Cited by 2,267Epigenetics and DNA MethylationGenomics and Chromatin DynamicsCancer-related gene regulation

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Linking DNA methylation and histone modification: patterns and paradigms

Cedar, Howard, Bergman, Yehudit·2009·Nature Reviews Genetics

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Abstract

Both DNA methylation and histone modification are involved in establishing patterns of gene repression during development. Certain forms of histone methylation cause local formation of heterochromatin, which is readily reversible, whereas DNA methylation leads to stable long-term repression. It has recently become apparent that DNA methylation and histone modification pathways can be dependent on one another, and that this crosstalk can be mediated by biochemical interactions between SET domain histone methyltransferases and DNA methyltransferases. Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.

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“Accumulating evidence also suggests that DNA methylation and histone modification are coordinately maintained and these two pathways are dependent on one another [55,56].”
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“7) in wild-type liver, and 344 their presumed loss of activity upon hypermethylation (54, 55) is expected to contribute to the loss of 345”
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“Depending on the site of modification, histone methylation could result either inactivation or suppression of gene expression and in contrast, DNA methylation results in gene suppression (Cedar and Bergman, 2009; Rose and Klose, 2014).”
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“Together, these various modifications alter the degree of compaction and the transcriptional activity of chromatin and play a fundamental role in the determination of active euchromatin and silenced heterochromatin ( Cedar and Bergman 2009 ).”
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“Regardless, given the complex molecular mechanisms involved in G9a/GLP targeting in other contexts (Cedar and Bergman, 2009), additional investigations are needed to define the precise functions of ZNF644 and WIZ in G9a/GLP-mediated silencing during neurogenesis.”
Background
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“While histone acetylation and DNA methylation pathways can depend on each other [28].”
Background

Authors: Cedar, H., & Bergman, Y.
Affiliations: Hebrew University of Jerusalem (IL)
Corresponding author: Cedar, Howard
ORCID: Cedar, Howard
Bergman, Yehudit
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2009-05
Volume: 10
Issue: 5
Pages: 295-304
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2540
OpenAlex: W1976626368
Cited by: 2,267
References: 108
Citations by year: 2026: 50 · 2025: 68 · 2024: 87 · 2023: 90 · 2022: 107 · 2021: 135 · 2020: 130 · 2019: 119 · 2018: 131 · 2017: 165 · 2016: 169 · 2015: 183 · 2014: 169 · 2013: 163 · 2012: 184
FWCI: 12.31
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Keywords: DNA methylation, histone modifications, epigenetic crosstalk, gene repression, heterochromatin, DNA methyltransferases, chromatin structure, somatic cell reprogramming, carcinogenesis, development (biology)
MeSH terms: Histone Methyltransferases, Animals, DNA, Heterochromatin, Histones, Humans, Models, Biological, Neoplasms, Histone-Lysine N-Methyltransferase, DNA-Cytosine Methylases, DNA Methylation

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Linking DNA methylation and histone modification: patterns and paradigms

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