Gut Microbiota and Diarrhea: An Updated Review

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634 · see citing works

Gut microbiota in human metabolic health and disease

Fan, Y., & Pedersen, O. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0433-9 · Cited by 4,724 · see citing works

Role of the normal gut microbiota

Jandhyala, S. M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i29.8787 · Cited by 3,001 · see citing works

Diet–microbiota interactions as moderators of human metabolism

Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257 · see citing works

An Epidemic, Toxin Gene–Variant Strain of Clostridium difficile

McDonald, L. C., Killgore, G., Thompson, A. D., Owens, R. C., Kazakova, S. V., Sambol, S. P., Johnson, S., & Gerding, D. N. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051590 · Cited by 1,997 · see citing works

Global Epidemiology of Campylobacter Infection

Kaakoush, N. O., Castaño‐Rodríguez, N., Mitchell, H. M., & Man, S. M. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00006-15 · Cited by 1,542 · see citing works

Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015

Troeger, C., Forouzanfar, M. H., Rao, P. C., Khalil, I., Brown, A., Reiner, R. C., Fullman, N., Thompson, R. L., Abajobir, A. A., Ahmed, M. B., et al. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30276-1 · Cited by 1,421 · see citing works

Escherichia coli that Cause Diarrhea: Enterotoxigenic, Enteropathogenic, Enteroinvasive, Enterohemorrhagic, and Enteroadherent

Levine, M. M. (1987) · The Journal of Infectious Diseases · doi:10.1093/infdis/155.3.377 · Cited by 1,244 · see citing works

Diarrheagenic Escherichia coli

Gomes, T. A. T., Elias, W. P., Scaletsky, I. C. A., Guth, B. E. C., Rodrigues, J. F., Piazza, R. M. F., Ferreira, L. C. D. S., & Martinez, M. B. (2016) · Brazilian Journal of Microbiology · doi:10.1016/j.bjm.2016.10.015 · Cited by 1,183 · see citing works

Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections

Crump, J. A., Sjölund-Karlsson, M., Gordon, M. A., & Parry, C. M. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00002-15 · Cited by 1,165 · see citing works

<i>Candida albicans</i> Biofilms and Human Disease

Nobile, C. J., & Johnson, A. D. (2015) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091014-104330 · Cited by 1,057 · see citing works

Gut Microbiota Dysbiosis in Postweaning Piglets: Understanding the Keys to Health

Gresse, R., Chaucheyras‐Durand, F., Fleury, M., de Wiele, T. V., Forano, É., & Blanquet‐Diot, S. (2017) · Trends in Microbiology · doi:10.1016/j.tim.2017.05.004 · Cited by 903 · see citing works

Salmonella : A review on pathogenesis, epidemiology and antibiotic resistance

Eng, S.-K., Pusparajah, P., Mutalib, N. A., Ser, H., Chan, K., & Lee, L. (2015) · Frontiers in Life Science · doi:10.1080/21553769.2015.1051243 · Cited by 861 · see citing works

Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis

Costello, S. P., Hughes, P. A., Waters, O. R., Bryant, R. V., Vincent, A. D., Blatchford, P. A., Katsikeros, R., Makanyanga, J. C., Campaniello, M. A., Mavrangelos, C., et al. (2019) · JAMA · doi:10.1001/jama.2018.20046 · Cited by 855 · see citing works

Adhesion mechanisms mediated by probiotics and prebiotics and their potential impact on human health

Monteagudo-Mera, A., Rastall, R. A., Gibson, G. R., Charalampopoulos, D., & Chatzifragkou, A. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-09978-7 · Cited by 743 · see citing works

Rotavirus infection

Crawford, S. E., Ramani, S., Tate, J. E., Parashar, U. D., Svensson, L., Hagbom, M., Franco, M. A., Greenberg, H. B., O’Ryan, M., Kang, G., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.83 · Cited by 736 · see citing works

Clostridium difficile infection: review

Czepiel, J., Dróżdż, M., Pituch, H. M., Kuijper, E. J., Perucki, W. H., Mielimonka, A., Goldman, S., Wultańska, D., Garlicki, A., & Biesiada, G. (2019) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-019-03539-6 · Cited by 710 · see citing works

Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection

Ott, S. J., Waetzig, G. H., Rehman, A., Moltzau-Anderson, J., Bharti, R., Grasis, J. A., Cassidy, L., Tholey, A., Fickenscher, H., Seegert, D., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.11.010 · Cited by 695 · see citing works

Age-Dependent Diarrhea Induced by a Rotaviral Nonstructural Glycoprotein

Ball, J. M., Tian, P., Zeng, C. Q. ‐., Morris, A. P., & Estes, M. K. (1996) · Science · doi:10.1126/science.272.5258.101 · Cited by 687 · see citing works

Regulated virulence controls the ability of a pathogen to compete with the gut microbiota

Kamada, N., Kim, Y.-G., Sham, H. P., Vallance, B. A., Puente, J. L., Martens, E. C., & Núñez, G. (2012) · Science · doi:10.1126/science.1222195 · Cited by 682 · see citing works

Dectin‐1 mediates macrophage recognition of Candida albicans yeast but not filaments

Gantner, B. N., Simmons, R. M., & Underhill, D. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600594 · Cited by 671 · see citing works

Microbial Ecology along the Gastrointestinal Tract

Hillman, E. T., Lu, H., Yao, T., & Nakatsu, C. H. (2017) · Microbes and Environments · doi:10.1264/jsme2.me17017 · Cited by 586 · see citing works

Probiotics in the Treatment and Prevention of Acute Infectious Diarrhea in Infants and Children: A Systematic Review of Published Randomized, Double-Blind, Placebo-Controlled Trials

Szajewska, H., & Mrukowicz, J. Z. (2001) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200110002-00004 · Cited by 509 · see citing works

The microbiota-gut-brain axis in obesity.

Torres-Fuentes, C., Schellekens, H., Dinan, T., & Cryan, J. (2017) · The Lancet Gastroenterology and Hepatology · doi:10.1016/s2468-1253(17)30147-4 · Cited by 506 · see citing works

Can probiotics modulate human disease by impacting intestinal barrier function?

Bron, P. A., Kleerebezem, M., Brummer, R.-J., Cani, P. D., Mercenier, A., MacDonald, T. T., Garcia-Ródenas, C. L., & Wells, J. M. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114516004037 · Cited by 499 · cited 2× · see citing works

Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome: a double-blind, randomised, placebo-controlled, parallel-group, single-centre trial

Johnsen, P. H., Hilpüsch, F., Cavanagh, J. P., Leikanger, I. S., Kolstad, C., Valle, P. C., & Goll, R. (2018) · The Lancet Gastroenterology &amp; Hepatology · doi:10.1016/s2468-1253(17)30338-2 · Cited by 437 · see citing works

Self-destructive cooperation mediated by phenotypic noise

Ackermann, M., Stecher, B., Freed, N. E., Songhet, P., Hardt, W., & Doebeli, M. (2008) · Nature · doi:10.1038/nature07067 · Cited by 420 · see citing works

Pathogenesis of Intestinal and Systemic Rotavirus Infection

Ramig, R. F. (2004) · Journal of Virology · doi:10.1128/jvi.78.19.10213-10220.2004 · Cited by 379 · see citing works

Intestinal microbiota and diet in IBS: causes, consequences, or epiphenomena?

