The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The multiple lives of NMD factors: balancing roles in gene and genome regulation
Open accessAbstract
Nonsense-mediated mRNA decay (NMD) largely functions to ensure the quality of gene expression. However, NMD is also crucial to regulating appropriate expression levels for certain genes and for maintaining genome stability. Furthermore, just as NMD serves cells in multiple ways, so do its constituent proteins. Recent studies have clarified that UPF and SMG proteins, which were originally discovered to function in NMD, also have roles in other pathways, including specialized pathways of mRNA decay, DNA synthesis and cell-cycle progression, and the maintenance of telomeres. These findings suggest a delicate balance of metabolic events — some not obviously related to NMD — that can be influenced by the cellular abundance, location and activity of NMD factors and their binding partners.
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Cites
ATM and related protein kinases: safeguarding genome integrity
Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395
RNA regulons: coordination of post-transcriptional events
Keene, J. D. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2111 · Cited by 1,321
Cited by
Functional consequences of developmentally regulated alternative splicing
Kalsotra, A., & Cooper, T. A. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3052 · Cited by 729
NMD: a multifaceted response to premature translational termination
Kervestin, S., & Jacobson, A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3454 · Cited by 572
Yap, K., Lim, Z. Q., Khandelia, P., Friedman, B., & Makeyev, E. V. (2012) · Genes & Development · doi:10.1101/gad.188037.112 · Cited by 286
Ezkurdia, I., del Pozo, A., Frankish, A., Rodriguez, J. M., Harrow, J., Ashman, K., Valencia, A., & Tress, M. L. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss100 · Cited by 89
Preventing Dangerous Nonsense: Selection for Robustness to Transcriptional Error in Human Genes
Cusack, B. P., Arndt, P. F., Duret, L., & Crollius, H. R. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002276 · Cited by 46
Metadata
- Authors
- Isken, O., & Maquat, L. E.
- Venue
- Nature Reviews Genetics
- Published
- 2008-09
- Volume
- 9
- Issue
- 9
- Pages
- 699-712
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2072590456
- Cited by
- 305
- References
- 3
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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