Cited by 1,145Schizophrenia research and treatmentPharmacology and Obesity TreatmentHIV-related health complications and treatments

The DOI matches its Crossref record; 130 of the 131 references it cites were found in a registry or an index.

Metabolic and cardiovascular adverse effects associated with antipsychotic drugs.

De Hert, Marc, Detraux, Johan, van Winkel, Ruud, Yu, Weiping, Correll, Christoph U.·2012·Nature Reviews Endocrinology

DOI 10.1038/nrendo.2011.156

Open this paper in CoChat — free account

Abstract

Antipsychotic medications can induce cardiovascular and metabolic abnormalities (such as obesity, hyperglycemia, dyslipidemia and the metabolic syndrome) that are associated with an increased risk of type 2 diabetes mellitus and cardiovascular disease. Controversy remains about the contribution of individual antipsychotic drugs to this increased risk and whether they cause sudden cardiac death through prolongation of the corrected QT interval. Although some drug receptor-binding affinities correlate with specific cardiovascular and metabolic abnormalities, the exact pharmacological mechanisms underlying these associations remain unclear. Antipsychotic agents with prominent metabolic adverse effects might cause abnormalities in glucose and lipid metabolism via both obesity-related and obesity-unrelated molecular mechanisms. Despite existing guidelines and recommendations, many antipsychotic-drug-treated patients are not assessed for even the most easily measurable metabolic and cardiac risk factors, such as obesity and blood pressure. Subsequently, concerns have been raised over the use of these medications, especially pronounced in vulnerable pediatric patients, among whom their use has increased markedly in the past decade and seems to have especially orexigenic effects. This Review outlines the metabolic and cardiovascular risks of various antipsychotic medications in adults and children, defines the disparities in health care and finally makes recommendations for screening and monitoring of patients taking these agents.

Integrity signals

Registry

Crossref · 10.1038/nrendo.2011.156

Cites

130 of 130 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>
Chobanian, A. V. (2003) · JAMA · doi:10.1001/jama.289.19.2560 · Cited by 25,386
Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
Lieberman, J. A., Stroup, T. S., McEvoy, J. P., Swartz, M. S., Rosenheck, R. A., Perkins, D. O., Keefe, R. S. E., Davis, S. M., Davis, C. E., Lebowitz, B. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051688 · Cited by 5,892
Bipolar Disorder
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515
International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes
The International Expert Committee (2009) · Diabetes Care · doi:10.2337/dc09-9033 · Cited by 3,185
Systematic review and meta-analysis
Gillies, A. (2019) · CRC Press eBooks · doi:10.1201/9781315377315-19 · Cited by 2,876
Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care
DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488
A Population-Based Study
Christakis, D., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., & Yapanel, U. H. (2009) · Cited by 2,290
ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death
Zipes, D. P., Camm, A. J., Borggrefe, M., Buxton, A. E., CHAITMAN, B. R., FROMER, M. A., Gregoratos, G., Klein, G. J., Myerburg, R. J., Quiñones, M. A., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.07.010 · Cited by 1,975

Show all 131 references

Research works printed but not linked: 1

Citrome, L. Risk–benefit analysis of available treatments for schizophrenia. Psychiatric Times 1, 27–30 (2007).

