Biallelic Inactivation of BRCA2 in Fanconi Anemia

Cancer risks in BRCA2 mutation carriers.

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RING Finger Proteins

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Interaction of the Fanconi Anemia Proteins and BRCA1 in a Common Pathway

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein

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Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas.

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Stable Interaction between the Products of the BRCA1 and BRCA2 Tumor Suppressor Genes in Mitotic and Meiotic Cells

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Involvement of Brca2 in DNA Repair

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The emerging genetic and molecular basis of Fanconi anaemia

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Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos.Preprint

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Convergence of the Fanconi Anemia and Ataxia Telangiectasia Signaling Pathways

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Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

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Positional Cloning of a Novel Fanconi Anemia Gene, FANCD2

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Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation.

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Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification

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Brca2 is required for embryonic cellular proliferation in the mouse.Preprint

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Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9

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Evidence for at Least Eight Fanconi Anemia Genes

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Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions

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Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining

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Fanconi's anemia and malignancies

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Fanconi anemia and DNA repair

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Moderate frequency of BRCA1 and BRCA2 germ-line mutations in Scandinavian familial breast cancer.

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A polymorphic stop codon in BRCA2

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Complementation Analysis in Fanconi Anemia: Assignment of the Reference FA-H Patient to Group A

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Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene.

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Reassessment of Cancer Predisposition of Fanconi Anemia Heterozygotes 2 3

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Studies of gene transfer and reversion to mitomycin C resistance in Fanconi anemia cells

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Hepatocyte-mediated SCE induction by indirect mutagens: Importance of hepatocyte density and cell-to-cell contact

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Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

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Cell-cycle checkpoints and cancer

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ATM and related protein kinases: safeguarding genome integrity

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Germline Mutations in Predisposition Genes in Pediatric Cancer

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BRCA1 and BRCA2: 1994 and beyond

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Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

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Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2

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The Fanconi anaemia/BRCA pathway

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Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

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Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

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Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

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Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

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Therapeutic opportunities within the DNA damage response

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The emerging landscape of breast cancer susceptibility

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Ten Genes for Inherited Breast Cancer

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Fanconi anemia is associated with a defect in the BRCA2 partner PALB2

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A Systematic Genetic Assessment of 1,433 Sequence Variants of Unknown Clinical Significance in the BRCA1 and BRCA2 Breast Cancer–Predisposition Genes

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Recombinational DNA repair and human disease

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BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ

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Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

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The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia

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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

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The FANCJ/MutLα interaction is required for correction of the cross‐link response in FA‐J cells

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BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

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Mechanisms of interstrand DNA crosslink repair and human disorders

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Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair

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Pathways for repairing and tolerating the spectrum of oxidative DNA lesions

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A Novel Breast Cancer–Associated <i>BRIP1</i> ( <i>FANCJ/BACH1</i> ) Germ-line Mutation Impairs Protein Stability and Function

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Hereditary Breast Cancer and the BRCA1-Associated FANCJ/BACH1/BRIP1

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DNA double-strand breaks: Their production, recognition, and repair in eukaryotes

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Inheritance of deleterious mutations at both BRCA1 and BRCA2 in an international sample of 32, 295 women

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DNA repair mechanisms protect our genome from carcinogenesis

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Hereditary breast cancer: From molecular pathology to tailored therapies

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Efficient DNA interstrand crosslinking by 6-thioguanine and UVA radiation

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Dominant versus recessive: Molecular mechanisms in metabolic disease

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Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair

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The Fanconi anemia genes

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Identification of two complementation groups in Fanconi anemia

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Evidence for at Least Eight Fanconi Anemia Genes

Joenje, H., Oostra, A. B., Wijker, M., di Summa, F. M., van Berkel, C. G. M., Rooimans, M. A., Ebell, W., van Weel, M., Pronk, J. C., Buchwald, M., et al. (1997) · The American Journal of Human Genetics · doi:10.1086/514881 · Cited by 267 · see citing works

Classification of Fanconi anemia patients by complementation analysis: evidence for a fifth genetic subtype

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Complementation group assignments in fanconi anemia fibroblast cell lines from North America

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