Adipose tissue browning and metabolic health

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664

Identification and Importance of Brown Adipose Tissue in Adult Humans

Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864

Cold-Activated Brown Adipose Tissue in Healthy Men

van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160

Functional Brown Adipose Tissue in Healthy Adults

Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909

Mechanisms linking obesity with cardiovascular disease

Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802

Adipocyte differentiation from the inside out

Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491

PRDM16 controls a brown fat/skeletal muscle switch

Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans

Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., et al. (2009) · Diabetes · doi:10.2337/db09-0530 · Cited by 1,848

Transcriptional control of adipocyte formation

Farmer, S. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.001 · Cited by 1,836

Unexpected evidence for active brown adipose tissue in adult humans

Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824

Brown adipose tissue activity controls triglyceride clearance

Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608

Developmental Origin of Fat: Tracking Obesity to Its Source

Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

Haemmerle, G., Lass, A., Zimmermann, R., Gorkiewicz, G., Meyer, C., Rozman, J., Heldmaier, G., Maier, R., Theussl, C., Eder, S., et al. (2006) · Science · doi:10.1126/science.1123965 · Cited by 1,375

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.017 · Cited by 1,370

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

Wang, Y.-X., Lee, C.-H., Tiep, S., Yu, R. T., Ham, J., Kang, H., & Evans, R. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00269-1 · Cited by 1,296

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,273

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053942 · Cited by 1,263

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

Stanford, K. I., Middelbeek, R. J. W., Townsend, K. L., An, D., Nygaard, E. B., Hitchcox, K. M., Markan, K. R., Nakano, K., Hirshman, M. F., Tseng, Y.-H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62308 · Cited by 1,180

Transcriptional Control of Brown Fat Determination by PRDM16

Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.001 · Cited by 1,174

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

Zechner, R., Zimmermann, R., Eichmann, T. O., Kohlwein, S. D., Haemmerle, G., Lass, A., & Madeo, F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.018 · Cited by 1,169

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099

The role of exercise and PGC1α in inflammation and chronic disease

Handschin, C., & Spiegelman, B. M. (2008) · Nature · doi:10.1038/nature07206 · Cited by 1,083

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075

FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise

Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Nguyen, K. D., Qiu, Y., Cui, X., Goh, Y. P. S., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R. M., & Chawla, A. (2011) · Nature · doi:10.1038/nature10653 · Cited by 1,038

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

Settembre, C., De Cegli, R., Mansueto, G., Saha, P. K., Vetrini, F., Visvikis, O., Huynh, T., Carissimo, A., Palmer, D., Jürgen Klisch, T., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2718 · Cited by 1,022

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

Ouellet, V., Labbé, S. M., Blondin, D. P., Phoenix, S., Guérin, B., Haman, F., Turcotte, É. E., Richard, D., & Carpentier, A. C. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60433 · Cited by 985

Recruited brown adipose tissue as an antiobesity agent in humans

Yoneshiro, T., Aita, S., Matsushita, M., Kayahara, T., Kameya, T., Kawai, Y., Iwanaga, T., & Saito, M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67803 · Cited by 966

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

van der Lans, A. A. J. J., Hoeks, J., Brans, B. T., Vijgen, G. H. E. J., Visser, M. G. W., Vosselman, M. J., Hansen, J., Jörgensen, J. A., Wu, J., Mottaghy, F. M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68993 · Cited by 860

Bi-directional interconversion of brite and white adipocytes

Rosenwald, M., Perdikari, A., Rülicke, T., & Wolfrum, C. (2013) · Nature Cell Biology · doi:10.1038/ncb2740 · Cited by 833

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

Qiang, L., Wang, L., Kon, N., Zhao, W., Lee, S., Zhang, Y., ROSENBAUM, M. S., Zhao, Y., Gu, W. J., Farmer, S. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.027 · Cited by 816

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

Barbatelli, G., Murano, I., Madsen, L., Hao, Q., Jimenez, M., Kristiansen, K., Giacobino, J., Matteis, R. D., & Cinti, S. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00600.2009 · Cited by 788

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

Kim, K. H., Jeong, Y. T., Oh, H., Kim, S. H., Cho, J. M., Kim, Y.-N., Kim, S. S., Kim, D. H., Hur, K. Y., Kim, H. K., et al. (2013) · Nature Medicine · doi:10.1038/nm.3014 · Cited by 774