Sorted by citations

Items 501–600 of 1,000

Long-Term Metabolic Effects in French-Canadian Children and Adolescents Treated with Second-Generation Antipsychotics in Monotherapy or Polytherapy: A 24-Month Descriptive Retrospective Study
Ilies, D., Huet, A.-S., Lacourse, É., Roy, G., Stip, É., & Amor, L. B. (2017) · The Canadian Journal of Psychiatry · doi:10.1177/0706743717718166 · Cited by 15
Treatment of Diabetic Ketoacidosis Associated With Antipsychotic Medication
Vuk, A., Baretić, M., Osvatić, M. M., Filipčić, I., Jovanović, N., & Kuzman, M. R. (2017) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000772 · Cited by 15
Primary care prevention of the cardiovascular health crisis for people with severe mental illnesses: The elephant in the room
Palmer, V. J., Lewis, M., Stylianopolous, V., & Furler, J. (2018) · Australian Journal of General Practice · doi:10.31128/ajgp-09-18-4692 · Cited by 15
Lipid alterations in adolescents with early-onset psychosis may be independent of antipsychotic medication
Wedervang‐Resell, K., Friis, S., Lonning, V., Smelror, R. E., Johannessen, C. H., Agartz, I., Ulven, S. M., Holven, K. B., Andreassen, O. A., & Myhre, A. M. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.11.039 · Cited by 15
Impact of Lurasidone and Other Antipsychotics on Body Weight: Real-World, Retrospective, Comparative Study of 15,323 Adults with Schizophrenia
Pochiero, I., Calisti, F., Comandini, A., Vecchio, A. D., Costamagna, I., Rosignoli, M. T., Cattaneo, A., Nunna, S., Peduto, I., Heiman, F., et al. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s320611 · Cited by 15
How to Mitigate Risk of Premature Cardiovascular Disease Among Children and Adolescents with Mental Health Conditions
Xu, W., Zimmermann, M., Forkey, H. C., Griffin, J. L., Wilds, C., Morgan, W. S., Byatt, N., & McNeal, C. J. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-00998-9 · Cited by 15
Characteristics and predictors of off‐label use of antipsychotics in general population sample
Pirhonen, E., Haapea, M., Rautio, N., Nordström, T., Turpeinen, M., Laatikainen, O., Koponen, H., Silvan, J., Miettunen, J., & Jääskeläinen, E. (2022) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13472 · Cited by 14
Type 2 Diabetes in Children and Adolescents on Atypical Antipsychotics
Pramyothin, P., & Khaodhiar, L. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0623-4 · Cited by 16
Risk Factors of Metabolic Syndrome Among Patients Receiving Antipsychotics: A Retrospective Study
Hammoudeh, S., Lawati, H. J. A., Ghuloum, S., Iram, H., Yehya, A., Becetti, I., AlFakhri, N., Ghabrash, H., Shehata, M., Ajmal, N., et al. (2019) · Community Mental Health Journal · doi:10.1007/s10597-019-00537-y · Cited by 15
Integrated treatment of schizophrenia
Altamura, A. C., Fagiolini, A. M., Galderisi, S., Rocca, P., & Rossi, A. (2015) · Use Siena air (University of Siena) · Cited by 14
Strategies to deal with comorbid physical illness in psychosis
Docherty, M. J., Stubbs, B., & Gaughran, F. (2016) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796016000056 · Cited by 16
Aerobic Exercise Improves the Overall Outcome of Type 2 Diabetes Mellitus Among People With Mental Disorders
He, J., Liu, F., Xu, P., Xu, T., Yu, H., Wu, B., Wang, H., Chen, J., Zhang, K., Zhang, J., et al. (2024) · Depression and Anxiety · doi:10.1155/da/6651804 · Cited by 18
Cardiovascular Profile of Valbenazine: Analysis of Pooled Data from Three Randomized, Double-Blind, Placebo-Controlled Trials
Thai-Cuarto, D., O’Brien, C. F., Jimenez, R., Liang, G. S. L., & Burke, J. (2017) · Drug Safety · doi:10.1007/s40264-017-0623-1 · Cited by 14
Bipolar disorder and medical comorbidities: A Portuguese population-based observational retrospective study (2008–2015)
Henriques, F., Ferreira, A. R., Gonçalves‐Pinho, M., Freitas, A., & Fernandes, L. P. N. S. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.10.090 · Cited by 15
Potential Therapeutic Targeting Neurotransmitter Receptors in Diabetes
Pan, X., Tao, S., & Tong, N. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.884549 · Cited by 14
Are probiotics effective in reducing the metabolic side effects of psychiatric medication? A scoping review of evidence from clinical studies
Mötteli, S., Vetter, S., Colla, M., & Hotzy, F. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02735-z · Cited by 14
Efficacy and safety of low-frequency repetitive transcranial magnetic stimulation in adolescents with first-episode major depressive disorder: A randomized, double-blind, sham-controlled pilot trial
Gu, L.-M., Deng, C.-J., Shang, D., Huang, S., Nie, S., Yang, X.-H., Ning, Y.-P., Huang, X., Balbuena, L., Xiang, Y., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.11.001 · Cited by 15