Rajilić-Stojanović, M., Jonkers, D. M., Salonen, A., Hanevik, K., Raes, J., Jalanka, J., de Vos, W. M., Manichanh, C., Golic, N., Enck, P., et al. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.427 · Cited by 359 · see citing works

Accurate and efficient data acquisition methods for high-resolution angle-resolved photoemission microscopy

Iwasawa, H., Takita, H., Goto, K., Mansuer, W., Miyashita, T., Schwier, E. F., Ino, A., Shimada, K., & Aiura, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-34894-7 · Cited by 358 · see citing works

Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome: results from a randomised, double-blind placebo-controlled study

Halkjær, S. I., Christensen, A. H., Lo, B. Z. S., Browne, P. D., Günther, S., Hansen, L. H., & Petersen, A. M. (2018) · Gut · doi:10.1136/gutjnl-2018-316434 · Cited by 340 · see citing works

A Microbiota-Derived Bacteriocin Targets the Host to Confer Diarrhea Resistance in Early-Weaned Piglets

Hu, J., Ma, L., Nie, Y., Chen, J., Zheng, W., Wang, X., Xie, C., Zheng, Z., Wang, Z., Yang, T., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.11.006 · Cited by 334 · see citing works

Host–Pathogen Interaction in Invasive Salmonellosis

de Jong, H. K., Parry, C. M., van der Poll, T., & Wiersinga, W. J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002933 · Cited by 331 · see citing works

Fecal microbiota transplantation in metabolic syndrome: History, present and future

de Groot, P. F., Frissen, M. N., de Clercq, N. C., & Nieuwdorp, M. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1293224 · Cited by 322 · see citing works

Dose–Response Efficacy of a Proprietary Probiotic Formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for Antibiotic-Associated Diarrhea and Clostridium difficile -Associated Diarrhea Prophylaxis in Adult Patients

Gao, X. W., Mubasher, M., Fang, C. Y., Reifer, C., & Miller, L. E. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.11 · Cited by 318 · see citing works

Infectious diarrhea

Hodges, K., & Gill, R. K. (2010) · Gut Microbes · doi:10.4161/gmic.1.1.11036 · Cited by 278 · see citing works

Probiotic Bifidobacteria Protect Mice from Lethal Infection with Shiga Toxin-Producing Escherichia coli O157:H7

Asahara, T., Shimizu, K., Nomoto, K., Hamabata, T., Ozawa, A., & Takeda, Y. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2240-2247.2004 · Cited by 277 · see citing works

Characterization of the virulence of a non-RT027, non-RT078 and binary toxin-positive Clostridium difficile strain associated with severe diarrhea

Li, C., Harmanus, C., Zhu, D., Meng, X., Wang, S., Duan, J., Liu, S., Fu, C., Zhou, P., Liu, R., et al. (2018) · Emerging Microbes & Infections · doi:10.1038/s41426-018-0211-1 · Cited by 246 · see citing works

Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation

Zhang, W., Zou, G.-L., Li, B., Du, X., Sun, Z., Sun, Y., & Jiang, X. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2002.02044 · Cited by 233 · see citing works

Nutritional Keys for Intestinal Barrier Modulation

De Santis, S., Cavalcanti, E., Mastronardi, M., Jirillo, E., & Chieppa, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00612 · Cited by 232 · see citing works

Diarrhoeal disease and subsequent risk of death in infants and children residing in low-income and middle-income countries: analysis of the GEMS case-control study and 12-month GEMS-1A follow-on study

Levine, M. M., Nasrin, D., Acácio, S., Bassat, Q., Powell, H., Tennant, S. M., Sow, S. O., Sur, D., Zaidi, A. K. M., Faruque, A. S. G., et al. (2019) · The Lancet Global Health · doi:10.1016/s2214-109x(19)30541-8 · Cited by 203 · see citing works

Recent insights into Shigella: a major contributor to the global diarrhoeal disease burden

Baker, S. G., & The, H. C. (2018) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000475 · Cited by 200 · see citing works

From Hype to Hope: The Gut Microbiota in Enteric Infectious Disease

McKenney, P. T., & Pamer, E. G. (2015) · Cell · doi:10.1016/j.cell.2015.11.032 · Cited by 182 · see citing works

The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen’s virulence factors, and the host’s mucosal immune response

Kaiser, P., Diard, M., Stecher, B., & Hardt, W. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01070.x · Cited by 181 · see citing works

Metagenomic Sequencing with Strain-Level Resolution Implicates Uropathogenic E. coli in Necrotizing Enterocolitis and Mortality in Preterm Infants

Ward, D. V., Scholz, M., Zolfo, M., Taft, D. H., Schibler, K. R., Tett, A., Segata, N., & Morrow, A. L. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.015 · Cited by 173 · see citing works

Changes in gut microbial populations, intestinal morphology, expression of tight junction proteins, and cytokine production between two pig breeds after challenge with Escherichia coli K88: A comparative study1

Gao, Y., Han, F., Huang, X., Rong, Y., Yi, H., & Wang, Y. (2013) · Journal of Animal Science · doi:10.2527/jas.2013-6528 · Cited by 163 · see citing works

Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea

Camilleri, M., Sellin, J. H., & Barrett, K. E. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.014 · Cited by 163 · see citing works

NSP4 elicits age-dependent diarrhea and Ca2+mediated I−influx into intestinal crypts of CF mice

Morris, A. P., Scott, J., Ball, J. M., Zeng, C. Q. ‐., O’Neal, W. K., & Estes, M. K. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.2.g431 · Cited by 152 · see citing works

Fecal Microbiota Transplantation Beneficially Regulates Intestinal Mucosal Autophagy and Alleviates Gut Barrier Injury

Cheng, S., Ma, X., Geng, S., Jiang, X., Li, Y., Hu, L., Lǐ, J., Wang, Y., & Han, X. (2018) · mSystems · doi:10.1128/msystems.00137-18 · Cited by 151 · see citing works

Additional Candida albicans administration enhances the severity of dextran sulfate solution induced colitis mouse model through leaky gut-enhanced systemic inflammation and gut-dysbiosis but attenuated by Lactobacillus rhamnosus L34

Panpetch, W., Hiengrach, P., Nilgate, S., Tumwasorn, S., Somboonna, N., Wilantho, A., Chatthanathon, P., Prueksapanich, P., & Leelahavanichkul, A. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1662712 · Cited by 151 · see citing works

Drivers of the reduction in childhood diarrhea mortality 1980-2015 and interventions to eliminate preventable diarrhea deaths by 2030

Black, R. E., Fontaine, O., Lamberti, L. M., Bhan, M. K., Huicho, L., Arifeen, S. E., Masanja, H., Walker, C. L. F., Mengestu, T. K., Pearson, L., et al. (2019) · Journal of Global Health · doi:10.7189/jogh.09.020801 · Cited by 145 · see citing works

Impact of prebiotics on immune response: from the bench to the clinic

Pujari, R., & Banerjee, G. (2020) · Immunology and Cell Biology · doi:10.1111/imcb.12409 · Cited by 145 · see citing works

Fecal Microbiota Transplantation: a Future Therapeutic Option for Obesity/Diabetes?

Aron‐Wisnewsky, J., Clément, K., & Nieuwdorp, M. (2019) · Current Diabetes Reports · doi:10.1007/s11892-019-1180-z · Cited by 144 · see citing works

Gut microbiome, prebiotics, intestinal permeability and diabetes complications

Snelson, M., de Pasquale, C., Ekinci, E. I., & Coughlan, M. T. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101507 · Cited by 142 · see citing works

NSP4 Enterotoxin of Rotavirus Induces Paracellular Leakage in Polarized Epithelial Cells

Tafazoli, F., Zeng, C. Q. ‐., Estes, M. K., Magnusson, K., & Svensson, L. (2001) · Journal of Virology · doi:10.1128/jvi.75.3.1540-1546.2001 · Cited by 124 · see citing works

Prebiotic and Probiotic Fortified Milk in Prevention of Morbidities among Children: Community-Based, Randomized, Double-Blind, Controlled Trial

Sazawal, S., Dhingra, U., Hiremath, G. S., Sarkar, A., Dhingra, P., Dutta, A., Verma, P., Menon, V. P., & Black, R. E. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012164 · Cited by 123 · see citing works

A Systematic Review of the Effect of Rotavirus Vaccination on Diarrhea Outcomes Among Children Younger Than 5 Years

Lamberti, L. M., Ashraf, S., Walker, C. L. F., & Black, R. E. (2016) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000001232 · Cited by 123 · see citing works

Administration of Exogenous Melatonin Improves the Diurnal Rhythms of the Gut Microbiota in Mice Fed a High-Fat Diet

