Cited by 47Nutrition, Genetics, and DiseaseGenetic Associations and EpidemiologyParaoxonase enzyme and polymorphisms

Nutrigenetics of cholesterol metabolism: observational and dietary intervention studies in the postgenomic era

Abdullah, Mohammad M.H., Jones, Peter J.H., Eck, Peter K.·2015·Nutrition Reviews

Abstract

Cholesterol metabolism is a well-defined responder to dietary intakes and a classic biomarker of cardiovascular health. For this reason, circulating cholesterol levels have become key in shaping nutritional recommendations by health authorities worldwide for better management of cardiovascular disease, a leading cause of mortality and one of the most costly health problems globally. Data from observational and dietary intervention studies, however, highlight a marked between-individual variability in the response of cholesterol metabolism to similar dietary protocols, a phenomenon linked to genetic heterogeneity. This review summarizes the postgenomic evidence of polymorphisms within cholesterol-associated genes relative to fasting circulating cholesterol levels under diverse nutritional conditions. A number of cholesterol-related gene-diet interactions are confirmed, which may have clinical importance, supporting a deeper look into the rapidly emerging field of nutrigenetics for meaningful conclusions that may eventually lead to genetically targeted dietary recommendations in the era of personalized nutrition.

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Crossref · 10.1093/nutrit/nuv016

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Authors
Abdullah, M. M. H., Jones, P. J. H., & Eck, P. K.
Affiliations
University of Manitoba (CA)
Venue
Nutrition Reviews
Published
2015-06-27
Volume
73
Issue
8
Pages
523-543
ISSN
  • 0029-6643 (ISSN-L)
  • 1753-4887
OpenAlex
W2259402803
Cited by
47
References
114
Citations by year
2026: 4 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 1 · 2016: 7 · 2015: 1
FWCI
0.69
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords
nutrigenetics, cholesterol metabolism, circulating cholesterol, gene-diet interaction, genetic polymorphism, cardiovascular disease, personalized nutrition, dietary intervention, interindividual variability, cardiovascular risk markers
MeSH terms
Cholesterol, Diet, Feeding Behavior, Humans, Nutritional Status, Polymorphism, Genetic, Lipid Metabolism, Nutrigenomics

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