Methods for using clinical laboratory test results as baseline confounders in multi‐site observational database studies when missing data are expected
Raebel, M. A., Shetterly, S. M., Lu, C. Y., Flory, J., Gagne, J. J., Harrell, F. E., Haynes, K., Herrinton, L. J., Patorno, E., Popovic, J. R., et al. (2016) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.4015 · Cited by 14
Diet and cardiometabolic side effects in children treated with second-generation antipsychotics
Barker, M. K., Sable, C. M., Montgomery, S. E., Chow, L., Green, T., Panagiotopoulos, C., & Devlin, A. M. (2017) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2017.09.013 · Cited by 14
Metabolic Syndrome among Schizophrenic Patients: A Comparative Cross-Sectional Study in the Middle Belt of Ghana
Owusu–Ansah, A., Anto, B. P., Obirikorang, C., Agyare, C., Acheampong, E., Kwofie, S., Anto, E. O., & Batu, E. N. (2018) · Schizophrenia Research and Treatment · doi:10.1155/2018/6542983 · Cited by 14
The Cord Blood Insulin and Mitochondrial DNA Content Related Methylome
Reimann, B., Janssen, B. G., Alfano, R., Ghantous, A., Espín-Pérez, A., de Kok, T. M. C. M., Saenen, N. D., Cox, B., Robinson, O., Chadeau‐Hyam, M., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00325 · Cited by 15
Effect of aripiprazole as an adjunct to atypical antipsychotics on weight and metabolic profile: a 12-week open-label trial
Gupta, B., Kt, C., Neo, L. Q., Tang, C. Y. Z., Hariram, J., Tan, G. C.-Y., Verma, S. K., Basu, S., Appan, D. P., Ting, C.-C., et al. (2021) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253211046765 · Cited by 16
Opioid antagonism mitigates antipsychotic-associated weight gain: focus on olanzapine
McIntyre, R. S., Citrome, L., Cummings, H., Todtenkopf, M. S., Tan, L. A., Harris‐White, M. E., & Akerman, S. C. (2022) · CNS Spectrums · doi:10.1017/s1092852922000116 · Cited by 15
Estimation of cardiac QTc intervals in people prescribed antipsychotics: a comparison of correction factors
Andric, T., Winckel, K., Tanzer, T. D., Hollingworth, S., Smith, L., Isoardi, K., Tan, O., & Siskind, D. J. (2022) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253221104947 · Cited by 14
Tapered discontinuation vs. maintenance therapy of antipsychotic medication in patients with first-episode schizophrenia: Obstacles, findings, and lessons learned in the terminated randomized clinical trial TAILOR
Stürup, A. E., Hjorthøj, C. R., Albert, N., Dolmer, S., Birk, M., Ebdrup, B. H., Eplov, L. F., Jensen, H., Vernal, D. L., Speyer, H., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.910703 · Cited by 14
Emerging Drugs and Indications for Cardio-Metabolic Disorders in People with Severe Mental Illness
Kouidrat, Y., Amad, A., & Binder, M. D. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150619093128 · Cited by 14
Cardiovascular effects of acute treatment with the antipsychotic drug olanzapine in rats
Leung, J. Y. T., Pang, C. C. Y., Procyshyn, R. M., & Barr, A. M. (2014) · Vascular Pharmacology · doi:10.1016/j.vph.2014.06.003 · Cited by 15
Second-generation antipsychotics in a tertiary care hospital
Niedrig, D., Gött, C., Fischer, A., Müller, S. T., Greil, W., Bucklar, G., & Russmann, S. (2015) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000103 · Cited by 15
Depot risperidone-induced adverse metabolic alterations in female rats
Horská, K., Kučerová, J., Karpíšek, M., Suchý, P., Opatřilová, R., & Kotolová, H. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117691466 · Cited by 14
Mechanisms of action and processes of yoga-based group intervention for inpatients with schizophrenia spectrum disorders–A longitudinal qualitative study
Töbelmann, L., Hahne, I., Schulze, T., Bergmann, N., Fuchs, L., Zierhut, M., Hahn, E., & Böge, K. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1086468 · Cited by 13
“SSD are frequently accompanied by comorbidities such as depression, anxiety (3, 4), and metabolic syndrome due to side effects of antipsychotic medication (5, 6).”
Background
Cardiovascular and metabolic risk of antipsychotics in children and young adults: a multinational self-controlled case series study
Man, K. K. C., Shao, S., Chang, Y.-C., Chi, M., Jeong, H. E., Lin, S., Su, C., Shin, J., Wong, K. H. T. W., Wong, I. C. K., et al. (2021) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796021000494 · Cited by 15
The effect on relapse rate and psychiatric symptomatology: Switching a combination of first- and second-generation antipsychotic polypharmacy to antipsychotic monotherapy in long-term inpatients with schizophrenia and related disorders. A pragmatic randomized open-label trial (SwAP trial)
