The DOI matches its Crossref record; 105 of the 106 references it cites were found in a registry or an index.
JmjC-domain-containing proteins and histone demethylation
Abstract
Histone methylation has important roles in regulating gene expression and forms part of the epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove methyl marks from histones have recently been identified, revealing a new level of plasticity within this epigenetic modification system. Here we analyse the evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins and discuss their cellular functions in relation to their potential enzymatic activities.
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“whilst several epigenetic therapies targeting the prototypical oncogene MYC through transcriptional repression generated much excitement, it is now clear that this is only transiently effective as cancer cells evolve multiple adaptive responses to retain MYC expression 184-186 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [185]
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“Preclinical modelling of resistance mechanisms has shown that resistance to these therapies largely emerge through cellular reprogramming and transcriptional plasticity 184-186 .”
From The roles of DNA, RNA and histone methylation in ageing and cancer (2019) · cites this paper as [185]
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ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
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Metadata
- Authors
- Klose, R. J., Kallin, E. M., & Zhang, Y.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Zhang, Yi
- Venue
- Nature Reviews Genetics
- Published
- 2006-09
- Volume
- 7
- Issue
- 9
- Pages
- 715-727
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W1982409009
- Cited by
- 1,290
- References
- 106
- Citations by year
- 2026: 40 · 2025: 47 · 2024: 53 · 2023: 69 · 2022: 57 · 2021: 83 · 2020: 64 · 2019: 73 · 2018: 84 · 2017: 58 · 2016: 66 · 2015: 83 · 2014: 80 · 2013: 57 · 2012: 68
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Keywords
- Jumonji C domain, histone demethylation, histone methylation, chromatin modification, epigenetic inheritance, protein evolution, gene expression regulation
- MeSH terms
- Histone Methyltransferases, Amino Acid Sequence, Animals, Gene Expression Regulation, Histones, Humans, Molecular Sequence Data, Nuclear Proteins, Oxidoreductases, N-Demethylating, Phylogeny, Histone-Lysine N-Methyltransferase, Protein Methyltransferases, Transcription, Genetic, Sequence Alignment, Protein Structure, Tertiary, Amino Acid Motifs, Epigenesis, Genetic
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