Yin, J., Li, Y., Han, H. L., Ma, J., Liu, G., Wu, X., Huang, X., Fang, R., Baba, K., Bin, P., et al. (2020) · mSystems · doi:10.1128/msystems.00002-20 · Cited by 120 · see citing works

Modulation of microbiota as treatment for intestinal inflammatory disorders: An uptodate

Gallo, A., Passaro, G., Gasbarrini, A., Landolfi, R., & Montalto, M. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i32.7186 · Cited by 118 · see citing works

Salmonella enterica

Knodler, L. A., & Elfenbein, J. R. (2019) · Trends in Microbiology · doi:10.1016/j.tim.2019.05.002 · Cited by 115 · see citing works

Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease

Mileto, S. J., Jardé, T., Childress, K. O., Jensen, J. L., Rogers, A. P., Kerr, G., Hutton, M. L., Sheedlo, M. J., Bloch, S. C., Shupe, J. A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1915255117 · Cited by 107 · see citing works

Influence of intestinal anaerobes and organic acids on the growth of enterohaemorrhagic Escherichia coli O157:H7

Ryouichi, S. H. I. N., Suzuki, M., & Morishita, Y. (2002) · Journal of Medical Microbiology · doi:10.1099/0022-1317-51-3-201 · Cited by 106 · see citing works

Global emergence of environmental non‐O1 / O139 Vibrio cholerae infections linked with climate change: a neglected research field?

Vezzulli, L., Baker‐Austin, C., Kirschner, A. K. T., Pruzzo, C., & Martínez-Urtaza, J. (2020) · Environmental Microbiology · doi:10.1111/1462-2920.15040 · Cited by 105 · see citing works

Virulence Regulation and Innate Host Response in the Pathogenicity of Vibrio cholerae

Ramamurthy, T., Nandy, R. K., Mukhopadhyay, A. K., Dutta, S., Mutreja, A., Okamoto, K., Miyoshi, S.-I., Nair, G. B., & Ghosh, A. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.572096 · Cited by 99 · see citing works

Advances in the diagnosis and treatment of Clostridium difficile infections

Peng, Z., Ling, L., Stratton, C. W., Li, C., Polage, C. R., Wu, B., & Tang, Y. (2018) · Emerging Microbes & Infections · doi:10.1038/s41426-017-0019-4 · Cited by 97 · see citing works

Review on pathogenicity mechanism of enterotoxigenic Escherichia coli and vaccines against it.

Mirhoseini, A., Amani, J., & Nazarian, S. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.02.032 · Cited by 94 · see citing works

The molecular mechanism for activating IgA production by Pediococcus acidilactici K15 and the clinical impact in a randomized trial

Kawashima, T., Ikari, N., Kouchi, T., Kowatari, Y., Kubota, Y., Shimojo, N., & Tsuji, N. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-23404-4 · Cited by 92 · see citing works

Fecal Microbiota Transplantation Controls Murine Chronic Intestinal Inflammation by Modulating Immune Cell Functions and Gut Microbiota Composition

Burrello, C., Giuffrè, M. R., Macandog, A. D. G., Díaz‐Basabe, A., Cribiù, F. M., Lopez, G., Borgo, F., Nezi, L., Caprioli, F., Vecchi, M. L., et al. (2019) · Cells · doi:10.3390/cells8060517 · Cited by 84 · see citing works

Shigella flexneri: an emerging pathogen

Nisa, I., Qasim, M., Yasin, N., Ullah, R., & Ali, A. (2020) · Folia Microbiologica · doi:10.1007/s12223-020-00773-w · Cited by 84 · see citing works

Protective action of Bacillus clausii probiotic strains in an in vitro model of Rotavirus infection

Paparo, L., Tripodi, L., Bruno, C., Pisapia, L., Damiano, C., Pastore, L., & Canani, R. B. (2020) · Scientific Reports · doi:10.1038/s41598-020-69533-7 · Cited by 84 · see citing works

Clostridium difficile Modulates the Gut Microbiota by Inducing the Production of Indole, an Interkingdom Signaling and Antimicrobial Molecule

Darkoh, C., Plants-Paris, K., Bishoff, D. E., & DuPont, H. L. (2019) · mSystems · doi:10.1128/msystems.00346-18 · Cited by 81 · see citing works

Emergence of an Outbreak-Associated Clostridium difficile Variant with Increased Virulence

Quesada-Gómez, C., López‐Ureña, D., Acuña-Amador, L., Villalobos-Zúñiga, M. A., Du, T., Freire, R. S., Guzmán‐Verri, C., Gamboa-Coronado, M. D. M., Lawley, T. D., Moreno, E., et al. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.03058-14 · Cited by 80 · see citing works

Gut microbiota-mediated protection against diarrheal infections

Vogt, S. L., & Finlay, B. B. (2016) · Journal of Travel Medicine · doi:10.1093/jtm/taw086 · Cited by 78 · see citing works

Efficacy of <i>Lactobacillus rhamnosus</i> GG in treatment of acute pediatric diarrhea: A systematic review with meta-analysis

Li, Y.-T., Xu, H., Ye, J.-Z., Wu, W.-R., Shi, D., Fang, D.-Q., Liu, Y., & Li, L.-J. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i33.4999 · Cited by 77 · see citing works

Probiotics, mechanisms of action, and clinical perspectives for diarrhea management in children

do Carmo, M. S., Santos, C. I. D., Araújo, M. C., Girón, J. A., Fernandes, E. S., & Monteiro-Neto, V. (2018) · Food &amp; Function · doi:10.1039/c8fo00376a · Cited by 75 · see citing works

Bacterial and Fungal Microbiota Changes Distinguish C. difficile Infection from Other Forms of Diarrhea: Results of a Prospective Inpatient Study

Sangster, W., Hegarty, J. P., Schieffer, K. M., Wright, J., Hackman, J., Toole, D. R., Lamendella, R., & Stewart, D. B. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00789 · Cited by 72 · see citing works

VIRAL CAUSES OF DIARRHEA

Goodgame, R. (2001) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70210-7 · Cited by 70 · see citing works

Detection of 23 Gastrointestinal Pathogens Among Children Who Present With Diarrhea

Stockmann, C. R., Pavia, A. T., Graham, B., Vaughn, M., Crisp, R., Poritz, M. A., Thatcher, S. A., Korgenski, E. K., Barney, T., Daly, J. A., et al. (2016) · Journal of the Pediatric Infectious Diseases Society · doi:10.1093/jpids/piw020 · Cited by 69 · see citing works

Opportunities of prebiotics for the intestinal health of monogastric animals

Azad, M. A. K., Gao, J., Ma, J., Li, T., Tan, B., Huang, X., & Yin, J. (2020) · Animal nutrition · doi:10.1016/j.aninu.2020.08.001 · Cited by 69 · see citing works

Development of Microbiome Biobanks – Challenges and Opportunities

Ryan, M. J., Schloter, M., Berg, G., KOSTIC, T. M., Kinkel, L. L., Eversole, K., Macklin, J., Schelkle, B., Κάζου, Μ., Sarand, I., et al. (2020) · Trends in Microbiology · doi:10.1016/j.tim.2020.06.009 · Cited by 67 · see citing works

Mechanisms and immunomodulatory properties of pre- and probiotics

Peters, V. B. M., van de Steeg, E., van Bilsen, J. H. M., & Meijerink, M. (2019) · Beneficial Microbes · doi:10.3920/bm2018.0066 · Cited by 66 · see citing works

Virulence assessment of six major pathogenic Candida species in the mouse model of invasive candidiasis caused by fungal translocation

Hirayama, T., Miyazaki, T., Ito, Y., Wakayama, M., Shibuya, K., Yamashita, K., Takazono, T., Saijo, T., Shimamura, S., Yamamoto, K., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-60792-y · Cited by 66 · see citing works

Strain-Specific Probiotic Properties of Bifidobacteria and Lactobacilli for the Prevention of Diarrhea Caused by Rotavirus in a Preclinical Model