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.001 · Cited by 773

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

Ohno, H., Shinoda, K., Spiegelman, B. M., & Kajimura, S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.019 · Cited by 770

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

Haemmerle, G., Moustafa, T., Wölkart, G., Büttner, S., Schmidt, A. G., van de Weijer, T., Hesselink, M. K. C., Jaeger, D., Kienesberger, P. C., Zierler, K. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2439 · Cited by 767

Autophagy regulates adipose mass and differentiation in mice

Singh, R., Xiang, Y., Wang, Y., Baikati, K., Cuervo, A. M., Luu, Y. K., Tang, Y., Pessin, J. E., Schwartz, G. J., & Czaja, M. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39228 · Cited by 765

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., et al. (2012) · Science · doi:10.1126/science.1215327 · Cited by 760

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

Orava, J., Nuutila, P., Lidell, M. E., Oikonen, V., Noponen, T., Viljanen, T., Scheinin, M., Taittonen, M. T., Niemi, T. S., Enerbäck, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.012 · Cited by 745

Endocannabinoid control of food intake and energy balance

Marzo, V. D., & Matias, I. (2005) · Nature Neuroscience · doi:10.1038/nn1457 · Cited by 740

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages

Timmons, J. A., Wennmalm, K., Larsson, O., Walden, T. B., Lassmann, T., Petrovic, N., Hamilton, D. L., Gimeno, R. E., Wahlestedt, C., Baar, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610615104 · Cited by 732

Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism

Tran, T. T., Yamamoto, Y., Gesta, S., & Kahn, C. R. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.004 · Cited by 731

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., & Cinti, S. (2009) · The FASEB Journal · doi:10.1096/fj.09-133546 · Cited by 725

In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding

Lee, Y., Petkova, A. P., Mottillo, E. P., & Granneman, J. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.009 · Cited by 710

Evidence for two types of brown adipose tissue in humans

Lidell, M. E., Betz, M. J., Leinhard, O. D., Heglind, M., Elander, L., Slawik, M., Mussack, T., Nilsson, D., Romu, T., Nuutila, P., et al. (2013) · Nature Medicine · doi:10.1038/nm.3017 · Cited by 689

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

Cypess, A. M., White, A. P., Vernochet, C., Schulz, T. J., Xue, R., Sass, C. A., Huang, T. L., Roberts‐Toler, C., Weiner, L. S., Sze, C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3112 · Cited by 683

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.050 · Cited by 677

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

Sharp, L. Z., Shinoda, K., Ohno, H., Scheel, D. W., Tomoda, E., Ruiz, L., Hu, H., Wang, L. L., Pavlova, Z., Gilsanz, V., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049452 · Cited by 652

Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3155 · Cited by 635

Evidence for a role of developmental genes in the origin of obesity and body fat distribution.

Gesta, S., Blüher, M., Yamamoto, Y., Norris, A., Berndt, J., Kralisch, S., Boucher, J., Lewis, C., & Kahn, C. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0601752103 · Cited by 635

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616

p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene

Cao, W., Daniel, K. W., Robidoux, J., Puigserver, P., Medvedev, A. V., Bai, X., Floering, L. M., Spiegelman, B. M., & Collins, S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.3057-3067.2004 · Cited by 605

Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes

Himms-Hagen, J., Melnyk, A., Zingaretti, M. C., Ceresi, E., Barbatelli, G., & Cinti, S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c670 · Cited by 593

Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues

Waldén, T. B., Hansen, I. R., Timmons, J. A., Cannon, B., & Nedergaard, J. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00249.2011 · Cited by 591

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of 18F-FDG-Detected BAT in Humans

Ouellet, V., Routhier-Labadie, A., Bellemare, W., Lakhal‐Chaieb, L., Turcotte, É. E., Carpentier, A. C., & Richard, D. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0989 · Cited by 578

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

Whittle, A. J., Carobbio, S., Martins, L., Slawik, M., Hondares, E., Vázquez, M. J., Morgan, D., Csikasz, R. I., Gallego, R., Rodriguez-Cuenca, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.066 · Cited by 573

FOXC2 Is a Winged Helix Gene that Counteracts Obesity, Hypertriglyceridemia, and Diet-Induced Insulin Resistance

Cederberg, A., Grønning, L. M., Åhrén, B., Taskén, K., Carlsson, P., & Enerbäck, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00474-3 · Cited by 557

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.

