eltzschig, H. K. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00848-6 · Cited by 245
Self-citationFoundations of circadian medicine
Kramer, A., Lange, T., Spies, C., Finger, A.-M., Berg, D., & Oster, H. (2022) · PLOS Biology · doi:10.1371/journal.pbio.3001567 · Cited by 99
“This variation is explained by daily rhythms in pharmacokinetics and pharmacodynamics of most short-lived drugs [2,50,54].”
BackgroundDefining circadian disruption in neurodegenerative disorders
Colwell, C. S. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148288 · Cited by 90
Salemi, M., Mogavero, M. P., Lanza, G., Mongioì, L. M., Calogero, A. E., & Ferri, R. (2022) · Cells · doi:10.3390/cells11121930 · Cited by 39
Lei, Y., Liao, F., Tian, Y., Wang, Y., Xia, F., & Wang, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1321176 · Cited by 35
Metadata
- Authors
- Ruan, W., Yuan, X., & Eltzschig, H. K.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2021-02-15
- Volume
- 20
- Issue
- 4
- Pages
- 287-307
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W3132148284
- Cited by
- 486
- References
- 268
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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