Azagra-Boronat, I., Massot‐Cladera, M., Knipping, K., Garssen, J., Amor, K. B., Knol, J., Franch, À., Castell, M., Rodríguez-Lagunas, M. J., & Pérez-Cano, F. J. (2020) · Nutrients · doi:10.3390/nu12020498 · Cited by 62 · see citing works

Antivirulence Activity of the Human Gut Metabolome

Antunes, L. C. M., McDonald, J. A. K., Schroeter, K., Carlucci, C., Ferreira, R. B. R., Wang, M., Yurist‐Doutsch, S., Gill, H., Jacobson, K., DAVIES, J. E., et al. (2014) · mBio · doi:10.1128/mbio.01183-14 · Cited by 58 · see citing works

Emerging Role of Probiotics in the Management of H elicobacter Pylori Infection: Histopathologic Perspectives

Emara, M., Elhawari, S. A., Yousef, S., Radwan, M. I., & Abdel‐Aziz, H. R. (2015) · Helicobacter · doi:10.1111/hel.12237 · Cited by 57 · see citing works

Probiotics Down-Regulate Genes in Serovar Typhimurium Pathogenicity Islands 1 and 2

Bayoumi, M. A., & Griffiths, M. W. (2010) · Journal of Food Protection · doi:10.4315/0362-028x-73.3.452 · Cited by 51 · see citing works

Efficacy of Fecal Microbiota Transplantation for Recurrent C. Difficile Infection in Inflammatory Bowel Disease

Tariq, R., Disbrow, M. B., DiBaise, J. K., Orenstein, R., Saha, S., Solanky, D., Loftus, E. V., Pardi, D. S., & Khanna, S. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz299 · Cited by 51 · see citing works

Preventive Effect of a Synbiotic Combination of Galacto- and Fructooligosaccharides Mixture With Bifidobacterium breve M-16V in a Model of Multiple Rotavirus Infections

Rigo-Adrover, M. D. M., van Limpt, K., Knipping, K., Garssen, J., Knol, J., Costabile, A., Franch, À., Castell, M., & Pérez-Cano, F. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01318 · Cited by 48 · see citing works

Infection with Toxin A-Negative, Toxin B-Negative, Binary Toxin-Positive Clostridium difficile in a Young Patient with Ulcerative Colitis

Androga, G. O., Hart, J., Foster, N. F., CHARLES, A. K., Forbes, D., & Riley, T. V. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.01810-15 · Cited by 45 · see citing works

Probiotic Mixture Golden Bifido Prevents Neonatal Escherichia coli K1 Translocation via Enhancing Intestinal Defense

Zeng, Q., He, X., Puthiyakunnon, S., Xiao, H., Gong, Z., Boddu, S., Chen, L., Tian, H., Huang, S., & Cao, H. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01798 · Cited by 40 · see citing works

Dendritic cells and Brucella spp. interaction: the sentinel host and the stealthy pathogen

Ávila-Calderón, E. D., Flores‐Romo, L., Sharon, W., Donis‐Maturano, L., Becerril-García, M. A., Arreola, M. G. A., Arellano-Reynoso, B., Güemes, F. S., & Contreras-Rodríguez, A. (2019) · Folia Microbiologica · doi:10.1007/s12223-019-00691-6 · Cited by 36 · see citing works

A fermented milk concentrate and a combination of short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides/pectin-derived acidic oligosaccharides protect suckling rats from rotavirus gastroenteritis

Rigo-Adrover, M., Pérez-Berezo, T., Ramos-Romero, S., van Limpt, K., Knipping, K., Garssen, J., Knol, J., Franch, À., Castell, M., & Pérez-Cano, F. J. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114516004566 · Cited by 34 · see citing works

Chronic diarrhea

Chu, C. S., Rotondo‐Trivette, S., & Michail, S. K. (2020) · Current problems in pediatric and adolescent health care · doi:10.1016/j.cppeds.2020.100841 · Cited by 33 · see citing works

Diversity of bacterial lactase genes in intestinal contents of mice with antibiotics-induced diarrhea

Long, C., He, L., Guo, Y.-F., Liu, Y., Xiao, N., & Tan, Z. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i42.7584 · Cited by 30 · see citing works

Characterization of diarrheagenic Escherichia coli strains associated with diarrhea in children, Khouzestan, Iran

Broujerdi, S. M., Ardakani‬, M. R., & Rezatofighi, S. E. (2018) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.9538 · Cited by 30 · see citing works

Effects of Debaryomyces hansenii treatment on intestinal microorganisms in mice with antibiotics-induced diarrhea

He, L., Long, C., Liu, Y., Guo, Y.-F., Xiao, N., & Tan, Z. (2017) · 3 Biotech · doi:10.1007/s13205-017-0953-9 · Cited by 27 · see citing works

Effects of Lactobacillus rhamnosus GG on the maturation and differentiation of dendritic cells in rotavirus-infected mice

Jiang, Y., Ye, L., Cui, Y., Yang, G., Yang, W., Wang, J., Hu, J., Gu, W., Shi, C., Huang, H., et al. (2017) · Beneficial Microbes · doi:10.3920/bm2016.0157 · Cited by 26 · see citing works

Vibrio cholerae autoinducer-1 enhances the virulence of enteropathogenic Escherichia coli

Gorelik, O., Levy, N., Shaulov, L., Yegodayev, K. M., Meijler, M. M., & Sal‐Man, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-40859-1 · Cited by 26 · see citing works

Role ofCandida in indirect pathogenesis of antibiotic associated diarrhoea in infants

Ponnuvel, K. M., Rajkumar, R., Menon, T., & Sankaranarayanan, V. S. (1996) · Mycopathologia · doi:10.1007/bf00632335 · Cited by 23 · see citing works

Isolation and evaluation of Candida species and their association with CD4+ T cells counts in HIV patients with diarrhoea

Awoyeni, A., Olaniran, O., Odetoyin, B., Hassan-Olajokun, R. E., Olopade, B. O., Afolayan, D., & Adekunle, O. T. (2017) · African Health Sciences · doi:10.4314/ahs.v17i2.5 · Cited by 21 · see citing works

Cell Death Signaling Pathway Induced by Cholix Toxin, a Cytotoxin and eEF2 ADP-Ribosyltransferase Produced by Vibrio cholerae

Ogura, K., Yahiro, K., & Moss, J. (2020) · Toxins · doi:10.3390/toxins13010012 · Cited by 19 · see citing works

Diarrhea Among Children in Developing Countries

Nataro, J. P. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4726-9_5 · Cited by 16 · see citing works

Shigellahost: Pathogen interactions: Keeping bacteria in the loop

Liu, G., Pilla, G., & Tang, C. M. (2019) · Cellular Microbiology · doi:10.1111/cmi.13062 · Cited by 13 · see citing works

Bacterial Lactase Gene Characteristics in Intestinal Contents of Antibiotic-Associated Diarrhea Mice Treated with Debaryomyces hansenii

Wu, Y., Tang, Y., Xiao, N., Wang, C., & Tan, Z. (2020) · Medical Science Monitor · doi:10.12659/msm.920879 · Cited by 11 · see citing works

Cross-Reactivity, Epitope Mapping, and Potency of Monoclonal Antibodies to Class 5 Fimbrial Tip Adhesins of Enterotoxigenic Escherichia coli

Liu, Y., Shahabudin, S., Farid, S., Lee, L. H., McVeigh, A. L., Maciel, M., Poole, S., Broadman, M., Prouty, M. G., & Savarino, S. J. (2020) · Infection and Immunity · doi:10.1128/iai.00246-20 · Cited by 11 · see citing works

Effects of Bifidobacterium bifidum in Mice Infected with Citrobacter rodentium

Wen, B., Taïbi, A., Villa, C., Lee, S. H., Sagaidak, S., & Comelli, E. M. (2019) · Microorganisms · doi:10.3390/microorganisms7020051 · Cited by 9 · see citing works

Microbiota medicine: towards clinical revolution

Gebrayel, P., Nicco, C., Khodor, S. A., Biliński, J., Caselli, E., Comelli, E. M., Egert, M., Giaroni, C., Karpiński, T. M. M., Łoniewski, I., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03296-9 · Cited by 288 · see citing works

Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota

Anjana, A., & Tiwari, S. K. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.851140 · Cited by 280 · see citing works

Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders

Sasso, J. M., Ammar, R. M., Tenchov, R., Lemmel, S. A., Kelber, O., Grieswelle, M., & Zhou, Q. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00127 · Cited by 218 · see citing works

Exploring the gut microbiota: lifestyle choices, disease associations, and personal genomics

Matute, S. P., & Iyavoo, S. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1225120 · Cited by 134 · see citing works

Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers

Hajjo, R., Sabbah, D. A., & Bawab, A. Q. A. (2022) · Diagnostics · doi:10.3390/diagnostics12071742 · Cited by 100 · see citing works

Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions

Syromyatnikov, M., Nesterova, E. Y., Gladkikh, M. I., Dmitrievna, S. Y., Vladimirovna, G. M., & Popov, V. N. (2022) · Microorganisms · doi:10.3390/microorganisms10091866 · Cited by 91 · see citing works

Exploring the universal healthy human gut microbiota around the World

Piquer-Esteban, S., Ruiz‐Ruiz, S., Arnau, V., Dı́az-Villanueva, W., & Moyá, A. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.12.035 · Cited by 67 · see citing works

Smart capsules for sensing and sampling the gut: status, challenges and prospects

Rehan, M., Al-Bahadly, I. H., Thomas, D. G., Young, W., Cheng, L. K., & Avci, E. (2023) · Gut · doi:10.1136/gutjnl-2023-329614 · Cited by 73 · see citing works

Gut microbial profiles and the role in lipid metabolism in Shaziling pigs

Ma, J., Duan, Y., Li, R., Liang, X., Li, T., Huang, X., Yin, Y., & Yin, J. (2022) · Animal nutrition · doi:10.1016/j.aninu.2021.10.012 · Cited by 59 · see citing works

Revisiting the intestinal microbiome and its role in Diarrhea and constipation

Iancu, M. A., Profir, M., Roşu, O. A., Ionescu, R. F., Cretoiu, S. M., & Gaspar, B. S. (2023) · Microorganisms · doi:10.3390/microorganisms11092177 · Cited by 53 · see citing works

Microscopic colitis: Etiopathology, diagnosis, and rational management

Nielsen, O. H., Fernández‐Bañares, F., Sato, T., & Pardi, D. S. (2022) · eLife · doi:10.7554/elife.79397 · Cited by 52 · see citing works

Which Probiotic Is the Most Effective for Treating Acute Diarrhea in Children? A Bayesian Network Meta-Analysis of Randomized Controlled Trials

Li, Z., Zhu, G., Li, C., Lai, H., Liu, X., & Zhang, L. (2021) · Nutrients · doi:10.3390/nu13124319 · Cited by 52 · see citing works

Dynamics of oxidative stress and immune responses in neonatal calves during diarrhea

Fu, Z., Yang, Y. M., Ma, L., Malmuthuge, N., Guan, L. L., & Bu, D. (2023) · Journal of Dairy Science · doi:10.3168/jds.2023-23630 · Cited by 53 · see citing works

Effects of postbiotics on chronic diarrhea in young adults: a randomized, double-blind, placebo-controlled crossover trial assessing clinical symptoms, gut microbiota, and metabolite profiles

Guo, S., Ma, T., Kwok, L., Quan, K., Li, B., Wang, H., Zhang, H., Menghe, B., & Chen, Y. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2395092 · Cited by 52 · see citing works

Pathogenesis and therapy of radiation enteritis with gut microbiota

Yang, Q., Qin, B., Hou, W., Qin, H., & Yin, F.-F. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1116558 · Cited by 44 · see citing works

Nutritional Management of Oncological Symptoms: A Comprehensive Review

Garutti, M., Noto, C., Pastò, B., Cucciniello, L., Alajmo, M., Casirati, A., Pedrazzoli, P., Caccialanza, R., & Puglisi, F. (2023) · Nutrients · doi:10.3390/nu15245068 · Cited by 47 · see citing works

Gut microbiota composition in chemotherapy and targeted therapy of patients with metastatic colorectal cancer

Chen, Y., Chuang, C.-H., Miao, Z., Yip, K., Liu, C., Li, L., Wu, D., Cheng, T., Lin, C., & Wang, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.955313 · Cited by 37 · see citing works

Diarrhea with deficiency kidney-yang syndrome caused by adenine combined with Folium senna was associated with gut mucosal microbiota

Zhu, J., Li, X., Deng, N., Peng, X., & Tan, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1007609 · Cited by 38 · see citing works

Effects of mannan oligosaccharides and Lactobacillus mucosae on growth performance, immune response, and gut health of weanling pigs challenged with Escherichia coli lipopolysaccharides

Li, Y. S., Andres, J. V. S., Trenhaile-Grannemann, M. D., van Sambeek, D. M., Moore, K., Winkel, S. M., Fernando, S. C., Burkey, T. E., & Miller, P. S. (2021) · Journal of Animal Science · doi:10.1093/jas/skab286 · Cited by 31 · see citing works

Lactiplantibacillus plantarum P9 for chronic diarrhea in young adults: a large double-blind, randomized, placebo-controlled trial

Yang, N., Ma, T., Xie, Y., Li, Q., Li, Y., Zheng, L., Li, Y., Xiao, Q., Sun, Z., Zuo, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51094-2 · Cited by 29 · see citing works

Metagenomic and metabolomic analyses reveal the role of gut microbiome-associated metabolites in diarrhea calves

Shi, Z., Wang, Y., Yan, X., Ma, X., Duan, A., Hassan, F., Wang, W., & Deng, T. (2023) · mSystems · doi:10.1128/msystems.00582-23 · Cited by 28 · see citing works

The gut–heart axis: a review of gut microbiota, dysbiosis, and cardiovascular disease development

Abdulrahim, A. O., Doddapaneni, N. S. P., Salman, N., Giridharan, A., Thomas, J., Sharma, K., Abboud, E., Rochill, K., Shreelakshmi, B., Gupta, V., et al. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002789 · Cited by 31 · see citing works

Complex probiotics alleviate ampicillin-induced antibiotic-associated diarrhea in mice

Li, W., Zhang, S., Wang, Y., Bian, H., Yu, S., Huang, L., & Ma, W. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1156058 · Cited by 28 · see citing works

Prevalence and Load of the Campylobacter Genus in Infants and Associated Household Contacts in Rural Eastern Ethiopia: a Longitudinal Study from the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) Project

Deblais, L., Ojeda, A. E., Brhane, M., Mummed, B., Hassen, K. A., Ahmedo, B. U., Weldesenbet, Y. D., Amin, J. K., Ahmed, I. A., Usmane, I. A., et al. (2023) · Applied and Environmental Microbiology · doi:10.1128/aem.00424-23 · Cited by 25 · see citing works

Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea

Xue, H., Mei, C., Wang, F., & Tang, X. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3596 · Cited by 22 · see citing works

Alterations of the gut microbiota in coronavirus disease 2019 and its therapeutic potential

Xiang, H., & Liu, Q. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i47.6689 · Cited by 22 · see citing works

Promising probiotic-fermented soymilk for alleviating acute diarrhea: insights into the microbiome and metabolomics

Madjirebaye, P., Peng, Z., Mueed, A., Huang, T., Peng, F., Allasra, Y., Benar, M. E., Hu, Z., Xie, M., & Xiong, T. (2024) · Food & Function · doi:10.1039/d3fo05690b · Cited by 22 · see citing works

Status quo of the public’s knowledge of probiotics based on video-sharing platforms

Jiang, C., Xu, J., Xu, C., Chen, S.-Y., Chen, J.-Y., Xia, J.-S., Liao, Z., Zou, W.-B., & Fang, X. (2023) · BMC Public Health · doi:10.1186/s12889-023-15456-7 · Cited by 19 · see citing works

Intestinal mucosal flora of the intestine-kidney remediation process of diarrhea with deficiency kidney-yang syndrome in Sishen Pill treatment: Association with interactions between Lactobacillus johnsonii, Ca2+-Mg2+-ATP-ase, and Na+-K+-ATP-ase

