ANGPTL4 — the link binding obesity and glucose intolerance

Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota

Janssen, A. W. F., Katiraei, S., Bartosinska, B., Eberhard, D., Willems van Dijk, K., & Kersten, S. (2018) · Diabetologia · doi:10.1007/s00125-018-4583-5 · Cited by 96 · see citing works

Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases

Leal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382 · see citing works

Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?

Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83 · see citing works

Fecal microbiota transplantation in obesity metabolism: A meta analysis and systematic review

Zecheng, L., Donghai, L., Runchuan, G., Yuan, Q., Qi, J., Yijia, Z., Shuaman, R., Xiaoqi, L., Yi, W., Ni, M., et al. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110803 · Cited by 69 · see citing works

The Pathogenic Role of Long Non-coding RNA H19 in Atherosclerosis via the miR-146a-5p/ANGPTL4 Pathway

Huang, S.-F., Zhao, G., Peng, X., & Ye, W.-C. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.770163 · Cited by 48 · see citing works

Gut microbiota and short chain fatty acids partially mediate the beneficial effects of inulin on metabolic disorders in obese ob/ob mice

Guo, J., Zhang, M., Wang, H., Li, N., Lu, Z., Li, L., Hui, S., & Xu, H. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14063 · Cited by 44 · see citing works

Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease

Srivastava, S. P., Zhou, H., Shenoi, R., Morris, M., Lainez, B., Goedeke, L., Rajendran, B. K., Setia, O., Aryal, B. K., Kanasaki, K., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn6068 · Cited by 40 · see citing works

ANGPTL4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a

Jung, K. H., Son, M. K., YAN, H. H., Fang, Z., Kim, J.-Y., Kim, S. J., Park, J. H., Lee, J. E., Yoon, Y., Seo, M.-S., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201911222 · Cited by 33 · see citing works

The regulation of glucose and lipid metabolism through the interaction of dietary polyphenols and polysaccharides via the gut microbiota pathway

Jia, Y., Liu, Y., Wu, Y., Feng, C., Zhang, H., Ren, F., & Liu, H. (2024) · Food & Function · doi:10.1039/d4fo00585f · Cited by 27 · see citing works

ANGPTL4 attenuates palmitic acid-induced endothelial cell injury by increasing autophagy

Zhan, W., Tian, W., Zhang, W., Tian, H., & Sun, T. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110410 · Cited by 22 · see citing works

Adropin and glucagon-like peptide-2 are associated with glucose metabolism in obese children

Chen, R., Yuan, X., Ouyang, Q., Lin, X., Ai, Z., Zhang, Y., & Yang, X. (2019) · World Journal of Pediatrics · doi:10.1007/s12519-019-00296-6 · Cited by 17 · see citing works

ANGPTL4-mediated microglial lipid droplet accumulation: Bridging Alzheimer's disease and obesity

Li, N., Wang, X., Lin, R., Yang, F., Chang, H.-C., Gu, X., Shu, J., Liu, G., Yu, Y., Wei, W., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106741 · Cited by 15 · see citing works

Proteomic Profiling of Donkey Milk Exosomes Highlights Bioactive Proteins with Immune-Related Functions

Liu, Y., Ma, Q., Khan, M. Z., Wang, M., Xiang, F., Zhang, X., Kou, X., Li, S., Wang, C., & Li, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072892 · Cited by 12 · see citing works

Oleic and palmitic acids induce hepatic angiopoietin-like 4 expression predominantly via PPAR- γ in Larimichthys crocea

Xiang, X., Han, S., Xu, D., Chen, Q., Ji, R., Zhao, Z., Du, J., Mai, K., & Ai, Q. (2021) · British Journal Of Nutrition · doi:10.1017/s000711452100386x · Cited by 9 · see citing works

Angiopoietin‐like protein 4 induces growth hormone variant secretion and aggravates insulin resistance during pregnancy, linking obesity to gestational diabetes mellitus

Kuo, C., Wang, S., Juan, H.-C., Chen, S., Kuo, C., Kuo, H., Lin, S., & Li, H. (2024) · BioFactors · doi:10.1002/biof.2076 · Cited by 8 · see citing works

Cross-talk between ANGPTL4 gene SNP Rs1044250 and weight management is a risk factor of metabolic syndrome

Tong, Z., Peng, J., Lan, H., Sai, W.-W., Li, Y., Xie, J., Tan, Y., Zhang, W., Zhong, M., & Wang, Z. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02739-z · Cited by 6 · see citing works

COL6A3-derived endotrophin mediates the effect of obesity on coronary artery disease: an integrative proteogenomics analysisPreprint

Yoshiji, S., Lu, T., Butler‐Laporte, G., Carrasco-Zanini, J., Chen, Y., Liang, K. Y. H., Willett, J., Su, C., Wang, S., Adra, D., et al. (2023) · medRxiv · doi:10.1101/2023.04.19.23288706 · Cited by 5 · see citing works

Flow Velocity Modulates Growth, Oxidative Stress, and Transcriptomic Responses in Spotted Sea Bass (Lateolabrax maculatus)

Li, S., Liu, Y., Wang, Q., Zhu, Z., Li, W., Li, C., Fei, F., Liu, B., & Shao, C. (2025) · Marine Biotechnology · doi:10.1007/s10126-025-10423-2 · Cited by 4 · see citing works

Insights from the high-altitude animal gut adaptation model: mechanisms of obesity regulation via microbiota-derived metabolite homeostasis and the gut-X axis

Cao, L., & Zhu, W. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1795452 · Cited by 3 · see citing works

Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney diseasePreprint

Srivastava, S. P., Zhou, H., Shenoi, R., Morris, M., Lainez, B., Takagaki, Y., Rajendran, B. K., Setia, O., Aryal, B. K., Kanasaki, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.08.652142 · Cited by 2 · see citing works

Early-life proteomic and microbiome features signal obesity risk across 26 years of follow-up

Ahrens, A. P., Dias, R., Hyötyläinen, T., White, P. A., Orešič, M., Triplett, E. W., & Ludvigsson, J. (2026) · mSystems · doi:10.1128/msystems.01424-25

Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota

Janssen, A. W. F., Katiraei, S., Bartosinska, B., Eberhard, D., Willems van Dijk, K., & Kersten, S. (2018) · Diabetologia · doi:10.1007/s00125-018-4583-5 · Cited by 96 · see citing works

Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism

Kersten, S. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100150 · Cited by 146 · see citing works

Angiopoietin-Like Protein 4 Overexpression in Visceral Adipose Tissue from Obese Subjects with Impaired Glucose Metabolism and Relationship with Lipoprotein Lipase

Barchetta, I., Chiappetta, C., Ceccarelli, V., Cimini, F. A., Bertoccini, L., Gaggini, M., Cristofano, C. D., Silecchia, G., Lenzi, A., Leonetti, F., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197197 · Cited by 34 · see citing works

ANGPTL4: a multifunctional protein involved in metabolism and vascular homeostasis

Fernandez-Hernando, C. F., & Suárez, Y. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000580 · Cited by 162 · see citing works

Study on the Effect of Angiopoietin-like Protein 4 on Glucose and Lipid Metabolism

Wang, Y. (2014) · Medical Recapitulate