Cited by 746Sleep and related disordersObstructive Sleep Apnea ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Insomnia disorder

Morin, Charles M., Drake, Christopher L., Harvey, Allison G., Krystal, Andrew D., Manber, Rachel, Riemann, Dieter, Spiegelhalder, Kai·2015·Nature Reviews Disease Primers

DOI 10.1038/nrdp.2015.26

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Abstract

Insomnia disorder affects a large proportion of the population on a situational, recurrent or chronic basis and is among the most common complaints in medical practice. The disorder is predominantly characterized by dissatisfaction with sleep duration or quality and difficulties initiating or maintaining sleep, along with substantial distress and impairments of daytime functioning. It can present as the chief complaint or, more often, co-occurs with other medical or psychiatric disorders, such as pain and depression. Persistent insomnia has been linked with adverse long-term health outcomes, including diminished quality of life and physical and psychological morbidity. Despite its high prevalence and burden, the aetiology and pathophysiology of insomnia is poorly understood. In the past decade, important changes in classification and diagnostic paradigms have instigated a move from a purely symptom-based conceptualization to the recognition of insomnia as a disorder in its own right. These changes have been paralleled by key advances in therapy, with generic pharmacological and psychological interventions being increasingly replaced by approaches that have sleep-specific and insomnia-specific therapeutic targets. Psychological and pharmacological therapies effectively reduce the time it takes to fall asleep and the time spent awake after sleep onset, and produce a modest increase in total sleep time; these are outcomes that correlate with improvements in daytime functioning. Despite this progress, several challenges remain, including the need to improve our knowledge of the mechanisms that underlie insomnia and to develop more cost-effective, efficient and accessible therapies.

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Authors: Morin, C. M., Drake, C. L., Harvey, A. G., Krystal, A. D., Manber, R., Riemann, D., & Spiegelhalder, K.
Affiliations: Université Laval (CA)
Henry Ford Hospital (US)
University of California, Berkeley (US)
Duke University (US)
Stanford Medicine (US)
University of Freiburg (DE)
Corresponding author: Morin, Charles M.
ORCID: Morin, Charles M.
Drake, Christopher L.
Harvey, Allison G.
Krystal, Andrew D.
Manber, Rachel
Riemann, Dieter
Spiegelhalder, Kai
Venue: Nature Reviews Disease Primers
Publisher: Springer Science and Business Media LLC
Published: 2015-09-03
Volume: 1
Issue: 1
Pages: 15026-15026
ISSN: 2056-676X (ISSN-L)
DOI: 10.1038/nrdp.2015.26
OpenAlex: W4211107190
Cited by: 746
References: 191
Citations by year: 2026: 72 · 2025: 120 · 2024: 111 · 2023: 119 · 2022: 97 · 2021: 75 · 2020: 65 · 2019: 34 · 2018: 20 · 2017: 23 · 2016: 6 · 2015: 4
FWCI: 2.28
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Disease Primers (publishedVersion)
PubMed (publishedVersion)
Corpus Université Laval (Université Laval) (submittedVersion)
Funders: Canadian Institutes of Health Research (MOP42504)
National Institute of Mental Health (R01MH091053, R01MH105513)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: insomnia, sleep onset insomnia, sleep maintenance insomnia, insomnia classification, insomnia pathophysiology, insomnia treatment, pharmacotherapy, psychotherapy, quality of life, comorbid depression, chronic insomnia
MeSH terms: Activities of Daily Living, Depression, Humans, Sleep Initiation and Maintenance Disorders, Pain, Quality of Life, Stress, Psychological

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