Kopecky, J., Clarke, G., Enerbäck, S., Spiegelman, B., & Kozak, L. P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118363 · Cited by 553

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

Bal, N. C., Maurya, S. K., Sopariwala, D. H., Sahoo, S. K., Gupta, S. C., Shaikh, S. A., Pant, M., Rowland, L. A., Bombardier, É., Goonasekera, S. A., et al. (2012) · Nature Medicine · doi:10.1038/nm.2897 · Cited by 553

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

Jespersen, N. Z., Larsen, T. J., Peijs, L., Daugaard, S., Homøe, P., Loft, A., de Jong, J. M. A., Mathur, N., Cannon, B., Nedergaard, J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.011 · Cited by 550

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537

Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

Ahmadian, M., Abbott, M. J., Tang, T., Hudak, C. S. S., Kim, Y., Bruss, M. D., Hellerstein, M. K., Lee, H., Samuel, V. T., Shulman, G. I., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.002 · Cited by 536

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

Schulz, T. J., Huang, T. L., Tran, T. T., Zhang, H., Townsend, K. L., Shadrach, J. L., Cerletti, M., McDougall, L. E., Giorgadze, N., Tchkonia, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010929108 · Cited by 479

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

Vegiopoulos, A., Müller‐Decker, K., Strzoda, D., Schmitt, I. M., Chichelnitskiy, E., Ostertag, A., Díaz, M. B., Rozman, J., de Angelis, M. H., Nüsing, R. M., et al. (2010) · Science · doi:10.1126/science.1186034 · Cited by 463

SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues

Picard, F., Géhin, M., Annicotte, J., Rocchi, S., Champy, M., O’Malley, B. W., Chambon, P., & Auwerx, J. H. (2002) · Cell · doi:10.1016/s0092-8674(02)01169-8 · Cited by 444

Transcriptional Control of Brown Fat Development

Kajimura, S., Seale, P., & Spiegelman, B. M. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.005 · Cited by 430

Brown Adipose Tissue, Whole‐Body Energy Expenditure, and Thermogenesis in Healthy Adult Men

Yoneshiro, T., Aita, S., Matsushita, M., Kameya, T., Nakada, K., Kawai, Y., & Saito, M. (2010) · Obesity · doi:10.1038/oby.2010.105 · Cited by 428

Impact of Age on the Relationships of Brown Adipose Tissue With Sex and Adiposity in Humans

Pfannenberg, C., Werner, M. K., Ripkens, S., Stef, I., Deckert, A., Schmadl, M., Reimold, M., Häring, H., Claussen, C. D., & Stefan, N. (2010) · Diabetes · doi:10.2337/db10-0004 · Cited by 428

Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells

Gupta, R. K., Mepani, R. J., Kleiner, S., Lo, J. C., Khandekar, M. J., Cohen, P., Frontini, A., Bhowmick, D. C., Ye, L., Cinti, S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.010 · Cited by 426

Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

Tang, Q.-Q., Otto, T. C., & Lane, M. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403100101 · Cited by 415

The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells

Tran, K., Gealekman, O., Frontini, A., Zingaretti, M. C., Morroni, M., Giordano, A., Smorlesi, A., Perugini, J., Matteis, R. D., Sbarbati, A., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.008 · Cited by 396

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1

Tsukiyama–Kohara, K., Poulin, F., Kohara, M., DeMaria, C. T., Cheng, A., Wu, Z., Gingras, A., Katsume, A., Elchebly, M., Spiegelman, B. M., et al. (2001) · Nature Medicine · doi:10.1038/nm1001-1128 · Cited by 392

White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis

Cao, L., Choi, E., Liu, X., Martin, A. S., Wang, C., Xu, X., & During, M. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.020 · Cited by 390

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

Schulz, T. J., Huang, P. C., Huang, T. L., Xue, R., McDougall, L. E., Townsend, K. L., Cypess, A. M., Mishina, Y. M., Gussoni, E., & Tseng, Y. (2013) · Nature · doi:10.1038/nature11943 · Cited by 389

FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets

Nishino, N., Tamori, Y., Tateya, S., Kawaguchi, T., Shibakusa, T., Mizunoya, W., Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34090 · Cited by 388

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

Hondares, E., Rosell, M., Gonzalez, F. J., Giralt, M., Iglesias, R., & Villarroya, F. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.001 · Cited by 377

