The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Adipose tissue browning and metabolic health
Open accessAbstract
Accumulation of excess white adipose tissue (WAT) has deleterious consequences for metabolic health. The activation of brown adipose tissue (BAT), the primary organ for heat production, confers beneficial effects on adiposity, insulin resistance and hyperlipidaemia, at least in mice. As the amount of metabolically active BAT seems to be particularly low in patients with obesity or diabetes mellitus who require immediate therapy, new avenues are needed to increase the capacity for adaptive thermogenesis. In this light, we review the findings that BAT in human adults might consist of not only classic brown adipocytes but also inducible brown adipocytes (also called beige, brown-in-white, or brite adipocytes), which are phenotypically distinct from both white and brown adipocytes. Stimulating the development of beige adipocytes in WAT (so called 'browning') might reduce adverse effects of WAT and could help to improve metabolic health. This article focuses on the development and regulatory control of beige adipocytes at the transcriptional and hormonal levels. Emerging insights into the metabolic role of beige adipocytes are also discussed, along with the developments that can be expected from these promising targets for therapy of metabolic disease in the future.
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“induction of beige adipocytes by exercise or functional enhancement of existing BAT has shown to improve total energy expenditure and insulin sensitivity, contributing to fat and weight loss [16,17,18,19]”
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“BAT can indeed participate in the uptake and metabolism of circulating glucose and FFAs [17].”
Citations
Cites
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Adipose tissue dysfunction as determinant of obesity-associated metabolic complications
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Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome
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Metadata
- Authors
- Bartelt, A., & Heeren, J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Bartelt, Alexander
- ORCID
- Bartelt, Alexander
- Venue
- Nature Reviews Endocrinology
- Published
- 2013-10-22
- Volume
- 10
- Issue
- 1
- Pages
- 24-36
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2079482653
- Cited by
- 1,177
- References
- 161
- Citations by year
- 2026: 61 · 2025: 77 · 2024: 106 · 2023: 105 · 2022: 111 · 2021: 112 · 2020: 119 · 2019: 102 · 2018: 86 · 2017: 80 · 2016: 79 · 2015: 63 · 2014: 70
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- adipose tissue browning, beige adipocytes, brown adipose tissue, white adipose tissue, thermogenesis, obesity, insulin resistance, hyperlipidemia, diabetes mellitus, adipogenesis, transcriptional regulation, hormonal regulation, metabolic disease treatment
- MeSH terms
- Adaptation, Physiological, Animals, Adipose Tissue, Brown, Disease Models, Animal, Humans, Metabolic Diseases, Metabolism, Thermogenesis, Mice, Adipocytes, Brown, Adipocytes, White
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