Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2
Open accessAbstract
BRCA2 mutations predispose carriers to breast and ovarian cancer and can also cause other cancers and Fanconi anemia. BRCA2 acts as a "caretaker" of genome integrity by enabling homologous recombination (HR)-based, error-free DNA double-strand break repair (DSBR) and intra-S phase DNA damage checkpoint control. Described here is the identification of PALB2, a BRCA2 binding protein. PALB2 colocalizes with BRCA2 in nuclear foci, promotes its localization and stability in key nuclear structures (e.g., chromatin and nuclear matrix), and enables its recombinational repair and checkpoint functions. In addition, multiple, germline BRCA2 missense mutations identified in breast cancer patients but of heretofore unknown biological/clinical consequence appear to disrupt PALB2 binding and disable BRCA2 HR/DSBR function. Thus, PALB2 licenses key cellular biochemical properties of BRCA2 and ensures its tumor suppression function.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The DR-U2OS cell line used in the study carries one integrated copy of the DR-GFP reporter.
“The DR-U2OS cell line containing a single integrated copy of the DR-GFP reporter was used46,47.”
From BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing (2017) · cites this paper as [47]
Cites
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683 · see citing works
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature · doi:10.1038/nature03443 · Cited by 5,198 · see citing works
Ford, D., Easton, D., Stratton, M. R., Narod, S., Goldgar, D., Devilee, P., Bishop, D., Weber, B., Lenoir, G., Chang-Claude, J., et al. (1998) · American Journal of Human Genetics · doi:10.1086/301749 · Cited by 2,766 · see citing works
Debnath, J., Muthuswamy, S. K., & Brugge, J. S. (2003) · Methods · doi:10.1016/s1046-2023(03)00032-x · Cited by 2,001 · see citing works
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713 · see citing works
Biallelic Inactivation of <i>BRCA2</i> in Fanconi Anemia
Howlett, N. G., Taniguchi, T., Olson, S., Cox, B., Waisfisz, Q., de Die-Smulders, C., Persky, N., Grompe, M., Joenje, H., Pals, G., et al. (2002) · Science · doi:10.1126/science.1073834 · Cited by 1,149 · see citing works
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,071 · see citing works
BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks
Moynahan, M. E., Pierce, A. J., & Jasin, M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00174-5 · Cited by 1,007 · see citing works
Self-citationMolecular views of recombination proteins and their control
West, S. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1127 · Cited by 947 · see citing works
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
Scully, R., Chen, J., Ochs, R. L., Keegan, K., Hoekstra, M., Feunteun, J., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80503-6 · Cited by 900 · see citing works
Self-citationGroisman, R., Polanowska, J., Kuraoka, I., Sawada, J.-I., Saijo, M., Drapkin, R., Kisselev, A. F., Tanaka, K., & Nakatani, Y. (2003) · Cell · doi:10.1016/s0092-8674(03)00316-7 · Cited by 739 · see citing works
Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein
Davies, A. A., Masson, J., McIlwraith, M. J., Stasiak, A. Z., Stasiak, A., Venkitaraman, A. R., & West, S. C. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00175-7 · Cited by 720 · see citing works
BRCA2 Function in DNA Binding and Recombination from a BRCA2-DSS1-ssDNA Structure
Yang, H., Jeffrey, P. D., Miller, J. J., Kinnucan, E., Sun, Y., Thomä, N. H., Zheng, N., Chen, P., Lee, W., & Pavletich, N. P. (2002) · Science · doi:10.1126/science.297.5588.1837 · Cited by 705 · see citing works
Insights into DNA recombination from the structure of a RAD51–BRCA2 complex
Pellegrini, L., Yu, D. S., Lo, T., Anand, S., Lee, M., Blundell, T. L., & Venkitaraman, A. R. (2002) · Nature · doi:10.1038/nature01230 · Cited by 704 · see citing works
BRCA1 and BRCA2 and the genetics of breast and ovarian cancer
Welcsh, P. L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.7.705 · Cited by 648 · see citing works
Chen, J., Silver, D. P., Walpita, D., Cantor, S. B., Gazdar, A. F., Tomlinson, G. E., Couch, F. J., Weber, B. L., Ashley, T., Livingston, D. M., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80276-2 · Cited by 635 · see citing works
Self-citationInvolvement of Brca2 in DNA Repair
Patel, K. J., Yu, V. P. C. C., Lee, H., Corcoran, A. E., Thistlethwaite, F. C., Evans, M. J., Colledge, W. H., Friedman, L. S., Ponder, B. A. J., & Venkitaraman, A. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80035-0 · Cited by 631 · see citing works
Wooster, R., & Weber, B. (2003) · New England Journal of Medicine · doi:10.1056/nejmra012284 · Cited by 600 · see citing works
Wong, A. K. C., Pero, R. S., Ormonde, P. A., Tavtigian, S. V., & Bartel, P. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.31941 · Cited by 539 · see citing works
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
Esashi, F., Christ, N., Gannon, J., Liu, Y., Hunt, T., Jasin, M., & West, S. C. (2005) · Nature · doi:10.1038/nature03404 · Cited by 473 · see citing works
Self-citationEMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer
Hughes‐Davies, L., Huntsman, D. D., Ruas, M., Fuks, F., Bye, J. M., Chin, S., Milner, J., Brown, L. A., Hsu, F. D., Gilks, C. B., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00930-9 · Cited by 422 · see citing works
BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo.
