Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931 · see citing works

Atherosclerosis

Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880 · see citing works

Atherosclerosis

Glass, C. K., & Witztum, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00238-0 · Cited by 3,049 · see citing works

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works

Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications

Fabbrini, E., Sullivan, S., & Klein, S. (2010) · Hepatology · doi:10.1002/hep.23280 · Cited by 2,100 · see citing works

Human Fatty Liver Disease: Old Questions and New Insights

Cohen, J. C., Horton, J. D., & Hobbs, H. H. (2011) · Science · doi:10.1126/science.1204265 · Cited by 2,089 · see citing works

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, É., Shyy, J. Y.-J., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.009 · Cited by 1,783 · see citing works

Molecular mediators of hepatic steatosis and liver injury

Browning, J. D., & Horton, J. D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422422 · Cited by 1,772 · see citing works

Regulation of hepatic glucose metabolism in health and disease

Petersen, M. C., Vatner, D. F., & Shulman, G. I. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.80 · Cited by 1,155 · see citing works

Dyslipidemia in type 2 diabetes mellitus

Mooradian, A. D. (2009) · Nature Reviews Endocrinology · doi:10.1038/ncpendmet1066 · Cited by 1,053 · see citing works

Cytokines and the hepatic acute phase response

Moshage, H. (1997) · Journal of Pathology · doi:10.1002/(sici)1096-9896(199703)181:3 · Cited by 1,035 · see citing works

The interaction of hepatic lipid and glucose metabolism in liver diseases

Bechmann, L. P., Hannivoort, R. A., Gerken, G., Hotamışlıgil, G. S., Trauner, M., & Canbay, A. E. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.08.025 · Cited by 1,033 · see citing works

Role of Obesity and Lipotoxicity in the Development of Nonalcoholic Steatohepatitis: Pathophysiology and Clinical Implications

Cusi, K. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.003 · Cited by 917 · see citing works

Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes · doi:10.2337/diabetes.54.3.603 · Cited by 911 · see citing works

Common variants associated with plasma triglycerides and risk for coronary artery disease

Do, R., Willer, C. J., Schmidt, E. M., Sengupta, S., Gao, C., Peloso, G. M., Gustafsson, S., Kanoni, S., Ganna, A., Chen, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2795 · Cited by 862 · see citing works

AMP-activated protein kinase: the current landscape for drug development

Steinberg, G. R., & Carling, D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0019-2 · Cited by 774 · see citing works

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease

Softic, S., Cohen, D. E., & Kahn, C. R. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4054-0 · Cited by 709 · see citing works

Endoplasmic reticulum stress, obesity and diabetes

Cnop, M., Foufelle, F., & Velloso, L. A. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.07.010 · Cited by 680 · see citing works

Direct effects of thyroid hormones on hepatic lipid metabolism

Sinha, R. A., Singh, B. K., & Yen, P. M. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.10 · Cited by 665 · see citing works

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

Klarin, D. M., Program, T. V. M. V., Damrauer, S. M., Cho, K., Sun, Y. V., Teslovich, T. M., Honerlaw, J. P., GAGNON, D. R., DuVall, S. L., Li, J., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0222-9 · Cited by 594 · see citing works

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

Prakash, T. P., Graham, M., Yu, J., Carty, R., Low, A., Chappell, A., Schmidt, K., Zhao, C., Aghajan, M., Murray, H., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku531 · Cited by 588 · see citing works

Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene

Kersten, S., Mandard, S., Tan, N. S., Escher, P., METZGER, D., Chambon, P., Gonzalez, F. J., Desvergne, B., & Wahli, W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004029200 · Cited by 560 · see citing works

Exome-wide association study of plasma lipids in >300,000 individuals

Charge Diabetes Working Group, Liu, D. J., Program, V. M. V., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X. Q., Mahajan, A., Saleheen, D., Emdin, C. A., et al. (2017) · Nature Genetics · doi:10.1038/ng.3977 · Cited by 546 · see citing works

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

Pike, L. S., Smift, A., Croteau, N. J., Ferrick, D. A., & Wu, M. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.10.022 · Cited by 473 · see citing works

A systems study reveals concurrent activation of AMPK and mTOR by amino acids

Pezze, P. D., Ruf, S., Sonntag, A., Langelaar‐Makkinje, M., Philip, H., Heberle, A. M., Navas, P. R., van Eunen, K., Tölle, R. C., Schwarz, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms13254 · Cited by 445 · see citing works

Fatty acids as modulators of the cellular production of reactive oxygen species

Schönfeld, P., & Wojtczak, L. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.029 · Cited by 441 · see citing works

Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes

Hummasti, S., & Hotamışlıgil, G. S. (2010) · Circulation Research · doi:10.1161/circresaha.110.225698 · Cited by 434 · see citing works

The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity

Mandard, S., Zandbergen, F., van Straten, E., Wahli, W., Kuipers, F., Müller, M., & Kersten, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506519200 · Cited by 433 · see citing works

Transgenic Angiopoietin-Like (Angptl)4 Overexpression and Targeted Disruption of Angptl4 and Angptl3: Regulation of Triglyceride Metabolism

Köster, A., Chao, Y. B., Mosior, M., Ford, A., Gonzalez-DeWhitt, P. A., Hale, J. E., Li, D., Qiu, Y., Fraser, C. C., Yang, D. D., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0476 · Cited by 427 · cited 1× · see citing works

Adiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci

Stender, S., Kozlitina, J., Nordestgaard, B. G., Tybjærg‐Hansen, A., Hobbs, H. H., & Cohen, J. C. (2017) · Nature Genetics · doi:10.1038/ng.3855 · Cited by 421 · see citing works

An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases

Bhandary, B., Marahatta, A., Kim, H., & Chae, H. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms14010434 · Cited by 407 · see citing works

Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism

Liemburg-Apers, D. C., Willems, P. H. G. M., Koopman, W. J. H., & Grefte, S. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1520-y · Cited by 391 · see citing works

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

Xu, A., Lam, M. C., Chan, K. W., Wang, Y., Zhang, J., Hoo, R. L. C., Xu, J. Y., Chen, B., Chow, W.-S., Tso, A. W. K., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408452102 · Cited by 318 · see citing works

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD

Garcia, D., Hellberg, K., Chaix, A., Wallace, M., Herzig, S., Badur, M. G., Lin, T. C., Shokhirev, M. N., Pinto, A. F. M., Ross, D. S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.036 · Cited by 291 · see citing works

Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages

Lichtenstein, L., Mattijssen, F., de Wit, N. J. W., Georgiadi, A., Hooiveld, G. J. E. J., van der Meer, R., He, Y., Qi, L., Koster, A. M., Tamsma, J. T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.002 · Cited by 269 · see citing works

Angiopoietin-like 4: a decade of research

Zhu, P., Goh, Y. Y., Chin, H. F. A., Kersten, S., & Tan, N. S. (2011) · Bioscience Reports · doi:10.1042/bsr20110102 · Cited by 261 · see citing works

ANGPTL4 in Metabolic and Cardiovascular Disease

Aryal, B. K., Price, N. L., Suárez, Y., & Fernandez-Hernando, C. F. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.05.010 · Cited by 239 · see citing works

Triglyceride-rich lipoproteins as a causal factor for cardiovascular disease

Toth, P. (2016) · Vascular Health and Risk Management · doi:10.2147/vhrm.s104369 · Cited by 237 · see citing works

Obesity and nonalcoholic fatty liver disease: current perspectives

Sarwar, R., Pierce, N., & Koppe, S. (2018) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s146339 · Cited by 232 · see citing works

Ectopic lipid storage and insulin resistance: a harmful relationship

Borén, J., Taskinen, M., Olofsson, S. ‐., & Levin, M. C. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12071 · Cited by 230 · see citing works

Regulation of AMPK Activation by CD36 Links Fatty Acid Uptake to β-Oxidation

Samovski, D., Sun, J., Pietka, T., Gross, R. W., Eckel, R. H., Su, X., Stahl, P. D., & Abumrad, N. A. (2014) · Diabetes · doi:10.2337/db14-0582 · Cited by 218 · see citing works

The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance

Farese, R. V., Zechner, R., Newgard, C. B., & Walther, T. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.004 · Cited by 207 · see citing works

Regulation of lipoprotein lipase by Angptl4

Dijk, W., & Kersten, S. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.12.005 · Cited by 199 · see citing works

Angptl4 Upregulates Cholesterol Synthesis in Liver via Inhibition of LPL- and HL-Dependent Hepatic Cholesterol Uptake

Lichtenstein, L., Berbée, J. F. P., van Dijk, S. J., van Dijk, K. W., Bensadoun, A., Kema, I. P., Voshol, P. J., Müller, M. M., Rensen, P. C. N., & Kersten, S. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.151894 · Cited by 196 · see citing works

Interorgan Metabolic Crosstalk in Human Insulin Resistance

Gancheva, S., Jeleník, T., Álvarez-Hernández, E., & Roden, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00015.2017 · Cited by 194 · see citing works

Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice

Desai, U. S., Lee, E.-C., Chung, K., Gao, C., Gay, J. P., Key, B., Hansen, G. M., Machajewski, D., Platt, K. A., Sands, A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705041104 · Cited by 192 · see citing works

Postprandial lipoprotein metabolism: VLDL vs chylomicrons

Nakajima, K., Nakano, T., Tokita, Y., Nagamine, T., Inazu, A., Kobayashi, J., Mabuchi, H., Stanhope, K. L., Havel, P. J., Okazaki, M., et al. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.04.018 · Cited by 179 · see citing works

AMPK Activation Reduces Hepatic Lipid Content by Increasing Fat Oxidation In Vivo

Foretz, M., Even, P. C., & Viollet, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092826 · Cited by 177 · see citing works

Palmitate-mediated Alterations in the Fatty Acid Metabolism of Rat Neonatal Cardiac Myocytes

Hickson-Bick, D. L. M., Buja, L. M., & McMillin, J. B. (2000) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1999.1098 · Cited by 170 · see citing works

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

Gusarova, V., O’Dushlaine, C. T., Teslovich, T. M., Benotti, P. N., Mirshahi, T., Gottesman, O., Hout, C. V. V., Murray, M. F., Mahajan, A., Nielsen, J. B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04611-z · Cited by 145 · see citing works

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis

Aryal, B. K., Singh, A. K., Zhang, X., Varela, L., Rotllán, N., Goedeke, L., Chaube, B., Camporez, J. P., Vatner, D. F., Horváth, T. L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97918 · Cited by 131 · see citing works

Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight

Kim, H.-K., Youn, B., Shin, M.-S., NamKoong, C., Park, K. H., Baik, J., Kim, J. B., Park, J., Lee, K., Kim, Y., et al. (2010) · Diabetes · doi:10.2337/db10-0145 · Cited by 127 · see citing works

Fatty acids stimulate AMP‐activated protein kinase and enhance fatty acid oxidation in L6 myotubes

Watt, M. J., Steinberg, G. R., Chen, Z., Kemp, B. E., & Febbraio, M. A. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.107318 · Cited by 120 · see citing works

Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis

Singh, A. K., Aryal, B. K., Chaube, B., Rotllán, N., Varela, L., Horváth, T. L., Suárez, Y., & Fernandez-Hernando, C. F. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.03.011 · Cited by 115 · see citing works

ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression

Aryal, B., Rotllán, N., Araldi, E., Ramírez, C. M., He, S., Chousterman, B. G., Fenn, A. M., Wanschel, A. C. B. A., Madrigal‐Matute, J., Warrier, N., et al. (2016) · Nature Communications · doi:10.1038/ncomms12313 · Cited by 114 · see citing works

Covalent activation of heart AMP‐activated protein kinase in response to physiological concentrations of long‐chain fatty acids

Clark, H. S., Carling, D., & Saggerson, D. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04151.x · Cited by 105 · see citing works

Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota

Janssen, A. W. F., Katiraei, S., Bartosinska, B., Eberhard, D., Willems van Dijk, K., & Kersten, S. (2018) · Diabetologia · doi:10.1007/s00125-018-4583-5 · Cited by 96 · see citing works

New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk

Kersten, S. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000600 · Cited by 94 · see citing works

Design and cloning of lentiviral vectors expressing small interfering RNAs

Tiscórnia, G., Singer, O., & Verma, I. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.36 · Cited by 92 · see citing works

Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition

Hu, H., Lee, S., Sousa‐Lima, I., Kim, S. S., Hwang, W. M., Dagon, Y., Yang, W.-M., Cho, S., Kang, M., Seo, J. A., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci63562 · Cited by 89 · see citing works

Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism

Kristensen, K. K., Leth-Espensen, K. Z., Mertens, H. D. T., Birrane, G., Muthuraman, M., Olivecrona, G., Jørgensen, T. J. D., Young, S. G., & Ploug, M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1920202117 · Cited by 77 · see citing works

Oxidative stress improves coronary endothelial function through activation of the pro-survival kinase AMPK

Shafique, E., Choy, W. C., Liu, Y., Feng, J., Cordeiro, B., Lyra, A., Arafah, M., Yassin-Kassab, A., Zanetti, A. V. D., Clements, R., et al. (2013) · Aging · doi:10.18632/aging.100569 · Cited by 76 · see citing works

Hepatic Catabolism of Remnant Lipoproteins: Where the Action Is

Havel, R. J., & Hamilton, R. L. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000115382.53810.24 · Cited by 58 · see citing works

Hepatic lipase treatment of chylomicron remnants increases exposure of apolipoprotein E.

Brasaemle, D. L., Cornely-Moss, K., & Bensadoun, A. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40737-0 · Cited by 53 · see citing works

Purification of 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver.

Kleinsek, D. A., Ranganathan, S., & Porter, J. W. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.4.1431 · Cited by 52 · see citing works

Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice

Oteng, A., Ruppert, P. M. M., Boutens, L., Dijk, W., van Dierendonck, X. A. M. H., Olivecrona, G., Stienstra, R., & Kersten, S. (2019) · Journal of Lipid Research · doi:10.1194/jlr.m094128 · Cited by 51 · see citing works

Hepatic fatty acid synthesis and partitioning: the effect of metabolic and nutritional state

Hodson, L. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118002653 · Cited by 49 · see citing works

Angiopoietin-like protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice

Wang, Y., Liu, L.-M., Li, W., Ye, W., Meng, X., Chen, F., Xiao, Q., Chen, J.-Y., & Zhou, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5637 · Cited by 46 · see citing works

Plasma ANGPTL‐4 is Associated with Obesity and Glucose Tolerance: Cross‐Sectional and Longitudinal Findings

Barja-Fernández, S., Moreno‐Navarrete, J. M., Folgueira, C., Xifra, G., Sabater, M., Castelao, C., Fernø, J., Leis, R., Diéguez, C., Casanueva, F. F., et al. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800060 · Cited by 43 · see citing works

Mapping the sites of the lipoprotein lipase (LPL)–angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition

Gutgsell, A. R., Ghodge, S. V., Bowers, A. A., & Neher, S. B. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005932 · Cited by 41 · see citing works

Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice

Spitler, K. M., Shetty, S. K., Cushing, E. M., Sylvers-Davie, K. L., & Davies, B. S. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-87020-5 · Cited by 38 · see citing works

Variants inANGPTL4and the Risk of Coronary Artery Disease

Morrison, A. R., Fu, Y., & O’Donnell, C. J. (2016) · New England Journal of Medicine · doi:10.1056/nejmc1607380 · Cited by 24 · see citing works

A Simplified Scintillation Proximity Assay for Fatty Acid Synthase Activity: Development and Comparison with Other FAS Activity Assays

Bays, N. W., Hill, A. D., & Kariv, I. (2009) · SLAS DISCOVERY · doi:10.1177/1087057109335746 · Cited by 20 · see citing works

ANGPTL4 gene E40K variation protects against obesity‐associated dyslipidemia in participants with obesity

Bailetti, D., Bertoccini, L., Mancina, R. M., Barchetta, I., Capoccia, D., Cossu, E., Pujia, A., Lenzi, A., Leonetti, F., Cavallo, M. G., et al. (2018) · Obesity Science & Practice · doi:10.1002/osp4.311 · Cited by 19 · see citing works

ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents

Barja-Fernández, S., Folgueira, C., Castelao, C., Pena-León, V., González-Sáenz, P., Vázquez‐Cobela, R., Aguilera, C. M., Gil‐Campos, M., Bueno, G., Gil, Á., et al. (2019) · Nutrients · doi:10.3390/nu11061340 · Cited by 19 · see citing works

Mouse hepatic lipase alleles with variable effects on lipoprotein composition and size

Pratt, S. M., Chiu, S., Espinal, G. M., Shibata, N. M., Wong, H., & Warden, C. H. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m002378 · Cited by 4 · see citing works

Addressing dyslipidemic risk beyond LDL-cholesterol

Tall, A. R., Thomas, D. G., Gonzalez-Cabodevilla, A. G., & Goldberg, I. J. (2022) · Journal of Clinical Investigation · doi:10.1172/jci148559 · Cited by 150 · see citing works

Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism

Kersten, S. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100150 · Cited by 146 · see citing works