Shakir, M., Willems, A. E., van Harten, P. N., van Lutterveld, R., & Tenback, D. E. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.03.008 · Cited by 13
Antipsychotic treatments; focus on lurasidone
Sumiyoshi, T. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00102 · Cited by 13
Association between high BMI and high homocysteine levels in Chinese patients with bipolar disorder
Mu, L., Yu, F., Xia, J., Lang, X., Haque, A., Wu, H. E., & Zhang, X. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.08.032 · Cited by 13
Efficacy of Atypical Antipsychotics in the Management of Acute Agitation and Aggression in Hospitalized Patients with Schizophrenia or Bipolar Disorder: Results from a Systematic Review.
Yu, X., Correll, C. U., Xiang, Y., Xu, Y., Jizhong, H., Yang, F., Wang, G., Si, T., Kane, J. M., & Masand, P. S. (2016) · Europe PMC (PubMed Central) · doi:10.11919/j.issn.1002-0829.216072 · Cited by 14
Problems managed and medications prescribed during encounters with people with autism spectrum disorder in Australian general practice
Birch, R. C., Foley, K., Pollack, A., Britt, H. C., Lennox, N. G., & Trollor, J. N. (2017) · Autism · doi:10.1177/1362361317714588 · Cited by 17
Influence of polygenic risk scores on lipid levels and dyslipidemia in a psychiatric population receiving weight gain-inducing psychotropic drugs
Delacrétaz, A., Santos, P. L., Saigí-Morgui, N., Vandenberghe, F., Glatard, A., Gholam‐Rezaee, M., von Gunten, A., Conus, P., & Eap, C. B. (2017) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000313 · Cited by 13
Antipsychotic Medication Adherence and Diabetes-Related Hospitalizations Among Medicaid Recipients With Diabetes and Schizophrenia
Egglefield, K., Cogan, L., Leckman‐Westin, E., & Finnerty, M. T. (2019) · Psychiatric Services · doi:10.1176/appi.ps.201800505 · Cited by 13
Statin discontinuation and new antipsychotic use after an acute hospital stay vary by hospital
Coe, A. B., Vincent, B. M., & Iwashyna, T. J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232707 · Cited by 15
Continuous versus extended antipsychotic dosing in schizophrenia: Less is more
Servonnet, A., Uchida, H., & Samaha, A. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113076 · Cited by 14
Daily Dose Effects of Risperidone on Weight and Other Metabolic Parameters
Piras, M., Dubath, C., Gholam, M., Laaboub, N., Grosu, C., Gamma, F., Solida, A., Plessen, K. J., von Gunten, A., Conus, P., et al. (2022) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.21m14110 · Cited by 13
The Role of Mental Health Services in Addressing HIV Infection Among Women With Serious Mental Illness
Seeman, M. V. (2015) · Psychiatric Services · doi:10.1176/appi.ps.201400411 · Cited by 13
Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients
Delacrétaz, A., Glatard, A., Dubath, C., Gholam‐Rezaee, M., Sanchez-Mut, J. V., Gräff, J., von Gunten, A., Conus, P., & Eap, C. B. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0792-0 · Cited by 12
Antipsychotic effects on anthropometric outcomes in anorexia nervosa: a retrospective chart review of hospitalized children and adolescents
Frank, B., Arnold, S., Jaite, C., & Correll, C. U. (2023) · Journal of Eating Disorders · doi:10.1186/s40337-023-00862-4 · Cited by 13
New horizons in schizophrenia in older people
Meesters, P. D. (2023) · Age and Ageing · doi:10.1093/ageing/afad161 · Cited by 12
Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): Study protocol
Agarwal, S. M., Dissanayake, J., Agid, O., Bowie, C. R., Brierley, N., Chintoh, A. F., Luca, V. D., Diaconescu, A. O., Gerretsen, P., Graff‐Guerrero, A., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0288354 · Cited by 13
Cultural diversity in physical diseases among patients with mental illnesses
Larsen, J. I., Andersen, U. A., Becker, T. M., Bickel, G. G., Bork, B., Cordes, J., Frasch, K., Jacobsen, B. A., Jensen, S. O. W., Kilian, R., et al. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412463614 · Cited by 12
Improving the integration of mental health services in primary health care at the macro level
Bywood, P. T., Brown, L. J., & Raven, M. K. (2015) · Flinders Academic Commons (Flinders University) · Cited by 12
Initial psychometric evaluation of the physical health attitude scale and a survey of mental health nurses
Özaslan, Z., Bilgin, H., Yalçın, S. U., & Haddad, M. (2019) · Journal of Psychiatric and Mental Health Nursing · doi:10.1111/jpm.12553 · Cited by 15
Neither Cathodal nor Anodal Transcranial Direct Current Stimulation on the Left Dorsolateral Prefrontal Cortex alone or Applied During Moderate Aerobic Exercise Modulates Executive Function
Thomas, F., Pixa, N. H., Berger, A., Cheng, M., Doppelmayr, M. M., & Steinberg, F. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.017 · Cited by 15
