The DOI matches its Crossref record; 227 of the 227 references it cites were found in a registry or an index.
What do drug transporters really do?
Open accessAbstract
Potential drug–drug interactions mediated by the ATP-binding cassette (ABC) transporter and solute carrier (SLC) transporter families are of clinical and regulatory concern. However, the endogenous functions of these drug transporters are not well understood. Discussed here is evidence for the roles of ABC and SLC transporters in the handling of diverse substrates, including metabolites, antioxidants, signalling molecules, hormones, nutrients and neurotransmitters. It is suggested that these transporters may be part of a larger system of remote communication ('remote sensing and signalling') between cells, organs, body fluid compartments and perhaps even separate organisms. This broader view may help to clarify disease mechanisms, drug–metabolite interactions and drug effects relevant to diabetes, chronic kidney disease, metabolic syndrome, hypertension, gout, liver disease, neuropsychiatric disorders, inflammatory syndromes and organ injury, as well as prenatal and postnatal development.
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Cited by
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Therapeutic advances of miRNAs: A preclinical and clinical update
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Kidney-on-a-Chip technology for drug-induced nephrotoxicity screening
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Application of nanotechnology to improve the therapeutic benefits of statins
Korani, S., Korani, M., Bahrami, S., Johnston, T. P., Butler, A. E., Banach, M., & Sahebkar, A. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2018.09.023 · Cited by 51
Metadata
- Authors
- Nigam, S. K.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2014-12-05
- Volume
- 14
- Issue
- 1
- Pages
- 29-44
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2003562401
- Cited by
- 527
- References
- 227
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- green
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