The role of hepatokines in metabolism

Stefan, Norbert, Häring, Hans-Ulrich·2013·Nature Reviews Endocrinology

Cited by (500)

Items 101–200 of 500

  1. Proinflammatory and Antiinflammatory Attributes of Fetu Iν-A: A Novel Hepatokine Modulating Cardiovascular and Glycemic Outcomes in Metabolic Syndrome
    Satinath Mukhopadhyay, Samim Ali Mondal, Manoj Kumar, Deep Dutta · 2014 · Endocrine Practice
  2. Regulation of the novel adipokines/ hepatokines fetuin A and fetuin B in gestational diabetes mellitus
    Susan Kralisch, Annett Hoffmann, Ulrike Lössner, Jürgen Kratzsch, Matthias Blüher, Michael Stümvoll, Mathias Faßhauer, Thomas Ebert · 2016 · Metabolism
  3. Increased adipose tissue secretion of Fetuin-A, lipopolysaccharide-binding protein and high-mobility group box protein 1 in metabolic syndrome
    Ishwarlal Jialal, Sridevi Devaraj, Ahmed Bettaieb, Fawaz G. Haj, BEVERLEY A. ADAMS-HUET · 2015 · Atherosclerosis
  4. AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells
    Jinmi Lee, Seok‐Woo Hong, Se Eun Park, Eun‐Jung Rhee, Cheol‐Young Park, Ki-Won Oh, Sung‐Woo Park, Won‐Young Lee · 2015 · Molecular and Cellular Endocrinology
  5. FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs
    Kook Hwan Kim, Myung‐Shik Lee · 2015 · Journal of Endocrinology
  6. Fetuin-A levels and risk of type 2 diabetes mellitus: a systematic review and meta-analysis
    Vivian Yawei Guo, Bing Cao, Chunyan C. Cai, Kenneth K.Y. Cheng, Bernard M.Y. Cheung · 2017 · Acta Diabetologica
  7. A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes
    Shanshan Yang, Chengyu Liu, Mengmeng Jiang, Xiaoqian Liu, Lingling Geng, Yiyuan Zhang, Shuhui Sun, Kang Wang, Jian Bo Yin, Shuai Ma et al. · 2023 · Protein & Cell
  8. Hormetic and regulatory effects of lipid peroxidation mediators in pancreatic beta cells
    Giuseppe Maulucci, Bareket Daniel, Ofir Cohen, Yossef Avrahami, Shlomo Sasson · 2016 · Molecular Aspects of Medicine
  9. Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis
    Filip, Rafał, Radzki, Radosław, Bieńko, Marek · 2018 · Clinical Interventions in Aging
  10. Interaction between plasma fetuin‐A and free fatty acids predicts changes in insulin sensitivity in response to long‐term exercise
    Sindre Lee-Ødegård, Frode Norheim, Hanne Løvdal Gulseth, Torgrim Mikal Langleite, Kristoffer Jensen Kolnes, Daniel Steensen Tangen, Hans Kristian Stadheim, Gregor D. Gilfillan, Torgeir Holen, Kåre I. Birkeland et al. · 2017 · Physiological Reports
  11. The Impact of Organokines on Insulin Resistance, Inflammation, and Atherosclerosis
    Kyung Mook Choi · 2016 · Endocrinology and Metabolism
  12. Glucose Homeostasis: Regulation by Peripheral Circadian Clocks in Rodents and Humans
    Frédéric Gachon, Ursula Loizides‐Mangold, Volodymyr Petrenko, Charna Dibner · 2017 · Endocrinology
  13. Nonalcoholic fatty liver disease as a sentinel marker for the development of diabetes mellitus in non-obese subjects
    Soon Sun Kim, Hyo Jung Cho, Hyun Ji Kim, Dae Ryong Kang, Jacob R. Berry, Jin Hong Kim, M J Yang, Soo‐Jin Kim, Soojin Kim, Jae Youn Cheong et al. · 2017 · Digestive and Liver Disease
  14. Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells
    Dorothea I. Siegel-Axel, Susanne Ullrich, Norbert Stefan, Kilian Rittig, Felicia Gerst, Christian Klingler, Ulrike Schmidt, Birgit Schreiner, Elko Randrianarisoa, Hans‐Eberhard Schaller et al. · 2014 · Diabetologia