Cariprazine in the Management of Negative Symptoms of Schizophrenia: State of the art and Future Perspectives
Correll, C. U., Demyttenaere, K., Fagiolini, A. M., Hajak, G., Pallanti, S., Racagni, G., & Singh, S. P. (2020) · Future Neurology · doi:10.2217/fnl-2020-0012 · Cited by 12
Sex Differences in the Association of HOMA-IR Index and BDNF in Han Chinese Patients With Chronic Schizophrenia
Yang, Y., Zhang, Y., Wang, J., Ning, X., Zhang, Y., Zhao, T., Zhong, Y., Liu, Z., Xia, L., Li, W., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.656230 · Cited by 13
The Effects of Use of Long-Term Second-Generation Antipsychotics on Liver and Kidney Function: A Prospective Study
Papatriantafyllou, E., Efthymiou, D., Markopoulou, M., Sakellariou, E.-M., & Vassilopoulou, Ε. (2022) · Diseases · doi:10.3390/diseases10030048 · Cited by 12
Changes in BMI in hospitalized patients during treatment with antipsychotics, depending on gender and other factors
Sušilová, L., Češková, E., Hampel, D., Sušil, A., & Šimůnek, J. (2017) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2017.1291818 · Cited by 12
Overlooked fatal infectious diseases after long-term antipsychotic use in patients with psychiatric illness
Li, L., Ye, X., Zhao, Z., Gao, P., & Jiang, Y. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.09.033 · Cited by 12
Patterns of Prescription of Psychotropic Medications and Their Adherence among Patients with Schizophrenia in Two Psychiatric Hospitals in Accra, Ghana: A Cross-Sectional Survey
Ashong, S., Kretchy, I. A., Afrane, B. A., & Aikins, A. D. (2018) · Psychiatry Journal · doi:10.1155/2018/9850594 · Cited by 12
The prevalence, risk factors and clinical correlates of diabetes mellitus in Chinese patients with schizophrenia
Huo, L., Zhang, G., Du, X., Jia, Q., Qian, Z.-K., Chen, D., Xiu, M., Wu, F., Soares, J. C., Huang, X., et al. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2019.12.029 · Cited by 12
A comparison of the metabolic side-effects of the second-generation antipsychotic drugs risperidone and paliperidone in animal models
Boyda, H. N., Procyshyn, R. M., Tse, L., Yuen, J. W. Y., Honer, W. G., & Barr, A. M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246211 · Cited by 12
Somatic Problems and Dual Disorder Patients
Binder, M. D., Vancampfort, D., & Detraux, J. (2014) · Springer eBooks · doi:10.1007/978-3-642-45375-5_23 · Cited by 13
Transcriptomic Analysis of the Amygdala in Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder Reveals Differentially Altered Metabolic Pathways
Zhang, X., Valeri, J., Eladawi, M. A., Gisabella, B., Garrett, M. R., Vallender, E. J., McCullumsmith, R. E., Pantazopoulos, H., & O'Donovan, S. M. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae193 · Cited by 18
Adverse Cardiovascular Effects of Psychotropic Medications
Androshchuk, V., Montarello, N., & Rajani, R. (2025) · British Journal of Hospital Medicine · doi:10.12968/hmed.2024.0773 · Cited by 14
Is there an interrelationship between the effects of antipsychotics on psychopathology and on metabolism?
Chukhin, E., Terevnikov, V., Takala, P., Hakko, H. H., Putkonen, H., Räsänen, P. K., Stenberg, J., Eronen, M., & Joffe, G. (2015) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2015.1074283 · Cited by 11
Barriers, attitudes, confidence, and knowledge of nurses regarding metabolic health screening and intervention in people with mental illness: a pilot study from Uganda
Vancampfort, D., Watkins, A., Ward, P. B., Probst, M., Binder, M. D., Damme, T. V., & Mugisha, J. (2019) · African Health Sciences · doi:10.4314/ahs.v19i3.30 · Cited by 11
Lurasidone and risk for metabolic syndrome: results from short- and long-term clinical studies in patients with schizophrenia
Tocco, M., Newcomer, J. W., Mao, Y., Pikalov, A., & Loebel, A. D. (2020) · CNS Spectrums · doi:10.1017/s1092852920001698 · Cited by 11
Preclinical atherosclerosis in adolescents with psychotic or bipolar disorders investigated with carotid high‐frequency ultrasound
Bohman, H., Agartz, I., Mansouri, S., Naessén, T., & Lundberg, M. (2020) · Brain and Behavior · doi:10.1002/brb3.1862 · Cited by 11
Metabolic events associated with the use of antipsychotics in children, adolescents and young adults: a multinational sequence symmetry study
Man, K. K. C., Shao, S., Chaiyakunapruk, N., Dilokthornsakul, P., Kubota, K., Li, J., Ooba, N., Pratt, N. L., Pottegård, A., Rasmussen, L., et al. (2020) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-020-01674-6 · Cited by 12
Proinflammatory biomarkers are associated with prediabetes in patients with schizophrenia
