Genomic imprinting and parent-of-origin effects on complex traits
Open accessAbstract
Parent-of-origin effects occur when the phenotypic effect of an allele depends on whether it is inherited from the mother or the father. Several phenomena can cause parent-of-origin effects, but the best characterized is parent-of-origin-dependent gene expression associated with genomic imprinting. The development of new mapping approaches applied to the growing abundance of genomic data has demonstrated that imprinted genes can be important contributors to complex trait variation. Therefore, to understand the genetic architecture and evolution of complex traits, including complex diseases and traits of agricultural importance, it is crucial to account for these parent-of-origin effects. Here, we discuss patterns of phenotypic variation associated with imprinting, evidence supporting its role in complex trait variation and approaches for identifying its molecular signatures.
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Genomic imprinting patterns can have major effects on the embryonic phenotype.
“Genomic imprinting patterns can have major effects on the embryonic phenotype 192,193”
From Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms (2018) · cites this paper as [192]
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- Authors
- Lawson, H. A., Cheverud, J. M., & Wolf, J. B.
- Affiliations
- Washington University in St. Louis (US)
- Loyola University Chicago (US)
- University of Bath (GB)
- Corresponding author
- Wolf, Jason B.
- Venue
- Nature Reviews Genetics
- Published
- 2013-08-06
- Volume
- 14
- Issue
- 9
- Pages
- 609-617
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC3926806
- OpenAlex
- W2005122856
- Cited by
- 262
- References
- 83
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- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
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- PubMed Central (acceptedVersion)
- The University of Bath Online Publications Store (The University of Bath) (submittedVersion)
- Pure (University of Bath) (submittedVersion, other-oa)
- Funders
- National Institutes of Health
- Biotechnology and Biological Sciences Research Council (BB/C516936/1)
- National Institute of Diabetes and Digestive and Kidney Diseases (K01DK095003, P30DK056341)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- genomic imprinting, parent-of-origin effects, complex traits, imprinted genes, genetic architecture, complex diseases, agronomic traits, gene mapping
- MeSH terms
- Alleles, Epistasis, Genetic, Humans, Models, Genetic, Phenotype, Genomic Imprinting, Quantitative Trait, Heritable, Multifactorial Inheritance, Quantitative Trait Loci
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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