Yuan, S. F., Lee, S. Y., Chen, G., Song, M., Tomlinson, G. E., & Lee, E. Y.-H. P. (1999) · PubMed · Cited by 409 · see citing works
Chen, P., Chen, C., Chen, Y., Xiao, J., Sharp, Z. D., & Lee, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5287 · Cited by 394 · see citing works
Molecular pathogenesis of Fanconi anemia: recent progress
Taniguchi, T., & D’Andrea, A. D. (2006) · Blood · doi:10.1182/blood-2005-10-4240 · Cited by 387 · see citing works
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair
Nakanishi, K., Yang, Y.-G., Pierce, A. J., Taniguchi, T., Digweed, M., D'Andrea, A. D., Wang, Z.-Q., & Jasin, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407796102 · Cited by 384 · see citing works
Self-citationBRCA2 germline mutations in male breast cancer cases and breast cancer families
Couch, F. J., Farid, L. M., DeShano, M. L., Tavtigian, S. V., Calzone, K., Campeau, L., Peng, Y., Bogden, B., Chen, Q., Neuhausen, S. L., et al. (1996) · Nature Genetics · doi:10.1038/ng0596-123 · Cited by 362 · see citing works
Self-citationThe BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA–ssDNA junction
Yang, H., Li, Q., Fan, J., Holloman, W. K., & Pavletich, N. P. (2005) · Nature · doi:10.1038/nature03234 · Cited by 335 · see citing works
Functional Interaction of Monoubiquitinated FANCD2 and BRCA2/FANCD1 in Chromatin
Wang, X., Andreassen, P. R., & D’Andrea, A. D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5850-5862.2004 · Cited by 332 · see citing works
Tutt, A. N. J., Gabriel, A., Bertwistle, D., Connor, F., Paterson, H., Peacock, J., Ross, G., & Ashworth, A. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80479-5 · Cited by 321 · see citing works
Yu, V. P. C. C., Koehler, M., Steinlein, C., Schmid, M., Hanakahi, L. A., van Gool, A. J., West, S. C., & Venkitaraman, A. R. (2000) · Genes & Development · doi:10.1101/gad.14.11.1400 · Cited by 321 · see citing works
Abnormal Cytokinesis in Cells Deficient in the Breast Cancer Susceptibility Protein BRCA2
Daniels, M. J., Wang, Y., Lee, M.-Y., et al. (2004) · Science · doi:10.1126/science.1102574 · Cited by 319 · see citing works
Immunoaffinity Purification of Mammalian Protein Complexes
Nakatani, Y., & Ogryzko, V. V. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)70037-8 · Cited by 285 · see citing works
der Zwet, M. K.-V., Overkamp, W. J., van Lange, R. E. E., Essers, J., van Duijn-Goedhart, A., Wiggers, I., Swaminathan, S., van Buul, P. V., Errami, A., Tan, R., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.2.669-679.2002 · Cited by 267 · see citing works
Xia, F., Taghian, D. G., DeFrank, J. S., Zeng, Z., Willers, H., Iliakis, G. E., & Powell, S. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151253498 · Cited by 263 · see citing works
Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility proteinPreprint
Lomonosov, M., Anand, S., Sangrithi, M. N., Davies, R. C., & Venkitaraman, A. R. (2003) · Genes & Development · doi:10.1101/gad.279003 · Cited by 256 · see citing works
