Cited by 83Nutrition and Health in AgingMuscle Physiology and DisordersAdipokines, Inflammation, and Metabolic Diseases

Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?

Guo, Ai, Li, Kai, Xiao, Qian·2020·Experimental Gerontology

Abstract

Sarcopenic obesity (SO) is a condition characterized by the occurrence of both sarcopenia and obesity and imposes a heavy burden on the health of the elderly. Controversies and challenges regarding the definition, diagnosis and treatment of SO still remain because of its complex pathogenesis and limitations. Over the past few decades, numerous studies have revealed that myokines secreted from skeletal muscle play significant roles in the regulation of muscle mass and function as well as metabolic homeostasis. Abnormalities in myokines may trigger and promote the pathogenesis underlying age-related and metabolic diseases, including obesity, sarcopenia, type 2 diabetes (T2D), and SO. This review mainly focuses on the role of myokines as potential biomarkers for the early diagnosis and therapeutic targets in SO.

Integrity signals

Registry

Crossref · 10.1016/j.exger.2020.111022

Cites

282 of 282 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Numerous families of secreted signaling molecules bearing the suffix "-kines," such as myokines, osteokines, adipokines, and hepatokines, have been identified in more recent times.

    “Hormones were identified and subsequently leveraged for use as therapeutics throughout the 20th century but it is only in more recent times that numerous families of secreted signaling molecules bearing the suffix “‐kines” such as myokines, 243 osteokines, adipokines, 244 and hepatokines 245 have been identified. 242”

Cites

1 retracted

Flagged first, then by citations

4 of the 286 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Guo, A., Li, K., & Xiao, Q.
Affiliations
The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
Corresponding author
Xiao, Qian
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2020-10
Volume
139
Pages
111022
ISSN
0531-5565 (ISSN-L)
OpenAlex
W3043914821
Cited by
83
References
286
Citations by year
2026: 7 · 2025: 18 · 2024: 9 · 2023: 20 · 2022: 16 · 2021: 12 · 2020: 1
FWCI
1.57
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Chongqing Medical University
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
sarcopenic obesity, myokines, skeletal muscle, biomarkers, therapeutic target, sarcopenia, obesity, type 2 diabetes, aging, metabolic homeostasis, muscle mass and function
MeSH terms
Aged, Diabetes Mellitus, Type 2, Humans, Obesity, Biomarkers, Muscle, Skeletal, Sarcopenia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review