The adipose organ at a glance

Cinti, S. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009662 · Cited by 370

Nuclear receptor corepressor RIP140 regulates fat accumulation

Leonardsson, G., Steel, J. H., Christian, M., Pocock, V., Milligan, S., Bell, J., So, P.-W., Medina-Gomez, G., Vidal-Puig, A., White, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401013101 · Cited by 366

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

Singh, A. K., Riederer, B., Krabbenhöft, A., Rausch, B., Bonhagen, J., Lehmann, U., de Jonge, H. R., Donowitz, M., Yun, C. C., Weinman, E. J., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35541 · Cited by 364

C/EBPα is required for differentiation of white, but not brown, adipose tissue

Linhart, H., Ishimura‐Oka, K., DeMayo, F. J., Kibe, T., Repka, D., Poindexter, B. J., Bick, R. J., & Darlington, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211416898 · Cited by 349

Evidence against a Beneficial Effect of Irisin in Humans

Raschke, S., Elsen, M., Gassenhuber, J., Sommerfeld, M. R., Schwahn, U., Brockmann, B., Jung, R., Wisløff, U., Tjønna, A. E., Raastad, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073680 · Cited by 327

BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis

Qian, S., Tang, Y., Li, X., Liu, Y., Zhang, Y.-Y., Huang, H.-Y., Xue, R.-D., Yu, H.-Y., Guo, L., Gao, H.-D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215236110 · Cited by 320

Mir193b–365 is essential for brown fat differentiation

Sun, L., Xie, H., Mori, M. A., Alexander, R., Yuan, B., Hattangadi, S. M., Liu, Q., Kahn, C. R., & Lodish, H. F. (2011) · Nature Cell Biology · doi:10.1038/ncb2286 · Cited by 313

Rb regulates fate choice and lineage commitment in vivo

Calo, E., Quintero-Estades, J. A., Danielian, P. S., Nedelcu, S., Berman, S. D., & Lees, J. A. (2010) · Nature · doi:10.1038/nature09264 · Cited by 312

Peroxisome Proliferator-activated Receptor α (PPARα) Induces PPARγ Coactivator 1α (PGC-1α) Gene Expression and Contributes to Thermogenic Activation of Brown Fat

Hondares, E., Rosell, M., Díaz-Delfín, J., Olmos, Y., Monsalve, M., Iglesias, R., Villarroya, F., & Giralt, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.252775 · Cited by 302

Myostatin Knockout Drives Browning of White Adipose Tissue through Activating the AMPK-PGC1α-Fndc5 Pathway in Muscle

Shan, T., Liang, X., Bi, P., & Kuang, S. (2013) · The FASEB Journal · doi:10.1096/fj.12-225755 · Cited by 301

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation

Hansen, J. B., Jørgensen, C., Petersen, R. K., Hallenborg, P., De Matteis, R., Bøye, H. A., Petrovic, N., Enerbäck, S., Nedergaard, J., Cinti, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0301964101 · Cited by 287

Pharmacological and nutritional agents promoting browning of white adipose tissue

Bonet, M. L., Oliver, P., & Palou, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.12.002 · Cited by 286

miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit

Chen, Y., Siegel, F., Kipschull, S., Haas, B., Fröhlich, H., Meister, G., & Pfeifer, A. (2013) · Nature Communications · doi:10.1038/ncomms2742 · Cited by 282

UCP1 mRNA does not produce heat

Nedergaard, J., & Cannon, B. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.009 · Cited by 272

Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans

Orava, J., Nuutila, P., Noponen, T., Parkkola, R. K., Viljanen, T., Enerbäck, S., Rissanen, A., Pietiläinen, K. H., & Virtanen, K. A. (2013) · Obesity · doi:10.1002/oby.20456 · Cited by 271

Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice

Toh, S. Y., Gong, J., Du, G., Li, J. Z., Yang, S., Ye, J., Yao, H., Zhang, Y., Xue, B., Li, Q., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002890 · Cited by 267

MyomiR-133 regulates brown fat differentiation through Prdm16

Trajkovski, M., Ahmed, K., Esau, C., & Stoffel, M. (2012) · Nature Cell Biology · doi:10.1038/ncb2612 · Cited by 263

Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-Induced Obesity

Lodhi, I. J., Yin, L., Jensen-Urstad, A. P. L., Funai, K., Coleman, T., Baird, J. H., Ramahi, M. K. E., Razani, B., Song, H., Hsu, F., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.013 · Cited by 253

Fat cells directly sense temperature to activate thermogenesis

Li, Y., Wu, J., Cohen, P., Kazak, L., Khandekar, M. J., Jedrychowski, M. P., Zeng, X., Gygi, S. P., & Spiegelman, B. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310261110 · Cited by 250

Remodeling of White Adipose Tissue after Retinoic Acid Administration in Mice

Mercader, J., Ribot, J., Murano, I., Felipe, F., Cinti, S., Bonet, M. L., & Palou, A. (2006) · Endocrinology · doi:10.1210/en.2006-0760 · Cited by 244

Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells

Mori, M., Nakagami, H., Rodriguez-Araujo, G., Nimura, K., & Kaneda, Y. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001314 · Cited by 243

Brown adipose tissue transplantation improves whole-body energy metabolism

Liu, X., Zheng, Z., Zhu, X., Meng, M., Li, L., Shen, Y., Chi, Q., Wang, D., Zhang, Z., Li, C., et al. (2013) · Cell Research · doi:10.1038/cr.2013.64 · Cited by 242

Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue

Galmozzi, A., Mitro, N., Ferrari, A., Gers, E., Gilardi, F., Godio, C., Cermenati, G., Gualerzi, A., Donetti, E., Rotili, D., et al. (2012) · Diabetes · doi:10.2337/db12-0548 · Cited by 242

Chapter 21 Interleukin‐6 and Insulin Resistance

Kim, J., Bachmann, R. A., & Chen, J. (2009) · Vitamins & Hormones · doi:10.1016/s0083-6729(08)00621-3 · Cited by 224

Twist-1 Is a PPARδ-Inducible, Negative-Feedback Regulator of PGC-1α in Brown Fat Metabolism

Pan, D., Fujimoto, M., Lopes, A., & Wang, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.051 · Cited by 224

Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

Kiefer, F. W., Vernochet, C., O’Brien, P., Spoerl, S., Brown, J. D., Nallamshetty, S., Zeyda, M., Stulnig, T. M., Cohen, D. E., Kahn, C. R., et al. (2012) · Nature Medicine · doi:10.1038/nm.2757 · Cited by 210

Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue

Xu, X., Ying, Z., Cai, M., Xu, Z., Li, Y., Jiang, S. Y., Tzan, K., Wang, A., Parthasarathy, S., He, G., et al. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00806.2010 · Cited by 206

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

Mottillo, E. P., Bloch, A. E., Leff, T., & Granneman, J. G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374041 · Cited by 205

UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity

Madsen, L., Pedersen, L. M., Lillefosse, H. H., Fjære, E., Brønstad, I., Hao, Q., Petersen, R. K., Hallenborg, P., Ma, T., Matteis, R. D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011391 · Cited by 204

Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α

Scimè, A., Grenier, G., Huh, M. S., Gillespie, M. A., Bevilacqua, L., Harper, M.-E., & Rudnicki, M. A. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.002 · Cited by 199

Central Control of Brown Adipose Tissue Thermogenesis

Morrison, S. F., Madden, C. J., & Tupone, D. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00005 · Cited by 199

Expression of the Irisin Precursor FNDC5 in Skeletal Muscle Correlates With Aerobic Exercise Performance in Patients With Heart Failure

Lecker, S. H., Zavin, A., Cao, P., Arena, R. A., Allsup, K., Daniels, K. M., Joseph, J., Schulze, P. C., & Forman, D. E. (2012) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.969543 · Cited by 199

A Novel Regulatory Pathway of Brown Fat Thermogenesis

Alvarez, R., de Andrés, J., Yubero, P., Viñas, O., Mampel, T., Iglesias, R., Giralt, M., & Villarroya, F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5666 · Cited by 194

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

Zhang, C., McFarlane, C., Lokireddy, S., Masuda, S., Ge, X., Gluckman, P. D., Sharma, M., & Kambadur, R. (2012) · Diabetologia · doi:10.1007/s00125-011-2304-4 · Cited by 192

Thiazolidinediones and Rexinoids Induce Peroxisome Proliferator-Activated Receptor-Coactivator (PGC)-1α Gene Transcription: An Autoregulatory Loop Controls PGC-1α Expression in Adipocytes via Peroxisome Proliferator-Activated Receptor-γ Coactivation