Møller, M., Fredholm, S., Jensen, M. E., Wörtwein, G., Larsen, J. R., Vilsbøll, T., Ødum, N., & Fink‐Jensen, A. (2020) · CNS Spectrums · doi:10.1017/s1092852920002217 · Cited by 11
Polypharmacy in children and adolescents initiating antipsychotic drug in 2008–2016: a nationwide register study
Varimo, E. A., Saastamoinen, L., Rättö, H., & Aronen, E. T. (2022) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2022.2042597 · Cited by 11
Antipsychotic-Like Actions of the Satiety Peptide, Amylin, in Ventral Striatal Regions Marked by Overlapping Calcitonin Receptor and RAMP-1 Gene Expression
Baisley, S. K., Bremer, Q. Z., Bakshi, V. P., & Baldo, B. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2260-13.2014 · Cited by 11
Long-term mortality after poisoning with antipsychotics
Toft, S., Horwitz, H., & Dalhoff, K. (2017) · Clinical Toxicology · doi:10.1080/15563650.2017.1284328 · Cited by 11
Polygenic risk score for schizophrenia was not associated with glycemic level (HbA1c) in patients with non-affective psychosis: Genetic Risk and Outcome of Psychosis (GROUP) cohort study
Habtewold, T. D., Islam, M. A., Liemburg, E. J., Bartels‐Velthuis, A. A., van Beveren, N. J. M., Cahn, W., de Haan, L., Delespaul, P., Meijer, C. J., Myin‐Germeys, I., et al. (2020) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2020.109968 · Cited by 11
Functioning in schizophrenia: a Delphi study covering the perspective of physiotherapists
Nuño, L., Barrios, M., Vancampfort, D., Rojo, E., Gómez‐Benito, J., & Guilera, G. (2020) · Disability and Rehabilitation · doi:10.1080/09638288.2020.1748729 · Cited by 11
Association of antipsychotics adherence and cardiovascular disease among newly diagnosed schizophrenia patients: A national cohort among Koreans
Chang, J., Kim, J. A., Kim, K., Choi, S., Kim, S. M., Nam, Y.-Y., Park, S., Goo, A. J., & Park, S. M. (2020) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2020.102161 · Cited by 11
Grand Challenges in Cancer Endocrinology: Endocrine Related Cancers, an Expanding Concept
Belfiore, A., & Perks, C. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00141 · Cited by 11
Double jeopardy: diabetes and severe mental illness. Addressing the special needs of this vulnerable group
Blanchard, E., & Samaras, K. (2014) · Diabetes Management · doi:10.2217/dmt.14.24 · Cited by 10
Acute Metabolic Complications of Diabetes
Newland‐Jones, P., Patel, M. A., & Dhatariya, K. (2024) · doi:10.1002/9781119697473.ch41 · Cited by 11
P-glycoprotein mediates the pharmacokinetic interaction of olanzapine with fluoxetine in rats
Xu, Y., Lu, J., Yao, B., Zhang, Y., Huang, S., Liu, J., Zhang, Y., Guo, Y., & Wang, X. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115735 · Cited by 9
Risk of renal impairment in atypical antipsychotics: a systematic review and meta-analysis
Ong, L. T., Chee, N. M. Z., & Loh, A. J. C. (2024) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-024-03714-5 · Cited by 10
Susceptibility of persons with schizophrenia to extreme heat: A critical review of physiological, behavioural, and social factors
Kirby, N. V., Tetzlaff, E. J., Kidd, S. A., Brown, E. E., Bezgrebelna, M., Yoon, L., Henderson, S. B., & Kenny, G. P. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.179965 · Cited by 13
Diabetes in late-life schizophrenia: Prevalence, factors, and association with clinical symptoms
Huo, L., Lu, X., Wu, F., Huang, X., Ning, Y., & Zhang, X. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.09.026 · Cited by 10
Hospitalisation time is associated with weight gain in forensic mental health patients with schizophrenia or bipolar disorder
Pedersen, A. L. W., Gildberg, F. A., Hjorth, P., Højlund, M., & Andersen, K. (2022) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2022.2053202 · Cited by 10
Gene Polymorphisms of Hormonal Regulators of Metabolism in Patients with Schizophrenia with Metabolic Syndrome
Boiko, A. S., Pozhidaev, I. V., Paderina, D. Z., Mednova, I. A., Александровна, Г. А., Fedorenko, O. Y., Kornetova, E. G., Semke, A. V., Bokhan, N. A., LOONEN, A. J. M., et al. (2022) · Genes · doi:10.3390/genes13050844 · Cited by 10
Olanzapine/samidorphan combination consistently mitigates weight gain across various subgroups of patients
Meyer, J. M., Simmons, A., Jiang, Y., Graham, C. E., Yagoda, S., & McDonnell, D. (2022) · CNS Spectrums · doi:10.1017/s1092852922000967 · Cited by 10
Serious Adverse Drug Reactions to Antipsychotics in Minors with Multiple Disabilities: Preventability and Potential Cost Savings by Therapeutic Drug Monitoring
Fekete, S., Güntzel, T., Egberts, K. M., Geissler, J. M., Neubert, A. C., Gerlach, M., Romanos, M., & Taurines, R. (2022) · Pharmacopsychiatry · doi:10.1055/a-1963-7631 · Cited by 10