Ferroptosis Signaling and Regulators in Atherosclerosis

Wang, Y., Zhao, Y., Ye, T., Yang, L. M., Shen, Y., & Li, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.809457 · Cited by 135 · see citing works

Mouse models of atherosclerosis in translational research

Ilyas, I., Little, P. J., Liu, Z., Xu, Y., Kamato, D., Berk, B. C., Weng, J., & Xu, S. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.06.009 · Cited by 115 · see citing works

Triglyceride-rich lipoproteins and cardiovascular diseases

Xu, D., Xie, L., Cheng, C., Xue, F., & Sun, C. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1409653 · Cited by 73 · see citing works

Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis

Chaube, B., Citrin, K. M., Sahraei, M., Singh, A. K., de Urturi, D. S., Ding, W., Pierce, R. W., Raaisa, R., CARDONE, R. L., Kibbey, R. G., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43900-0 · Cited by 70 · see citing works

Dual role of ANGPTL4 in inflammation

Zuo, Y., He, Z., Chen, Y., & Dai, L. (2023) · Inflammation Research · doi:10.1007/s00011-023-01753-9 · Cited by 64 · see citing works

Hepatokines and Non-Alcoholic Fatty Liver Disease: Linking Liver Pathophysiology to Metabolism

Kim, T. H., Hong, D.-G., & Yang, Y. M. (2021) · Biomedicines · doi:10.3390/biomedicines9121903 · Cited by 52 · see citing works

Astrocytic lipid metabolism determines susceptibility to diet-induced obesity

Varela, L., Kim, J. G., Fernández‐Tussy, P., Aryal, B. K., Liu, Z. W., Fernandez-Hernando, C. F., & Horváth, T. L. (2021) · Science Advances · doi:10.1126/sciadv.abj2814 · Cited by 44 · see citing works

Targeting the vasculature in cardiometabolic disease

Boutagy, N. E., Singh, A. K., & Sessa, W. C. (2022) · Journal of Clinical Investigation · doi:10.1172/jci148556 · Cited by 45 · see citing works

The Regulation of Triacylglycerol Metabolism and Lipoprotein Lipase Activity

Wen, Y., Chen, Y., & Konrad, R. J. (2022) · Advanced Biology · doi:10.1002/adbi.202200093 · Cited by 43 · see citing works

Severe hypertriglyceridemia: Existing and emerging therapies

Malick, W. A., Do, R., & Rosenson, R. S. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108544 · Cited by 44 · see citing works

Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease

Srivastava, S. P., Zhou, H., Shenoi, R., Morris, M., Lainez, B., Goedeke, L., Rajendran, B. K., Setia, O., Aryal, B. K., Kanasaki, K., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn6068 · Cited by 40 · see citing works

The Role of Endothelial Progenitor Cells in Atherosclerosis and Impact of Anti-Lipemic Treatments on Endothelial Repair

Altabas, V., & Biloš, L. S. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052663 · Cited by 36 · see citing works

Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases

Pellegata, N. S., Berriel Diaz, M., Rohm, M., & Herzig, S. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10058-y · Cited by 33 · see citing works

Hepatokines: unveiling the molecular and cellular mechanisms connecting hepatic tissue to insulin resistance and inflammation

Miao, X., Alidadipour, A., Saed, V., Sayyadi, F., Jadidi, Y., Davoudi, M., Amraee, F., Jadidi, N., & Afrisham, R. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02335-9 · Cited by 34 · see citing works

Hepatokines and MASLD: The GLP1-Ras-FGF21-Fetuin-A Crosstalk as a Therapeutic Target

Milani, I., Codini, M., Guarisco, G., Chinucci, M., Gaita, C., Leonetti, F., & Capoccia, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910795 · Cited by 33 · see citing works

Associations of Circulating ANGPTL3, C-Terminal Domain–Containing ANGPTL4, and ANGPTL3/8 and ANGPTL4/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality

Silbernagel, G., Chen, Y., Li, H., Lemen, D., Wen, Y., Zhen, Y., Rief, M., Kleber, M. E., Delgado, G., Sarzynski, M. A., et al. (2024) · Circulation · doi:10.1161/circulationaha.124.069272 · Cited by 30 · see citing works

ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy

Deng, M., Kutrolli, E., Sadewasser, A., Michel, S., Joibari, M. M., Jaschinski, F., Olivecrona, G., Nilsson, S. K., & Kersten, S. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100237 · Cited by 30 · see citing works

Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice

Shrestha, N., Chaturvedi, P., Zhu, X., Dee, M. J., George, V., Janney, C., Egan, J. O., Liu, B., Foster, M., Marsala, L. I., et al. (2023) · Aging Cell · doi:10.1111/acel.13806 · Cited by 27 · see citing works

MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice

Smolka, C., Schlösser, D., Hohnloser, C., Bemtgen, X., Jänich, C., Schneider, L. A., Martin, J., Pfeifer, D., Moser, M., Hasselblatt, P., et al. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00364-6 · Cited by 27 · see citing works

Rho A/ROCK1 signaling-mediated metabolic reprogramming of valvular interstitial cells toward Warburg effect accelerates aortic valve calcification via AMPK/RUNX2 axis

Liu, H., Yin, H., Wang, Z., Yuan, Q., Xu, F., Chen, Y., & Li, C. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05642-1 · Cited by 25 · see citing works

Interorgan communication with the liver: novel mechanisms and therapeutic targets

Zhao, J., Zhang, X., Li, Y., Yu, J., Chen, Z., Niu, Y., Ran, S., Wang, S., Ye, W., Luo, Z., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1314123 · Cited by 28 · see citing works

Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds

Sun, J., Xie, F., Wang, J., Luo, J., Chen, T., Jiang, Q., Xi, Q., Liu, G. E., & Zhang, Y. (2024) · Microbiome · doi:10.1186/s40168-023-01743-3 · Cited by 29 · see citing works

