Minireview: transgenerational epigenetic inheritance: focus on endocrine disrupting compounds
Open accessAbstract
The idea that what we eat, feel, and experience influences our physical and mental state and can be transmitted to our offspring and even to subsequent generations has been in the popular realm for a long time. In addition to classic gene mutations, we now recognize that some mechanisms for inheritance do not require changes in DNA. The field of epigenetics has provided a new appreciation for the variety of ways biological traits can be transmitted to subsequent generations. Thus, transgenerational epigenetic inheritance has emerged as a new area of research. We have four goals for this minireview. First, we describe the topic and some of the nomenclature used in the literature. Second, we explain the major epigenetic mechanisms implicated in transgenerational inheritance. Next, we examine some of the best examples of transgenerational epigenetic inheritance, with an emphasis on those produced by exposing the parental generation to endocrine-disrupting compounds (EDCs). Finally, we discuss how whole-genome profiling approaches can be used to identify aberrant epigenomic features and gain insight into the mechanism of EDC-mediated transgenerational epigenetic inheritance. Our goal is to educate readers about the range of possible epigenetic mechanisms that exist and encourage researchers to think broadly and apply multiple genomic and epigenomic technologies to their work.
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BPA alters AVP and OT neuron numbers and innervation of sexually dimorphic regions associated with social and aggressive behaviors in multiple species, and is anxiogenic in multiple species.
“Altered AVP and OT neuron numbers and innervation of sexually dimorphic regions associated with social and aggressive behaviors in multiple species; anxiogenic in multiple species”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [63]
The ‘EDCs and Transgenerational Epigenetic Inheritance’ section reports BPA-related changes in social interaction in mice, but does not address AVP or OT neuron numbers, innervation, aggression, or anxiogenic effects across species. Its discussion of anxiety-like behavior concerns vinclozolin, not BPA (pages unavailable in our copy). Searches for AVP/OT innervation and BPA-related anxiety found no passage establishing the attributed claim. (LLM, conf=0.76)
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Avilès, A., & Siaussat, D. (2025) · Environmental Science and Pollution Research · doi:10.1007/s11356-025-36773-x · Cited by 2 · see citing works
Epigenomic Measurements in Brain Tissues
Satterlee, J. S. (2022) · Springer eBooks · doi:10.1007/978-3-030-88832-9_148 · Cited by 2 · see citing works
Jorge, B. C., Stein, J., Reis, A. C. C., Manoel, B. D. M., Nagaoka, L. T., & Arena, A. C. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-30089-4 · Cited by 2 · see citing works
Scandolara, T. B., Coradi, C., Valentim, J. M. B. D. M., Fagundes, T. R., Fiuza, B. S., dos Santos, C. V. P., Rodrigues, G. C., Bedin, L. L., Kern, R., Neres, E., et al. (2025) · Journal of Agromedicine · doi:10.1080/1059924x.2025.2578009 · Cited by 2 · see citing works
Transgenerational effects of imprinting
Stuppia, L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816363-4.00018-3 · Cited by 2 · see citing works
Endocrine Disrupting Chemicals Induced Childhood Obesity
Mallhi, T. H., Khokhar, A., Khan, Y. H., Alotaibi, N. H., & Khan, A. (2020) · Emerging contaminants and associated treatment technologies · doi:10.1007/978-3-030-45923-9_10 · Cited by 2 · see citing works
Environmental Epigenetics: The Envirogenomic Interface
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A Bisphenol by Any Other Name…
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Role of Pesticides as EDCs in Metabolic Disorders
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Pesticides as endocrine distruptors of the reproductive system (literature review and own research)
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Elimination of endocrine disrupting pollutants from refinery wastewater
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The Advent of Biological Evolution and Humankind
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Sexual EDC-ucation: What we Have Learned About Endocrine-Disrupting Chemicals and Reproduction
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Epigenomic Measurements in Brain Tissues
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- Authors
- Rissman, E. F., & Adli, M.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Adli, Mazhar
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2014-08-01
- Volume
- 155
- Issue
- 8
- Pages
- 2770-2780
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC4098001
- OpenAlex
- W2139340966
- Cited by
- 113
- References
- 126
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 7 · 2021: 9 · 2020: 16 · 2019: 13 · 2018: 9 · 2017: 11 · 2016: 13 · 2015: 14
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences (R01ES022759)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- transgenerational epigenetic inheritance, endocrine disruptors, epigenetic mechanisms, parental exposure, epigenetic profiling, epigenetic memory
- MeSH terms
- Animals, Humans, Genomics, Inheritance Patterns, Epigenesis, Genetic, Endocrine Disruptors
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