The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes
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Since December 2019, a newly identified coronavirus (2019 novel coronavirus, 2019-nCov) is causing outbreak of pneumonia in one of largest cities, Wuhan, in Hubei province of China and has draw significant public health attention. The same as severe acute respiratory syndrome coronavirus (SARS-CoV), 2019-nCov enters into host cells via cell receptor angiotensin converting enzyme II (ACE2). In order to dissect the ACE2-expressing cell composition and proportion and explore a potential route of the 2019-nCov infection in digestive system infection, 4 datasets with single-cell transcriptomes of lung, esophagus, gastric, ileum and colon were analyzed. The data showed that ACE2 was not only highly expressed in the lung AT2 cells, esophagus upper and stratified epithelial cells but also in absorptive enterocytes from ileum and colon. These results indicated along with respiratory systems, digestive system is a potential routes for 2019-nCov infection. In conclusion, this study has provided the bioinformatics evidence of the potential route for infection of 2019-nCov in digestive system along with respiratory tract and may have significant impact for our healthy policy setting regards to prevention of 2019-nCoV infection.
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High ACE2 expression has been found in several specific cell types across organs, including type II alveolar cells of lung, upper and stratified esophageal epithelial cells, absorptive enterocytes of ileum and colon, cholangiocytes, myocardial cells, kidney proximal tubule cells, and bladder urothelial cells.
“High ACE2 expression was identified in type II alveolar cells (AT2) of lung10–12, esophagus upper and stratified epithelial cells, absorptive enterocytes from ileum and colon12, cholangiocytes13, myocardial cells, kidney proximal tubule cells, and bladder urothelial cells10.”
From High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa (2020) · cites this paper as [12]
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Effect of SARS-CoV-2 infection upon male gonadal function: A single center-based studyPreprint
Ma, L., Xie, W., Li, D., Shi, L., Mao, Y., Xiong, Y., Zhang, Y., & Zhang, M. (2020) · medRxiv · doi:10.1101/2020.03.21.20037267 · Cited by 287 · see citing works
Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2
Salamanna, F., Maglio, M., Landini, M. P., & Fini, M. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.594495 · Cited by 283 · see citing works
Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques
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Self-citationACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19
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Delivery of infection from asymptomatic carriers of COVID-19 in a familial cluster
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On the whereabouts of SARS-CoV-2 in the human body: A systematic review
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Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19
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COVID-19-associated gastrointestinal and liver injury: clinical features and potential mechanisms
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Diet Supplementation, Probiotics, and Nutraceuticals in SARS-CoV-2 Infection: A Scoping Review
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Environmental contamination by SARS-CoV-2 in a designated hospital for coronavirus disease 2019
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COVID-19 and the Digestive System
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Clinical manifestation and disease progression in COVID-19 infection
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Novel Coronavirus disease (COVID-19) in newborns and infants: what we know so far
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SARS‐CoV‐2, the pandemic coronavirus: Molecular and structural insights
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Taste and Smell Disorders in COVID-19 Patients: Role of Interleukin-6
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Coronavirus: Update Related to the Current Outbreak of COVID-19
Gabutti, G., d’Anchera, E., Sandri, F., Savio, M., & Stefanati, A. (2020) · Infectious Diseases and Therapy · doi:10.1007/s40121-020-00295-5 · Cited by 172 · see citing works
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Nutrition of the COVID-19 patient in the intensive care unit (ICU): a practical guidance
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The transmission modes and sources of COVID-19: A systematic review
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Quantum machine learning for chemistry and physics
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Diarrhea Is Associated With Prolonged Symptoms and Viral Carriage in Corona Virus Disease 2019
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Direct Evidence of Active SARS-CoV-2 Replication in the Intestine
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COVID-19 and male reproductive function: a prospective, longitudinal cohort study
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COVID‐19 and non‐alcoholic fatty liver disease: Two intersecting pandemics
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Qi, J., Zhou, Y., Hua, J., Zhang, L., Bian, J., Liu, B., Zhao, Z., & Jin, S. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18010284 · Cited by 134 · see citing works
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Dietary Supplements and Nutraceuticals under Investigation for COVID-19 Prevention and Treatment
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Gastrointestinal manifestations in COVID-19
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Early CT features and temporal lung changes in COVID-19 pneumonia in Wuhan, China
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COVID-19 Pandemic: Epidemiology, Etiology, Conventional and Non-Conventional Therapies
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SARS-CoV-2 (Covid-19) vaccines structure, mechanisms and effectiveness: A review
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Coronavirus disease (COVID-19): a scoping review
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Self-citationSevere COVID-19: A Review of Recent Progress With a Look Toward the Future
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Advances in research on ACE2 as a receptor for 2019-nCoV
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Review article: prevention, diagnosis and management of COVID‐19 in the IBD patient
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Digestive symptoms of COVID-19 and expression of ACE2 in digestive tract organs
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- Authors
- Zhang, H., Kang, Z., Gong, H., Xu, D., Wang, J., Li, Z., Cui, X., Xiao, J., Meng, T., Zhou, W., Liu, J., & Xu, H.
- Affiliations
- Second Military Medical University (CN)
- Tongji University (CN)
- Center for Life Sciences (CN)
- Corresponding author
- Meng, Tong
- Zhou, Wang
- Liu, Jianmin
- Xu, Huji
- ORCID
- Venue
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Published
- 2020-01-31
- OpenAlex
- W3004151654
- Cited by
- 658
- References
- 38
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 39 · 2023: 31 · 2022: 46 · 2021: 154 · 2020: 384
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- SARS-CoV-2, ACE2 receptor, gastrointestinal infections, enterocytes, intestinal epithelium, esophageal epithelium, single-cell transcriptomics, infection route, COVID-19 prevention
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