  15. A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes
    Norbert Stefan, Harald Staiger, Robert J. Wagner, Jürgen Machann, Fritz Schick, Hans‐Ulrich Häring, Andreas Fritsche · 2015 · Diabetologia
  16. An integrated multi-omics analysis reveals osteokines involved in global regulation
    Liang, Wenquan, Wei, Tiantian, Hu, Le, Chen, Meijun, Tong, Liping, Zhou, Wu, Duan, Xingwei, Zhao, Xiaoyang, Zhou, Weijie, Jiang, Qing et al. · 2024 · Cell Metabolism
  17. Hepatokines—A novel group of exercise factors
    Weigert, Cora, Hoene, Miriam, Plomgaard, Peter · 2019 · Pflügers Archiv - European Journal of Physiology
  18. LECT2 induces atherosclerotic inflammatory reaction via CD209 receptor-mediated JNK phosphorylation in human endothelial cells
    Hwang, Hwan-Jin, Jung, Tae Woo, Hong, Ho Cheol, Seo, Ji A., Kim, Sin Gon, Kim, Nan Hee, Choi, Kyung Mook, Choi, Dong Seop, Baik, Sei Hyun, Yoo, Hye Jin · 2015 · Metabolism
  19. Novel strategies for glycaemic control and preventing diabetic complications applying the clustering-based classification of adult-onset diabetes mellitus: A perspective
    Hayato Tanabe, Hiroaki Masuzaki, Michio Shimabukuro · 2021 · Diabetes Research and Clinical Practice
  20. Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure
    Sakie Katsumura, Nadeem. Siddiqui, Michael Rock Goldsmith, Jaime H. Cheah, Teppei Fujikawa, Genki Minegishi, Atsushi Yamagata, Yukako Yabuki, Kaoru Kobayashi, Mikako Shirouzu et al. · 2022 · Cell Metabolism
  21. Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice
    Marion Peyrou, Lucie Bourgoin, Anne-Laure Poher, Jordi Altirriba, Christine Maeder, Aurélie Caillon, Margot Fournier, Xavier Montet, Françoise Rohner‐Jeanrenaud, Michelangelo Foti · 2014 · Journal of Hepatology
  22. Hepatic Small Ubiquitin‐Related Modifier (SUMO)–Specific Protease 2 Controls Systemic Metabolism Through SUMOylation‐Dependent Regulation of Liver–Adipose Tissue Crosstalk
    Yang Liu, Xin Dou, Weiyu Zhou, Meng Ding, Ling Liu, Ruo‐qi Du, Liang Guo, Shuwen Qian, Yan Tang, Qi‐qi Yang et al. · 2021 · Hepatology
  23. Saturation of subcutaneous adipose tissue expansion and accumulation of ectopic fat associated with metabolic dysfunction during late and post-pubertal growth
    Lauren E. Gyllenhammer, Tanya L. Alderete, Claudia M. Toledo‐Corral, Marc J. Weigensberg, Michael I. Goran · 2015 · International Journal of Obesity
  24. Kinetics of circulating fetuin-A may predict mortality independently from adiponectin, high molecular weight adiponectin and prognostic factors in critically ill patients with sepsis: A prospective study
    Ιrene Karampela, Evangelia Kandri, Georgios Antonakos, Evangelos D. Vogiatzakis, Gerasimos Socrates Christodoulatos, Athina Nikolaidou, George Dimοpoulos, Apostolos Armaganidis, Μaria Dalamaga · 2017 · Journal of Critical Care
  25. The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis
    Mouchiroud, Mathilde, Camiré, Étienne, Aldow, Manal, Caron, Alexandre, Jubinville, Éric, Turcotte, Laurie, Kaci, Inès, Beaulieu, Marie-Josée, Roy, Christian, Labbé, Sébastien M. et al. · 2019 · JCI Insight
  26. Lipid Accumulation and Insulin Resistance: Bridging Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Kidney Disease