Zhu, J., Li, X., Deng, N., Zhou, K., Qiao, B., Li, D., & Tan, Z. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16166 · Cited by 20 · see citing works

Artemisia annua L. polysaccharide improves the growth performance and intestinal barrier function of broilers challenged with Escherichia coli

Guo, S., Shi, B., Xing, Y., Xu, Y., Jin, X., Hong, L., Zhang, S., Qiao, M., & Yan, S. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1390815 · Cited by 20 · see citing works

Intestinal Colonization With Bifidobacterium longum Subspecies Is Associated With Length at Birth, Exclusive Breastfeeding, and Decreased Risk of Enteric Virus Infections, but Not With Histo-Blood Group Antigens, Oral Vaccine Response or Later Growth in Three Birth Cohorts

Colston, J. M., Taniuchi, M., Ahmed, T., Ferdousi, T., Kabir, F., Mduma, E. R., Nshama, R., Iqbal, N. T., Haque, R., Ahmed, T., et al. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.804798 · Cited by 20 · see citing works

Genomic insights into antimicrobial potential and optimization of fermentation conditions of pig-derived Bacillus subtilis BS21

Wu, D., Fu, L., Cao, Y., Dong, N., & Li, D. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1239837 · Cited by 21 · see citing works

Fucoidan Alleviates Intestine Damage in Mice Induced by LPS via Regulation of Microbiota

(2024) · Pakistan Veterinary Journal · doi:10.29261/pakvetj/2024.190 · Cited by 19 · see citing works

Intestinal tryptophan metabolism in disease prevention and swine production

Hu, Z., Feng, L., Jiang, Q., Wang, W., Tan, B., Tang, X., & Yin, Y. (2023) · Animal nutrition · doi:10.1016/j.aninu.2023.08.002 · Cited by 19 · see citing works

Association of Short‐Chain Fatty Acids with Gut Microbiota and Lipid Metabolism in Mice with Diarrhea Induced by High‐Fat Diet in a Fatigued State

Qiao, B., Liu, J., Peng, X., Cai, Y., Peng, M., Li, X., Tan, Z., & Deng, N. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300452 · Cited by 19 · see citing works

Effects of prebiotics on the gut microbiota in vitro associated with functional diarrhea in children

Zhi, D., Li, J., Li, W., Fu, H., Ding, J., Ren, G., Zhou, L., Pi, X., & Ye, X. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1233840 · Cited by 19 · see citing works

Varied microbial community assembly and specialization patterns driven by early life microbiome perturbation and modulation in young ruminants

Pan, Z., Ma, T., Steele, M. A., & Guan, L. L. (2024) · ISME Communications · doi:10.1093/ismeco/ycae044 · Cited by 21 · see citing works

The underlying causes, treatment options of gut microbiota and food habits in type 2 diabetes mellitus: a narrative review

Adhikary, K., Sarkar, R., Maity, S., Banerjee, I., Chatterjee, P., Bhattacharya, K., Ahuja, D., Sinha, N. K., & Maiti, R. (2024) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2024-0043 · Cited by 18 · see citing works

Combining 16S rRNA Sequencing and Metabolomics Data to Decipher the Interactions between Gut Microbiota, Host Immunity, and Metabolites in Diarrheic Young Small Ruminants

Wang, X., Niu, L., Wang, Y., Zhan, S., Wang, L., Dai, D., Cao, J., Guo, J., Li, L., Zhang, H., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411423 · Cited by 18 · see citing works

Microbial colony sequencing combined with metabolomics revealed the effects of chronic hexavalent chromium and nickel combined exposure on intestinal inflammation in mice

Gu, Y., Zheng, S., Huang, C., Cao, X., Liu, P., Yu, Z., Li, G., Hu, G., Gao, X., & Guo, X. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169853 · Cited by 18 · see citing works

An insight into the health beneficial of probiotics dairy products: a critical review

He, J., Li, W., Deng, J., Lin, Q., Bai, J., Zhang, L., & Fang, Y. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2090493 · Cited by 19 · see citing works

Cinnamon (Cinnamomum cassia) water extract improves diarrhea symptoms by changing the gut environment: a randomized controlled trial

Park, S.-Y., Kim, Y. D., Kim, M. S., Kim, K., & Kim, J. Y. (2023) · Food & Function · doi:10.1039/d2fo01835g · Cited by 17 · see citing works

Chitosan Enhances Intestinal Health in Cats by Altering the Composition of Gut Microbiota and Metabolites

Mo, R., Zhang, M., Wang, H., Liu, T., Liu, P., & Wu, Y. (2023) · Metabolites · doi:10.3390/metabo13040529 · Cited by 17 · see citing works

Revitalizing myocarditis treatment through gut microbiota modulation: unveiling a promising therapeutic avenue

Wang, J., Zhang, X., Yang, X., Yu, H., Bu, M.-M., Fu, J., Zhang, Z., Xu, H., Hu, J., Lu, J., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1191936 · Cited by 18 · see citing works

Effects of dietary traditional Chinese medicine residues on growth performance, intestinal health and gut microbiota compositions in weaned piglets

Sun, W., Chen, Z., Huang, Z., Wan, A., Zhou, M., & Gao, J. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1283789 · Cited by 17 · see citing works

Targeting the Gut-Kidney Axis in Diarrhea with Kidney-Yang Deficiency Syndrome: The Role of Sishen Pills in Regulating TMAO-Mediated Inflammatory Response

Xie, S., Fang, L., Deng, N., Shen, J., Tan, Z., & Peng, X. (2024) · Medical Science Monitor · doi:10.12659/msm.944185 · Cited by 17 · see citing works

Total glycosides contribute to the anti-diarrheal effects of Qiwei Baizhu Powder via regulating gut microbiota and bile acids

Xie, G., Deng, N., Zheng, T., Peng, X., Zhang, S., & Tan, Z. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.945263 · Cited by 16 · see citing works

Assembly of novel microbial genomes from gut metagenomes of rhesus macaque ( Macaca mulatta )

Yang, S., Fan, Z., Li, J., Wang, X., Yue, B., Yue, B., He, M., Zhang, A., & Li, J. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2188848 · Cited by 16 · see citing works

The dysfunction in intestinal microorganisms and enzyme activity as significant contributors to diarrhea with kidney-yang deficiency syndrome

Zhou, M., Li, X., Wang, X., Deng, N., Cai, Y., & Tan, Z. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1324938 · Cited by 16 · see citing works

Interaction between gut microbiota and COVID-19 and its vaccines

Leung, J. S. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i40.5801 · Cited by 15 · see citing works

Emerging insights into inflammatory bowel disease from the intestinal microbiota perspective: a bibliometric analysis

Zhang, A., Wang, F., Li, D., Wang, C.-Z., Yao, H., Wan, J., & Yuan, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1264705 · Cited by 16 · see citing works

Virulence genes, antimicrobial resistance profile, phylotyping and pathotyping of diarrheagenic Escherichia coli isolated from children in Southwest Mexico

Tapia-Pastrana, G., Rojas-Bautista, M., Hernández-Pérez, P., Santiago-Martínez, O., Gómez-Rodríguez, L. C., Terrazas-Luna, V., Montes-Yedra, J., Bautista-Avendaño, A. A., García‐López, E. S., León-Sicairos, N. M., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300304 · Cited by 16 · see citing works

Effectiveness of Psychobiotic Bifidobacterium breve BB05 in Managing Psychosomatic Diarrhea in College Students by Regulating Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled Trial

Wang, Y., Wang, Y., Ding, K., Liu, Y., Liu, D., Chen, W., Zhang, X., Luo, C., Zhang, H., Xu, T., et al. (2024) · Nutrients · doi:10.3390/nu16131989 · Cited by 19 · see citing works

Probiotics Administration in Cystic Fibrosis: What Is the Evidence?

