Cited by 113Epigenetics and DNA MethylationBirth, Development, and HealthEffects and risks of endocrine disrupting chemicals

Minireview: transgenerational epigenetic inheritance: focus on endocrine disrupting compounds

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Rissman, Emilie F., Adli, Mazhar·2014·Endocrinology

Abstract

The idea that what we eat, feel, and experience influences our physical and mental state and can be transmitted to our offspring and even to subsequent generations has been in the popular realm for a long time. In addition to classic gene mutations, we now recognize that some mechanisms for inheritance do not require changes in DNA. The field of epigenetics has provided a new appreciation for the variety of ways biological traits can be transmitted to subsequent generations. Thus, transgenerational epigenetic inheritance has emerged as a new area of research. We have four goals for this minireview. First, we describe the topic and some of the nomenclature used in the literature. Second, we explain the major epigenetic mechanisms implicated in transgenerational inheritance. Next, we examine some of the best examples of transgenerational epigenetic inheritance, with an emphasis on those produced by exposing the parental generation to endocrine-disrupting compounds (EDCs). Finally, we discuss how whole-genome profiling approaches can be used to identify aberrant epigenomic features and gain insight into the mechanism of EDC-mediated transgenerational epigenetic inheritance. Our goal is to educate readers about the range of possible epigenetic mechanisms that exist and encourage researchers to think broadly and apply multiple genomic and epigenomic technologies to their work.

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  • BPA alters AVP and OT neuron numbers and innervation of sexually dimorphic regions associated with social and aggressive behaviors in multiple species, and is anxiogenic in multiple species.

    “Altered AVP and OT neuron numbers and innervation of sexually dimorphic regions associated with social and aggressive behaviors in multiple species; anxiogenic in multiple species”

    From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [63]

    The ‘EDCs and Transgenerational Epigenetic Inheritance’ section reports BPA-related changes in social interaction in mice, but does not address AVP or OT neuron numbers, innervation, aggression, or anxiogenic effects across species. Its discussion of anxiety-like behavior concerns vinclozolin, not BPA (pages unavailable in our copy). Searches for AVP/OT innervation and BPA-related anxiety found no passage establishing the attributed claim. (LLM, conf=0.76)

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Research works printed but not linked: 1

  1. Berger SL, Kouzarides T, Shiekhattar R, Shilatifard A. An opera- tional definition of epigenetics. Genes Dev. 2009;23:781-783.

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Authors
Rissman, E. F., & Adli, M.
Affiliations
University of Virginia (US)
Corresponding author
Adli, Mazhar
Venue
Endocrinology
Published
2014-08-01
Volume
155
Issue
8
Pages
2770-2780
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
OpenAlex
W2139340966
Cited by
113
References
126
Citations by year
2026: 2 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 16 · 2019: 13 · 2018: 9 · 2017: 11 · 2016: 13 · 2015: 14
FWCI
1.19
Type
journal article
Language
en
Open access
Locations
  • Endocrinology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Environmental Health Sciences (R01ES022759)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords
transgenerational epigenetic inheritance, endocrine disruptors, epigenetic mechanisms, parental exposure, epigenetic profiling, epigenetic memory
MeSH terms
Animals, Humans, Genomics, Inheritance Patterns, Epigenesis, Genetic, Endocrine Disruptors

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