Metabolic profile in first episode drug naïve patients with psychosis and its relation to cognitive functions and social cognition: a case control study
Sayed, S. E., Gomaa, S., Alhazmi, A., ElKalla, I., & Khalil, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-31829-9 · Cited by 11
Polygenic risk scores analyses of psychiatric and metabolic traits with antipsychotic-induced weight gain in schizophrenia: an exploratory study
Yoshida, K., Marshe, V. S., Elsheikh, S. S. M., Maciukiewicz, M., Tiwari, A. K., Brandl, E. J., Lieberman, J. A., Meltzer, H. Y., Kennedy, J. L., & Müller, D. J. (2023) · The Pharmacogenomics Journal · doi:10.1038/s41397-023-00305-y · Cited by 10
Efficacy and safety of direct oral anticoagulants in older adults with atrial fibrillation: a prospective single-centre cohort study
Catalani, F., Campello, E., Occhipinti, G., Zorzi, A., Sartori, M., Zanforlini, B. M., Franchin, A., Simioni, P., & Sergi, G. (2023) · Internal and Emergency Medicine · doi:10.1007/s11739-023-03375-9 · Cited by 10
Identifying problematic drugs based on the characteristics of their targets
Lopes, T. J. S., Shoemaker, J. E., Matsuoka, Y., Kawaoka, Y., & Kitano, H. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00186 · Cited by 11
Efficacy and safety of aripiprazole once-monthly in obese and nonobese patients with schizophrenia: a post hoc analysis
Binder, M. D., Eramo, A., Landsberg, W., Kostic, D., Tsai, L.-F., & Baker, R. A. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s80479 · Cited by 10
Assessment of cardiovascular risk in an Italian psychiatric outpatient sample: A chart review of patients treated with second‐generation antipsychotics
Severi, E., Ferrara, M., Tedeschini, E., Vacca, F., Mungai, F., Amendolara, R., Baccari, F., & Starace, F. (2017) · International Journal of Mental Health Nursing · doi:10.1111/inm.12407 · Cited by 10
Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs
Xu, M., Wang, Y., Yang, F., Wu, C., Wang, Z., Ye, B., Jiang, X., Zhao, Q., Li, J., Liu, Y., et al. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.01.038 · Cited by 10
Risperidone adjunctive therapy duration in the maintenance treatment of bipolar I disorder: A post hoc analysis
Valdes, M., Bertolín, S., Qian, H., Wong, H., Lam, R. W. M., & Yatham, L. N. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.01.003 · Cited by 10
Pharmacological interventions for prevention of weight gain in people with schizophrenia
Agarwal, S. M., Ahsan, Z. A., Lockwood, J., Duncan, M. J., Takeuchi, H., Cohn, T. A., Taylor, V. H., Remington, G. J., Faulkner, G., & Hahn, M. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013337 · Cited by 11
Association between the -2548G/A polymorphism of the leptin gene and antipsychotic-induced weight gain: Analysis of the CATIE sample and meta-analysis
Yoshida, K., Maciukiewicz, M., Zai, C. C. H., Gonçalves, V. F., Brandl, E. J., Lieberman, J. A., Meltzer, H. Y., Tiwari, A. K., Kennedy, J. L., & Müller, D. J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109952 · Cited by 11
Long-Term Metabolic Monitoring of Youths Treated with Second-Generation Antipsychotics 5 Years after Publication of the CAMESA Guidelines Are We Making Progress? Surveillance Métabolique à Long Terme des Jeunes Traités par Antipsychotiques de Deuxième Génération, Cinq ans Après la publication des Lignes Directrices Camesa: Faisons-Nous des Progrès?
Jazi, S., Amor, L. B., Abadie, P., Ménard, M.-L., Choquette, R., Berthiaume, C., Mottron, L., & Ilies, D. (2020) · The Canadian Journal of Psychiatry · doi:10.1177/0706743720974847 · Cited by 9
Prevalence of severe cardiovascular disease in patients with schizophrenia
Marche, J.-C., Bannay, A., Baillot, S., Masson, V. D., Leveque, P., Schmitt, C., Laprévote, V., Schwan, R., & Dobre, D. (2021) · L Encéphale · doi:10.1016/j.encep.2021.02.008 · Cited by 10
Prediabetic increase in hemoglobin A1c compared with impaired fasting glucose in patients receiving antipsychotic drugs
Manu, P., Correll, C. U., Wampers, M., van Winkel, R., Yu, W., Mitchell, A. J., & Binder, M. D. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.05.002 · Cited by 10
Long-Term Risperidone Treatment Induces Visceral Adiposity Associated with Hepatic Steatosis in Mice: A Magnetic Resonance Approach
Auger, F., Duriez, P., Martin‐Nizard, F., Durieux, N., Bordet, R., & Pétrault, O. (2014) · Schizophrenia Research and Treatment · doi:10.1155/2014/429291 · Cited by 13
Medical Needs in the Treatment of Psychotic Disorders
Leweke, F. M., Odorfer, T., & Bumb, J. M. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25761-2_7 · Cited by 10
Psychiatric aspects of diabetes mellitus
Doherty, A. M. (2015) · BJPsych Advances · doi:10.1192/apt.bp.114.013532 · Cited by 10