Esposito, S., Testa, I., Zani, E. M., Cunico, D., Torelli, L., Grandinetti, R., Fainardi, V., Pisi, G., & Principi, N. (2022) · Nutrients · doi:10.3390/nu14153160 · Cited by 15 · see citing works

Importance of Zinc Nanoparticles for the Intestinal Microbiome of Weaned Piglets

Baholet, D., Skalíčková, S., Bátik, A., Malyugina, S., Skládanka, J., & Horký, P. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.852085 · Cited by 15 · see citing works

Comparative analysis of changes in diarrhea and gut microbiota in Beigang pigs

Wang, M., Zheng, H., Wang, S., Luo, H., Li, Z., Song, X., Xu, H., Li, P., Sun, S., Wang, Y., et al. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106441 · Cited by 14 · see citing works

Bacteroides thetaiotaomicron: A symbiotic ally against diarrhea along with modulation of gut microbial ecological networks via tryptophan metabolism and AHR-Nrf2 signaling

Luo, Y., Lan, C., Ren, W., Wu, A., Yu, B., He, J., & Chen, D. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.04.016 · Cited by 14 · see citing works

The efficacy of probiotics, prebiotics, and synbiotics on anxiety, depression, and sleep: a systematic review and meta-analysis of randomized controlled trials

Zhang, J., Zhu, L., Meng, Q., Wang, Z., & Zhu, H. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07644-z · Cited by 13 · see citing works

Gut microbiome alterations in ICU patients with enteral nutrition-related diarrhea

Ni, W., Jiao, X., Zou, H., Jing, M., Xia, M., Zhu, S., & Li, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1051687 · Cited by 13 · see citing works

Multi-omics strategy reveals potential role of antimicrobial resistance and virulence factor genes responsible for Simmental diarrheic calves caused by Escherichia coli

Shi, Z., Lan, Y., Wang, Y., Yan, X., Ma, X., Hassan, F., Rushdi, H. E., Xu, Z., Wang, W., & Deng, T. (2024) · mSystems · doi:10.1128/msystems.01348-23 · Cited by 14 · see citing works

Low molecular weight galactomannan alleviates diarrhea induced by senna leaf in mice via intestinal barrier improvement and gut microbiota modulation

Bi, J., Fu, X., Jiang, Y., Wang, J., Li, D., Xiao, M., & Mou, H. (2025) · Food & Function · doi:10.1039/d4fo04375h · Cited by 13 · see citing works

Seaweed polysaccharide relieves hexavalent chromium-induced gut microbial homeostasis

Mu, J., Guo, Z., Wang, X., Wang, X., Fu, Y., Li, X., Zhu, F., Hu, G., & Ma, X. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1100988 · Cited by 13 · see citing works

Diarrheal-associated gut dysbiosis in cancer and inflammatory bowel disease patients is exacerbated by Clostridioides difficile infection

Kulecka, M., Żeber‐Lubecka, N., Bałabas, A., Czarnowski, P., Bagińska, K., Głowienka, M., Kluska, A., Piątkowska, M., Dąbrowska, M., Waker, E., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1190910 · Cited by 13 · see citing works

Specific cultivation-independent enumeration of viable cells in probiotic products using a combination of fluorescence in situ hybridization and flow cytometry

Snaidr, L., Mühlhahn, P., Beimfohr, C., Kreuzer, C., Richly, C., & Snaidr, J. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1410709 · Cited by 12 · see citing works

Seasonal differences in intestinal flora are related to rats’ intestinal water metabolism

Li, J., Sun, Y., Wang, R., Ma, S., Shi, L., Wang, K., Zhang, H., Wang, T., & Liu, L. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1109696 · Cited by 12 · see citing works

Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition

Jie, Z., Yu, L., Yi, F., Zhang, H., Li, F., Li, X., Wei, Y. Z., & Wang, Z. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/5394514 · Cited by 12 · see citing works

Probiotic Weizmannia coagulans MTCC 5856 as adjunct therapy in children's acute diarrhea—a randomized, double-blind, placebo-controlled study

Majeed, M. A., Nagabhushanam, K., Arumugam, S., Chadalavada, N., Seepana, J., Annamalai, T., Murali, A., Prakasan, P., & Mundkur, L. (2024) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1338126 · Cited by 11 · see citing works

Nedd4-2–dependent Ubiquitination Potentiates the Inhibition of Human NHE3 by Cholera Toxin and Enteropathogenic Escherichia coli

Jenkin, K. A., Han, Y., Lin, S., He, P., & Yun, C. C. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.11.006 · Cited by 11 · see citing works

Dientamoeba fragilis associated with microbiome diversity changes in acute gastroenteritis patients

Muhsin‐Sharafaldine, M., Rahman, L. A., Suwanarusk, R., Grant, J., Parslow, G., French, N. P., Tan, K. S., Russell, B., Morgan, X. C., & Ussher, J. E. (2023) · Parasitology International · doi:10.1016/j.parint.2023.102788 · Cited by 11 · see citing works

Natural Products with Potential Effects on Hemorrhoids: A Review

Liang, Y., Ren, T., Li, R., Yu, Z., Wang, Y., Zhang, X., Qin, Z., Li, J., Hu, J., & Luo, C. (2024) · Molecules · doi:10.3390/molecules29112673 · Cited by 10 · see citing works

Antimicrobial peptide AP2 ameliorates Salmonella Typhimurium infection by modulating gut microbiota

Li, L., Fu, A., Mo, Q., Wan, Y., Zhou, Y., Zeng, Z., Shan, A., Zhang, X., Li, W., & Li, W. (2025) · BMC Microbiology · doi:10.1186/s12866-025-03776-0 · Cited by 11 · see citing works

Polysaccharide from Atractylodes macrocephala Koidz. alleviates pyrotinib-induced diarrhea through regulating cAMP/LKB1/AMPK/CFTR pathway and restoring gut microbiota and metabolites

Ran, P., Jiang, F., Pan, L., Shu, Y., Hu, F., Wang, Y., Zhao, R. Y., Wang, W., Mu, H., Wang, J., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142512 · Cited by 10 · see citing works

Gut Microbial Alterations in Diarrheal Baer's Pochards (Aythya baeri)

Li, X., Qin, X., Song, Y., Han, J., Li, Z., & Zhang, J. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.756486 · Cited by 10 · see citing works

Effects of sweeteners on host physiology by intestinal mucosal microbiota: Example-addition sweeteners in Qiweibaizhu Powder on intestinal mucosal microbiota of mice with antibiotic-associated diarrhea

Qiao, B., Liu, J., Xiao, N., Tan, Z., & Peng, M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1038364 · Cited by 10 · see citing works

Abrupt Dietary Change and Gradual Dietary Transition Impact Diarrheal Symptoms, Fecal Fermentation Characteristics, Microbiota, and Metabolic Profile in Healthy Puppies

Liao, P., Yang, K., Huang, H., Xin, Z., Jian, S., Wen, C., He, S., Zhang, L., & Deng, B. (2023) · Animals · doi:10.3390/ani13081300 · Cited by 10 · see citing works

Beneficial Effects of Limosilactobacillus fermentum CECT 5716 Administration to Infants Delivered by Cesarean Section

Blanco-Rojo, R., Maldonado, J. A., Schaubeck, M., Özen, M., López‐Huertas, E., & Olivares, M. M. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.906924 · Cited by 10 · see citing works

Hericium caput-medusae (Bull.:Fr.) Pers. fermentation concentrate polysaccharides improves intestinal bacteria by activating chloride channels and mucus secretion

Zhao, C., Sun, C. L., Yuan, J., Tsopmejio, I. S. N., Li, Y., Jiang, Y., & Song, H. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115721 · Cited by 10 · see citing works

Microbial Interventions to Improve Neonatal Gut Health

Nakandalage, R., Guan, L. L., & Malmuthuge, N. (2023) · Microorganisms · doi:10.3390/microorganisms11051328 · Cited by 10 · see citing works

Synergistic Effect of Postbiotic Yeast ABB C22® on Gut Inflammation, Barrier Function, and Protection from Rotavirus Infection in In Vitro Models