Hondares, E., Mora, O., Yubero, P., de la Concepción, M. L. R., Iglesias, R., Giralt, M., & Villarroya, F. (2006) · Endocrinology · doi:10.1210/en.2006-0070 · Cited by 189

Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals

Bruns†, O. T., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Lauterwasser, J., Nikolić, M. S., Mollwitz†, B., Merkel, M., Bigall, N. C., et al. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2008.405 · Cited by 165

Cardiovascular responses to cold exposure

Sun, Z. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e108 · Cited by 161

A Role for Bone Morphogenetic Protein-4 in Adipocyte Development

Bowers, R. R., & Lane, M. D. (2007) · Cell Cycle · doi:10.4161/cc.6.4.3804 · Cited by 153

Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs

Villanueva, C. J., Vergnes, L., Wang, J., Drew, B. G., Hong, C., Tu, Y., Hu, Y., Xu, P., Xu, F., Sáez, E., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.016 · Cited by 152

Increased cGMP promotes healthy expansion and browning of white adipose tissue

Mitschke, M. M., Hoffmann, L. S., Gnad, T., Scholz, D., Katja, K., Mayer, P., Haas, B., Sassmann, A., Pfeifer, A., & Kilić, A. (2013) · The FASEB Journal · doi:10.1096/fj.12-221580 · Cited by 148

Synaptic plasticity in neuronal circuits regulating energy balance

Zeltser, L. M., Seeley, R. J., & Tschöp, M. H. (2012) · Nature Neuroscience · doi:10.1038/nn.3219 · Cited by 147

miR-133a Regulates Adipocyte Browning In Vivo

Liu, W., Bi, P., Shan, T., Yang, X., Yin, H., Wang, Y.-X., Liu, N., Rudnicki, M. A., & Kuang, S. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003626 · Cited by 147

Identification of brown adipose tissue in mice with fat–water IDEAL‐MRI

Hu, P., Smith, D. L., Nayak, K. S., Goran, M. I., & Nagy, T. R. (2010) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22162 · Cited by 144

Tumor necrosis factor α mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity

Nisoli, E., Briscini, L., Giordano, A., Tonello, C., Wiesbrock, S. M., Uysal, K. T., Cinti, S., Carruba, M. O., & Hotamışlıgil, G. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.8033 · Cited by 135

p62 Links β-adrenergic input to mitochondrial function and thermogenesis

Müller, T. D., Lee, S. J., Jastroch, M., Kabra, D. G., Stemmer, K., Aichler, M., Abplanalp, B., Ananthakrishnan, G., Bhardwaj, N. J., Collins, S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64209 · Cited by 127

Adenosine 5′-Monophosphate-Activated Protein Kinase-Mammalian Target of Rapamycin Cross Talk Regulates Brown Adipocyte Differentiation

Vila‐Bedmar, R., Lorenzo, M., & Fernández‐Veledo, S. (2010) · Endocrinology · doi:10.1210/en.2009-0810 · Cited by 108

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity

Staiger, H., Böhm, A., Scheler, M., Berti, L., Machann, J., Schick, F., Machicao, F. E., Fritsche, A., Stefan, N., Weigert, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061903 · Cited by 107

Nutrient preference and diet-induced adiposity in C57BL/6ByJ and 129P3/J mice

Bachmanov, A. A., Reed, D. R., Tordoff, M. G., Price, R. A., & Beauchamp, G. K. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00412-7 · Cited by 107

Dual-Energy CT of the Heart

Vliegenthart, R., Pelgrim, G. J., Ebersberger, U., Rowe, G. W., Oudkerk, M., & Schoepf, U. J. (2012) · American Journal of Roentgenology · doi:10.2214/ajr.12.9208 · Cited by 104

Vascular endothelial growth factor is important for brown adipose tissue development and maintenance

Bagchi, M., Kim, L. A., Boucher, J., Walshe, T. E., Kahn, C. R., & D'Amore, P. A. (2013) · The FASEB Journal · doi:10.1096/fj.12-221812 · Cited by 101

Measurement of Human Brown Adipose Tissue Volume and Activity Using Anatomic MR Imaging and Functional MR Imaging

Chen, Y. I., Cypess, A. M., Chen, Y. I., Palmer, M. R., Kolodny, G. M., Kahn, C. R., & Kwong, K. K. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.117275 · Cited by 99

