Charting histone modifications and the functional organization of mammalian genomes
Abstract
A succession of technological advances over the past decade have enabled researchers to chart maps of histone modifications and related chromatin structures with increasing accuracy, comprehensiveness and throughput. The resulting data sets highlight the interplay between chromatin and genome function, dynamic variations in chromatin structure across cellular conditions, and emerging roles for large-scale domains and higher-ordered chromatin organization. Here we review a selection of recent studies that have probed histone modifications and successive layers of chromatin structure in mammalian genomes, the patterns that have been identified and future directions for research.
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Important strides have been made in single-cell DNA sequencing as well as in analysis of copy-number variations (CNVs) and point mutations from single-cell DNA data.
“While our focus has been on single-cell transcriptomics, important strides have also been made in single-cell DNA sequencing77,194 as well as in analysis of copy-number variations (CNVs)11 and point mutations15,195 from single-cell DNA data.”
From Revealing the vectors of cellular identity with single-cell genomics (2016) · cites this paper as [194]
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- Authors
- Zhou, V. W., Goren, A., & Bernstein, B. E.
- Affiliations
- Howard Hughes Medical Institute (US)
- Broad Institute (US)
- Corresponding author
- Bernstein, Bradley E.
- Venue
- Nature Reviews Genetics
- Published
- 2010-11-30
- Volume
- 12
- Issue
- 1
- Pages
- 7-18
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W1992213480
- Cited by
- 1,147
- References
- 117
- Citations by year
- 2026: 34 · 2025: 32 · 2024: 34 · 2023: 40 · 2022: 49 · 2021: 68 · 2020: 68 · 2019: 72 · 2018: 70 · 2017: 85 · 2016: 109 · 2015: 123 · 2014: 108 · 2013: 117 · 2012: 86
- FWCI
- 7.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- histone modifications, chromatin structure, chromatin domains, higher-order chromatin organization, regulatory elements, gene structure, chromatin accessibility, epigenetics
- MeSH terms
- Animals, Chromatin, Histones, Humans, Protein Processing, Post-Translational, Regulatory Sequences, Nucleic Acid, Genome, Mice
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