    Xinyi Cao, Na Wang, Min Jae Yang, Chun Zhang · 2025 · International Journal of Molecular Sciences
  27. The weight of nutrients: kynurenine metabolites in obesity and exercise
    Shamim Dadvar, Duarte M. S. Ferreira, Igor Červenka, Jorge Lira Ruas · 2018 · Journal of Internal Medicine
  28. Increased Expression of the Mitochondrial Derived Peptide, MOTS-c, in Skeletal Muscle of Healthy Aging Men Is Associated with Myofiber Composition
    D’Souza, Randall F., Woodhead, Jonathan S. T., Hedges, Christopher P., Zeng, Nina, Wan, Junxiang, Kumagai, Hiroshi, Lee, Changhan, Cohen, Pinchas, Cameron-Smith, David, Mitchell, Cameron J. et al. · 2020 · Aging
  29. Non‐alcoholic fatty liver disease and sarcopenia additively increase mortality: a Korean nationwide survey
    Joon Ho Moon, Bo Kyung Koo, Won Kyum Kim · 2021 · Journal of Cachexia Sarcopenia and Muscle
  30. Hormonal regulation of metabolism—recent lessons learned from insulin and estrogen
    Zhipeng Tao, Zhiyong Cheng · 2023 · Clinical Science
  31. Myokines: Metabolic regulation in obesity and type 2 diabetes
    Chen, Zhi-Tian, Weng, Zhi-Xuan, Lin, Jiandie D, Meng, Zhuo-Xian · 2024 · Life Metabolism
  32. Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms
    Takahashi, Hirokazu, Kotani, Kazuhiko, Tanaka, Kenichi, Egucih, Yuichiro, Anzai, Keizo · 2018 · Frontiers in Endocrinology
  33. Metabolic Signatures of Cultured Human Adipocytes from Metabolically Healthy versus Unhealthy Obese Individuals
    Anja Böhm, Anna Halama, Tobias Meile, Marty Zdichavsky, Rainer Lehmann, Cora Weigert, Andreas Fritsche, Norbert Stefan, Alfred Königsrainer, Hans-Ulrich Häring et al. · 2014 · PLoS ONE
  34. Obesity and renal disease: not all fat is created equal and not all obesity is harmful to the kidneys.
    N. Stefan, F. Artunc, N. Heyne, J. Machann, E. Schleicher, H. Häring · 2016 · Nephrology, Dialysis and Transplantation
  35. Role of exercise-induced hepatokines in metabolic disorders
    Ennequin, Gaël, Sirvent, Pascal, Whitham, Martin · 2019 · American Journal of Physiology-Endocrinology and Metabolism
  36. Digestive system in psoriasis: an update
    Daniel Pietrzak, Aldona Pietrzak, Dorota Krasowska, Andrzej Borzęcki, Kinga Franciszkiewicz-Pietrzak, Beata Polkowska-Pruszyńska, Maja Baranowska, Kristian Reich · 2017 · Archives of Dermatological Research
  37. Circulating IGFBP-2 levels are incrementally linked to correlates of the metabolic syndrome and independently associated with VLDL triglycerides
    Sophie Carter, Zhuo Li, Isabelle Lemieux, Natalie Alméras, Angelo Tremblay, Jean Bergeron, Paul Poirier, Yves Deshaies, Jean‐Pierre Després, Frédéric Picard · 2014 · Atherosclerosis
  38. Novel phenotypes of prediabetes?
    Hans‐Ulrich Häring · 2016 · Diabetologia
  39. Subcutaneous adipose tissue biology in metabolic syndrome
    Ishwarlal Jialal, Sridevi Devaraj · 2018 · Hormone Molecular Biology and Clinical Investigation
  40. Inflammatory markers in children and adolescents with type 2 diabetes mellitus
    Thomas Reinehr · 2019 · Clinica Chimica Acta
  41. Muscle Loss in Chronic Liver Diseases: The Example of Nonalcoholic Liver Disease
    Jean Pascal De Bandt, Prasanthi Jegatheesan, N. El-Hafaia · 2018 · Nutrients
  42. Hepatocellular Carcinoma and Obesity, Type 2 Diabetes Mellitus, Cardiovascular Disease: Causing Factors, Molecular Links, and Treatment Options
