Health benefits of exercise — more than meets the eye!
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Skeletal muscle operates as an endocrine organ, producing and releasing myokines that exert autocrine, paracrine, and hormonal influences on various tissues.
“Skeletal muscle operates as an endocrine organ, producing and releasing myokines that exert autocrine, paracrine, and hormonal influences on various tissues [97], including IGF-1 [90], IL-6 [91], irisin [98], β-aminoisobutyric acid (BAIBA) [99], myostatin [100], fibroblast growth factor 21 (FGF21) [101], meteorin-like factor (metrnl) [102], brain-derived neurotrophic factor (BDNF) [103], and apel”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [97]
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- Authors
- Febbraio, M. A.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Corresponding author
- Febbraio, Mark A.
- ORCID
- Febbraio, Mark A.
- Venue
- Nature Reviews Endocrinology
- Published
- 2017-01-04
- Volume
- 13
- Issue
- 2
- Pages
- 72-74
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2567812618
- Cited by
- 106
- References
- 10
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 7 · 2023: 9 · 2022: 20 · 2021: 15 · 2020: 13 · 2019: 15 · 2018: 9 · 2017: 3
- FWCI
- 9.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- physical activity, exercise medicine, tissue crosstalk, metabolic disorders, cancer, retinal degeneration, memory loss, age-related diseases
- MeSH terms
- Cardiorespiratory Fitness, Animals, Breast Neoplasms, Cardiovascular Diseases, Cathepsin B, Colonic Neoplasms, Diabetes Mellitus, Type 2, Exercise Therapy, Female, Humans, Erectile Dysfunction, Killer Cells, Natural, Male, Memory Disorders, Metabolic Diseases, Neoplasms, Osteoarthritis, Osteoporosis, Oxygen Consumption, Physical Conditioning, Animal, Polycystic Ovary Syndrome, Retinal Degeneration, Exercise, Osteocalcin, Interleukin-6, Brain-Derived Neurotrophic Factor, Mice
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