Cited by 663DNA Repair MechanismsBRCA gene mutations in cancerPARP inhibition in cancer therapy

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Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

Wang, Weidong·2007·Nature Reviews Genetics

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Abstract

Fanconi anaemia (FA) has recently become an attractive model to study breast cancer susceptibility (BRCA) genes, as three FA genes, FANCD1, FANCN and FANCJ, are identical to the BRCA genes BRCA2, PALB2 and BRIP1. Increasing evidence shows that FA proteins function as signal transducers and DNA-processing molecules in a DNA-damage response network. This network consists of many proteins that maintain genome integrity, including ataxia telangiectasia and Rad3 related protein (ATR), Bloom syndrome protein (BLM), and BRCA1. Now that the gene that is defective in the thirteenth and last assigned FA complementation group (FANCI) has been identified, I discuss what is known about FA proteins and their interactive network, and what remains to be discovered.

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PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene
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Fanconi, G. Familiaere infantile perniziosaartige Anaemie (pernizioeses Blutbild and konstitution). Jahrbuch Kinderheild 117, 257–280 (1927) (in German).

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Authors: Wang, W.
Affiliations: National Institutes of Health (US)
Corresponding author: Wang, Weidong
ORCID: Wang, Weidong
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2007-10
Volume: 8
Issue: 10
Pages: 735-748
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2159
OpenAlex: W2010216792
Cited by: 663
References: 107
Citations by year: 2026: 6 · 2025: 9 · 2024: 11 · 2023: 5 · 2022: 15 · 2021: 10 · 2020: 17 · 2019: 20 · 2018: 12 · 2017: 28 · 2016: 24 · 2015: 31 · 2014: 40 · 2013: 52 · 2012: 52
FWCI: 6.87
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: Fanconi anemia, BRCA genes, DNA damage response, genome stability, BRCA2, FANCJ, FANCI, PALB2, BRIP1, ATR, Bloom syndrome protein, BRCA1, signal transduction, DNA repair, breast cancer susceptibility
MeSH terms: Fanconi Anemia Complementation Group N Protein, Animals, Chromatin, DNA, DNA Damage, DNA Repair, DNA-Binding Proteins, Fanconi Anemia, Humans, Nuclear Proteins, Signal Transduction, RNA Helicases, BRCA2 Protein, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases, Fanconi Anemia Complementation Group Proteins

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Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

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