    Chunye Zhang, Shuai Liu, Ming Jun Yang · 2021 · Frontiers in Endocrinology
  43. Normal weight dyslipidemia: Is it all about the liver?
    David Højland Ipsen, Pernille Tveden‐Nyborg, Jens Lykkesfeldt · 2016 · Obesity
  44. Proteomic profiling of skeletal and cardiac muscle in cancer cachexia: alterations in sarcomeric and mitochondrial protein expression
    Angie M. Y. Shum, Anne Poljak, Nicholas L. Bentley, Nigel A. Turner, Timothy C. Tan, Patsie Polly · 2018 · Oncotarget
  45. Citrulline and Nonessential Amino Acids Prevent Fructose-Induced Nonalcoholic Fatty Liver Disease in Rats
    Prasanthi Jegatheesan, Stéphanie Beutheu, Gabrielle Ventura, Esther Nubret, Gilles Sarfati, Ina Bergheim, Jean Pascal De Bandt · 2015 · Journal of Nutrition
  46. Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism
    Kook Hwan Kim, Myung‐Shik Lee · 2013 · Reviews in Endocrine and Metabolic Disorders
  47. Fatty liver index as a simple predictor of incident diabetes from the KoGES-ARIRANG study
    Dhananjay Yadav, Eun Hee Choi, Song Vogue Ahn, Sang Baek Koh, Ki‐Chul Sung, Jang‐Young Kim, Ji Hye Huh · 2016 · Medicine
  48. The association between circulating fetuin-A levels and type 2 diabetes mellitus risk: systematic review and meta-analysis of observational studies
    Farzad Roshanzamir, Maryam Sadat Miraghajani, Mohammad Hossein Rouhani, Marjan Mansourian, Reza Ghiasvand, Sayyed Morteza Safavi · 2017 · Journal of Endocrinological Investigation
  49. Hepatic F-Box Protein FBXW7 Maintains Glucose Homeostasis Through Degradation of Fetuin-A
    Jiejie Zhao, Xuelian Xiong, Yao Li, Xing Liu, Tao Wang, Hong Zhang, Yang Jiao, Jingjing Jiang, Huijie Zhang, Qi‐Qun Tang et al. · 2018 · Diabetes
  50. Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism
    Tae Hyun Kim, Dong-Gyun Hong, Yoon Mee Yang · 2021 · Biomedicines
  51. Diabetische Angiopathien
    Uwe Gröber · 2021 · Zeitschrift für Orthomolekulare Medizin
  52. The Evolving Role of Fetuin-A in Nonalcoholic Fatty Liver Disease: An Overview from Liver to the Heart
    Teoman Doğru, Ali Kırık, Hasan Gürel, Ali Abbas Rizvi, Manfredi Rizzo, Alper Sönmez · 2021 · International Journal of Molecular Sciences
  53. Extracellular Vesicles-Based Cell-Free Therapy for Liver Regeneration
    Mustapha Najimi, Haider Khawaja · 2022 · Springer eBooks
  54. Rapid sandwich ELISA-based in vitro diagnostic procedure for the highly-sensitive detection of human fetuin A
    Sandeep Kumar Vashist, E. Marion Schneider, John H. T. Luong · 2014 · Biosensors and Bioelectronics
  55. No differential effect of beverages sweetened with fructose, high-fructose corn syrup, or glucose on systemic or adipose tissue inflammation in normal-weight to obese adults: a randomized controlled trial
    Jessica N. Kuzma, Gail Cromer, Derek K. Hagman, Kara L. Breymeyer, Christian Ludwig Roth, Karen E. Foster‐Schubert, Sarah Holte, David S. Weigle, Mario Kratz · 2016 · American Journal of Clinical Nutrition
  56. Secretomics to Discover Regulators in Diseases
    Parkyong Song, Yonghoon Kwon, Jae‐Yeol Joo, Do-Geun Kim, Jong Hyuk Yoon · 2019 · International Journal of Molecular Sciences
  57. Lower hand grip strength in older adults with non-alcoholic fatty liver disease: a nationwide population-based study
    Kim, Beom-Jun, Ahn, Seong Hee, Lee, Seung Hun, Hong, Seongbin, Hamrick, Mark W., Isales, Carlos M., Koh, Jung-Min · 2019 · Aging
  58. Liver-targeting drugs and their effect on blood glucose and hepatic lipids
    Amalia Gastaldelli, Norbert Stefan, Hans‐Ulrich Häring · 2021 · Diabetologia
  59. Linoleic acid exerts antidiabetic effects by inhibiting protein tyrosine phosphatases associated with insulin resistance
    Sun‐Young Yoon, Dohee Ahn, Ji Young Hwang, Min Ji Kang, Sang Jeon Chung · 2021 · Journal of Functional Foods
  60. Non-Alcoholic Fatty Liver and Metabolic Syndrome in Children: A Vicious Circle
    Arianna Alterio, Anna Alisi, Daniela Liccardo, Valério Nobili · 2014 · Hormone Research in Paediatrics
  61. Dyslipidemia: Obese or Not Obese—That Is Not the Question
    David Højland Ipsen, Pernille Tveden‐Nyborg, Jens Lykkesfeldt · 2016 · Current Obesity Reports
  62. Prediabetes Induced by Fructose-Enriched Diet Influences Cardiac Lipidome and Proteome and Leads to Deterioration of Cardiac Function prior to the Development of Excessive Oxidative Stress and Cell Damage
    Gergő Szűcs, Andrea Sója, Mária Péter, Márta Sárközy, Bella Bruszel, Andrea Siska, Imre Földesi, Zoltán Szabó, Tamás Janáky, László Vı́gh et al. · 2019 · Oxidative Medicine and Cellular Longevity
  63. Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification
    Kristin Fritsche, Andrea Ziková, Philip Marx‐Stoelting, Albert Braeuning · 2023 · International Journal of Molecular Sciences
  64. Fibroblast Growth Factor 21 and Fetuin-A in Obese Adolescents With and Without Type 2 Diabetes
    Thomas Reinehr, Beate Karges, Thomas Meißner, Susanna Wiegand, Maria Fritsch, Reinhard Walter Holl, Joachim Woelfle · 2015 · The Journal of Clinical Endocrinology & Metabolism