Postprandial exercise regulates tissue-specific triglyceride uptake through angiopoietin-like proteins

Liu, X., Zhang, Y., Han, B., Li, L., Li, Y., Ma, Y., Kang, S., Li, Q., Kong, L., Huang, K., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.181553 · Cited by 25 · see citing works

ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-κB pathway

Zhang, X., Yuan, S., Zhang, X., Zhang, T., Meng, C., Zhuang, K., & Dang, S. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112706 · Cited by 23 · see citing works

Genetic Mimicry Analysis Reveals the Specific Lipases Targeted by the ANGPTL3-ANGPTL8 Complex and ANGPTL4

Landfors, F., Chorell, E., & Kersten, S. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100313 · Cited by 24 · see citing works

Assessing the impact of perfluoroalkyl substances on liver health: a comprehensive study using multi-donor human liver spheroids

Golden‐Mason, L., Salomon, M. P., Matsuba, C., Wang, Y., Setiawan, V. W., Chatzi, L., & Maretti-Mira, A. C. (2025) · Environment International · doi:10.1016/j.envint.2025.109763 · Cited by 24 · see citing works

Chronic high-fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice

Spitler, K. M., Shetty, S. K., Cushing, E. M., Sylvers-Davie, K. L., & Davies, B. S. J. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00144.2021 · Cited by 23 · see citing works

Indole-3-carbinol and chlorogenic acid combination modulates gut microbiome and attenuates nonalcoholic steatohepatitis in a murine model

Bacil, G. P., Romualdo, G. R., Rodrigues, J., & Barbisan, L. F. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113513 · Cited by 23 · see citing works

PFOS-elicited metabolic perturbation in liver and fatty acid metabolites in testis of adult mice

Lee, W. K., Lam, T. K. Y., Tang, H. C., Ho, T. C., Wan, H. T., & Wong, C. K. C. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1302965 · Cited by 22 · see citing works

Silencing of Angiopoietin‐Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF‐κB Pathway

Jia, C., Li, X., Pan, J., Ma, H., Wu, D., Lü, H., Wang, W., Zhang, X., & Yi, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1135827 · Cited by 22 · see citing works

Angiopoietin-like proteins and postprandial partitioning of fatty acids

DiDonna, N., Chen, Y. Q., & Konrad, R. J. (2021) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000798 · Cited by 20 · see citing works

Viruses and neurodegeneration: a growing concern

Shouman, S., Hesham, N., & Salem, T. Z. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-024-06025-6 · Cited by 19 · see citing works

Familial chylomicronemia syndrome and treatments to target hepatic APOC3 mRNA

Brinton, E. A., Eckel, R. H., Gaudet, D., Ballantyne, C. M., Baker, B. F., Ginsberg, H. N., & Witztum, J. L. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119114 · Cited by 20 · see citing works

Impact of loss-of-function in angiopoietin-like 4 on the human phenome

Gagnon, E., Bourgault, J., Gobeil, É., Thériault, S., & Arsenault, B. J. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.117558 · Cited by 17 · see citing works

Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia and atherosclerosis development in APOE*3-Leiden.CETP mice

Modder, M., Panhuis, W. I. H., Li, M., Afkir, S., Dorn, A. L., Pronk, A. C. M., Streefland, T. C. M., Lalai, R. A., Pierrou, S. E., Nilsson, S. K., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae195 · Cited by 17 · see citing works

Social Bonds Retain Oxytocin-Mediated Brain-Liver Axis to Retard Atherosclerosis

Ko, S., Anzai, A., Liu, X., Kinouchi, K., Yamanoi, K., Torimitsu, T., Ichihara, G., Kitakata, H., Shirakawa, K., Katsumata, Y., et al. (2024) · Circulation Research · doi:10.1161/circresaha.124.324638 · Cited by 19 · see citing works

ANGPTL4: A Comprehensive Review of 25 Years of Research

Ramos, P., Shi, Q., Kleberg, J., Maharjan, C. K., Zhang, W., & Kolb, R. H. (2025) · Cancers · doi:10.3390/cancers17142364 · Cited by 20 · see citing works

ANGPTL4: a new mode in the regulation of intravascular lipolysis

Ploug, M. (2021) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000800 · Cited by 16 · see citing works

Using Synthetic ApoC-II Peptides and nAngptl4 Fragments to Measure Lipoprotein Lipase Activity in Radiometric and Fluorescent Assays

Oldham, D., Wang, H., Mullen, J., Lietzke, E. E., Sprenger, K. G., Reigan, P., Eckel, R. H., & Bruce, K. D. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.926631 · Cited by 14 · see citing works

Angiopoietin-like protein inhibitors: Promising agents for the treatment of familial hypercholesterolemia and atherogenic dyslipidemia

Vahdat‐Lasemi, F., Farhoudi, L., Hosseinikhah, S. M., Santos, R. D., & Sahebkar, A. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119235 · Cited by 14 · see citing works

Hepatic PTEN Signaling Regulates Systemic Metabolic Homeostasis through Hepatokines-Mediated Liver-to-Peripheral Organs Crosstalk

Berthou, F., Sobolewski, C., Abegg, D., Fournier, M., Maeder, C., Dolicka, D., de Sousa, M. C., Adibekian, A., & Foti, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073959 · Cited by 13 · see citing works

Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4

Wang, X., Chang, H.-C., Gu, X., Han, W., Mao, S., Lu, L., Jiang, S., Ding, H., Han, S., Qu, X., et al. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111932 · Cited by 12 · see citing works

ANGPTL4—A protein involved in glucose metabolism, lipid metabolism, and tumor development

Xu, Z., & Jiang, G. (2024) · The Journal of Gene Medicine · doi:10.1002/jgm.3740 · Cited by 12 · see citing works

