The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia
Open accessAbstract
In recent years, the intestinal mucosa has proven to be an intriguing organ to study tissue oxygenation. The highly vascularized lamina propria juxtaposed to an anaerobic lumen containing trillions of metabolically active microbes results in one of the most austere tissue microenvironments in the body. Studies to date have determined that a healthy mucosa contains a steep oxygen gradient along the length of the intestine and from the lumen to the serosa. Advances in technology have allowed multiple independent measures and indicate that, in the healthy mucosa of the small and large intestine, the lumen-apposed epithelia experience Po 2 conditions of <10 mmHg, so-called physiologic hypoxia. This unique physiology results from a combination of factors, including countercurrent exchange blood flow, fluctuating oxygen demands, epithelial metabolism, and oxygen diffusion into the lumen. Such conditions result in the activation of a number of hypoxia-related signaling processes, including stabilization of the transcription factor hypoxia-inducible factor. Here, we review the principles of mucosal oxygen delivery, metabolism, and end-point functional responses that result from this unique oxygenation profile.
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1 retracted
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Cited by
A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip
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The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
Yang, T., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0018-2 · Cited by 753
Regulation of Immunity and Inflammation by Hypoxia in Immunological Niches
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Keeley, T. P., & Mann, G. E. (2019) · Physiological Reviews · doi:10.1152/physrev.00041.2017 · Cited by 329
Metadata
- Authors
- Zheng, L., Kelly, C. J., & Colgan, S. P.
- Venue
- American Journal of Physiology-Cell Physiology
- Publisher
- American Physiological Society
- Published
- 2015-09-15
- Volume
- 309
- Issue
- 6
- Pages
- C350-C360
- ISSN
- 0363-6143 (ISSN-L)
- 1522-1563
- OpenAlex
- W2217024838
- Cited by
- 499
- References
- 141
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Zheng, L., Kelly, C. J., & Colgan, S. P. (2015). Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00191.2015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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