Cited by 346Chromosomal and Genetic VariationsEvolution and Genetic DynamicsDNA Repair Mechanisms

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An evolutionary view of human recombination

Coop, Graham, Przeworski, Molly·2007·Nature Reviews Genetics

DOI 10.1038/nrg1947

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Abstract

Recombination has essential functions in mammalian meiosis, which impose several constraints on the recombination process. However, recent studies have shown that, in spite of these roles, recombination rates vary tremendously among humans, and show marked differences between humans and closely related species. These findings provide important insights into the determinants of recombination rates and raise new questions about the selective pressures that affect recombination over different genomic scales, with implications for human genetics and evolutionary biology.

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Authors: Coop, G., & Przeworski, M.
Affiliations: University of Chicago (US)
Corresponding author: Przeworski, Molly
ORCID: Coop, Graham
Przeworski, Molly
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2006-12-05
Volume: 8
Issue: 1
Pages: 23-34
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg1947
OpenAlex: W2085231911
Cited by: 344
References: 143
Citations by year: 2026: 5 · 2025: 15 · 2024: 12 · 2023: 12 · 2022: 18 · 2021: 53 · 2020: 10 · 2019: 14 · 2018: 13 · 2017: 25 · 2016: 15 · 2015: 17 · 2014: 12 · 2013: 14 · 2012: 12
FWCI: 1.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: University of Chicago
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: meiotic recombination, recombination rate variation, mammalian meiosis, recombination hotspots, recombination rate evolution, comparative genomics, human genetics
MeSH terms: Animals, Crossing Over, Genetic, Biological Evolution, Female, Humans, Male, Mammals, Meiosis, Models, Genetic, Recombination, Genetic, Selection, Genetic, Sex Characteristics, Species Specificity, Linkage Disequilibrium, Genome, Human

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An evolutionary view of human recombination

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