Integration of transcriptomics and metabolomics reveal cytotoxic mechanisms of Polyethylene terephthalate microplastics in BEAS-2B cells

Chu, J., Yang, Y., Zhang, K., Fu, Y., & Yuan, B. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.115125 · Cited by 12 · see citing works

Non-alcoholic fatty liver disease and liver secretome

Khan, M. S., Lee, C.-H., & Kim, S. G. (2022) · Archives of Pharmacal Research · doi:10.1007/s12272-022-01419-w · Cited by 11 · see citing works

Brain-acting hepatokines: its impact on energy balance and metabolism

Giovanini, L., Wanionok, N. E., Perelló, M., & Cornejo, M. P. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1589110 · Cited by 14 · see citing works

ANGPTL4-the Link Binding Lipid Metabolism and Inflammation

Zhang, Y., Liang, J., Li, Z., Zuo, Y., & Dai, L. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673320024240829070906 · Cited by 11 · see citing works

Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry

Lai, Z., Wang, C., Liu, X., Sun, H., Guo, Z., Shao, J., Li, K., Chen, J., Wang, J., Lei, X., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04723-1 · Cited by 11 · see citing works

Identifying novel drug targets for calcific aortic valve disease through Mendelian randomization

Xu, D., Lu, J., Yang, Y., Hu, W., Chen, J., Xue, J., Yang, S., Cao, N., Hu, H., Qian, N., et al. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119110 · Cited by 10 · see citing works

Fucoidan, as a marine bioactive substance, has shown great potential in regulating the bone-gut axis

Zhao, Z., Sun, H., Fu, Y., Liang, X., Fan, T., Li, X., Zhu, L., Xu, L., Wang, X., Li, J., et al. (2023) · Algal Research · doi:10.1016/j.algal.2023.103323 · Cited by 10 · see citing works

The Progression of Treatment for Refractory Hypercholesterolemia: Focus on the Prospect of Gene Therapy

Li, Z.-F., & Wu, N. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.911429 · Cited by 10 · see citing works

A high Diabetes Risk Reduction Score (DRRS) is associated with a better cardio-metabolic profile among obese individuals

Siri, G., Nikrad, N., Keshavari, S., Jamshidi, S., Fayyazishishavan, E., Ardekani, A. M., Farhangi, M. A., & Jafarzadeh, F. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-023-01279-5 · Cited by 10 · see citing works

RNA interference-based therapies for the control of atherosclerosis risk factors

Kettunen, S., Ruotsalainen, A., & Ylä‐Herttuala, S. (2022) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000972 · Cited by 10 · see citing works

Oleuropein as a Therapeutic Agent for Non-alcoholic Fatty Liver Disease During Hepatitis C

Sotoudeheian, M., Hoseini, S., Mirahmadi, S., Farahmandian, N., & Pazoki–Toroudi, H. (2023) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-023-00396-5 · Cited by 9 · see citing works

Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway

Zhang, Y., Zhu, Z., Sun, L., Yin, W., Liang, Y. J., Chen, H., Bi, Y., Zhai, W., Yin, Y., & Zhang, W. (2023) · Nutrients · doi:10.3390/nu15081838 · Cited by 8 · see citing works

Transcription factor ETV4 plays a critical role in the development of non-alcoholic fatty liver disease

Gadiraju, B., Magisetty, J., & Kondreddy, V. K. R. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137235 · Cited by 8 · see citing works

MiR-203 is an anti-obese microRNA by targeting apical sodium-dependent bile acid transporter

Liu, X., Cheng, F., Bai, X., Zhao, T., Zhao, L., Wang, L., Li, M., Wu, X., Chen, X., Tang, P., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104708 · Cited by 8 · see citing works

Characterization of sexual dimorphism in ANGPTL4 levels and function

Deng, M., & Kersten, S. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100526 · Cited by 7 · see citing works

Angiopoietin‐like protein 4 induces growth hormone variant secretion and aggravates insulin resistance during pregnancy, linking obesity to gestational diabetes mellitus

Kuo, C., Wang, S., Juan, H.-C., Chen, S., Kuo, C., Kuo, H., Lin, S., & Li, H. (2024) · BioFactors · doi:10.1002/biof.2076 · Cited by 8 · see citing works

Advancing the clinical assessment of glomerular podocyte pathology in kidney biopsies via super-resolution microscopy and angiopoietin-like 4 staining

Liu, X., Wang, S., Liu, G., Wang, Y., Shang, S., Zou, G., Jiang, S., Wang, X., Li, Y., & Li, W. (2024) · Theranostics · doi:10.7150/thno.101498 · Cited by 7 · see citing works

The role of AMP-activated protein kinase activators on energy balance and cellular metabolism in type 2 diabetes mellitus

Aydın, S., Tekinalp, S. G., Tuzcu, B., Çam, F., Sevik, M. O., Tatar, E., Kalaskar, D. M., & Çam, M. E. (2024) · Obesity Medicine · doi:10.1016/j.obmed.2024.100577 · Cited by 8 · see citing works

PPARβ/δ as a promising molecular drug target for liver diseases: A focused review

Meng, X., Wang, L., Du, Y.-C., Cheng, D., & Zeng, T. (2024) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2024.102343 · Cited by 7 · see citing works

Differential Effects of Bariatric Surgery on Plasma Levels of ANGPTL3 and ANGPTL4.