Transcriptional activation functions in BRCA2
Milner, J., Ponder, B. A. J., Hughes‐Davies, L., Seltmann, M., & Kouzarides, T. (1997) · Nature · doi:10.1038/386772a0 · Cited by 211 · see citing works
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways
Hussain, S. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh135 · Cited by 207 · see citing works
BRCA2-dependent and independent formation of RAD51 nuclear foci
Tarsounas, M., Davies, D. C., & West, S. C. (2003) · Oncogene · doi:10.1038/sj.onc.1206263 · Cited by 205 · see citing works
Marston, N. J., Richards, W. J., Hughes, D. A., Bertwistle, D., Marshall, C. J., & Ashworth, A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4633 · Cited by 186 · see citing works
Wu, W. K. K., Wong, H. P. S., Luo, S. W., Chan, K., Huang, F. Y., Hui, M. K. C., Lam, E. K. Y., Shin, V. Y., Ye, Y. N., Yang, Y. H., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0205 · Cited by 183 · see citing works
Modifiers of risk of hereditary breast and ovarian cancer
Narod, S. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc726 · Cited by 179 · see citing works
Risk factors for pancreatic cancer
Lowenfels, A. B., & Maisonneuve, P. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20461 · Cited by 175 · see citing works
Truncated BRCA2 is cytoplasmic: Implications for cancer-linked mutations
Spain, B. H., Larson, C. J., Shihabuddin, L. S., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13920 · Cited by 169 · see citing works
Targeting the DNA repair defect of BRCA tumours
Turner, N. C., Tutt, A. N. J., & Ashworth, A. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.03.006 · Cited by 162 · see citing works
Schoenfeld, A. R., Apgar, S., Dolios, G., Wang, R., & Aaronson, S. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.17.7444-7455.2004 · Cited by 157 · see citing works
Marmorstein, L. Y., Kinev, A. V., Chan, G. K. T., Bochar, D. A., Beniya, H., Epstein, J. A., Yen, T. J., & Shiekhattar, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00209-4 · Cited by 147 · see citing works
Dynamic Control of Rad51 Recombinase by Self-Association and Interaction with BRCA2
Yu, D. S., Sonoda, E., Takeda, S., Huang, C. L.-H., Pellegrini, L., Blundell, T. L., & Venkitaraman, A. R. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00394-0 · Cited by 126 · see citing works
Functional Evaluation and Cancer Risk Assessment of BRCA2 Unclassified Variants
Wu, K., Hinson, S. R., Ohashi, A., Farrugia, D. J., Wendt, P., Tavtigian, S. V., Deffenbaugh, A. M., Goldgar, D. E., & Couch, F. J. (2005) · Cancer Research · doi:10.1158/0008-5472.417.65.2 · Cited by 122 · see citing works
Self-citationDirect interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1
Hussain, S. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg266 · Cited by 116 · see citing works
Prostate cancer susceptibility genes: lessons learned and challenges posed.
