Cited by 2,267Epigenetics and DNA MethylationGenomics and Chromatin DynamicsCancer-related gene regulation

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Linking DNA methylation and histone modification: patterns and paradigms

Cedar, Howard, Bergman, Yehudit·2009·Nature Reviews Genetics

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Abstract

Both DNA methylation and histone modification are involved in establishing patterns of gene repression during development. Certain forms of histone methylation cause local formation of heterochromatin, which is readily reversible, whereas DNA methylation leads to stable long-term repression. It has recently become apparent that DNA methylation and histone modification pathways can be dependent on one another, and that this crosstalk can be mediated by biochemical interactions between SET domain histone methyltransferases and DNA methyltransferases. Relationships between DNA methylation and histone modification have implications for understanding normal development as well as somatic cell reprogramming and tumorigenesis.

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“Recent evidence indicates that relationships between DNA methylation and histone modification have implications for understanding mechanisms of gene repression in cancer (Cedar & Bergman, 2009).”
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“…of DNA methylation and various histone modifications, which contribute to the so-called epigenetic regulatory mechanisms of gene expression, which can in turn be influenced by environmental factors and cellular signals (Cedar and Bergman, 2009; Bräutigam et al., 2013; Kinoshita and Seki, 2014).”
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Suv39h1 Mediates AP-2α-Dependent Inhibition of C/EBPα Expression during Adipogenesis
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Down-Regulation of H3K4me3 by MM-102 Facilitates Epigenetic Reprogramming of Porcine Somatic Cell Nuclear Transfer Embryos
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Functional validation of putative tumor suppressor gene C13ORF18 in cervical cancer by Artificial Transcription Factors
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Authors: Cedar, H., & Bergman, Y.
Affiliations: Hebrew University of Jerusalem (IL)
Corresponding author: Cedar, Howard
ORCID: Cedar, Howard
Bergman, Yehudit
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2009-05
Volume: 10
Issue: 5
Pages: 295-304
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2540
OpenAlex: W1976626368
Cited by: 2,267
References: 108
Citations by year: 2026: 50 · 2025: 68 · 2024: 87 · 2023: 90 · 2022: 107 · 2021: 135 · 2020: 130 · 2019: 119 · 2018: 131 · 2017: 165 · 2016: 169 · 2015: 183 · 2014: 169 · 2013: 163 · 2012: 184
FWCI: 12.31
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Keywords: DNA methylation, histone modifications, epigenetic crosstalk, gene repression, heterochromatin, DNA methyltransferases, chromatin structure, somatic cell reprogramming, carcinogenesis, development (biology)
MeSH terms: Histone Methyltransferases, Animals, DNA, Heterochromatin, Histones, Humans, Models, Biological, Neoplasms, Histone-Lysine N-Methyltransferase, DNA-Cytosine Methylases, DNA Methylation

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Linking DNA methylation and histone modification: patterns and paradigms

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