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The Role of Endothelial Progenitor Cells in Atherosclerosis and Impact of Anti-Lipemic Treatments on Endothelial Repair

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Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases

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Hepatokines: unveiling the molecular and cellular mechanisms connecting hepatic tissue to insulin resistance and inflammation

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Hepatokines and MASLD: The GLP1-Ras-FGF21-Fetuin-A Crosstalk as a Therapeutic Target

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Associations of Circulating ANGPTL3, C-Terminal Domain–Containing ANGPTL4, and ANGPTL3/8 and ANGPTL4/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality

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ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy

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Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice

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MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice

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Rho A/ROCK1 signaling-mediated metabolic reprogramming of valvular interstitial cells toward Warburg effect accelerates aortic valve calcification via AMPK/RUNX2 axis

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Interorgan communication with the liver: novel mechanisms and therapeutic targets

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Integrated meta-omics reveals the regulatory landscape involved in lipid metabolism between pig breeds

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Postprandial exercise regulates tissue-specific triglyceride uptake through angiopoietin-like proteins

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ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-κB pathway

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Genetic Mimicry Analysis Reveals the Specific Lipases Targeted by the ANGPTL3-ANGPTL8 Complex and ANGPTL4

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Assessing the impact of perfluoroalkyl substances on liver health: a comprehensive study using multi-donor human liver spheroids

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Chronic high-fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice

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Indole-3-carbinol and chlorogenic acid combination modulates gut microbiome and attenuates nonalcoholic steatohepatitis in a murine model

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PFOS-elicited metabolic perturbation in liver and fatty acid metabolites in testis of adult mice

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Silencing of Angiopoietin‐Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF‐κB Pathway

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Angiopoietin-like proteins and postprandial partitioning of fatty acids

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Viruses and neurodegeneration: a growing concern

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Familial chylomicronemia syndrome and treatments to target hepatic APOC3 mRNA

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Impact of loss-of-function in angiopoietin-like 4 on the human phenome

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Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia and atherosclerosis development in APOE*3-Leiden.CETP mice

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Social Bonds Retain Oxytocin-Mediated Brain-Liver Axis to Retard Atherosclerosis

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ANGPTL4: A Comprehensive Review of 25 Years of Research

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ANGPTL4: a new mode in the regulation of intravascular lipolysis

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Using Synthetic ApoC-II Peptides and nAngptl4 Fragments to Measure Lipoprotein Lipase Activity in Radiometric and Fluorescent Assays

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Angiopoietin-like protein inhibitors: Promising agents for the treatment of familial hypercholesterolemia and atherogenic dyslipidemia

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Hepatic PTEN Signaling Regulates Systemic Metabolic Homeostasis through Hepatokines-Mediated Liver-to-Peripheral Organs Crosstalk

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Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4

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ANGPTL4—A protein involved in glucose metabolism, lipid metabolism, and tumor development

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Integration of transcriptomics and metabolomics reveal cytotoxic mechanisms of Polyethylene terephthalate microplastics in BEAS-2B cells

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Non-alcoholic fatty liver disease and liver secretome

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Brain-acting hepatokines: its impact on energy balance and metabolism

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ANGPTL4-the Link Binding Lipid Metabolism and Inflammation

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Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry

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Identifying novel drug targets for calcific aortic valve disease through Mendelian randomization

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Fucoidan, as a marine bioactive substance, has shown great potential in regulating the bone-gut axis

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The Progression of Treatment for Refractory Hypercholesterolemia: Focus on the Prospect of Gene Therapy

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A high Diabetes Risk Reduction Score (DRRS) is associated with a better cardio-metabolic profile among obese individuals

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RNA interference-based therapies for the control of atherosclerosis risk factors

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Oleuropein as a Therapeutic Agent for Non-alcoholic Fatty Liver Disease During Hepatitis C

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Hepatic G Protein-Coupled Receptor 180 Deficiency Ameliorates High Fat Diet-Induced Lipid Accumulation via the Gi-PKA-SREBP Pathway

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Transcription factor ETV4 plays a critical role in the development of non-alcoholic fatty liver disease

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MiR-203 is an anti-obese microRNA by targeting apical sodium-dependent bile acid transporter

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Characterization of sexual dimorphism in ANGPTL4 levels and function