Simard, J., Dumont, M., Labuda, D., Sinnett, D., Meloche, C., El-Alfy, M., Berger, L., Lees, E., Labrie, F., & Tavtigian, S. (2003) · Endocrine-Related Cancer · doi:10.1677/erc.0.0100225 · Cited by 110 · see citing works
BRCA2 associates with acetyltransferase activity when bound to P/CAF
Fuks, F., Milner, J., & Kouzarides, T. (1998) · Oncogene · doi:10.1038/sj.onc.1202475 · Cited by 107 · see citing works
Lee, M.-Y., Daniels, M. J., & Venkitaraman, A. R. (2003) · Oncogene · doi:10.1038/sj.onc.1207223 · Cited by 93 · see citing works
Nordling, M., Karlsson, P., Wahlström, J., Engwall, Y., Wallgren, A., & Martinsson, T. (1998) · PubMed · Cited by 93 · see citing works
Lu, H., Guo, X., Meng, X., Liu, J., Allen, C., Wray, J. W., Nickoloff, J. A., & Shen, Z. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1949-1957.2005 · Cited by 86 · see citing works
BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription
Shin, S., & Verma, I. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1132020100 · Cited by 81 · see citing works
BRCA1 and BRCA2 as ovarian cancer susceptibility genes
Sowter, H., & Ashworth, A. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi136 · Cited by 71 · see citing works
Dynamics of DNA repair suggested by the subcellular localization of Brca1 and Brca2 proteins
Huber, L. J., & Chodosh, L. A. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20517 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075 · see citing works
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
Polo, S. E., & Jackson, S. P. (2011) · Genes & Development · doi:10.1101/gad.2021311 · Cited by 1,092 · see citing works
Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins
Prakash, R., Zhang, Y., Feng, W., & Jasin, M. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016600 · Cited by 869 · see citing works
Self-citationExomic Sequencing Identifies <i>PALB2</i> as a Pancreatic Cancer Susceptibility Gene
Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C.-H., Palmisano, E., Brune, K., Jaffee, E. M., et al. (2009) · Science · doi:10.1126/science.1171202 · Cited by 826 · see citing works
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins
Wang, W. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2159 · Cited by 663 · see citing works
Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer
Reid, S., Schindler, D., Hanenberg, H., Barker, K., Hanks, S., Kalb, R., Neveling, K., Kelly, P., Seal, S., Freund, M., et al. (2007) · Nature Genetics · doi:10.1038/ng1947 · Cited by 642 · see citing works
The emerging landscape of breast cancer susceptibility
Stratton, M. R., & Rahman, N. (2008) · Nature Genetics · doi:10.1038/ng.2007.53 · Cited by 487 · see citing works
Ten Genes for Inherited Breast Cancer
Walsh, T., & King, M.-C. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.010 · Cited by 477 · see citing works
RETRACTED ARTICLE: A mechanism for the suppression of homologous recombination in G1 cells
Orthwein, A., Noordermeer, S. M., Wilson, M. D., Landry, S., Enchev, R. I., Sherker, A., Munro, M., Pinder, J., Salsman, J., Dellaire, G., et al. (2015) · Nature · doi:10.1038/nature16142 · Cited by 471 · see citing works
Self-citationRetractedFanconi anemia is associated with a defect in the BRCA2 partner PALB2
Xia, B., Dorsman, J. C., Ameziane, N., de Vries, Y., Rooimans, M. A., Sheng, Q., Pals, G., Errami, A., Gluckman, E., Llera, J., et al. (2007) · Nature Genetics · doi:10.1038/ng1942 · Cited by 465 · see citing works
Self-citationAdamson, B., Smogorzewska, A., Sigoillot, F. D., King, R. W., & Elledge, S. J. (2012) · Nature Cell Biology · doi:10.1038/ncb2426 · Cited by 433 · see citing works
DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing
Xue, C., & Greene, E. C. (2021) · Trends in Genetics · doi:10.1016/j.tig.2021.02.008 · Cited by 431 · see citing works
BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing
Zhao, W., Steinfeld, J. B., Liang, F., Chen, X., Maranon, D. G., Jian Ma, C., Kwon, Y., Rao, T., Wang, W., Sheng, C., et al. (2017) · Nature · doi:10.1038/nature24060 · Cited by 393 · see citing works
Hereditary breast and ovarian cancer: new genes in confined pathways
Nielsen, F. C., van Overeem Hansen, T., & Sørensen, C. S. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.72 · Cited by 367 · see citing works
Thompson, L. H. (2012) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2012.06.002 · Cited by 357 · see citing works
Collaboration and competition between DNA double‐strand break repair pathways
Kass, E. M., & Jasin, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.07.057 · Cited by 326 · see citing works
Self-citationWD40 repeat domain proteins: a novel target class?