Marcolin, L. C., Castellana, J. C., Melero, L. M., de Lecea, C., & Tintoré, M. (2024) · Applied Microbiology · doi:10.3390/applmicrobiol4020056 · Cited by 9 · see citing works

Effect of Panax ginseng and Fructus Mume on Intestinal Barrier and Gut Microbiota in Rats with Diarrhea

Zhao, M., Zhao, Q., Guan, Z., Liu, Q., Zhou, H., Huang, Q., & Huo, B. (2023) · Journal of Medicinal Food · doi:10.1089/jmf.2022.k.0069 · Cited by 9 · see citing works

Sugar-Sweetened Beverages and Allergy Traits at Second Year of Life: BRISA Cohort Study

Muniz, A. K. O. A., Vianna, É. O., Padilha, L. L., Nascimento, J. X. P. T., Batista, R. F. L., Barbieri, M. A., Bettiol, H., & Ribeiro, C. C. C. (2023) · Nutrients · doi:10.3390/nu15143218 · Cited by 9 · see citing works

Sodium acetate and sodium butyrate attenuate diarrhea in yak calves by regulating gut microbiota and metabolites

Kong, Q., Chen, X., Liu, Y., Ali, F. N., Idrees, A., Ataya, F. S., Shang, Z., & Li, K. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26564 · Cited by 9 · see citing works

Lactiplantibacillus argentoratensis AGMB00912 protects weaning mice from ETEC infection and enhances gut health

Yoon, K., Yang, J.-H., Yeom, S., Kim, S.-S., Park, J., Song, B., Eun, J., Park, S., Lee, J. H., Kim, H. B., et al. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1440134 · Cited by 10 · see citing works

Alternative Approaches to Counter Multidrug-Resistant Bacterial Pathogens

Saxena, D., Maitra, R., Dasgupta, A., & Chopra, S. (2024) · Springer eBooks · doi:10.1007/978-981-97-5272-0_5 · Cited by 8 · see citing works

Anti-Bacterial and Anti-Inflammatory Properties of Sophoridine and Its Effect on Diarrhea in Mice

Wang, J., Tao, H., Fan, Q., Wang, X., Han, B., Wang, X., & Wang, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052122 · Cited by 8 · see citing works

Lactobacillus gasseri relieves diarrhea caused by enterotoxin-producing Escherichia coli through inflammation modulation and gut microbiota regulation

Chen, C., Yue, Y., He, Z., Li, B., Zhao, J., Chen, W., & Yang, B. K. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.103186 · Cited by 8 · see citing works

Nutrition Considerations in Patients with Functional Diarrhea

Ford, C. K. (2023) · Current Gastroenterology Reports · doi:10.1007/s11894-023-00878-5 · Cited by 12 · see citing works

In Vitro Evaluation of Probiotic Properties of Two Novel Probiotic Mixtures, Consti-Biome and Sensi-Biome

Jang, Y. J., Min, B., Lim, J. H., & Kim, B. (2023) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2303.03011 · Cited by 8 · see citing works

The effect of nutritional interventions in acute radiation-induced diarrhoea in patients with primary pelvic cancer: A systematic review

Holm, M., Bye, A., Falkmer, S., Tobberup, R., Rasmussen, H. H., Lauridsen, C., Yilmaz, M., Søndergaard, J., & Poulsen, L. Ø. (2023) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2023.104038 · Cited by 7 · see citing works

The impact of a modified microbiota-accessible carbohydrate diet on gut microbiome and clinical symptoms in colorectal cancer patients following surgical resection

Kim, B., Lee, J., Jung, E. S., Lee, S., Suh, D. H., Park, Y. J., Kim, J., Kwak, J., & Lee, S. H. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1282932 · Cited by 7 · see citing works

Elaeagnus angustifolia L. fruit alleviates diarrhea via regulating intestinal microbiota and short chain fatty acids

Abulizi, X., Shi, M., Jia, Y.-M., Xu, L., Shi, L.-L., & Pan, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38646 · Cited by 7 · see citing works

Exposure to Environmental Pollutants and Risk of Diarrhea: A Systematic Review

Nwanaforo, E. O., Amadi, C. N., Frazzoli, C., Bede-Ojimadu, O. O., & Orisakwe, O. E. (2024) · Environmental Health Insights · doi:10.1177/11786302241304539 · Cited by 7 · see citing works

The role of gut microbiota in diarrhea and its alleviation through microbiota-targeted interventions

Tian, R., Chong, C.-J., Bai, Y., Chen, N., Qiao, R.-R., Wang, K., Wang, Y., Zhao, P., Zhao, C., Tang, Y., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1630823 · Cited by 7 · see citing works

Prevotella copri alleviates diarrhea in weaning piglets through gut microbiota modulation and arachidonic acid–AHR–NRF2 pathway activation

Lan, C., Ren, W., Wu, A., Yu, B., He, J., Luo, Y., & Chen, D. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01273-y · Cited by 7 · see citing works

Risk Factors and Quality of Life in Patients with Diffuse Pouchitis After Ileal Pouch Anal Anastomosis According to the Chicago Classification for J Pouch: a Retrospective Multicenter Cohort Study in China

Xu, W., Wang, Y., Hua, Z., Hu, H., Chen, W., Cai, Z., Cui, L., Wu, X., Lian, L., Ding, Z., et al. (2023) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-022-05563-y · Cited by 7 · see citing works

Clustering of Gastrointestinal Microorganisms in Human Stool Samples from Ghana

Backhaus, J., Kann, S., Hahn, A., Weinreich, F., Blohm, M., Tanida, K., Feldt, T., Sarfo, F. S., Cristanziano, V. D., Loderstädt, U., et al. (2024) · Pathogens · doi:10.3390/pathogens13070583 · Cited by 7 · see citing works

Research progress of traditional Chinese medicine on the treatment of diarrhea by regulating intestinal microbiota and its metabolites based on renal-intestinal axis

Zhou, T., Zhang, Y., Li, Z., Lu, C., & Zhao, H. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1483550 · Cited by 7 · see citing works

Bacillus pumilus 315 improves intestinal microbiota and barrier function to alleviate diarrhea of neonatal goats

Fan, D., Jiao, S., Fu, Y., Zhang, J., Zhuang, Y., Huang, J., Bi, Y., Zhang, J., & Zhang, N. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.10.008 · Cited by 7 · see citing works

Integrated Small Intestine Microbiota and Serum Metabolomics Reveal the Potential Mechanisms of Wine Steaming in Alleviating Rhubarb-Induced Diarrhea

Bai, Y., Tian, R., Yan, Q., Zhang, Q., Zhao, C., Yan, Y.-G., Li, Z., Yue, S., & Tang, Y. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s479654 · Cited by 6 · see citing works

The Impact of Combined Therapy with Lactobacillus acidophilus and Montmorillonite Powder on the Inflammatory Response in Pediatric Rotavirus Enteritis

Wei, Q., Song, L., Rao, R., Yang, H.-W., Wen, Y.-P., Lv, L., & Wang, L. (2024) · International Archives of Allergy and Immunology · doi:10.1159/000542593 · Cited by 6 · see citing works

Revisiting the intestinal microbiome and its role in Diarrhea and constipation

Iancu, M. A., Profir, M., Roşu, O. A., Ionescu, R. F., Cretoiu, S. M., & Gaspar, B. S. (2023) · Microorganisms · doi:10.3390/microorganisms11092177 · Cited by 53 · see citing works

Manipulating the gut microbiota to maintain health and treat disease

Scott, K. P., Antoine, J., Midtvedt, T., & van Hemert, S. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.25877 · Cited by 284 · see citing works

Gut microbiota-mediated protection against diarrheal infections

Vogt, S. L., & Finlay, B. B. (2016) · Journal of Travel Medicine · doi:10.1093/jtm/taw086 · Cited by 78 · see citing works

Diarrheal disease and gut microbiome

Ramamurthy, T., Kumari, S., & Ghosh, A. (2022) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2022.08.002 · Cited by 12 · see citing works

Microbiota Based Management of the Gastrointestinal Disorders

Mouli, V. P., & Ahuja, V. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00011-5