  65. Fetuin-B links nonalcoholic fatty liver disease to type 2 diabetes via inducing insulin resistance: Association and path analyses
    Zhibin Li, Mingzhu Lin, Changqin Liu, Dongmei Wang, Xiulin Shi, Chen Zheng, Yongwen Liu, Shuyu Yang, Xuejun Li · 2018 · Cytokine
  66. The methanolic extract of Thymus praecox subsp. skorpilii var. skorpilii restores glucose homeostasis, ameliorates insulin resistance and improves pancreatic β-cell function on streptozotocin/nicotinamide-induced type 2 diabetic rats
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  67. SeP is elevated in NAFLD and participates in NAFLD pathogenesis through AMPK/ACC pathway
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  68. Cellular senescence in liver diseases: From molecular drivers to therapeutic targeting
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  69. Comparison of the effect of ‘metabolically healthy but obese’ and ‘metabolically abnormal but not obese’ phenotypes on development of diabetes and cardiovascular disease in Chinese
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  70. Dissociation of Fatty Liver and Insulin Resistance in I148M PNPLA3 Carriers: Differences in Diacylglycerol (DAG) FA18:1 Lipid Species as a Possible Explanation
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  71. Nonalcoholic Fatty Liver Disease and Cardiovascular Diseases: The Heart of the Matter
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  72. Direct Inhibitory Effects of Pioglitazone on Hepatic Fetuin-A Expression
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  73. Serum fetuin‐A concentration predicts glycaemic outcomes in people with prediabetes: a prospective study from eastern India
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  74. Linking Cardiovascular Disease and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): The Role of Cardiometabolic Drugs in MASLD Treatment
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  76. Non-alcoholic fatty liver disease is a strong predictor of coronary artery calcification in metabolically healthy subjects: A cross-sectional, population-based study in middle-aged subjects
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  77. Identification of the Secreted Proteins Originated from Primary Human Hepatocytes and HepG2 Cells
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  78. Genome-wide association and Mendelian randomization study of fibroblast growth factor 21 reveals causal associations with hyperlipidemia and possibly NASH
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  79. Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice
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  80. Hepatic posttranscriptional network comprised of CCR4–NOT deadenylase and FGF21 maintains systemic metabolic homeostasis
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  81. Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome
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  82. Surface plasmon resonance-based immunoassay for human fetuin A
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  83. From infancy to aging: Biological and behavioral modifiers of Fetuin-A
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  84. Hepatokines as a Molecular Transducer of Exercise
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  85. Hepatocyte membrane potential regulates serum insulin and insulin sensitivity by altering hepatic GABA release
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  87. Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance
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  88. Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice
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  89. Phosphorylation status of fetuin-A is critical for inhibition of insulin action and is correlated with obesity and insulin resistance
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  91. Hepatokines and MASLD: The GLP1-Ras-FGF21-Fetuin-A Crosstalk as a Therapeutic Target
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  92. Organ Crosstalk and the Modulation of Insulin Signaling
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  93. Fatty liver index is a risk determinant of incident type 2 diabetes in a metabolically healthy population with obesity
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  94. The protective effect of human renal sinus fat on glomerular cells is reversed by the hepatokine fetuin-A
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  97. Contribution of Liver and Pancreatic Islet Crosstalk to β-Cell Function/Dysfunction in the Presence of Fatty Liver
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  98. GFT505 for the treatment of nonalcoholic steatohepatitis and type 2 diabetes
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  100. Recent advances in understanding the role of adipocytokines during non-alcoholic fatty liver disease pathogenesis and their link with hepatokines
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