Schapira, M., Tyers, M., Torrent, M., & Arrowsmith, C. H. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.179 · Cited by 335 · see citing works
BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study
Zhen, D. B., Rabe, K. G., Gallinger, S., Syngal, S., Schwartz, A. G., Goggins, M. G., Hruban, R. H., Cote, M. L., McWilliams, R. R., Roberts, N. J., et al. (2015) · Genetics in Medicine · doi:10.1038/gim.2014.153 · Cited by 295 · see citing works
The role of BRCA1 in DNA damage response
Wu, J., Lu, L.-Y., & Yu, X. (2010) · Protein & Cell · doi:10.1007/s13238-010-0010-5 · Cited by 235 · see citing works
Self-citationBOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks
Higgs, M. R., Reynolds, J. J., Winczura, A., Blackford, A. N., Borel, V., Miller, E. S., Zlatanou, A., Nieminuszczy, J., Ryan, E. L., Davies, N. J., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.007 · Cited by 194 · see citing works
Synthetic lethality of PARP inhibition in cancers lacking<i>BRCA1</i>and<i>BRCA2</i>mutations
Dedes, K. J., Wilkerson, P. M., Wetterskog, D., Weigelt, B., Ashworth, A., & Reis-Filho, J. S. (2011) · Cell Cycle · doi:10.4161/cc.10.8.15273 · Cited by 191 · see citing works
Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry
Zhao, W., Vaithiyalingam, S., San Filippo, J., Maranon, D. G., Jimenez-Sainz, J., Fontenay, G. V., Kwon, Y., Leung, S. G., Lu, L., Jensen, R. B., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.032 · Cited by 177 · see citing works
Mechanisms of BRCA1 Tumor Suppression
Silver, D. P., & Livingston, D. M. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0221 · Cited by 159 · see citing works
Self-citationPark, J.-Y., Singh, T. R., Nassar, N., Zhang, F., Freund, M., Hanenberg, H., Meetei, A. R., & Andreassen, P. R. (2014) · Oncogene · doi:10.1038/onc.2013.421 · Cited by 130 · see citing works
The role of BRCA1 in DNA double-strand repair: Past and present
Caestecker, K. W., & Van de Walle, G. R. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.11.013 · Cited by 108 · see citing works
BRCA1 tumor suppressor network: focusing on its tail
Wang, B. (2012) · Cell & Bioscience · doi:10.1186/2045-3701-2-6 · Cited by 78 · see citing works
Computed cancer interactome explains the effects of somatic mutations in cancers
Zhang, J., Pei, J., Durham, J., Bos, T., & Cong, Q. (2022) · Protein Science · doi:10.1002/pro.4479 · Cited by 31 · see citing works
- Authors
- Xia, B., Sheng, Q., Nakanishi, K., Ohashi, A., Wu, J., Christ, N., Liu, X., Jasin, M., Couch, F. J., & Livingston, D. M.
- Affiliations
- Harvard University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Mayo Clinic (US)
- Corresponding author
- Livingston, David M.
- ORCID
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 22
- Issue
- 6
- Pages
- 719-729
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2034702779
- Cited by
- 861
- References
- 57
- Citations by year
- 2026: 18 · 2025: 34 · 2024: 41 · 2023: 55 · 2022: 46 · 2021: 58 · 2020: 46 · 2019: 56 · 2018: 45 · 2017: 45 · 2016: 51 · 2015: 38 · 2014: 43 · 2013: 45 · 2012: 31
- FWCI
- 15.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute
- Human Frontier Science Program
- California Breast Cancer Research Program
- Novartis
- Breast Cancer Research Foundation
- Medical Research and Materiel Command
- National Institutes of Health
- American Cancer Society
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- BRCA2, PALB2, homologous recombination, DNA double-strand break repair, S-phase checkpoint, genome stability, tumor suppression, breast cancer, ovarian cancer, Fanconi anemia, protein-protein interaction, nuclear foci, chromatin, nuclear matrix
- MeSH terms
- Fanconi Anemia Complementation Group N Protein, Breast Neoplasms, Chromatin, DNA Damage, DNA Repair, Female, HeLa Cells, Humans, Nuclear Proteins, Ovarian Neoplasms, Protein Binding, Recombination, Genetic, Nuclear Matrix, S Phase, Germ-Line Mutation, Genetic Predisposition to Disease, Mutation, Missense, BRCA2 Protein, Tumor Suppressor Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review