Nutrigenetics of cholesterol metabolism: observational and dietary intervention studies in the postgenomic era
Abstract
Cholesterol metabolism is a well-defined responder to dietary intakes and a classic biomarker of cardiovascular health. For this reason, circulating cholesterol levels have become key in shaping nutritional recommendations by health authorities worldwide for better management of cardiovascular disease, a leading cause of mortality and one of the most costly health problems globally. Data from observational and dietary intervention studies, however, highlight a marked between-individual variability in the response of cholesterol metabolism to similar dietary protocols, a phenomenon linked to genetic heterogeneity. This review summarizes the postgenomic evidence of polymorphisms within cholesterol-associated genes relative to fasting circulating cholesterol levels under diverse nutritional conditions. A number of cholesterol-related gene-diet interactions are confirmed, which may have clinical importance, supporting a deeper look into the rapidly emerging field of nutrigenetics for meaningful conclusions that may eventually lead to genetically targeted dietary recommendations in the era of personalized nutrition.
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Candidate gene approaches have identified several potential gene-diet interactions for traits including blood cholesterol levels.
“While candidate genes approaches have identified several potential gene-diet interactions for traits including blood cholesterol levels, a major challenge has been lack of replication.74-77”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [76]
A major challenge for candidate gene approaches has been lack of replication.
“While candidate genes approaches have identified several potential gene-diet interactions for traits including blood cholesterol levels, a major challenge has been lack of replication.74-77”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [76]
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Flagged first, then by citations
Cited by
Sorted by citations
Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216 · see citing works
Dietary vitamin C in human health
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Self-citation
- Authors
- Abdullah, M. M. H., Jones, P. J. H., & Eck, P. K.
- Affiliations
- University of Manitoba (CA)
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-06-27
- Volume
- 73
- Issue
- 8
- Pages
- 523-543
- ISSN
- 0029-6643 (ISSN-L)
- 1753-4887
- OpenAlex
- W2259402803
- Cited by
- 47
- References
- 114
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 1 · 2016: 7 · 2015: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- nutrigenetics, cholesterol metabolism, circulating cholesterol, gene-diet interaction, genetic polymorphism, cardiovascular disease, personalized nutrition, dietary intervention, interindividual variability, cardiovascular risk markers
- MeSH terms
- Cholesterol, Diet, Feeding Behavior, Humans, Nutritional Status, Polymorphism, Genetic, Lipid Metabolism, Nutrigenomics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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