Bini, S., D’Erasmo, L., Astiarraga, B., Minicocci, I., Palumbo, M., Pecce, V., Polito, L., Costanzo, A. D., Haeusler, R. A., Arca, M., et al. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.08.019 · Cited by 7 · see citing works

ANGPTL4 is a potential driver of HCV-induced peripheral insulin resistance

Gomes, D. B. R., Sobolewski, C., Conzelmann, S., Schaer, T., Lefai, É., Alfaiate, D., Tseligka, E. D., Goossens, N., Tapparel, C., Negro, F., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-33728-5 · Cited by 7 · see citing works

Hypothalamic astrocytes: connecting brain and periphery in metabolic control

Thuc, O. L., Lechner, F. M., & García‐Cáceres, C. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09995-0 · Cited by 6 · see citing works

Single-cell transcriptomics reveals the impact of sex and age in the healthy human liver

Rahman, R. U., Epstein, E. T., Murphy, S. M., Amir-Zilberstein, L., Aubin, C., Delorey, T. M., Koene, H., Fernandes, L., Tanabe, K. K., Qadan, M., et al. (2026) · JHEP Reports · doi:10.1016/j.jhepr.2026.101773 · Cited by 6 · see citing works

Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD

Qin, W., Ding, Y., Zhang, W., Sun, L., Weng, J., Zheng, X., & Luo, S. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100740 · Cited by 6 · see citing works

Evaluating the Cardiometabolic Efficacy and Safety of Lipoprotein Lipase Pathway Targets in Combination With Approved Lipid-Lowering Targets: A Drug Target Mendelian Randomization Study

Gagnon, É., Gill, D., Chabot, D., Cronjé, H. T., Yuan, S., Brennan, S., Thériault, S., Burgess, S., Arsenault, B. J., & Dib, M. (2025) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.124.004933 · Cited by 8 · see citing works

Multilayer regulation of postprandial triglyceride metabolism in response to acute cold exposure

Zhang, Y., Zhou, S., Zhao, R., Xiong, C., Huang, Y., Zhang, M., & Wang, Y. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100751 · Cited by 5 · see citing works

Osteoclast-derived arachidonic acid triggers dormant lung adenocarcinoma cell activation

Liu, X., Qiu, R., Gui, P., Wei, L., Lu, Y., Deng, Y., Yang, X., Su, Y. H., Huang, Q., & Du, Y. (2025) · iScience · doi:10.1016/j.isci.2025.112167 · Cited by 5 · see citing works

BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine

Perera, D. J., Domenech, P., Babuadze, G. G., Naghibosadat, M., Alvarez, F., Koger-Pease, C., Labrie, L., Stuible, M., Durocher, Y., Piccirillo, C. A., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107612 · Cited by 5 · see citing works

Unveiling the bioinformatic genes and their involved regulatory mechanisms in type 2 diabetes combined with osteoarthritis

Mao, G., Xu, W.-H., Wan, L., Wang, H.-P., Xu, S., Zhang, L., Li, S., Zhang, J., Lai, Z.-M., Lan, Y., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1353915 · Cited by 7 · see citing works

Alisol B alleviates MASLD by activating liver autophagy and fatty acid oxidation via Ces2a

Zhang, C., Chen, L., Jiang, Y., Qiu, J., Lin, Y., Ren, G. R., Xu, F., Xi, J., Yu, Z., Rong, X., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114768 · Cited by 5 · see citing works

Deciphering the regulatory networks of human male germline development from embryo to adulthood

Chen, J., Yang, X., Cui, M., Yao, Z., Ouyang, Z., Qu, Z., Huang, Y., Zhu, Y., Zhao, J., & Chang, G. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167918 · Cited by 4 · see citing works

Exerkine-mediated organ interactions: A new interpretation of exercise on cardiovascular function improvement

Liu, R., Xi, Y., Duan, X., Zhao, Y., & Tian, Z. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123628 · Cited by 4 · see citing works

From model to man: Understanding Tregs' dual role in MASLD

Dywicki, J., Buitrago‐Molina, L. E., Baumann, A., Davalos-Misslitz, A., Hendriks, C. M., Hupa-Breier, K., Lieber, M., Schlué, J., Blüher, M., Bantel, H., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101619 · Cited by 6 · see citing works

Knockdown of ANGPTL4 inhibits adipogenesis of preadipocyte via autophagy

Ling, M., Qian, H., & Guo, H. (2024) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-024-00861-y · Cited by 4 · see citing works

Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study

Nowowiejska, J., Baran, A. M., Hermanowicz, J. M., Mikłosz, J., Kamiński, K. A., Kondraciuk, M., Dubatówka, M., Pawlak, D., & Flisiak, I. (2022) · Metabolites · doi:10.3390/metabo12090877 · Cited by 4 · see citing works

Assessing Receptor Activation in 2D and 3D Cultured Hepatocytes: Responses to a Single Compound and a Complex Mixture

Jamshed, L., Jamshed, S., Frank, R. A., Hewitt, L. M., Thomas, P. J., & Holloway, A. C. (2024) · Toxics · doi:10.3390/toxics12090631 · Cited by 3 · see citing works

Gut fungi exacerbates gallstone formation by activating neutrophil extracellular traps in the liver

Lu, D., ding, H., Feng, S., Hang, F., Tian, K., Huang, Z., Shi, Y., Xue, D., Liu, L., & Meng, X. (2026) · APOPTOSIS · doi:10.1007/s10495-025-02213-x · Cited by 3 · see citing works

Hepatocyte‐specific RAP1B deficiency ameliorates high‐fat diet‐induced obesity and liver inflammation in mice

Fu, Y., Hu, P., Hu, Y., Fang, Y., Zhou, Y., Shi, Y., Yang, K., Fu, T., Li, W., Gritskevitch, E., et al. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16309 · Cited by 2 · see citing works

New insights into Lambda-cyhalothrin-induced lipid metabolism disorder in liver: Crosstalk between oxidative stress and PPARα signaling pathway

Zhang, H., He, C., Pu, Z., Guo, L., Pan, L., Gong, H., Zhang, J., Laghari, F., Jin, S., & Zhang, R. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111872 · Cited by 2 · see citing works

Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin β 3 in the Glomerulus

Liu, S., Meng, M., Huang, C., He, L., Wang, P., Tang, Z., Ran, X., Gao, H., Guo, Y., He, Y., et al. (2025) · Journal of Diabetes Research · doi:10.1155/jdr/6683126 · Cited by 2 · see citing works

R-spondin 2 suppresses hepatic steatosis via activation of AMPK-ACC signaling

Aithabathula, R. V., Singla, B., Kathuria, I., Pervaiz, N., Sharma, B. K., Samake, T. I., Ofosu-Boateng, M., Gebreyesus, L. H., Gyamfi, M. A., Sprague, C., et al. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101551 · Cited by 2 · see citing works

Intestinal enteroendocrine cell subtype differentiation and hormone production in zebrafishPreprint

Morash, M., Kay, R. G., Soderblom, E. J., MacLean, G. H., Wen, J., Moore, P. J., Lickwar, C. R., Gribble, F. M., Reimann, F. M., Liddle, R. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.17.633579 · Cited by 2 · see citing works

Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney diseasePreprint

Srivastava, S. P., Zhou, H., Shenoi, R., Morris, M., Lainez, B., Takagaki, Y., Rajendran, B. K., Setia, O., Aryal, B. K., Kanasaki, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.08.652142 · Cited by 2 · see citing works

Dynamic and Homeostatic Neuron–Astrocyte Interactions at GABAergic Synapses

Clarke, D., Lacaille, J., & Robitaille, R. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04554-0 · Cited by 1 · see citing works

Role of L-Arginine in the Gut–Liver Axis of Female Mice: Mediating Ethanol’s Alterations in Hepatic Steatosis and Oxidative Stress

Daff, K., Han, Y., Feng, Z., Upadhyay, M., Sivampeta, V., Rajasekaran, A., Sangwan, N., & Cresci, G. (2026) · Antioxidants · doi:10.3390/antiox15050537 · Cited by 1 · see citing works

Sexually Dimorphic Effects of CYP2B6 in the Development of Fasting-Mediated Steatosis in Mice: Role of the Oxylipin Products 9-HODE and 9-HOTrE

Eccles, J. A., Johnson, T. D., & Baldwin, W. S. (2025) · Biomedicines · doi:10.3390/biomedicines13020295 · Cited by 1 · see citing works

Loss of cis-PTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinomaPreprint

Singh, A. K., Chaube, B., Citrin, K., Fowler, J. W., Lee, S., Catarino, J., Knight, J., Lowery, S. C., Shree, S., Boutagy, N., et al. (2023) · bioRxiv · doi:10.1101/2023.11.13.566870 · Cited by 1 · see citing works

Regulatory mechanisms of fasting

Ruppert, P. M. M. (2020) · doi:10.18174/527117

Reply

Subramanian, P., Gargani, S., Kontoyiannis, D. L., & Chavakis, T. (2022) · Hepatology · doi:10.1002/hep.32790

Angiopoietin-like 4 shapes the intrahepatic T-cell landscape via eIF2α signaling during steatohepatitis in diet-induced NAFLDPreprint

Low, Z. S., Chua, D., Cheng, H. S., Tee, R., Tan, W., Ball, C., Sahib, N. B. E., Ng, S. S., Qu, J. T., Liu, Y., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.10.523354

General Internal Medicine VI

Torun, C., Cüre, O., Cengiz, K., İlkkılıç, K., Algün, E., Donma, M. M., Tuncer, S. Ç., Altan, N., Dinçel, A. S., Kosava, F., et al. (2024) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.3053

Anti-Adipogenic Effects of Complanatoside a on 3t3-L1 Adipocytes and ZabrafishPreprint

Li, S., Zhou, C., Wang, M., Dong, Y., Mao, M., Zhou, M., Liu, C., Cao, M., & Wang, Y. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4802940

Identification and validation of the shared signature gene MMP9 and ANGPTL4 and its regulatory mechanisms in Type 2 Diabetes combined with OsteoarthritisPreprint

Mao, G., Xu, W., Wan, L., Wang, H., Xu, S., Zhang, L., Li, S., Liu, P., Lai, Z., Lan, Y., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4426524/v1

Patent highlights December 2023–January 2024

Mucke, H. A. (2024) · Pharmaceutical Patent Analyst · doi:10.1080/20468954.2024.2390353

Angptl4 is upregulated by microenvironmental factors during the wound healing process and promotes epidermal stem cell proliferation via PRL8a6

Yu, S., Ji, P., Du, T., Liu, Z., Yang, Y., Lv, Z., Xu, L., Jin, Q., Gong, W., Le, Y., et al. (2025) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2025145

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis

Aryal, B. K., Singh, A. K., Zhang, X., Varela, L., Rotllán, N., Goedeke, L., Chaube, B., Camporez, J. P., Vatner, D. F., Horváth, T. L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97918 · Cited by 131 · see citing works

Angiopoietin-like protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice

Wang, Y., Liu, L.-M., Li, W., Ye, W., Meng, X., Chen, F., Xiao, Q., Chen, J.-Y., & Zhou, Y. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5637 · Cited by 46 · see citing works

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

Xu, A., Lam, M. C., Chan, K. W., Wang, Y., Zhang, J., Hoo, R. L. C., Xu, J. Y., Chen, B., Chow, W.-S., Tso, A. W. K., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408452102 · Cited by 318 · see citing works

Angptl4 Upregulates Cholesterol Synthesis in Liver via Inhibition of LPL- and HL-Dependent Hepatic Cholesterol Uptake

Lichtenstein, L., Berbée, J. F. P., van Dijk, S. J., van Dijk, K. W., Bensadoun, A., Kema, I. P., Voshol, P. J., Müller, M. M., Rensen, P. C. N., & Kersten, S. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.151894 · Cited by 196 · see citing works

Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism

Kersten, S. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100150 · Cited by 146 · see citing works