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Angiopoietin‐like protein 4 induces growth hormone variant secretion and aggravates insulin resistance during pregnancy, linking obesity to gestational diabetes mellitus

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Advancing the clinical assessment of glomerular podocyte pathology in kidney biopsies via super-resolution microscopy and angiopoietin-like 4 staining

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The role of AMP-activated protein kinase activators on energy balance and cellular metabolism in type 2 diabetes mellitus

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PPARβ/δ as a promising molecular drug target for liver diseases: A focused review

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Differential Effects of Bariatric Surgery on Plasma Levels of ANGPTL3 and ANGPTL4.

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ANGPTL4 is a potential driver of HCV-induced peripheral insulin resistance

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Hypothalamic astrocytes: connecting brain and periphery in metabolic control

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Single-cell transcriptomics reveals the impact of sex and age in the healthy human liver

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Small molecule-driven LKB1 deacetylation is responsible for the inhibition of hepatic lipid response in NAFLD

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Evaluating the Cardiometabolic Efficacy and Safety of Lipoprotein Lipase Pathway Targets in Combination With Approved Lipid-Lowering Targets: A Drug Target Mendelian Randomization Study

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Multilayer regulation of postprandial triglyceride metabolism in response to acute cold exposure

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Osteoclast-derived arachidonic acid triggers dormant lung adenocarcinoma cell activation

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BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine

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Unveiling the bioinformatic genes and their involved regulatory mechanisms in type 2 diabetes combined with osteoarthritis

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Alisol B alleviates MASLD by activating liver autophagy and fatty acid oxidation via Ces2a

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Deciphering the regulatory networks of human male germline development from embryo to adulthood

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Exerkine-mediated organ interactions: A new interpretation of exercise on cardiovascular function improvement

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From model to man: Understanding Tregs' dual role in MASLD

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Knockdown of ANGPTL4 inhibits adipogenesis of preadipocyte via autophagy

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Angiopoietin-Like 4 (ANGPTL4) in Patients with Psoriasis, Lichen Planus and Vitiligo—A Pilot Study from the Bialystok+ Polish Longitudinal University Study

Nowowiejska, J., Baran, A. M., Hermanowicz, J. M., Mikłosz, J., Kamiński, K. A., Kondraciuk, M., Dubatówka, M., Pawlak, D., & Flisiak, I. (2022) · Metabolites · doi:10.3390/metabo12090877 · Cited by 4 · see citing works

Assessing Receptor Activation in 2D and 3D Cultured Hepatocytes: Responses to a Single Compound and a Complex Mixture

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Gut fungi exacerbates gallstone formation by activating neutrophil extracellular traps in the liver

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Hepatocyte‐specific RAP1B deficiency ameliorates high‐fat diet‐induced obesity and liver inflammation in mice

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New insights into Lambda-cyhalothrin-induced lipid metabolism disorder in liver: Crosstalk between oxidative stress and PPARα signaling pathway

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Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin β 3 in the Glomerulus

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R-spondin 2 suppresses hepatic steatosis via activation of AMPK-ACC signaling

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Intestinal enteroendocrine cell subtype differentiation and hormone production in zebrafishPreprint

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Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney diseasePreprint

Srivastava, S. P., Zhou, H., Shenoi, R., Morris, M., Lainez, B., Takagaki, Y., Rajendran, B. K., Setia, O., Aryal, B. K., Kanasaki, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.08.652142 · Cited by 2 · see citing works

Dynamic and Homeostatic Neuron–Astrocyte Interactions at GABAergic Synapses

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Role of L-Arginine in the Gut–Liver Axis of Female Mice: Mediating Ethanol’s Alterations in Hepatic Steatosis and Oxidative Stress

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Patent highlights December 2023–January 2024

Mucke, H. A. (2024) · Pharmaceutical Patent Analyst · doi:10.1080/20468954.2024.2390353

Angptl4 is upregulated by microenvironmental factors during the wound healing process and promotes epidermal stem cell proliferation via PRL8a6

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Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis

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Angiopoietin-like protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice

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Angptl4 Upregulates Cholesterol Synthesis in Liver via Inhibition of LPL- and HL-Dependent Hepatic Cholesterol Uptake

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