Brain–gut–adipose-tissue communication pathways at a glance

Yi, C., & Tschöp, M. H. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009902 · Cited by 98

Perilipin Overexpression in White Adipose Tissue Induces a Brown Fat-Like Phenotype

Sawada, T., Miyoshi, H., Shimada, K., Suzuki, A. K., Okamatsu‐Ogura, Y., Perfield, J. W., Kondo, T., Nagai, S., Shimizu, C., Yoshioka, N., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014006 · Cited by 88

Anatomical and Functional Assessment of Brown Adipose Tissue by Magnetic Resonance Imaging

Chen, Y. I., Cypess, A. M., Sass, C. A., Brownell, A., Jokivarsi, K. T., Kahn, C. R., & Kwong, K. K. (2012) · Obesity · doi:10.1038/oby.2012.22 · Cited by 87

Brown fat like gene expression in the epicardial fat depot correlates with circulating HDL-cholesterol and triglycerides in patients with coronary artery disease

Chechi, K., Blanchard, P.-G., Mathieu, P., Deshaies, Y., & Richard, D. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.06.008 · Cited by 76

How brown is brown fat? It depends where you look

Nedergaard, J., & Cannon, B. (2013) · Nature Medicine · doi:10.1038/nm.3187 · Cited by 74

Functional assessment of white and brown adipocyte development and energy metabolism in cell culture Dissociation of terminal differentiation and thermogenesis in brown adipocytes

Klaus, S., Ely, M., Encke, D., & Heldmaier, G. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.10.3171 · Cited by 74

Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity

Gaidhu, M. P., Frontini, A., Hung, S., Pistor, K., Cinti, S., & Ceddia, R. B. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m015354 · Cited by 70

The holy grail of metabolic disease

Bartelt, A., & Heeren, J. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328352dcef · Cited by 69

Effects of adipocyte lipoprotein lipase on de novo lipogenesis and white adipose tissue browning

Bartelt, A., Weigelt, C., Cherradi, M. L., Niemeier, A., Tödter, K., Heeren, J., & Scheja, L. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.11.011 · Cited by 59

Shox2 is a molecular determinant of depot-specific adipocyte function

Lee, K. Y., Yamamoto, Y., Boucher, J., Winnay, J. N., Gesta, S., Cobb, J. A., Blüher, M., & Kahn, C. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310331110 · Cited by 48

A new, powerful player in lipoprotein metabolism: brown adipose tissue

Bartelt, A., Merkel, M., & Heeren, J. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0858-3 · Cited by 45

Novel Aspects of Brown Adipose Tissue Biology

Heeren, J., & Münzberg, H. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.11.004 · Cited by 43

Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli

Miranda, S., González‐Rodríguez, Á., Revuelta‐Cervantes, J., Rondinone, C. M., & Valverde, Á. M. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.11.019 · Cited by 41

Insulin increases the adrenergic stimulation of 5′ deiodinase activity and mRNA expression in rat brown adipocytes; role of MAPK and PI3K

de Mena, R. M., & Obregón, M.-J. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01568 · Cited by 38

Brown Fat Develops a Brite Future

Klingenspor, M., Herzig, S., & Pfeifer, A. (2012) · Obesity Facts · doi:10.1159/000346337 · Cited by 27

Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle

Russell, A. P., Crisan, M., Léger, B., Corselli, M., McAinch, A. J., O’Brien, P. E., Cameron‐Smith, D., Péault, B., Casteilla, L., & Giacobino, J.-P. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.85 · Cited by 18

Nanocrystals, a New Tool to Study Lipoprotein Metabolism and Atherosclerosis

Heeren, J., & Bruns†, O. T. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112799095293 · Cited by 10

Aggregation-Induced Emission: Together We Shine, United We Soar!

Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270

Adipose tissue dysfunction as determinant of obesity-associated metabolic complications

Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G. A., Beguinot, F., & Miele, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092358 · Cited by 1,575

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

Choe, S. S., Huh, J. Y., Hwang, I. J., Kim, J. I., & Kim, J. B. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00030 · Cited by 1,206

Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Qi, X., Yun, C., Sun, L., Xia, J., Wu, Q., Wang, Y., Wang, L., Zhang, Y., Liang, X., Wang, L., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0509-0 · Cited by 881

Brown adipose tissue as a secretory organ

Villarroya, F., Cereijo, R., Villarroya, J., & Giralt, M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.136 · Cited by 697

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