Authors: De Hert, M., Detraux, J., van Winkel, R., Yu, W., & Correll, C. U.
Affiliations: KU Leuven (BE)
Zucker Hillside Hospital (US)
ORCID: Detraux, Johan
Correll, Christoph U.
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2011-10-18
Volume: 8
Issue: 2
Pages: 114-126
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/nrendo.2011.156
OpenAlex: W2014026290
Cited by: 1,145
References: 131
Citations by year: 2026: 85 · 2025: 75 · 2024: 62 · 2023: 91 · 2022: 97 · 2021: 99 · 2020: 84 · 2019: 77 · 2018: 73 · 2017: 85 · 2016: 74 · 2015: 75 · 2014: 65 · 2013: 52 · 2012: 44
FWCI: 6.96
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (submittedVersion)
Lirias (KU Leuven) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Keywords: antipsychotic drugs, type 2 diabetes, cardiovascular disease, metabolic side effects, obesity, hyperglycemia, dyslipidemia, metabolic syndrome, QT prolongation, sudden cardiac death, glucose metabolism, lipid metabolism, health care disparities, screening and monitoring
MeSH terms: Adult, Cardiovascular Diseases, Child, Diabetes Mellitus, Humans, Metabolic Diseases, Antipsychotic Agents, Weight Gain, Death, Sudden, Cardiac

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Metabolic and cardiovascular adverse effects associated with antipsychotic drugs.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks