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Cited by 687

The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.

Rotavirus infection

Open access
Crawford, Sue E., Ramani, Sasirekha, Tate, Jacqueline E., Parashar, Umesh D., Svensson, Lennart, Hagbom, Marie, Franco, Manuel A., Greenberg, Harry B., O'Ryan, Miguel, Kang, Gagandeep, Desselberger, Ulrich, Estes, Mary K.·2017·Nature Reviews Disease Primers

Abstract

Rotavirus infections are a leading cause of severe, dehydrating gastroenteritis in children <5 years of age. Despite the global introduction of vaccinations for rotavirus over a decade ago, rotavirus infections still result in >200,000 deaths annually, mostly in low-income countries. Rotavirus primarily infects enterocytes and induces diarrhoea through the destruction of absorptive enterocytes (leading to malabsorption), intestinal secretion stimulated by rotavirus non-structural protein 4 and activation of the enteric nervous system. In addition, rotavirus infections can lead to antigenaemia (which is associated with more severe manifestations of acute gastroenteritis) and viraemia, and rotavirus can replicate in systemic sites, although this is limited. Reinfections with rotavirus are common throughout life, although the disease severity is reduced with repeat infections. The immune correlates of protection against rotavirus reinfection and recovery from infection are poorly understood, although rotavirus-specific immunoglobulin A has a role in both aspects. The management of rotavirus infection focuses on the prevention and treatment of dehydration, although the use of antiviral and anti-emetic drugs can be indicated in some cases.

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Crossref · 10.1038/nrdp.2017.83

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Metadata

Authors
Crawford, S. E., Ramani, S., Tate, J. E., Parashar, U. D., Svensson, L., Hagbom, M., Franco, M. A., Greenberg, H. B., O'Ryan, M., Kang, G., Desselberger, U., & Estes, M. K.
Venue
Nature Reviews Disease Primers
Published
2017-11-09
Volume
3
Issue
1
Pages
17083-17083
ISSN
2056-676X (ISSN-L)
OpenAlex
W4211219645
Cited by
687
References
161
FWCI
5.98
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Rotavirus infection. https://app.cochat.ai/papers/10.1038/nrdp.2017.83
The paper
Crawford, S. E., Ramani, S., Tate, J. E., Parashar, U. D., Svensson, L., Hagbom, M., Franco, M. A., Greenberg, H. B., O'Ryan, M., Kang, G., Desselberger, U., & Estes, M. K. (2017). Rotavirus infection. Nature Reviews Disease Primers. https://doi.org/10.1038/nrdp.2017.83

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.