The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Next-generation genomics: an integrative approach
Open accessAbstract
Integrating results from diverse experiments is an essential process in our effort to understand the logic of complex systems, such as development, homeostasis and responses to the environment. With the advent of high-throughput methods — including genome-wide association (GWA) studies, chromatin immunoprecipitation followed by sequencing (ChIP–seq) and RNA sequencing (RNA–seq) — acquisition of genome-scale data has never been easier. Epigenomics, transcriptomics, proteomics and genomics each provide an insightful, and yet one-dimensional, view of genome function; integrative analysis promises a unified, global view. However, the large amount of information and diverse technology platforms pose multiple challenges for data access and processing. This Review discusses emerging issues and strategies related to data integration in the era of next-generation genomics.
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Chromatin modifications and their function
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Human DNA methylomes at base resolution show widespread epigenomic differences
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PPARγ signaling and metabolism: the good, the bad and the future
Ahmadian, M., Suh, J. M., Hah, N., Liddle, C., Atkins, A. R., Downes, M., & Evans, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3159 · Cited by 2,016
A comparative encyclopedia of DNA elements in the mouse genome
Yue, F., Cheng, Y., Breschi, A., Vierstra, J., Wu, W., Ryba, T., Sandstrom, R., Ma, Z., Davis, C., Pope, B. D., et al. (2014) · Nature · doi:10.1038/nature13992 · Cited by 1,781
Self-citationCharting histone modifications and the functional organization of mammalian genomes
Zhou, V. W., Goren, A., & Bernstein, B. E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2905 · Cited by 1,147
Methods of integrating data to uncover genotype-phenotype interactions
Ritchie, M. D., Holzinger, E. R., Li, R., Pendergrass, S. A., & Kim, D. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3868 · Cited by 1,085
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Metadata
- Authors
- Hawkins, R. D., Hon, G. C., & Ren, B.
- Venue
- Nature Reviews Genetics
- Published
- 2010-06-08
- Volume
- 11
- Issue
- 7
- Pages
- 476-486
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2078370799
- Cited by
- 593
- References
- 40
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- green
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